{"id":"https://openalex.org/W1554596985","doi":"https://doi.org/10.3233/jad-2012-111661","title":"Long-Term Pioglitazone Treatment Improves Learning and Attenuates Pathological Markers in a Mouse Model of Alzheimer's Disease","display_name":"Long-Term Pioglitazone Treatment Improves Learning and Attenuates Pathological Markers in a Mouse Model of Alzheimer's Disease","publication_year":2012,"publication_date":"2012-06-18","ids":{"openalex":"https://openalex.org/W1554596985","doi":"https://doi.org/10.3233/jad-2012-111661","mag":"1554596985","pmid":"https://pubmed.ncbi.nlm.nih.gov/22495349","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3378773"},"language":"en","primary_location":{"id":"doi:10.3233/jad-2012-111661","doi":"https://doi.org/10.3233/jad-2012-111661","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-2012-111661","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3378773","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110233198","display_name":"James L. Searcy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James L. Searcy","raw_affiliation_strings":["Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA","Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY 40536-0084, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY 40536-0084, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030787483","display_name":"Jeremiah T. Phelps","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremiah T. Phelps","raw_affiliation_strings":["Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061051142","display_name":"Tristano Pancani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tristano Pancani","raw_affiliation_strings":["Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008526202","display_name":"Inga Kadish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inga Kadish","raw_affiliation_strings":["Department of Cell Biology, University of Alabama, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Alabama, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029648219","display_name":"Jelena Popovi\u0107","orcid":"https://orcid.org/0000-0001-8565-1555","observed_orcids":["https://orcid.org/0000-0001-8565-1555"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jelena Popovic","raw_affiliation_strings":["Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022076132","display_name":"Katie L. Anderson","orcid":"https://orcid.org/0000-0002-5479-1042","observed_orcids":["https://orcid.org/0000-0002-5479-1042"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie L. Anderson","raw_affiliation_strings":["Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062999763","display_name":"Tina L. Beckett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina L. Beckett","raw_affiliation_strings":["Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael P. Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. Murphy","raw_affiliation_strings":["Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008952226","display_name":"Kuey-Chu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuey-Chu Chen","raw_affiliation_strings":["Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031130745","display_name":"Eric M. Blalock","orcid":"https://orcid.org/0000-0001-7242-9429","observed_orcids":["https://orcid.org/0000-0001-7242-9429"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric M. Blalock","raw_affiliation_strings":["Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110055859","display_name":"Philip W. Landfield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip W. Landfield","raw_affiliation_strings":["Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112207912","display_name":"Nada M. Porter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nada M. Porter","raw_affiliation_strings":["Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101436772","display_name":"Olivier Thibault","orcid":"https://orcid.org/0000-0002-3548-3466","observed_orcids":["https://orcid.org/0000-0002-3548-3466"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Olivier Thibault","raw_affiliation_strings":["Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101436772"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":10.0825,"has_fulltext":false,"cited_by_count":154,"citation_normalized_percentile":{"value":0.98781896,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"30","issue":"4","first_page":"943","last_page":"961"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thiazolidinediones","display_name":"thiazolidinediones","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.8856924176216125},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.6146813631057739},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5007388591766357},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46304088830947876},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4607907235622406},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4560217559337616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45340269804000854},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4473772943019867},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42690131068229675},