{"id":"https://openalex.org/W1555664508","doi":null,"title":"Gene expression and genetic association studies in eczema.","display_name":"Gene expression and genetic association studies in eczema.","publication_year":2007,"publication_date":"2007-12-28","ids":{"openalex":"https://openalex.org/W1555664508","mag":"1555664508"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26912650","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Gene_expression_and_genetic_association_studies_in_eczema/26912650","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/37927","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086324124","display_name":"Agne Lied\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Agne Lied\u00e9n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086324124"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/skin-barrier-dysfunction","display_name":"skin barrier dysfunction","score":0.9580000042915344},{"id":"https://openalex.org/keywords/filaggrin","display_name":"filaggrin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/transglutaminase-1","display_name":"transglutaminase 1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7020000219345093},{"id":"https://openalex.org/keywords/malassezia-sympodialis","display_name":"Malassezia sympodialis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5910000205039978},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.6470000147819519},{"id":"https://openalex.org/keywords/allergic-phenotype","display_name":"allergic phenotype","score":0.7760000228881836},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7310000061988831},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.8190000057220459},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.5849999785423279},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6169999837875366},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C190684412","wikidata":"https://www.wikidata.org/wiki/Q21201832","display_name":"Filaggrin","level":3,"score":0.8776510953903198},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7171598672866821},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.47980716824531555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4763505756855011},{"id":"https://openalex.org/C2777697326","wikidata":"https://www.wikidata.org/wiki/Q757678","display_name":"Atopy","level":3,"score":0.4660172760486603},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.4591270685195923},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43546047806739807},{"id":"https://openalex.org/C2779923671","wikidata":"https://www.wikidata.org/wiki/Q199602","display_name":"Itching","level":2,"score":0.42196351289749146},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.41804760694503784},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33407455682754517},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3111898899078369}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26912650","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Gene_expression_and_genetic_association_studies_in_eczema/26912650","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/37927","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/37927","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1555664508","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/handle/10616/37927/thesis.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/37927","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/37927","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":140,"referenced_works":["https://openalex.org/W67635794","https://openalex.org/W146662650","https://openalex.org/W1483876349","https://openalex.org/W1503066288","https://openalex.org/W1512518486","https://openalex.org/W1549393360","https://openalex.org/W1565787660","https://openalex.org/W1578395803","https://openalex.org/W1588744422","https://openalex.org/W1603787155","https://openalex.org/W1661544713","https://openalex.org/W1776228394","https://openalex.org/W1817337740","https://openalex.org/W1934712179","https://openalex.org/W1964916950","https://openalex.org/W1965037455","https://openalex.org/W1967455040","https://openalex.org/W1968765676","https://openalex.org/W1968787175","https://openalex.org/W1969961048","https://openalex.org/W1971214213","https://openalex.org/W1971543919","https://openalex.org/W1972857819","https://openalex.org/W1972964808","https://openalex.org/W1973705683","https://openalex.org/W1974735797","https://openalex.org/W1975579793","https://openalex.org/W1975988029","https://openalex.org/W1979416107","https://openalex.org/W1980168760","https://openalex.org/W1981481372","https://openalex.org/W1982636859","https://openalex.org/W1982906465","https://openalex.org