{"id":"https://openalex.org/W1554733871","doi":null,"title":"Neuromodulaci\u00f3n farmacol\u00f3gica en la enfermedad cerebrovascular","display_name":"Neuromodulaci\u00f3n farmacol\u00f3gica en la enfermedad cerebrovascular","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W1554733871","mag":"1554733871"},"language":"es","primary_location":{"id":"pmh:oai:doaj.org/article:409a273dd5e24ef1a8d4356aa349d4b0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/409a273dd5e24ef1a8d4356aa349d4b0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Cubana de Medicina, Vol 41, Iss 2, Pp 98-110 (2002)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/409a273dd5e24ef1a8d4356aa349d4b0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089969818","display_name":"Liv\u00e1n Rodr\u00edguez Mutuberr\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149409","display_name":"International Center of Neurologic Restoration","ror":"https://ror.org/04770s302","country_code":"CU","type":"facility","lineage":["https://openalex.org/I4210149409"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Liv\u00e1n Rodr\u00edguez Mutuberr\u00eda","raw_affiliation_strings":["Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, Ciudad de La Habana, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Internacional de Restauraci\u00f3n Neurol\u00f3gica, Ciudad de La Habana, Cuba","institution_ids":["https://openalex.org/I4210149409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052951451","display_name":"Reynaldo Galviz\u00fa S\u00e1nchez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reynaldo Galvizu S\u00e1nchez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Eduardo \u00c1lvarez Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eduardo \u00c1lvarez Gonz\u00e1lez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2064,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.54266564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebrovascular-disease","display_name":"cerebrovascular disease","score":0.843999981880188},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8799999952316284},{"id":"https://openalex.org/keywords/neurotrophic-drugs","display_name":"neurotrophic drugs","score":0.972000002861023},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.8730000257492065},{"id":"https://openalex.org/keywords/acute-stroke","display_name":"acute stroke","score":0.5419999957084656},{"id":"https://openalex.org/keywords/chronic-cerebrovascular-disease","display_name":"chronic cerebrovascular disease","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.6930000185966492},{"id":"https://openalex.org/keywords/neuroprotective-agents","display_name":"neuroprotective agents","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43033695220947266}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:409a273dd5e24ef1a8d4356aa349d4b0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/409a273dd5e24ef1a8d4356aa349d4b0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Cubana de Medicina, Vol 41, Iss 2, Pp 98-110 (2002)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:409a273dd5e24ef1a8d4356aa349d4b0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/409a273dd5e24ef1a8d4356aa349d4b0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revista Cubana de Medicina, Vol 41, Iss 2, Pp 98-110 (2002)","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W27960536","https://openalex.org/W127276580","https://openalex.org/W1585976806","https://openalex.org/W1803470478","https://openalex.org/W1965476204","https://openalex.org/W1974964904","https://openalex.org/W1985939052","https://openalex.org/W1988398446","https://openalex.org/W2003066583","https://openalex.org/W2004391230","https://openalex.org/W2004469687","https://openalex.org/W2018978860","https://openalex.org/W2023160202","https://openalex.org/W2041645861","https://openalex.org/W2043610467","https://openalex.org/W2053389966","https://openalex.org/W2054612378