{"id":"https://openalex.org/W15551075","doi":null,"title":"Gene delivery with cationic lipids : fundamentals and potential applications","display_name":"Gene delivery with cationic lipids : fundamentals and potential applications","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W15551075","mag":"15551075"},"language":"en","primary_location":{"id":"pmh:rug:oai:pure.rug.nl:publications/fec020b4-e639-49d1-b736-b6c06b44a6a9","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/fec020b4-e639-49d1-b736-b6c06b44a6a9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://research.rug.nl/en/publications/fec020b4-e639-49d1-b736-b6c06b44a6a9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038495074","display_name":"Luc Wasungu","orcid":"https://orcid.org/0000-0003-1416-5220","observed_orcids":["https://orcid.org/0000-0003-1416-5220"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Luc Wasungu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1416-5220","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038495074"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cationic-lipids","display_name":"cationic lipids","score":0.8690000176429749},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.8629999756813049},{"id":"https://openalex.org/keywords/non-viral-vectors","display_name":"non-viral vectors","score":0.8600000143051147},{"id":"https://openalex.org/keywords/lipoplexes","display_name":"lipoplexes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/polyplexes","display_name":"polyplexes","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cationic-polymers","display_name":"cationic polymers","score":0.8579999804496765},{"id":"https://openalex.org/keywords/viral-vectors","display_name":"viral vectors","score":0.6179999709129333},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.847000002861023},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.925000011920929},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6000000238418579},{"id":"https://openalex.org/keywords/transfection","display_name":"transfection","score":0.5910000205039978},{"id":"https://openalex.org/keywords/gene-expression-modulation","display_name":"gene expression modulation","score":0.4580000042915344},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.3310000002384186},{"id":"https://openalex.org/keywords/liposome-transfection","display_name":"liposome transfection","score":0.328000009059906},{"id":"https://openalex.org/keywords/liposome-membrane-permeability","display_name":"liposome membrane permeability","score":0.3370000123977661},{"id":"https://openalex.org/keywords/liposome-stability","display_name":"liposome stability","score":0.35100001096725464},{"id":"https://openalex.org/keywords/liposome-surface-modification","display_name":"liposome surface modification","score":0.34599998593330383},{"id":"https://openalex.org/keywords/liposome-targeting","display_name":"liposome targeting","score":0.3840000033378601},{"id":"https://openalex.org/keywords/liposome-internalization","display_name":"liposome internalization","score":0.4399999976158142},{"id":"https://openalex.org/keywords/liposome-fusion","display_name":"liposome fusion","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.832572877407074},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7051138281822205},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.608445942401886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6076927185058594},{"id":"https://openalex.org/C106285112","wikidata":"https://www.wikidata.org/wiki/Q7556570","display_name":"Therapeutic gene modulation","level":5,"score":0.5201261639595032},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5189332962036133},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49820446968078613},{"id":"https://openalex.org/C43953973","wikidata":"https://www.wikidata.org/wiki/Q7917858","display_name":"Vectors in gene therapy","level":5,"score":0.46814826130867004},{"id":"https://openalex.org/C34981463","wikidata":"https://www.wikidata.org/wiki/Q3311663","display_name":"Suicide gene","level":4,"score":0.4487433135509491},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4460328221321106},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.44235488772392273},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4292922019958496},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.2437443733215332},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:rug:oai:pure.rug.nl:publications/fec020b4-e639-49d1-b736-b6c06b44a6a9","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/fec020b4-e639-49d1-b736-b6c06b44a6a9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:15551075","doi":null,"is_oa":false,"landing_page_url":"https://pure.rug.nl/ws/files/33204419/12_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:rug:oai:pure.rug.nl:publications/fec020b4-e639-49d1-b736-b6c06b44a6a9","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/fec020b4-e639-49d1-b736-b6c06b44a6a9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1587227490","https://openalex.org/W1976532926","https://openalex.org/W1991533053","https://openalex.org/W2000130544","https://openalex.org/W2018116983","https://openalex.org/W2048674403","https://openalex.org/W2066582329","https://openalex.org/W2076941870"],"related_works":["https://openalex.org/W2888833044","https://openalex.org