{"id":"https://openalex.org/W1554889507","doi":"https://doi.org/10.4049/jimmunol.130.2.869","title":"Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides.","display_name":"Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides.","publication_year":1983,"publication_date":"1983-02-01","ids":{"openalex":"https://openalex.org/W1554889507","doi":"https://doi.org/10.4049/jimmunol.130.2.869","mag":"1554889507","pmid":"https://pubmed.ncbi.nlm.nih.gov/6294180"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.130.2.869","doi":"https://doi.org/10.4049/jimmunol.130.2.869","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.130.2.869","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085382251","display_name":"Margrith Wehrli Verghese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M W Verghese","raw_affiliation_strings":["Laboratory of Immune Effector Function, Howard Hughes Medical Institute, and the Division of Rheumatic and Genetic Diseases, Department of Medicine, Duke University Medical Center , Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immune Effector Function, Howard Hughes Medical Institute, and the Division of Rheumatic and Genetic Diseases, Department of Medicine, Duke University Medical Center , Durham, NC 27710","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020405246","display_name":"Ralph Snyderman M. D","orcid":"https://orcid.org/0009-0003-5252-5036","observed_orcids":["https://orcid.org/0009-0003-5252-5036"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Snyderman","raw_affiliation_strings":["Laboratory of Immune Effector Function, Howard Hughes Medical Institute, and the Division of Rheumatic and Genetic Diseases, Department of Medicine, Duke University Medical Center , Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immune Effector Function, Howard Hughes Medical Institute, and the Division of Rheumatic and Genetic Diseases, Department of Medicine, Duke University Medical Center , Durham, NC 27710","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.6146,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.90310182,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"130","issue":"2","first_page":"869","last_page":"873"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.08730000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.06759999692440033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenylyl-cyclase-activation","display_name":"adenylate cyclase activation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/macrophage-membrane","display_name":"macrophage membrane","score":0.8889999985694885},{"id":"https://openalex.org/keywords/guanine-nucleotides","display_name":"guanine nucleotides","score":0.9649999737739563},{"id":"https://openalex.org/keywords/gtpase-activity","display_name":"GTPase activity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.6370000243186951},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.890999972820282},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.9629999995231628},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.8119999766349792},{"id":"https://openalex.org/keywords/alpha-adrenergic-receptors","display_name":"alpha-adrenergic receptors","score":0.9319999814033508},{"id":"https://openalex.org/keywords/guanine-nucleotide-regulatory-protein","display_name":"guanine nucleotide regulatory protein","score":0.8169999718666077},{"id":"https://openalex.org/keywords/hormone-signaling","display_name":"hormone signaling","score":0.4620000123977661},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.7789999842643738},{"id":"https://openalex.org/keywords/gpp-nh-p","display_name":"Gpp(NH)p","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.6186670064926147},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5405133962631226},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5257224440574646},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.502877414226532},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.49638181924819946},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.4917161762714386},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.46942049264907837},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4691644608974457},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4492435157299042},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.4206223785877228},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41680359840393066},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41219067573547363},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3902268707752228},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3862546682357788},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3477858603000641},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18307659029960632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05307960510253906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006150","descriptor_name":"Guanine Nucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006165","descriptor_name":"Guanylyl Imidodiphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009239","descriptor_name":"N-Formylmethionine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009239","descriptor_name":"N-Formylmethionine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009240","descriptor_name":"N-Formylmethionine Leucyl-Phenylalanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013566","descriptor_name":"Sympathomimetics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.130.2.869","doi":"https://doi.org/10.4049/jimmunol.130.2.869","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.130.2.869","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:6294180","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6294180","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1635581242","display_name":"MACROPHAGE ACTIVATION--DEVELOPMENT AND REGULATION","funder_award_id":"P01CA029589","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7280420979","display_name":"HUMORAL AND CELLULAR MEDIATORS OF  INFLAMMATION","funder_award_id":"R01DE003738","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1977516555","https://openalex.org/W1571192847","https://openalex.org/W2037134559","https://openalex.org/W1565793031","https://openalex.org/W2043442465","https://openalex.org/W2465074225","https://openalex.org/W2399371631","https://openalex.org/W2058277131","https://openalex.org/W1594505663","https://openalex.org/W1975679304"],"abstract_inverted_index":{"Many":[0],"macrophage":[1,44,147,290],"functions":[2],"such":[3,264],"as":[4,102,265],"chemotaxis,":[5],"phagocytosis,":[6],"enzyme":[7],"secretion,":[8],"and":[9,84,132,150,310],"cytotoxicity":[10],"are":[11,23],"influenced":[12],"by":[13,56,119,176,214,222,256,286],"intracellular":[14,272],"cyclic":[15],"nucleotide":[16,312],"levels,":[17],"but":[18,171],"the":[19,35,70,76,81,164,167,177,183,217,295,301,306,317,320],"regulatory":[20,313],"mechanisms":[21],"involved":[22],"poorly":[24],"defined.":[25],"We":[26,59],"have":[27],"developed":[28],"methods":[29],"that":[30,190,242],"allowed":[31],"us":[32],"to":[33,152,189,274,293,322],"study":[34],"activation":[36,65,129,213,283],"of":[37,66,72,78,106,113,117,130,134,139,158,166,186,194,258,282,284,297,303],"AC":[38,46,68,92,114,154,159,212,285],"in":[39,47,69,91,125,146,197,216,235,278,288],"isolated":[40],"guinea":[41],"pig":[42],"(g.p.)":[43],"membranes.":[45],"these":[48,107],"membrane":[49,148,218],"preparations":[50,149],"could":[51,60],"be":[52],"stimulated":[53],"approximately":[54,97],"twofold":[55],"guanine":[57,73,311],"nucleotides.":[58,74],"not":[61,172],"obtain":[62],"any":[63],"hormonal":[64],"membrane-bound":[67,259],"absence":[71],"In":[75,181],"presence":[77],"GTP,":[79],"however,":[80],"hormones":[82,109,135,244,287],"isoproterenol":[83],"PGE1":[85,202],"elicited":[86],"an":[87,223],"additional":[88,271],"threefold":[89],"rise":[90],"activity,":[93],"which":[94,304,315],"subsided":[95],"after":[96],"15":[98],"min.":[99],"As":[100],"little":[101],"10(-8)":[103],"M":[104],"concentrations":[105],"two":[108],"induced":[110],"significant":[111],"elevations":[112],"activity.":[115],"Replacement":[116],"GTP":[118],"its":[120],"nonhydrolyzable":[121],"analogue":[122],"Gpp(NH)p":[123],"resulted":[124],"a":[126,298],"persistent":[127],"hormone-independent":[128],"AC,":[131,260,309],"addition":[133],"enhanced":[136],"this":[137],"level":[138],"activation.":[140,155],"Thus,":[141],"GTP-ase":[142],"activity":[143],"is":[144],"present":[145],"serves":[151],"regulate":[153],"Hormonal":[156],"stimulation":[157,193,257],"was":[160,174,220],"receptor":[161,321],"mediated,":[162],"because":[163],"effect":[165,252],"beta-adrenergic":[168,178,246],"agonist":[169],"isoproterenol,":[170],"PGE1,":[173],"inhibited":[175,221],"blocker":[179],"propranolol.":[180],"addition,":[182],"potency":[184],"series":[185],"PG":[187,215],"corresponded":[188],"observed":[191],"for":[192,230],"cAMP":[195,233,254,276],"production":[196,234,255],"intact":[198],"g.p.":[199,236,289],"macrophages,":[200],"i.e.,":[201],"=":[203],"PGE2":[204],"greater":[205,208],"than":[206,209],"PGA1":[207],"PGF2":[210],"alpha.":[211],"preparation":[219],"alpha-adrenergic":[224],"agonist,":[225],"thus":[226],"demonstrating":[227],"one":[228],"means":[229],"down":[231],"regulating":[232],"macrophages.":[237,279],"Our":[238],"studies":[239],"also":[240],"showed":[241],"certain":[243],"(e.g.,":[245],"agonists,":[247],"PG)":[248],"can":[249],"exert":[250],"their":[251],"on":[253],"whereas":[261],"other":[262],"agents":[263],"lectins":[266],"or":[267],"arachidonic":[268],"acid":[269],"require":[270],"components":[273,302],"elevate":[275],"levels":[277],"The":[280],"mechanism":[281],"membranes":[291],"appears":[292],"fit":[294],"model":[296],"ternary":[299],"complex,":[300],"include":[305],"hormone":[307],"receptor,":[308],"protein,":[314],"transmits":[316],"signal":[318],"from":[319],"AC.":[323]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
