{"id":"https://openalex.org/W1554668271","doi":"https://doi.org/10.1096/fasebj.4.6.2138579","title":"Mediation of renal vascular effects of epidermal growth factor by arachidonate metabolites","display_name":"Mediation of renal vascular effects of epidermal growth factor by arachidonate metabolites","publication_year":1990,"publication_date":"1990-04-01","ids":{"openalex":"https://openalex.org/W1554668271","doi":"https://doi.org/10.1096/fasebj.4.6.2138579","mag":"1554668271","pmid":"https://pubmed.ncbi.nlm.nih.gov/2138579"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.4.6.2138579","doi":"https://doi.org/10.1096/fasebj.4.6.2138579","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.4.6.2138579","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042782798","display_name":"Raymond Clement Harris","orcid":"https://orcid.org/0000-0001-8025-0883","observed_orcids":["https://orcid.org/0000-0001-8025-0883"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. C. Harris","raw_affiliation_strings":["Division of Nephrology Vanderbilt University Medical Center Nashville Tennessee 37212 USA","Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37212"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology Vanderbilt University Medical Center Nashville Tennessee 37212 USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37212","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010809013","display_name":"Karen A. Munger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. A. Munger","raw_affiliation_strings":["Division of Nephrology Vanderbilt University Medical Center Nashville Tennessee 37212 USA","Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37212"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology Vanderbilt University Medical Center Nashville Tennessee 37212 USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37212","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113770079","display_name":"K F Badr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. F. Badr","raw_affiliation_strings":["Division of Nephrology Vanderbilt University Medical Center Nashville Tennessee 37212 USA","Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37212"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology Vanderbilt University Medical Center Nashville Tennessee 37212 USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37212","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102964785","display_name":"Kiyohiko Takahashi","orcid":"https://orcid.org/0000-0002-3962-4078","observed_orcids":["https://orcid.org/0000-0002-3962-4078"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Takahashi","raw_affiliation_strings":["Division of Nephrology Vanderbilt University Medical Center Nashville Tennessee 37212 USA","Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37212"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology Vanderbilt University Medical Center Nashville Tennessee 37212 USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37212","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I901861585"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":1.8208,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.82187148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"6","first_page":"1654","last_page":"1660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":1.0},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolites","display_name":"arachidonic acid metabolites","score":0.9919999837875366},{"id":"https://openalex.org/keywords/renal-vasoconstriction","display_name":"renal vasoconstriction","score":0.8299999833106995},{"id":"https://openalex.org/keywords/renal-blood-flow","display_name":"renal blood flow","score":0.8190000057220459},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ibuprofen","display_name":"ibuprofen","score":0.9010000228881836},{"id":"https://openalex.org/keywords/thromboxane-a2","display_name":"thromboxane A2","score":0.7630000114440918},{"id":"https://openalex.org/keywords/prostaglandin-f2alpha","display_name":"prostaglandin F2alpha","score":0.7710000276565552},{"id":"https://openalex.org/keywords/eicosatetraynoic-acid","display_name":"eicosatetraynoic acid","score":0.8619999885559082},{"id":"https://openalex.org/keywords/ketoconazole","display_name":"ketoconazole","score":0.8600000143051147},{"id":"https://openalex.org/keywords/renal-hemodynamics","display_name":"renal hemodynamics","score":0.6039999723434448},{"id":"https://openalex.org/keywords/systemic-vasodilation","display_name":"systemic vasodilation","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7153880596160889},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6775662899017334},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.6421765089035034},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5898861885070801},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.5779476165771484},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5498903393745422},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5421150922775269},{"id":"https://openalex.org/C142225936","wikidata":"https://www.wikidata.org/wiki/Q1129139","display_name":"Renal blood