{"id":"https://openalex.org/W1554498669","doi":null,"title":"KCC2 as a multifunctional protein in brain development and disease","display_name":"KCC2 as a multifunctional protein in brain development and disease","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W1554498669","mag":"1554498669"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/41050","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/41050","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/41050","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091744185","display_name":"Martin Puskarjov","orcid":"https://orcid.org/0000-0001-7201-2615","observed_orcids":["https://orcid.org/0000-0001-7201-2615"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Martin Puskarjov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7201-2615","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091744185"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.09440000355243683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kcc2","display_name":"KCC2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/k-cl-cotransporter","display_name":"K+-Cl- cotransporter","score":0.8640000224113464},{"id":"https://openalex.org/keywords/chloride-homeostasis","display_name":"chloride homeostasis","score":0.6359999775886536},{"id":"https://openalex.org/keywords/post-translational-regulation","display_name":"post-translational regulation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/bdnf-trkb-signaling","display_name":"BDNF/TrkB signaling","score":0.9819999933242798},{"id":"https://openalex.org/keywords/calpain-cleavage","display_name":"calpain cleavage","score":0.7879999876022339},{"id":"https://openalex.org/keywords/nmda-receptor-activation","display_name":"NMDA receptor activation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/epileptic-seizures","display_name":"epileptic seizures","score":0.6759999990463257},{"id":"https://openalex.org/keywords/kainate-induced-seizures","display_name":"kainate-induced seizures","score":0.7910000085830688},{"id":"https://openalex.org/keywords/neonatal-hippocampus","display_name":"neonatal hippocampus","score":0.7089999914169312},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.4909999966621399},{"id":"https://openalex.org/keywords/glycine-receptor","display_name":"glycine receptor","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.50399249792099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29842087626457214},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11988025903701782}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/41050","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/41050","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:1554498669","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/bitstream/10138/41050/1/puskarjov_dissertation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/41050","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/41050","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":346,"referenced_works":["https://openalex.org/W17281879","https://openalex.org/W87609575","https://openalex.org/W99693212","https://openalex.org/W169967545","https://openalex.org/W1214933428","https://openalex.org/W1483455478","https://openalex.org/W1496503316","https://openalex.org/W1514662390","https://openalex.org/W1519160881","https://openalex.org/W1539985358","https://openalex.org/W1540999082","https://openalex.org/W1546941284","https://openalex.org/W1554045794","https://openalex.org/W1556008197","https://openalex.org/W1578110071","https://openalex.org/W1579964801","https://openalex.org/W1580029610","https://openalex.org/W1580090335","https://openalex.org/W1588629441","https://openalex.org/W1589121664","https://openalex.org/W1593588814","https://openalex.org/W1599277155","https://openalex.org/W1636188611","https://openalex.org/W1675513615","https://openalex.org/W1747729214","https://openalex.org/W1757204763","https://openalex.org/W1782310154","https://openalex.org/W1820347542","https://openalex.org/W1875383046","https://openalex.org/W1889684242","https://openalex.org/W1899908082","https://openalex.org/W1925649505","https