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.41318970918655396},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.39160043001174927},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3561564087867737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31086230278015137},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.25184908509254456}],"mesh":[{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3233/jad-2012-111661","doi":"https://doi.org/10.3233/jad-2012-111661","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-2012-111661","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmid:22495349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22495349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2532476","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3378773","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3378773","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3378773","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Alzheimers Dis","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2532476","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3378773","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G139649829","display_name":null,"funder_award_id":"AG-029268","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G184092307","display_name":"Mechanisms and use of antidiabetic agents in brain aging and Alzheimer's disease","funder_award_id":"R21AG029268","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2512053474","display_name":"Calcium Regulation in Brain Aging and Alzheimer's Disease","funder_award_id":"P01AG010836","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G287371288","display_name":null,"funder_award_id":"AG033649","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4035716779","display_name":null,"funder_award_id":"AG020251","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4328661011","display_name":"Estrogen, CA2+ Channels and (ca2+) in Hippocampal Aging","funder_award_id":"R01AG020251","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4378997842","display_name":null,"funder_award_id":"AG010836","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4797731823","display_name":"Center of Biomedical Research Excellence- Women's Health","funder_award_id":"P20RR015592","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G507895451","display_name":"Hippocampal Electrophysiology and Myelinogenesis in Healthy Cognitive Aging","funder_award_id":"R01AG034605","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5087351033","display_name":null,"funder_award_id":"AG034605","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G838520318","display_name":"A healthy brain aging strategy to restore insulin signaling and Ca homeostasis","funder_award_id":"R01AG033649","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000879140","display_name":"Chronic Stress, Glucocorticoids, and Progesterone in Brain Aging","funder_award_id":"R01AG037868","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332688","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":113,"referenced_works":["https://openalex.org/W17728281","https://openalex.org/W45534775","https://openalex.org/W1118098720","https://openalex.org/W1497413049","https://openalex.org/W1502434755","https://openalex.org/W1566564316","https://openalex.org/W1602771322","https://openalex.org/W1678111194","https://openalex.org/W1962254068","https://openalex.org/W1967375871","https://openalex.org/W1967464880","https://openalex.org/W1970976633","https://openalex.org/W1971745156","https://openalex.org/W1972965665","https://openalex.org/W1973614663","https://openalex.org/W1974297132","https://openalex.org/W1974973241","https://openalex.org/W1975355627","https://openalex.org/W1975561886","https://openalex.org/W1976619844","https://openalex.org/W1979336030","https://openalex.org/W1980524078","https://openalex.org/W1980905876","https://openalex.org/W1982100326","https://openalex.org/W1983282794","https://openalex.org/W1986503634","https://openalex.org/W1988278010","https://openalex.org/W1990060970","https://openalex.org/W1990179627","https://openalex.org/W1990300073","https://openalex.org/W1990724339","https://openalex.org/W1990774375","https://openalex.org/W1998933601","https://openalex.org/W1999546189","https://openalex.org/W1999856629","https://openalex.org/W2001851169","https://openalex.org/W2003158170","https://openalex.org/W2004852048","https://openalex.org/W2007379387","https://openalex.org/W2011506501","https://openalex.org/W2017875788","https://openalex.org/W2022148815","https://openalex.org/W2022178570","https://openalex.org/W2022317515","https://openalex.org/W2025931796","https://openalex.org/W2026587111","https://openalex.org/W2028607330","https://openalex.org/W2032327611","https://openalex.org/W2032627181","https://openalex.org/W2036409697","https://openalex.org/W2037611373","https://openalex.org/W2038639632","https://openalex.org/W2043841065","https://openalex.org/W2044604492","https://openalex.org/W2048622057","https://openalex.org/W2055488264","https://openalex.org/W2056007810","https://openalex.org/W2059382506","https://openalex.org/W2059552