{"id":"https://openalex.org/W1554775680","doi":null,"title":"Reduced genomic 5-methylcytosine content in human colonic neoplasia.","display_name":"Reduced genomic 5-methylcytosine content in human colonic neoplasia.","publication_year":1988,"publication_date":"1988-03-01","ids":{"openalex":"https://openalex.org/W1554775680","mag":"1554775680","pmid":"https://pubmed.ncbi.nlm.nih.gov/3342396"},"language":"en","primary_location":{"id":"pmid:3342396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3342396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074378026","display_name":"Andrew P. Feinberg","orcid":"https://orcid.org/0000-0002-8364-1991","observed_orcids":["https://orcid.org/0000-0002-8364-1991"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A P Feinberg","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111709539","display_name":"Charles W. Gehrke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C W Gehrke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109868498","display_name":"Kenneth C. Kuo","orcid":"https://orcid.org/0009-0003-1593-1406","observed_orcids":["https://orcid.org/0009-0003-1593-1406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K C Kuo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041376137","display_name":"Melanie Ehrlich","orcid":"https://orcid.org/0000-0002-8187-4476","observed_orcids":["https://orcid.org/0000-0002-8187-4476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ehrlich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1183,"has_fulltext":false,"cited_by_count":481,"citation_normalized_percentile":{"value":0.88029947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"48","issue":"5","first_page":"1159","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/5-methylcytosine","display_name":"5-methylcytosine","score":0.9309999942779541},{"id":"https://openalex.org/keywords/colonic-neoplasia","display_name":"colonic neoplasia","score":0.8600000143051147},{"id":"https://openalex.org/keywords/colon-adenoma","display_name":"colonic adenoma","score":0.8429999947547913},{"id":"https://openalex.org/keywords/colon-adenocarcinoma","display_name":"colon adenocarcinoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hypomethylation","display_name":"hypomethylation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/lynch-syndrome","display_name":"Lynch syndrome","score":0.9259999990463257},{"id":"https://openalex.org/keywords/tumor-dna-methylation","display_name":"tumor DNA methylation","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7856460213661194},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7572749853134155},{"id":"https://openalex.org/C2775926025","wikidata":"https://www.wikidata.org/wiki/Q238563","display_name":"5-Methylcytosine","level":5,"score":0.6488634347915649},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5895324349403381},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5598047971725464},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4928915500640869},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.48614880442619324},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47652968764305115},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4453476667404175},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.440030962228775},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.42728516459465027},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.4223420023918152},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3732150197029114},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3052983283996582},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.256902277469635}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005736","descriptor_name":"Gardner Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044503","descriptor_name":"5-Methylcytosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3342396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3342396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1554775680","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3342396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2029874395","https://openalex.org/W2004081391","https://openalex.org/W7095160573","https://openalex.org/W7098545828","https://openalex.org/W1522417671","https://openalex.org/W1978419388","https://openalex.org/W2811463598","https://openalex.org/W2146707779","https://openalex.org/W1882207118","https://openalex.org/W2078627116"],"abstract_inverted_index":{"DNA":[0,19,44,165],"methylation":[1,20,45],"appears":[2],"to":[3,180,185],"play":[4],"an":[5,112],"important":[6],"role":[7],"in":[8,18,24,29,46,62,71,89,93,125,131,161,175],"both":[9],"physiological":[10],"and":[11,16,28,32,50,65,80,122,136,139,147,156],"experimentally":[12],"modified":[13],"gene":[14],"expression,":[15],"alterations":[17],"have":[21,38,59,76,86,97,181],"been":[22,39],"described":[23],"animal":[25],"tumor":[26,33,116],"models":[27],"transformed":[30],"cells":[31],"cell":[34],"lines.":[35],"However,":[36],"there":[37,140],"comparatively":[40],"few":[41],"reports":[42,52],"on":[43],"primary":[47],"human":[48],"malignancies,":[49],"these":[51],"are":[53],"somewhat":[54],"contradictory.":[55],"While":[56],"individual":[57],"genes":[58,75],"shown":[60,77,87],"hypomethylation":[61,114],"colon":[63,134,178],"cancer":[64,186],"premalignant":[66,94],"adenomas":[67,135],"as":[68,70],"well":[69],"lung":[72],"cancer,":[73],"other":[74],"increased":[78],"methylation,":[79],"absolute":[81],"measures":[82],"of":[83,103,115,120,164],"5-methylcytosine":[84,104,127,173],"content":[85,105,128,174],"decreases":[88],"malignancies":[90],"but":[91],"not":[92],"adenomas.":[95],"We":[96],"used":[98],"a":[99,152,158,182],"sensitive":[100],"quantitative":[101,154],"measurement":[102],"by":[106],"high":[107],"performance":[108],"liquid":[109],"chromatography":[110],"revealing":[111],"unequivocal":[113],"DNA.":[117],"An":[118],"average":[119],"8":[121],"10%":[123],"reduction":[124],"genomic":[126],"was":[129,141],"seen":[130],"apparently":[132],"all":[133],"adenocarcinomas,":[137],"respectively,":[138],"no":[142],"significant":[143],"difference":[144],"between":[145],"benign":[146],"malignant":[148],"tumors.":[149],"This":[150],"is":[151],"substantial":[153],"alteration":[155],"suggests":[157],"pervasive":[159],"abnormality":[160],"the":[162,171],"control":[163],"methylation.":[166],"Surprisingly,":[167],"three":[168],"patients":[169],"with":[170],"highest":[172],"their":[176],"normal":[177],"appear":[179],"germline":[183],"predisposition":[184],"(Lynch":[187],"syndrome).":[188]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":29}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