://openalex.org/W1963614683","https://openalex.org/W1964660650","https://openalex.org/W1965286805","https://openalex.org/W1965453664","https://openalex.org/W1965865340","https://openalex.org/W1965968130","https://openalex.org/W1966342273","https://openalex.org/W1966537571","https://openalex.org/W1966999034","https://openalex.org/W1967180560","https://openalex.org/W1967251623","https://openalex.org/W1967546787","https://openalex.org/W1969521771","https://openalex.org/W1969672804","https://openalex.org/W1969703123","https://openalex.org/W1970631193","https://openalex.org/W1971208141","https://openalex.org/W1972058394","https://openalex.org/W1972578909","https://openalex.org/W1972803282","https://openalex.org/W1972988611","https://openalex.org/W1973967768","https://openalex.org/W1974879622","https://openalex.org/W1975768945","https://openalex.org/W1976450222","https://openalex.org/W1976681153","https://openalex.org/W1977013974","https://openalex.org/W1977268134","https://openalex.org/W1977539668","https://openalex.org/W1978052983","https://openalex.org/W1978222519","https://openalex.org/W1978269241","https://openalex.org/W1979017547","https://openalex.org/W1979524410","https://openalex.org/W1979761751","https://openalex.org/W1980869564","https://openalex.org/W1983449473","https://openalex.org/W1983855055","https://openalex.org/W1984539923","https://openalex.org/W1985714687","https://openalex.org/W1985793100","https://openalex.org/W1986315354","https://openalex.org/W1986910593","https://openalex.org/W1987490682","https://openalex.org/W1987545181","https://openalex.org/W1987861612","https://openalex.org/W1987878093","https://openalex.org/W1990235695","https://openalex.org/W1991342634","https://openalex.org/W1991534258","https://openalex.org/W1991545156","https://openalex.org/W1992147695","https://openalex.org/W1992840331","https://openalex.org/W1993025208","https://openalex.org/W1994547189","https://openalex.org/W1995733166","https://openalex.org/W1995946234","https://openalex.org/W1995994950","https://openalex.org/W1996803267","https://openalex.org/W1997674502","https://openalex.org/W1997950587","https://openalex.org/W1998025917","https://openalex.org/W1998600083","https://openalex.org/W1998693870","https://openalex.org/W1998966218","https://openalex.org/W2000201667","https://openalex.org/W2000678493","https://openalex.org/W2000757833","https://openalex.org/W2001421710","https://openalex.org/W2001952783","https://openalex.org/W2001954021","https://openalex.org/W2002044194","https://openalex.org/W2004846311","https://openalex.org/W2004995590","https://openalex.org/W2005003076","https://openalex.org/W2006276593","https://openalex.org/W2006329675","https://openalex.org/W2006526323","https://openalex.org/W2008374289","https://openalex.org/W2010537797","https://openalex.org/W2010944214","https://openalex.org/W2011209444","https://openalex.org/W2012080020","https://openalex.org/W2013632767","https://openalex.org/W2014104667","https://openalex.org/W2014232729","https://openalex.org/W2014902926","https://openalex.org/W2015020129","https://openalex.org/W2017791457","https://openalex.org/W2019909157","https://openalex.org/W2019930847","https://openalex.org/W2020197694","https://openalex.org/W2022689242","https://openalex.org/W2024642025","https://openalex.org/W2024875626","https://openalex.org/W2025548325","https://openalex.org/W2027914722","https://openalex.org/W2027917639","https://openalex.org/W2029790055","https://openalex.org/W2029941472","https://openalex.org/W2030188509","https://openalex.org/W2031766704","https://openalex.org/W2032149216","https://openalex.org/W2033087539","https://openalex.org/W2034906099","https://openalex.org/W2035376932","https://openalex.org/W2035682847","https://openalex.org/W2036342829","https://openalex.org/W2036475318","https://openalex.org/W2036499082","https://openalex.org/W2037901696","https://openalex.org/W2038215475","https://openalex.org/W2039353723","https://openalex.org/W2039479200","https://openalex.org/W2039630605","https://openalex.org/W2040046756","https://openalex.org/W2040159202","https://openalex.org/W2040574849","https://openalex.org/W2041357157