/W1983657656","https://openalex.org/W1984366394","https://openalex.org/W1984823135","https://openalex.org/W1989539292","https://openalex.org/W1990133675","https://openalex.org/W1992137367","https://openalex.org/W1992439632","https://openalex.org/W1993612113","https://openalex.org/W1994589395","https://openalex.org/W1995106901","https://openalex.org/W1998464125","https://openalex.org/W1999639094","https://openalex.org/W2003652884","https://openalex.org/W2005630031","https://openalex.org/W2006074245","https://openalex.org/W2006970476","https://openalex.org/W2010283596","https://openalex.org/W2012278879","https://openalex.org/W2018976775","https://openalex.org/W2020186773","https://openalex.org/W2021179053","https://openalex.org/W2022235108","https://openalex.org/W2022887225","https://openalex.org/W2023430120","https://openalex.org/W2024016078","https://openalex.org/W2024739222","https://openalex.org/W2025919335","https://openalex.org/W2026125421","https://openalex.org/W2026147138","https://openalex.org/W2028562972","https://openalex.org/W2028975619","https://openalex.org/W2030046145","https://openalex.org/W2034244225","https://openalex.org/W2034950600","https://openalex.org/W2035821609","https://openalex.org/W2035831689","https://openalex.org/W2037179755","https://openalex.org/W2037735997","https://openalex.org/W2038663100","https://openalex.org/W2045296874","https://openalex.org/W2045363939","https://openalex.org/W2045723944","https://openalex.org/W2047630543","https://openalex.org/W2050518329","https://openalex.org/W2050730569","https://openalex.org/W2050751211","https://openalex.org/W2052522043","https://openalex.org/W2058035002","https://openalex.org/W2059779473","https://openalex.org/W2060773534","https://openalex.org/W2061765860","https://openalex.org/W2064105477","https://openalex.org/W2065322111","https://openalex.org/W2066224059","https://openalex.org/W2066470115","https://openalex.org/W2067929224","https://openalex.org/W2068176013","https://openalex.org/W2072241656","https://openalex.org/W2072576191","https://openalex.org/W2072982170","https://openalex.org/W2073969417","https://openalex.org/W2077009876","https://openalex.org/W2078414501","https://openalex.org/W2079282933","https://openalex.org/W2079501979","https://openalex.org/W2080167581","https://openalex.org/W2080910868","https://openalex.org/W2087512006","https://openalex.org/W2087951142","https://openalex.org/W2088152216","https://openalex.org/W2090609872","https://openalex.org/W2090640877","https://openalex.org/W2095140813","https://openalex.org/W2097901958","https://openalex.org/W2099310552","https://openalex.org/W2100399346","https://openalex.org/W2104904748","https://openalex.org/W2104999336","https://openalex.org/W2118490061","https://openalex.org/W2119279196","https://openalex.org/W2120793327","https://openalex.org/W2122485484","https://openalex.org/W2124376809","https://openalex.org/W2127230663","https://openalex.org/W2129559300","https://openalex.org/W2131761283","https://openalex.org/W2134246923","https://openalex.org/W2134261811","https://openalex.org/W2137376407","https://openalex.org/W2138599292","https://openalex.org/W2147351691","https://openalex.org/W2149729302","https://openalex.org/W2152626773","https://openalex.org/W2154463442","https://openalex.org/W2155332527","https://openalex.org/W2155912911","https://openalex.org/W2162530578","https://openalex.org/W2162624882","https://openalex.org/W2168249156","https://openalex.org/W2168273675","https://openalex.org/W2168909179","https://openalex.org/W2187235905","https://openalex.org/W2413387607","https://openalex.org/W2470403278","https://openalex.org/W2593244680","https://openalex.org/W2612812586","https://openalex.org/W3134986606"],"related_works":["https://openalex.org/W1963484776","https://openalex.org/W974810042","https://openalex.org/W1589670989","https://openalex.org/W1994303190","https://openalex.org/W1662334156","https://openalex.org/W2034950600","https://openalex.org/W7099964047","https://openalex.org/W2042620584","https://openalex.org/W2521930376","https://openalex.org/W7008692655"],"abstract_inverted_index":{"Eczema":[0],"is":[1,65,73,267,307,448],"an":[2,66,148],"itching":[3],"relapsing":[4],"and":[5,38,103,205,275,289,310,351,396,483,508],"often":[6],"chronic":[7],"inflammatory":[8,150],"skin":[9,202],"disorder":[10],"associated":[11,225,292,336,479,484],"with":[12,40,80,226,231,241,337,480],"cutaneous":[13],"hyper":[14],"reactivity":[15],"to":[16,22,31,87,124,130,169,177,516],"environmental":[17],"triggers":[18],"that":[19,112,261,279,301],"are":[20,478],"innocuous":[21],"normal":[23],"individuals.":[24,134,398],"The":[25,77],"differentiation":[26],"of":[27,34,55,91,100,189,196,238,320,363,444,474],"epidermal":