{"id":"https://openalex.org/W1554380657","doi":"https://doi.org/10.2210/pdb4cln/pdb","title":"STRUCTURE OF A RECOMBINANT CALMODULIN FROM DROSOPHILA MELANOGASTER REFINED AT 2.2-ANGSTROMS RESOLUTION","display_name":"STRUCTURE OF A RECOMBINANT CALMODULIN FROM DROSOPHILA MELANOGASTER REFINED AT 2.2-ANGSTROMS RESOLUTION","publication_year":1991,"publication_date":"1991-06-24","ids":{"openalex":"https://openalex.org/W1554380657","doi":"https://doi.org/10.2210/pdb4cln/pdb","mag":"1554380657","pmid":"https://pubmed.ncbi.nlm.nih.gov/1939171"},"language":"en","primary_location":{"id":"doi:10.2210/pdb4cln/pdb","doi":"https://doi.org/10.2210/pdb4cln/pdb","is_oa":false,"landing_page_url":"https://doi.org/10.2210/pdb4cln/pdb","pdf_url":null,"source":{"id":"https://openalex.org/S7407063902","display_name":"Worldwide Protein Data Bank","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Worldwide Protein Data Bank","raw_type":"dataset"},"volume":null,"type":"dataset","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"D.A. Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.A. Taylor","raw_affiliation_strings":["Howard Hughes Medical Institute, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Houston, Texas","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083385424","display_name":"John S. Sack","orcid":"https://orcid.org/0000-0003-1542-9515","observed_orcids":["https://orcid.org/0000-0003-1542-9515"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.S. Sack","raw_affiliation_strings":["Howard Hughes Medical Institute, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Houston, Texas","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000428603","display_name":"John F. Maune","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.F. Maune","raw_affiliation_strings":["Howard Hughes Medical Institute, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Houston, Texas","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044932364","display_name":"Kathleen Beckingham","orcid":"https://orcid.org/0000-0003-1585-196X","observed_orcids":["https://orcid.org/0000-0003-1585-196X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Beckingham","raw_affiliation_strings":["Howard Hughes Medical Institute, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Houston, Texas","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091154586","display_name":"Florante A. Quiocho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F.A. Quiocho","raw_affiliation_strings":["Howard Hughes Medical Institute, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Houston, Texas","institution_ids":["https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1344073410"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":123,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"266","issue":"32","first_page":"21375","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.295199990272522,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9990000128746033},{"id":"https://openalex.org/keywords/recombinant-protein","display_name":"recombinant protein","score":0.7689999938011169},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.8119999766349792},{"id":"https://openalex.org/keywords/calcium-binding-domain","display_name":"calcium-binding domain","score":0.8550000190734863},{"id":"https://openalex.org/keywords/structure-refinement","display_name":"structure refinement","score":0.5339999794960022},{"id":"https://openalex.org/keywords/amino-acid-variation","display_name":"amino acid sequence variation","score":0.4860000014305115},{"id":"https://openalex.org/keywords/prokaryotic-expression","display_name":"prokaryotic expression","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.8275087475776672},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.6482739448547363},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.5581040382385254},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5539931058883667},{"id":"https://openalex.org/C42086223","wikidata":"https://www.wikidata.org/wiki/Q24723907","display_name":"EF hand","level":4,"score":0.5526583194732666},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.547203004360199},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.5025455951690674},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.49409249424934387},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4664112329483032},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.4581853449344635},{"id":"https://openalex.org/C71907059","wikidata":"https://www.wikidata.org/wiki/Q223323","display_name":"Root mean