","https://openalex.org/W2042011830","https://openalex.org/W2042131974","https://openalex.org/W2042398065","https://openalex.org/W2043074303","https://openalex.org/W2043827139","https://openalex.org/W2044834902","https://openalex.org/W2045221743","https://openalex.org/W2045535967","https://openalex.org/W2045631079","https://openalex.org/W2047481062","https://openalex.org/W2048355879","https://openalex.org/W2048489471","https://openalex.org/W2048620002","https://openalex.org/W2049075326","https://openalex.org/W2050049078","https://openalex.org/W2051395367","https://openalex.org/W2051429876","https://openalex.org/W2051573648","https://openalex.org/W2052479189","https://openalex.org/W2052655550","https://openalex.org/W2053491858","https://openalex.org/W2053632669","https://openalex.org/W2056096847","https://openalex.org/W2057241422","https://openalex.org/W2057684943","https://openalex.org/W2057913835","https://openalex.org/W2058347141","https://openalex.org/W2058820929","https://openalex.org/W2058910963","https://openalex.org/W2059067548","https://openalex.org/W2059754952","https://openalex.org/W2059803012","https://openalex.org/W2060239276","https://openalex.org/W2060394467","https://openalex.org/W2061046931","https://openalex.org/W2062146437","https://openalex.org/W2063091823","https://openalex.org/W2063663360","https://openalex.org/W2064217286","https://openalex.org/W2064420819","https://openalex.org/W2064983289","https://openalex.org/W2065226043","https://openalex.org/W2065691403","https://openalex.org/W2066284829","https://openalex.org/W2066410931","https://openalex.org/W2066782949","https://openalex.org/W2067656182","https://openalex.org/W2067955179","https://openalex.org/W2068811322","https://openalex.org/W2069080617","https://openalex.org/W2069226218","https://openalex.org/W2069586118","https://openalex.org/W2070882743","https://openalex.org/W2071306448","https://openalex.org/W2072125344","https://openalex.org/W2072329780","https://openalex.org/W2073626127","https://openalex.org/W2074329406","https://openalex.org/W2075976227","https://openalex.org/W2076401822","https://openalex.org/W2077682140","https://openalex.org/W2078261272","https://openalex.org/W2078633585","https://openalex.org/W2078981560","https://openalex.org/W2079917694","https://openalex.org/W2080855172","https://openalex.org/W2082053152","https://openalex.org/W2082503841","https://openalex.org/W2083023163","https://openalex.org/W2083548678","https://openalex.org/W2084712021","https://openalex.org/W2085779496","https://openalex.org/W2086485645","https://openalex.org/W2086674946","https://openalex.org/W2086869585","https://openalex.org/W2087235914","https://openalex.org/W2087588464","https://openalex.org/W2087826027","https://openalex.org/W2088002226","https://openalex.org/W2088475496","https://openalex.org/W2088767961","https://openalex.org/W2089126506","https://openalex.org/W2089128901","https://openalex.org/W2089509563","https://openalex.org/W2089880551","https://openalex.org/W2090362914","https://openalex.org/W2091811407","https://openalex.org/W2094510319","https://openalex.org/W2094776565","https://openalex.org/W2096120932","https://openalex.org/W2096624763","https://openalex.org/W2096695182","https://openalex.org/W2098336656","https://openalex.org/W2099218390","https://openalex.org/W2099387266","https://openalex.org/W2100001024","https://openalex.org/W2100326455","https://openalex.org/W2100561934","https://openalex.org/W2101604610","https://openalex.org/W2102329408","https://openalex.org/W2103195503","https://openalex.org/W2104166001","https://openalex.org/W2104254243","https://openalex.org/W2104592058","https://openalex.org/W2105416140","https://openalex.org/W2105549490","https://openalex.org/W2106520658","https://openalex.org/W2106733439","https://openalex.org/W2107824553","https://openalex.org/W2108286207","https://openalex.org/W2108428404","https://openalex.org/W2109309568","https://openalex.org/W2110169026","https://openalex.org/W2112888723","https://openalex.org/W2113500592","https://openalex.org/W2114519398","https://openalex.org/W2117058545","https://openalex.org/W2117329255","https://openalex.org/