flow","level":3,"score":0.5248777270317078},{"id":"https://openalex.org/C2776785769","wikidata":"https://www.wikidata.org/wiki/Q412212","display_name":"Thromboxane","level":3,"score":0.5078573822975159},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.45990630984306335},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.4326925575733185},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.43062663078308105},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4045943021774292},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23385515809059143},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21292516589164734},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06715753674507141},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007654","descriptor_name":"Ketoconazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015117","descriptor_name":"5,8,11,14-Eicosatetraynoic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015237","descriptor_name":"Dinoprost","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017482","descriptor_name":"Receptors, Thromboxane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1096/fasebj.4.6.2138579","doi":"https://doi.org/10.1096/fasebj.4.6.2138579","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.4.6.2138579","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:2138579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2138579","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2464398184","display_name":null,"funder_award_id":"DK 38226","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4922179294","display_name":"The Biology of Progressive Nephron Destruction","funder_award_id":"P50DK039261","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5151822017","display_name":"Role of Eicosanoids in Renal Function","funder_award_id":"P01DK038226","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G99241323","display_name":null,"funder_award_id":"DK39261","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W87001907","https://openalex.org/W1546756405","https://openalex.org/W1568181210","https://openalex.org/W1597529692","https://openalex.org/W1775749144","https://openalex.org/W1865845936","https://openalex.org/W1965144032","https://openalex.org/W1965407327","https://openalex.org/W1965526093","https://openalex.org/W1966207709","https://openalex.org/W1967125132","https://openalex.org/W1970516412","https://openalex.org/W1970793850","https://openalex.org/W1981420235","https://openalex.org/W1987108079","https://openalex.org/W1989713160","https://openalex.org/W1996289114","https://openalex.org/W1999514574","https://openalex.org/W2009496517","https://openalex.org/W2023033845","https://openalex.org/W2028542880","https://openalex.org/W2040909870","https://openalex.org/W2045332701","https://openalex.org/W2045619901","https://openalex.org/W2046386827","https://openalex.org/W2078239583","https://openalex.org/W2086416770","https://openalex.org/W2156179120","https://openalex.org/W2160414842","https://openalex.org/W2165191737","https://openalex.org/W2246272397","https://openalex.org/W2258382192","https://openalex.org/W2266355647","https://openalex.org/W2404727953","https://openalex.org/W2407825500","https://openalex.org/W2409503626","https://openalex.org/W2414458954","https://openalex.org/W2415159769"],"related_works":["https://openalex.org/W2337214979","https://openalex.org/W2404727953","https://openalex.org/W2135578012","https://openalex.org/W2073140803","https://openalex.org/W2342735854","https://openalex.org/W2222733372","https://openalex.org/W2255153930","https://openalex.org/W2410436964","https://openalex.org/W2168084344","https://openalex.org/W2285080790"],"abstract_inverted_index":{"In":[0],"the":[1,33,69,157,163,189,199,203,209],"rat,":[2],"intrarenal":[3,87],"infusion":[4,44,89],"of":[5,24,35,160,188,202,233,239,242],"epidermal":[6,18],"growth":[7,19],"factor":[8,20],"decreases":[9],"renal":[10,210,228],"blood":[11],"flow":[12],"and":[13,17,51,135,173,229],"glomerular":[14,136],"filtration":[15,137],"rate,":[16],"(EGF)":[21],"induces":[22],"contraction":[23],"cultured":[25],"rat":[26],"mesangial":[27],"cells.":[28],"The":[29],"present":[30],"studies":[31],"examined":[32],"role":[34],"arachidonic":[36,220],"acid":[37,221],"metabolites":[38],"in":[39,52,122,217],"this":[40],"response.":[41],"Intrarenal":[42],"EGF":[43,55,88,177,214,234],"increased":[45],"urinary":[46],"iPGF2":[47,57],"alpha":[48,58],"by":[49,59,119,156,198,219],"300%,":[50],"isolated":[53],"glomeruli":[54],"stimulated":[56],"38%,":[60],"but":[61,95],"did":[62,75],"not":[63,76],"affect":[64],"thromboxane":[65,70],"B2":[66],"production.":[67],"Furthermore,":[68],"A2":[71],"receptor":[72],"antagonist,":[73],"SQ29548,":[74],"block":[77],"EGF's":[78,193],"vasoconstrictive":[79,194],"effects.":[80],"After":[81],"selective":[82],"cyclooxygenase":[83,168],"inhibition":[84,169,224],"with":[85,185],"ibuprofen,":[86],"no":[90],"longer":[91],"produced":[92],"local":[93],"vasoconstriction":[94],"instead":[96],"led":[97],"to":[98,176,213,236],"systemic":[99,230,240],"vasodilation":[100,165],"(SBP:":[101],"117":[102],"+/-":[103,107,125,129,140,144],"10":[104],"vs.":[105,127,142],"98":[106],"7;":[108],"n":[109],"=":[110],"5;":[111],"P":[112,131,146],"less":[113,132,147],"than":[114,133,148],"0.05)":[115],"that":[116],"was":[117,154,171],"accompanied":[118],"significant":[120],"increases":[121],"RPF":[123],"(3.8":[124],"0.4":[126],"5.6":[128],"0.2;":[130],"0.01)":[134],"rate":[138],"(0.9":[139],"0.1":[141],"1.1":[143],"0.1;":[145],"0.05).":[149],"When":[150],"total":[151],"arachidonate":[152,244],"metabolism":[153],"inhibited":[155],"additional":[158],"administration":[159,187,201],"5,8,11,14-eicosatetraynoic":[161],"acid,":[162],"EGF-induced":[164],"observed":[166],"during":[167],"alone":[170],"abolished,":[172],"vasoconstrictor":[174],"responses":[175,212],"were":[178,183,196],"again":[179],"noted.":[180],"Similar":[181],"effects":[182,195],"noted":[184],"concomitant":[186],"c-P450":[190],"inhibitor":[191],"ketoconazole.":[192],"unaltered":[197],"simultaneous":[200],"angiotensin":[204],"II":[205],"antagonist":[206],"saralasin.":[207],"Thus,":[208],"hemodynamic":[211],"are":[215],"mediated":[216],"part":[218],"metabolites.":[222,245],"Cyclooxygenase":[223],"unmasks":[225],"a":[226],"potent":[227],"vasodilator":[231],"action":[232],"owing":[235],"its":[237],"stimulation":[238],"release":[241],"noncyclooxygenase":[243]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}