","https://openalex.org/W2059986551","https://openalex.org/W2069567366","https://openalex.org/W2081970096","https://openalex.org/W2086891165","https://openalex.org/W2114007783","https://openalex.org/W2121347730","https://openalex.org/W2149933303","https://openalex.org/W2240758399","https://openalex.org/W2315311487","https://openalex.org/W2336161314","https://openalex.org/W2414923458","https://openalex.org/W2913119547"],"related_works":["https://openalex.org/W4409574017","https://openalex.org/W4415217115","https://openalex.org/W2946429260","https://openalex.org/W4297310259","https://openalex.org/W2922237413","https://openalex.org/W2062339133","https://openalex.org/W7221191920","https://openalex.org/W2151127792","https://openalex.org/W4391425069","https://openalex.org/W4407293434"],"abstract_inverted_index":{"La":[0],"enfermedad":[1,127],"cerebrovascular":[2,128,249],"representa":[3],"la":[4,24,75,126],"tercera":[5],"causa":[6,26],"de":[7,16,27,70,74,82,90,95,105,115,121],"muerte":[8],"en":[9,14,29,37,41,63,67,79,125],"los":[10,30,64,71],"pa\u00edses":[11],"desarrollados":[12],"y":[13,18,47,57,78,92,108,118,130],"v\u00edas":[15],"desarrollo":[17,81],"sus":[19],"secuelas":[20],"se":[21],"comportan":[22],"como":[23],"primera":[25],"invalidez":[28],"adultos.":[31],"Las":[32],"orientaciones":[33],"terap\u00e9uticas":[34],"m\u00e1s":[35],"importantes":[36,60],"estos":[38],"pacientes":[39],"consisten":[40],"mejorar":[42],"el":[43,68,80,93],"flujo":[44],"sangu\u00edneo":[45],"cerebral":[46,77],"reducir":[48],"o":[49],"bloquear":[50],"las":[51,87],"consecuencias":[52],"metab\u00f3licas":[53],"a":[54],"nivel":[55],"subcelular":[56],"celular.":[58],"Los":[59],"avances":[61],"producidos":[62],"\u00faltimos":[65],"a\u00f1os":[66],"conocimiento":[69],"mecanismos":[72],"fisiopatol\u00f3gicos":[73],"isquemia":[76],"nuevos":[83],"f\u00e1rmacos":[84,116],"han":[85],"planteado":[86],"expectativas":[88],"reales":[89],"tratamiento":[91],"rechazo":[94],"actitudes":[96],"nihilistas.":[97],"Se":[98,111],"hizo":[99],"una":[100],"breve":[101],"revisi\u00f3n":[102],"del":[103],"concepto":[104],"plasticidad":[106],"neuronal":[107,230],"neuromodulaci\u00f3n":[109],"farmacol\u00f3gica.":[110],"expuso":[112],"un":[113],"grupo":[114],"neuroprotectores":[117],"neurotr\u00f3ficos,":[119],"algunos":[120],"forma":[122],"experimental,":[123],"usados":[124],"aguda":[129],"cr\u00f3nica.":[131],"Cardiovascular":[132],"disease":[133],"represents":[134],"the":[135,149,165,176,188,191,195,199,204,211,215,218,227],"third":[136],"cause":[137,151],"of":[138,152,167,175,190,194,206,214,220,226,229,239,252],"death":[139],"in":[140,154,187,198,245],"developed":[141],"and":[142,145,171,181,203,217,232,241,247],"developing":[143],"countries":[144],"its":[146],"sequelae":[147],"are":[148],"first":[150],"disability":[153],"adults.":[155],"The":[156,184],"most":[157],"important":[158],"therapeutic":[159],"procedures":[160],"for":[161],"these":[162],"patients":[163],"include":[164],"improvement":[166],"brain":[168,196],"blood":[169],"flow":[170],"reduction":[172],"or":[173],"blocking":[174],"metabolic":[177],"consequences":[178],"at":[179],"sub-cellular":[180],"cellular":[182],"levels.":[183],"fundamental":[185],"advances":[186],"knowledge":[189],"physiopathological":[192],"mechanisms":[193],"ischemia":[197],"last":[200],"few":[201],"years":[202],"development":[205],"new":[207],"drugs":[208,243],"have":[209],"disclosed":[210],"real":[212],"expectations":[213],"treatment":[216],"rejection":[219],"nihilistic":[221],"attitudes.":[222],"A":[223,237],"brief":[224],"review":[225],"concept":[228],"plasticity":[231],"pharmacological":[233],"neuromodulation":[234],"was":[235,257],"made.":[236],"group":[238],"neuroprotective":[240],"neurotrophic":[242],"used":[244],"acute":[246],"chronic":[248],"disease,":[250],"some":[251],"them":[253],"under":[254],"experimental":[255],"stage,":[256],"presented.":[258]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
