{"id":"https://openalex.org/W1554040187","doi":null,"title":"TRANSLATIONAL REGULATORY MECHANISMS OF THE RAT AND HUMAN MULTIDRUG RESISTANCE PROTEIN 2","display_name":"TRANSLATIONAL REGULATORY MECHANISMS OF THE RAT AND HUMAN MULTIDRUG RESISTANCE PROTEIN 2","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1554040187","mag":"1554040187"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1652","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/649","pdf_url":"https://uknowledge.uky.edu/gradschool_diss/649","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/gradschool_diss/649","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100320657","display_name":"Yuanyuan Zhang","orcid":"https://orcid.org/0000-0002-4382-024X","observed_orcids":["https://orcid.org/0000-0002-4382-024X"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuanyuan Zhang","raw_affiliation_strings":["#N##TAB##TAB##TAB##TAB# Univ. of Kentucky#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Univ. of Kentucky#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100320657"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrp2","display_name":"MRP2","score":0.9660000205039978},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.6850000023841858},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/upstream-open-reading-frames","display_name":"upstream open reading frames","score":0.9940000176429749},{"id":"https://openalex.org/keywords/5-untranslated-region","display_name":"5' untranslated region","score":0.9100000262260437},{"id":"https://openalex.org/keywords/leaky-scanning","display_name":"leaky scanning","score":0.7070000171661377},{"id":"https://openalex.org/keywords/reinitiation","display_name":"reinitiation","score":0.824999988079071},{"id":"https://openalex.org/keywords/transcription-start-site","display_name":"transcription start sites","score":0.7400000095367432},{"id":"https://openalex.org/keywords/transcript-isoforms","display_name":"mRNA isoforms","score":0.8650000095367432},{"id":"https://openalex.org/keywords/bile-flow","display_name":"bile flow","score":0.5809999704360962},{"id":"https://openalex.org/keywords/dubin-johnson-syndrome","display_name":"Dubin-Johnson syndrome","score":0.9079999923706055},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.36500000953674316},{"id":"https://openalex.org/keywords/human","display_name":"human","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.5883587002754211},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3607175350189209},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3546462953090668},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3451225161552429},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.23512554168701172},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22099274396896362}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1652","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/649","pdf_url":"https://uknowledge.uky.edu/gradschool_diss/649","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},{"id":"mag:1554040187","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1652&context=gradschool_diss","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:gradschool_diss-1652","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/gradschool_diss/649","pdf_url":"https://uknowledge.uky.edu/gradschool_diss/649","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Kentucky Doctoral Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1554040187.pdf","grobid_xml":"https://content.openalex.org/works/W1554040187.grobid-xml"},"referenced_works_count":110,"referenced_works":["https://openalex.org/W156357759","https://openalex.org/W1491077584","https://openalex.org/W1524216750","https://openalex.org/W1551420438","https://openalex.org/W1556342932","https://openalex.org/W1639795491","https://openalex.org/W1713545742","https://openalex.org/W1751582566","https://openalex.org/W1849730822","https://openalex.org/W1896389954","https://openalex.org/W1911655428","https://openalex.org/W1913136372","https://openalex.org/W1964813963","https://openalex.org/W1965129145","https://openalex.org/W1965635980","https://openalex.org/W1967658572","https://openalex.org/W1969152071","https://openalex.org/W1969586827","https://openalex.org/W1974338599","https://openalex.org/W1974670349","https://openalex.org/W1975405461","https://openalex.org/W1975646806","https://openalex.org/W1982542571","https://openalex.org/W1990869512","https://openalex.org/W1994363041","https://openalex.org/W2001779651","https://openalex.org/W2003535921","https://openalex.org/W2003776328","https://openalex.org/W2004253721","https://openalex.org/W2005763225","https://openalex.org/W2011628325","https://openalex.org/W2012021913","https://openalex.org/W2012170936","https://openalex.org/W2017643037","https://openalex.org/W2020177737","https://openalex.org/W2020850864","https://openalex.org/W2021841041","https://openalex.org/W2024644454","https://openalex.org/W2027195993","https://openalex.org/W2028914586","https://openalex.org/W2031580730","https://openalex.org/W2034914156","https://openalex.org/W2040324643","https://openalex.org/W2041760432","https://openalex.org/W2044309915","https://openalex.org/W2044732314","https://openalex.org/W2056509602","https://openalex.org/W2057913182","https://openalex.org/W2060297699","https://openalex