square","level":2,"score":0.45250073075294495},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.4524116516113281},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4493645429611206},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4380887746810913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.269278347492218},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1886672079563141},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.17356175184249878},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.060218364000320435},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2210/pdb4cln/pdb","doi":"https://doi.org/10.2210/pdb4cln/pdb","is_oa":false,"landing_page_url":"https://doi.org/10.2210/pdb4cln/pdb","pdf_url":null,"source":{"id":"https://openalex.org/S7407063902","display_name":"Worldwide Protein Data Bank","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Worldwide Protein Data Bank","raw_type":"dataset"},{"id":"pmid:1939171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1939171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.47999998927116394}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W174576902","https://openalex.org/W1512693490","https://openalex.org/W1516864086","https://openalex.org/W1533853543","https://openalex.org/W1566619188","https://openalex.org/W1571243084","https://openalex.org/W1593235330","https://openalex.org/W1608052268","https://openalex.org/W1966041739","https://openalex.org/W1972198084","https://openalex.org/W1979117430","https://openalex.org/W1985322317","https://openalex.org/W1998493256","https://openalex.org/W2011852447","https://openalex.org/W2021981318","https://openalex.org/W2030669640","https://openalex.org/W2037425244","https://openalex.org/W2037710668","https://openalex.org/W2042987185","https://openalex.org/W2058012486","https://openalex.org/W2059401704","https://openalex.org/W2065717154","https://openalex.org/W2069187446","https://openalex.org/W2070510843","https://openalex.org/W2078154491","https://openalex.org/W2088363148","https://openalex.org/W2092875818","https://openalex.org/W2096716204","https://openalex.org/W2110591420","https://openalex.org/W2135860264","https://openalex.org/W2137325004"],"related_works":["https://openalex.org/W4243556619","https://openalex.org/W2061095840","https://openalex.org/W2069187446","https://openalex.org/W1976566429","https://openalex.org/W2089119029","https://openalex.org/W2975669104","https://openalex.org/W4071648","https://openalex.org/W2067238658","https://openalex.org/W34502439","https://openalex.org/W2131327962"],"abstract_inverted_index":{"The":[0,67,101,119,181],"crystal":[1],"structure":[2,29,103],"of":[3,30,47,89,137,156,164,173,190,208,215,217],"calmodulin":[4],"(Mr":[5],"16,700,":[6],"148":[7],"residues)":[8],"from":[9,86],"Drosophila":[10,140],"melanogaster":[11],"as":[12],"expressed":[13],"in":[14,202],"a":[15,42,110,154,168,185],"bacterial":[16],"system":[17],"has":[18,81],"been":[19],"determined":[20],"and":[21,38,76,80,95,126,139,212],"refined":[22,39,151],"at":[23],"2.2-A":[24],"resolution.":[25],"Starting":[26],"with":[27,41,109],"the":[28,50,63,115,133,150,160,165,177,194,203,206,209,213,218],"mammalian":[31,107,138],"calmodulin,":[32,108],"we":[33],"produced":[34],"an":[35],"extensively":[36],"refitted":[37],"model":[40,68,152],"conventional":[43],"crystallographic":[44],"R":[45],"value":[46],"0.197":[48],"for":[49,92,98,176,193],"5,239":[51],"reflections":[52],"(F":[53],"greater":[54],"than":[55],"or":[56],"equal":[57],"to":[58,106],"2":[59],"sigma":[60],"(F))":[61],"within":[62],"10.0-2.2-A":[64],"resolution":[65],"range.":[66],"includes":[69],"1,164":[70],"protein":[71],"atoms,":[72],"4":[73],"calcium":[74],"ions,":[75],"78":[77],"water":[78],"molecules":[79],"root":[82,169,186],"mean":[83,170,187],"square":[84,171,188],"deviations":[85],"standard":[87],"values":[88],"0.018":[90],"A":[91,97,175,192],"bond":[93],"lengths":[94],"0.043":[96],"angle":[99],"distances.":[100],"overall":[102],"is":[104],"similar":[105],"seven-turn":[111],"central":[112,210],"helix":[113],"connecting":[114],"two":[116,161],"calcium-binding":[117,130,182],"domains.":[118],"\"dumb-bell\"":[120],"shaped":[121],"molecule":[122],"contains":[123],"seven":[124],"alpha-helices":[125],"four":[127],"\"EF":[128],"hand\"":[129],"sites.":[131],"Although":[132],"amino":[134,147,204],"acid":[135,148],"sequences":[136],"calmodulins":[141],"differ":[142],"by":[143],"only":[144],"three":[145],"conservative":[146],"changes,":[149],"reveals":[153],"number":[155],"significant":[157],"differences":[158,201],"between":[159],"structures.":[162],"Superimposition":[163],"structures":[166],"yields":[167],"deviation":[172,189],"1.22":[174],"1,120":[178],"equivalent":[179,196],"atoms.":[180,197],"domains":[183],"have":[184],"0.85":[191],"353":[195],"There":[198],"are":[199],"also":[200],"terminus,":[205],"bend":[207],"alpha-helix,":[211],"orientations":[214],"some":[216],"side":[219],"chains.":[220]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