796","https://openalex.org/W2059880102","https://openalex.org/W2060274086","https://openalex.org/W2060678630","https://openalex.org/W2068226389","https://openalex.org/W2069317363","https://openalex.org/W2071945356","https://openalex.org/W2074069151","https://openalex.org/W2080550827","https://openalex.org/W2083579642","https://openalex.org/W2083850312","https://openalex.org/W2087395189","https://openalex.org/W2096498757","https://openalex.org/W2097478521","https://openalex.org/W2099271519","https://openalex.org/W2099452973","https://openalex.org/W2106192181","https://openalex.org/W2109876897","https://openalex.org/W2110347660","https://openalex.org/W2112256576","https://openalex.org/W2113238381","https://openalex.org/W2114729479","https://openalex.org/W2117351839","https://openalex.org/W2117396078","https://openalex.org/W2118725696","https://openalex.org/W2119343648","https://openalex.org/W2119791710","https://openalex.org/W2123631984","https://openalex.org/W2131047041","https://openalex.org/W2132977458","https://openalex.org/W2134567873","https://openalex.org/W2138886810","https://openalex.org/W2143770895","https://openalex.org/W2147486806","https://openalex.org/W2147654688","https://openalex.org/W2149077676","https://openalex.org/W2151638758","https://openalex.org/W2152304945","https://openalex.org/W2152471765","https://openalex.org/W2158217645","https://openalex.org/W2160313172","https://openalex.org/W2160662703","https://openalex.org/W2160697532","https://openalex.org/W2160936941","https://openalex.org/W2162134510","https://openalex.org/W2163301650","https://openalex.org/W2166451813","https://openalex.org/W2166853536","https://openalex.org/W2168546553","https://openalex.org/W2327879418","https://openalex.org/W2330262417","https://openalex.org/W2336513583","https://openalex.org/W2405748918","https://openalex.org/W2916511598","https://openalex.org/W2917600742"],"related_works":["https://openalex.org/W2057091329","https://openalex.org/W1872421022","https://openalex.org/W2047665209","https://openalex.org/W2332520644","https://openalex.org/W1966244691","https://openalex.org/W3118369538","https://openalex.org/W2581601389","https://openalex.org/W4388041816","https://openalex.org/W1552902716","https://openalex.org/W2154973096"],"abstract_inverted_index":{"Thiazolidinediones":[0],"(TZDs)":[1],"are":[2,11],"agonists":[3],"at":[4,75,103],"peroxisome":[5],"proliferator-activated":[6],"gamma-type":[7],"(PPAR-\u03b3)":[8],"receptors":[9],"and":[10,33,93,131,134,137,143,178,182],"used":[12],"clinically":[13],"for":[14],"the":[15,54,80,99,121,218],"treatment":[16,164],"of":[17,78,85,155,171,175],"type":[18],"2":[19],"diabetes":[20],"where":[21],"they":[22],"have":[23,59],"been":[24,60],"shown":[25],"to":[26,213],"reestablish":[27],"insulin":[28],"sensitivity,":[29],"improve":[30],"lipid":[31,183],"profiles,":[32],"reduce":[34],"inflammation.":[35],"Recent":[36],"work":[37],"also":[38,207],"suggests":[39],"that":[40,196],"TZDs":[41,197],"may":[42,71],"be":[43,72],"beneficial":[44,115],"in":[45,53,180,217],"Alzheimer's":[46],"disease":[47,55],"(AD),":[48],"ameliorating":[49],"cognitive":[50,69,200],"decline":[51],"early":[52],"process.":[56],"However,":[57],"there":[58],"only":[61],"a":[62],"few":[63],"studies":[64,194],"identifying":[65],"mechanisms":[66],"through":[67],"which":[68],"benefits":[70],"exerted.":[73],"Starting":[74],"10":[76],"months":[77],"age,":[79],"triple":[81],"transgenic":[82],"mouse":[83],"model":[84],"AD":[86],"(3xTg-AD)":[87],"with":[88,98,203],"accelerated":[89],"amyloid-\u03b2":[90,130],"(A\u03b2)":[91],"deposition":[92],"tau":[94,132],"pathology":[95],"was":[96],"treated":[97],"TZD":[100,163],"pioglitazone":[101],"(PIO-Actos)":[102],"18":[104],"mg/Kg":[105],"body":[106],"weight/day.":[107],"After":[108],"four":[109],"months,":[110],"PIO-treated":[111],"animals":[112],"showed":[113],"multiple":[114],"effects,":[116],"including":[117,173],"improved":[118],"learning":[119],"on":[120],"active":[122],"avoidance":[123],"task,":[124],"reduced":[125],"serum":[126],"cholesterol,":[127],"decreased":[128],"hippocampal":[129,156],"deposits,":[133],"enhanced":[135],"short-":[136],"long-term":[138],"plasticity.":[139],"Electrophysiological":[140],"membrane":[141],"properties":[142],"post-treatment":[144],"blood":[145],"glucose":[146],"levels":[147],"were":[148],"unchanged":[149],"by":[150,211],"PIO.":[151],"Gene":[152],"microarray":[153],"analyses":[154],"tissue":[157],"identified":[158],"predicted":[159],"transcriptional":[160],"responses":[161],"following":[162],"as":[165,167],"well":[166],"potentially":[168],"novel":[169,214],"targets":[170,216],"TZDs,":[172],"facilitation":[174],"estrogenic":[176],"processes":[177],"decreases":[179],"glutamatergic":[181],"metabolic/cholesterol":[184],"dependent":[185],"processes.":[186],"Taken":[187],"together,":[188],"these":[189,209],"results":[190],"confirm":[191],"prior":[192],"animal":[193],"showing":[195],"can":[198],"ameliorate":[199],"deficits":[201],"associated":[202],"AD-related":[204],"pathology,":[205],"but":[206],"extend":[208],"findings":[210],"pointing":[212],"molecular":[215],"brain.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}