[28,48,198,446],"keratinocytes":[29],"leads":[30],"the":[32,59,81,98,142,153,156,187,190,221,236,254,262,302,318,325,342,353,475,512],"formation":[33],"a":[35,46,53,138,164,184,194,250,268,283,313,346,357,442],"physical":[36],"barrier":[37,49,63,92,178],"together":[39],"appropriate":[41],"innate":[42],"immune":[43],"responses":[44],"produce":[45],"functional":[47],"protecting":[50],"us":[51],"against":[52],"number":[54],"detrimental":[56],"factors":[57],"in":[58,69,83,94,180,186,200,203,211,272,285,296,317,327,349,389,451,486],"external":[60],"environment.":[61],"Epidermal":[62],"dysfunction":[64,93],"important":[67],"factor":[68],"eczema":[70,119,143,168,212,227,233,274,350,482],"development":[71,319],"but":[72],"still":[74],"poorly":[75],"understood.":[76],"overall":[78],"aim":[79],"studies":[82,326],"this":[84,206,328],"thesis":[85,329],"was":[86,208,224,234],"improve":[88],"our":[89],"understanding":[90],"eczema,":[95],"mainly":[96],"through":[97],"use":[99],"gene":[101,266,271,306,316,344,348,355,387,477,515],"expression":[102,188,388,507],"genetic":[104,218,509],"association":[105,230,510],"studies.":[106],"In":[107,159,256,323],"study":[108,160,257,297],"I":[109],"we":[110,162,259,299,340],"showed":[111,300],"antigen":[113],"presenting":[114],"dendritic":[115,390],"cells":[116,391],"(DCs)":[117],"from":[118,132,392],"affected":[120],"individuals":[121],"responds":[122],"differently":[123,385],"allergen":[125,154],"(Malassezia":[126],"sympodialis)":[127],"stimulation":[128,384],"compared":[129],"DCs":[131],"healthy":[133,397],"Our":[135],"results":[136],"indicate":[137],"diverse":[139],"response":[140,151],"among":[141],"patients,":[144],"where":[145],"some":[146],"exhibited":[147],"exaggerated":[149],"towards":[152],"on":[155],"DC":[157],"level.":[158],"II":[161],"used":[163],"mouse":[165],"model":[166],"for":[167,171,253],"search":[170],"new":[172,314,332,358],"differentially":[173,308,333],"expressed":[174,309,334],"genes,":[175],"related":[176],"function,":[179],"eczema.":[181,322,338,452,518],"We":[182,214],"found":[183],"reduction":[185],"cornulin":[191],"(CRNN)":[192],"gene,":[193],"marker":[195,443],"late":[197,445],"differentiation,":[199,447],"eczema-like":[201],"mice":[204],"finding":[207],"then":[209,215],"validated":[210],"patients.":[213],"tested":[216],"whether":[217],"variability":[219],"at":[220],"CRNN":[222],"locus":[223],"susceptibility.":[228],"Although":[229],"atopic":[232,273,321,393,481,517],"found,":[235],"effect":[237],"linkage":[239],"disequilibrium":[240],"filaggrin":[242,476],"(FLG)":[243],"variants":[244,281,473],"could":[245],"not":[246],"be":[247],"excluded":[248],"as":[249,345,356],"possible":[251],"explanation":[252],"association.":[255],"III":[258],"confirmed":[260,341],"previously":[263],"identified":[264,331,352],"FLG":[265,280,343],"major":[269],"susceptibility":[270,315,347,360],"present":[276],"data":[277],"supporting":[278],"play":[282],"role":[284],"determining":[286],"disease":[287],"severity":[288],"progression":[290],"into":[291],"allergic":[293],"phenotypes.":[294],"Finally,":[295],"IV":[298],"transglutaminase":[303,513],"1":[304,514],"(TGM1)":[305],"potentially":[311],"represents":[312],"summary,":[324],"have":[330],"genes":[335],"Furthermore,":[339],"TGM1":[354],"potential":[359],"gene.":[361],"List":[362],"scientific":[364],"papers":[365],"I.":[366],"Gabrielsson":[367],"S,":[368],"Buentke":[369],"E,":[370,409,458,500],"Lied\u00e9n":[371],"A,":[372,407,456,496,498],"Schmidt":[373],"M,":[374,376,378,431,433,435,464],"DAmato":[375,438],"Tengvall-Linder":[377],"Scheynius":[379],"A":[380],"(2004).":[381],"Malassezia":[382],"sympodialis":[383],"affects":[386],"dermatitis":[394],"patients":[395],"Acta":[399,489],"Derm":[400,490],"Venereol.":[401],"84(5):":[402],"339-45.":[403],"https://doi.org/10.1080/00015550410026957":[404],"II.":[405],"Lieden":[406,455,495],"Ekelund":[408,457,499],"Kuo":[410],"IC,":[411],"Kockum":[412,467,501],"I,":[413,468,502],"Huang":[414],"CH,":[415],"Mallbris":[416],"L,":[417],"Lee":[418,461],"SP,":[419,462],"Seng":[420],"LK,":[421],"Chin":[422],"GY,":[423],"Wahlgren":[424],"CF,":[425],"Palmer":[426,465],"CNA,":[427,466],"Bj\u00f6rksten":[428],"B,":[429],"St\u00e5hle":[430],"Nordensk\u00f6ld":[432],"Bradley":[434,469,503],"Chua":[436],"KY,":[437],"M":[439,470,504],"(2007).":[440,471,505],"Cornulin,":[441],"down":[449],"regulated":[450],"[Submitted]":[453,519],"III.":[454],"Link":[459],"J,":[460],"Damato":[463],"Loss-of-function":[472],"phenotypes":[485],"Swedish":[487],"families.":[488],"Venerol.":[491],"[Accepted]":[492],"https://doi.org/10.2340/00015555-0383":[493],"IV.":[494],"S\u00e4ff":[497],"Increased":[506],"links":[511]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}