W2118468276","https://openalex.org/W2118687598","https://openalex.org/W2118950242","https://openalex.org/W2118995823","https://openalex.org/W2120817558","https://openalex.org/W2121646382","https://openalex.org/W2122005721","https://openalex.org/W2122092731","https://openalex.org/W2122623728","https://openalex.org/W2124328917","https://openalex.org/W2124958630","https://openalex.org/W2127344436","https://openalex.org/W2127983299","https://openalex.org/W2128676313","https://openalex.org/W2128994172","https://openalex.org/W2129176777","https://openalex.org/W2129455633","https://openalex.org/W2129934770","https://openalex.org/W2130156018","https://openalex.org/W2130493951","https://openalex.org/W2131046634","https://openalex.org/W2131255875","https://openalex.org/W2134236497","https://openalex.org/W2135812219","https://openalex.org/W2136422049","https://openalex.org/W2137215947","https://openalex.org/W2139289922","https://openalex.org/W2141043781","https://openalex.org/W2141686625","https://openalex.org/W2143807595","https://openalex.org/W2143998666","https://openalex.org/W2145818012","https://openalex.org/W2145861425","https://openalex.org/W2146772573","https://openalex.org/W2147918634","https://openalex.org/W2147940269","https://openalex.org/W2148820240","https://openalex.org/W2150471537","https://openalex.org/W2151206192","https://openalex.org/W2152099367","https://openalex.org/W2153507803","https://openalex.org/W2155471406","https://openalex.org/W2155924534","https://openalex.org/W2156127424","https://openalex.org/W2156473266","https://openalex.org/W2157154651","https://openalex.org/W2157260779","https://openalex.org/W2157751549","https://openalex.org/W2158404383","https://openalex.org/W2159366883","https://openalex.org/W2160607236","https://openalex.org/W2161121393","https://openalex.org/W2162144684","https://openalex.org/W2162332184","https://openalex.org/W2162500823","https://openalex.org/W2162644678","https://openalex.org/W2162648242","https://openalex.org/W2163047259","https://openalex.org/W2163414525","https://openalex.org/W2164571708","https://openalex.org/W2164926859","https://openalex.org/W2166888791","https://openalex.org/W2166986783","https://openalex.org/W2167049113","https://openalex.org/W2167643582","https://openalex.org/W2169436026","https://openalex.org/W2171404927","https://openalex.org/W2171661590","https://openalex.org/W2185275195","https://openalex.org/W2230118829","https://openalex.org/W2245762304","https://openalex.org/W2267979056","https://openalex.org/W2322833765","https://openalex.org/W2415932563","https://openalex.org/W2435285487","https://openalex.org/W2952450708","https://openalex.org/W4254059493"],"related_works":["https://openalex.org/W2022415907","https://openalex.org/W3037855296","https://openalex.org/W2146772573","https://openalex.org/W1578110071","https://openalex.org/W3021475609","https://openalex.org/W4225416941","https://openalex.org/W1588629441","https://openalex.org/W1504478424","https://openalex.org/W4389024586","https://openalex.org/W2022805628"],"abstract_inverted_index":{"Active":[0],"extrusion":[1,148],"of":[2,59,83,87,98,118,145,165,171,204,217,223,231,245,258,269,306,312,318,339,359,386,393,407,415,444,459,466,481,492,498,509],"Cl-":[3,21,147],"from":[4,67,284,289],"the":[5,9,18,25,65,96,115,163,214,248,253,266,296,309,333,341,354,372,383,404,411,418,447,460,479,486,496,506],"neuronal":[6,146,320,355],"cytoplasm":[7],"by":[8,24,151,177,182,247],"neuron-specific":[10],"K-Cl":[11,342],"co-transporter":[12],"isoform":[13],"KCC2":[14,60,84,99,119,160,172,218,232,246,270,293,313,326,376,408,435,467,499],"is":[15,40,61,124,226,239,272,280,346,391,468],"necessary":[16,472],"for":[17,64,95,129,208,213,427,478],"hyperpolarizing":[19,70],"inhibitory":[20,51],"currents":[22],"mediated":[23,176,240],"GABA":[26],"receptors":[27],"(GABAARs).":[28],"Early":[29],"in":[30,46,121,155,162,191,201,308,314,349,382,430,439,442,505],"development":[31,101,508],"and":[32,43,73,85,102,188,229,243,261,352,361,410,511],"following":[33,233,371],"cellular":[34],"trauma":[35],"or":[36],"seizures,":[37],"GABAAR-mediated":[38,71],"signaling":[39],"often":[41,79],"depolarizing":[42,68,88],"may":[44],"even,":[45],"contrast":[47,196],"to":[48,69,81,174,185,197,282,316,331,357,396,423],"its":[49,105,130,183,189,394],"classical":[50],"action,":[52],"promote":[53],"action":[54],"potential":[55],"firing.":[56],"Developmental":[57],"up-regulation":[58,97,216],"largely":[62],"responsible":[63,94],"shift":[66],"signaling,":[72,179],"conditions":[74,279,317],"associated":[75],"with":[76,138],"brain":[77,419,448,487],"pathology":[78],"lead":[80],"loss":[82],"re-emergence":[86],"GABAAR":[89],"responses.":[90],"The":[91,110,399,457,490],"molecular":[92],"mechanisms":[93],"during":[100,417,446,485],"those":[103],"mediating":[104],"down-regulation,":[106],"however,":[107],"remain":[108],"elusive.":[109],"present":[111,297,461],"Thesis":[112],"demonstrates":[113],"that":[114,227,265,375,390,464],"low":[116],"level":[117],"protein":[120,161,259,262,271,429],"immature":[122],"neurons":[123],"not":[125,158,452,469],"a":[126,141,152,366,379,424,437,471,475],"limiting":[127],"factor":[128,504],"functional":[131,202,310,482,507],"activation.":[132],"A":[133],"single":[134],"seizure":[135],"episode":[136],"induced":[137],"kainate":[139],"triggers":[140],"fast":[142,199],"transient":[143],"enhancement":[144],"capacity":[149],"paralleled":[150],"large":[153],"increase":[154],"surface-expressed":[156],"but":[157,473],"total":[159],"hippocampus":[164],"neonatal":[166],"rodents.":[167],"This":[168],"post-translational":[169,300],"activation":[170,238,358],"appears":[173],"be":[175],"BDNF-TrkB":[178],"as":[180,302,323,344,500],"evidenced":[181],"sensitivity":[184],"Trk":[186],"inhibition":[187],"absence":[190],"BDNF":[192,210],"knockout":[193],"mice.":[194],"In":[195],"these":[198],"changes":[200,307],"expression":[203,311,409,465],"KCC2,":[205],"no":[206],"requirement":[207],"endogenous":[209],"was":[211],"observed":[212],"developmental":[215,405],"protein.":[219],"Another":[220],"key":[221],"finding":[222],"this":[224,428,493],"work":[225,462,494],"down-regulation":[228,276],"inactivation":[230],"intense":[234,413],"NMDA":[235],"receptor":[236],"(NMDAR)":[237],"via":[241],"cleavage":[242],"truncation":[244],"calcium-activated":[249],"protease":[250],"calpain.":[251],"Importantly,":[252,433],"data":[254],"obtained":[255],"using":[256],"inhibitors":[257],"degradation":[260,286],"synthesis":[263],"indicate":[264],"basal":[267],"turn-over":[268],"slow":[273],"and,":[274],"consequently,":[275],"under":[277],"pathological":[278],"likely":[281],"result":[283],"enhanced":[285,319],"rather":[287],"than":[288],"reduced":[290],"de":[291],"novo":[292],"synthesis.":[294],"Together,":[295],"findings":[298],"highlight":[299],"regulation":[301],"an":[303,501],"important":[304,502],"mediator":[305],"response":[315,356],"activity,":[321],"such":[322,365],"epileptic":[324],"seizures.":[325],"has":[327,368,377,451],"been":[328,453],"traditionally":[329],"regarded":[330],"have":[332],"most":[334,412],"clearly":[335],"defined":[336],"physio-logical":[337],"role":[338,381,426,438],"all":[340],"cotransporters,":[343],"it":[345],"uniquely":[347],"expressed":[348],"central":[350],"neurons,":[351],"determines":[353],"GABAA":[360],"glycine":[362],"receptors.":[363],"However,":[364],"view":[367],"changed":[369],"drastically":[370],"unexpected":[373],"observation":[374],"also":[378,474],"structural":[380],"morphological":[384],"maintenance":[385],"dendritic":[387],"spines,":[388],"one":[389],"independent":[392],"ability":[395],"transport":[397],"ions.":[398],"intimate":[400],"temporal":[401],"coincidence":[402],"between":[403],"onset":[406],"phase":[414],"synaptogenesis":[416],"growth":[420,449,488],"spurt":[421,450],"points":[422],"possible":[425],"synapse":[431],"formation.":[432],"whether":[434],"plays":[436],"spinogenesis":[440],"i.e.":[441],"induction":[443,480],"spines":[445,484],"investigated":[454],"so":[455],"far.":[456],"results":[458,491],"demonstrate":[463],"only":[470],"sufficient":[476],"condition":[477],"glutamatergic":[483,510],"spurt.":[489],"support":[495],"idea":[497],"synchronizing":[503],"GABAergic":[512],"signaling.":[513]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