/W1507408486","https://openalex.org/W4251349806","https://openalex.org/W2152653642","https://openalex.org/W4388043138","https://openalex.org/W2479391376","https://openalex.org/W1580973438","https://openalex.org/W4206595667","https://openalex.org/W6960087162","https://openalex.org/W3144607323"],"abstract_inverted_index":{"Principle":[0],"of":[1,8,37,58,77,80,92,103,105,110,130,143,146,152,158,191,195,210,214,269,282,286,315,401,411,436,444,469,472,482],"gene":[2,9,38,45,81,93,120,159,184,223,233,245,371,488],"therapy.Although":[3],"the":[4,15,32,34,78,101,108,144,150,188,212,226,264,276,280,299,304,356,361,399,434,441,470,480],"objectives":[5],"and":[6,107,172,221,243,289,326,342,345,417,427],"principles":[7],"therapy":[10,39,94,121,185,489],"have":[11,348],"been":[12,349],"well-defined":[13],"over":[14],"last":[16],"decades,":[17],"its":[18,127],"application":[19],"as":[20,321,332,369],"a":[21,43,47,52,59,132,141,176,181,408,448,466],"versatile,":[22],"therapeutically":[23],"successful":[24],"approach":[25],"has":[26],"not":[27,122,169,396],"yet":[28],"met":[29],"expectations.":[30],"At":[31],"onset,":[33],"primary":[35,128],"goal":[36,65,129],"was":[40,66,83],"to":[41,68,126,140,187,205,262,274,334,351,360,384,391,398,425,430],"replace":[42],"deficient":[44,133],"in":[46,86,112,180,207,216,272,313,387,451,454,461],"genetically":[48],"inherited":[49,73],"disease":[50],"with":[51,100],"normal":[53],"copy,":[54],"thereby":[55,98,338],"restoring":[56],"production":[57,281],"functional":[60],"protein.":[61],"Soon":[62],"afterwards,":[63],"this":[64],"extended":[67],"include":[69],"genetic":[70],"defects":[71,297],"beyond":[72],"disorders,":[74],"since":[75],"modulation":[76,142],"regulation":[79],"expression":[82,145,213],"also":[84,138],"involved":[85],"numerous":[87],"acquired":[88],"diseases.":[89],"The":[90,247],"potential":[91,189,290],"for":[95,218,229,266,279,433,460,487],"therapeutic":[96,177,219,322,438,463],"applications":[97],"grew":[99],"comprehension":[102],"mechanisms":[104],"diseases":[106],"implication":[109],"genes":[111,147,215,354],"these":[113,346,364,380],"events.":[114],"Nowadays,":[115],"it":[116,136,197],"is":[117,235,447],"clear":[118],"that":[119,167,173,456],"only":[123],"may":[124,309],"lead":[125,139],"replacing":[131],"gene,":[134],"but":[135,405],"could":[137,174],"acting":[148],"on":[149,225,253],"physiology":[151],"malignant":[153],"cells.":[154,357],"Furthermore,":[155],"by":[156,475],"means":[157],"therapy,":[160],"functions":[161],"might":[162],"be":[163,330,385],"integrated":[164],"into":[165,238,303,355],"cells":[166,217],"are":[168,366,377,382,395,423],"originally":[170],"present":[171],"serve":[175],"purpose.":[178],"Thus":[179],"modern":[182],"concept,":[183],"refers":[186],"use":[190,275,320,459],"nucleic":[192,230,336,403],"acids,":[193,337],"irrespective":[194],"whether":[196],"concerns":[198],"plasmid":[199],"DNA,":[200],"antisense":[201,414],"oligonucleotides":[202],"or":[203,256],"siRNA,":[204],"modulate":[206],"any":[208],"kind":[209],"way":[211],"purposes.Viral":[220],"non-viral":[222,244,370,421,445,476,485],"delivery.Depending":[224],"vectors":[227,249,308,381,422,446,477,486],"used":[228,331],"acid":[231],"transfer,":[232],"delivery":[234,268,372,400],"roughly":[236],"divided":[237],"two":[239],"main":[240],"categories:":[241],"viral":[242,283,300,307,362,392],"delivery.":[246],"first":[248],"developed":[250],"were":[251],"based":[252],"using":[254],"viruses":[255],"pseudo-viral":[257],"particles,":[258],"exploiting":[259],"their":[260,270,287,319,458],"ability":[261],"penetrate":[263],"cell":[265],"intracellular":[267],"genome":[271,301],"order":[273],"host":[277,305],"machinery":[278],"proteins.":[284],"Because":[285],"immunogenicity":[288],"oncogenicity,":[291],"possibly":[292],"resulting":[293],"from":[294],"mutational":[295],"insertion":[296],"when":[298],"integrates":[302],"genome,":[306],"pose":[310],"serious":[311],"problems":[312],"terms":[314],"safety,":[316],"thus":[317],"jeopardizing":[318],"drugs.":[323],"Cationic":[324],"lipids":[325],"cationic":[327],"polymers":[328],"can":[329,406],"well":[333],"complex":[335],"forming":[339],"so-called":[340],"lipoplexes":[341],"polyplexes,":[343],"respectively,":[344],"complexes":[347],"shown":[350],"similarly":[352],"deliver":[353],"As":[358],"opposed":[359],"vectors,":[363],"systems":[365],"collectively":[367],"known":[368],"systems.":[373],"Moreover":[374],"because":[375],"they":[376,394],"immunologically":[378],"inert":[379],"thought":[383],"safer":[386],"vivo.":[388],"In":[389],"contrast":[390],"particles":[393],"limited":[397],"coding":[402],"acids":[404],"accommodate":[407],"greater":[409],"variety":[410],"cargo,":[412],"including":[413],"ODNs,":[415],"siRNAs":[416],"entire":[418],"genes.":[419],"Finally,":[420],"easier":[424],"produce":[426],"better":[428,467],"amenable":[429],"chemical":[431],"modifications":[432],"purpose":[435],"effectuating":[437],"applications.":[439,464,490],"However":[440],"major":[442],"drawback":[443],"lower":[449],"efficiency":[450],"transfection,":[452],"especially":[453],"vivo,":[455],"hinders":[457],"vivo":[462],"Therefore,":[465],"knowledge":[468],"mechanism":[471],"transfection":[473],"mediated":[474],"will":[478],"allow":[479],"development":[481],"more":[483],"efficient":[484]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