.org/W2061240727","https://openalex.org/W2062832479","https://openalex.org/W2064299898","https://openalex.org/W2064618358","https://openalex.org/W2067603487","https://openalex.org/W2071924270","https://openalex.org/W2073823517","https://openalex.org/W2076435408","https://openalex.org/W2077796674","https://openalex.org/W2084860143","https://openalex.org/W2086210233","https://openalex.org/W2087064069","https://openalex.org/W2089978595","https://openalex.org/W2092103126","https://openalex.org/W2092584632","https://openalex.org/W2096478137","https://openalex.org/W2097409962","https://openalex.org/W2099390806","https://openalex.org/W2103401990","https://openalex.org/W2103862461","https://openalex.org/W2107790148","https://openalex.org/W2109134027","https://openalex.org/W2109535551","https://openalex.org/W2110511794","https://openalex.org/W2111020493","https://openalex.org/W2112930872","https://openalex.org/W2116654909","https://openalex.org/W2119336718","https://openalex.org/W2123093861","https://openalex.org/W2125457175","https://openalex.org/W2126777639","https://openalex.org/W2131459517","https://openalex.org/W2138989950","https://openalex.org/W2140158991","https://openalex.org/W2140403969","https://openalex.org/W2141019400","https://openalex.org/W2144033315","https://openalex.org/W2145766137","https://openalex.org/W2149918090","https://openalex.org/W2149960535","https://openalex.org/W2151508249","https://openalex.org/W2152174756","https://openalex.org/W2154128645","https://openalex.org/W2154283357","https://openalex.org/W2154381726","https://openalex.org/W2155568044","https://openalex.org/W2155654137","https://openalex.org/W2157112612","https://openalex.org/W2157199556","https://openalex.org/W2157497892","https://openalex.org/W2160486989","https://openalex.org/W2160984493","https://openalex.org/W2164646248","https://openalex.org/W2164775480","https://openalex.org/W2168861234","https://openalex.org/W2169992673","https://openalex.org/W2170119516","https://openalex.org/W2400840450","https://openalex.org/W2419054163","https://openalex.org/W2443862010","https://openalex.org/W2606484490"],"related_works":["https://openalex.org/W2157112612","https://openalex.org/W7096474941","https://openalex.org/W2155093567","https://openalex.org/W2778888402","https://openalex.org/W7095962534","https://openalex.org/W7097113763","https://openalex.org/W183656106","https://openalex.org/W2065178436","https://openalex.org/W2060297699","https://openalex.org/W2077738557"],"abstract_inverted_index":{"Multidrug":[0],"resistance":[1],"protein":[2],"2":[3],"(MRP2)":[4],"is":[5,24,52,198,266],"the":[6,9,13,64,73,83,116,122,145,154,159,168,180,191,194,203,208,217,242,246,256,267,271,276],"second":[7],"member":[8],"C":[10],"subfamily":[11],"in":[12,92,131,139,193,236,255],"superfamily":[14],"of":[15,30,38,44,50,72,100,109,115,128,156,170,177,202,216,233,245,275],"adenosine":[16],"triphosphate":[17],"(ATP)-binding":[18],"cassette":[19],"(ABC)":[20],"efflux":[21],"transporters.":[22],"MRP2":[23,51,65,75],"a":[25,199],"critical":[26],"player":[27],"for":[28],"generation":[29],"bile":[31,33],"acidindependent":[32],"flow":[34],"and":[35,41,46,58,76,135,158,182,207,211,263],"biliary":[36],"excretion":[37],"glutathione,":[39],"glucuronate":[40],"sulfate":[42],"conjugates":[43],"endo-":[45],"xenobiotics.":[47],"Dysfunctional":[48],"expression":[49,66,71],"associated":[53],"with":[54,251],"Dubin-Johnson":[55],"Syndrome.":[56],"Pathological":[57],"physiological":[59],"states":[60],"or":[61],"xenobiotics":[62],"change":[63],"level.":[67,85],"Under":[68],"some":[69],"conditions,":[70],"human":[74,160,183],"rat":[77,146,181,195,247,257],"Mrp2":[78,196,248],"proteins":[79],"are":[80,87,172],"regulated":[81],"at":[82,149,163],"translation":[84,104,133,178],"There":[86],"several":[88],"transcription":[89,230],"initiation":[90,231],"sites":[91,232],"MRP2/Mrp2":[93,101,234,277],"gene.":[94,278],"The":[95,107],"5\u2019":[96],"untranslated":[97],"regions":[98],"(5\u2019UTRs)":[99],"contains":[102],"multiple":[103,184,218,229],"start":[105],"codons.":[106],"focus":[108],"this":[110],"study,":[111],"therefore,":[112],"was":[113],"investigation":[114],"translational":[117,272],"regulatory":[118,273],"mechanisms":[119,274],"mediated":[120,189],"by":[121,190,222],"upstream":[123],"open":[124],"reading":[125],"frames":[126],"(uORF)":[127],"MRP2/Mrp2.":[129],"Using":[130],"vitro":[132],"assays":[134,138],"transient":[136],"cotransfection":[137],"HepG2":[140],"cells,":[141],"we":[142,227],"showed":[143],"that":[144,241],"uORF1":[147],"starting":[148,162],"position":[150,164],"-109":[151],"(relative":[152,166],"to":[153,167],"ATG":[155,169],"Mrp2)":[157],"uORF2":[161],"-105":[165],"MRP2)":[171],"two":[173],"major":[174],"cis-acting":[175],"inhibitors":[176],"among":[179],"uORFs,":[185],"respectively.":[186],"Translational":[187],"regulation":[188],"uORFs":[192],"mRNA":[197,249],"combined":[200],"effect":[201],"leaky":[204],"scanning":[205],"model":[206],"reinitiation":[209],"model,":[210],"also":[212,239],"results":[213],"from":[214],"interaction":[215],"uORFs.":[219],"In":[220],"addition,":[221],"Ribonuclease":[223],"Protection":[224],"Assays":[225],"(RPA),":[226],"detected":[228],"gene":[235],"tissues.":[237],"We":[238],"found":[240],"relative":[243],"abundance":[244],"isoforms":[250],"different":[252],"5\u2019UTRs":[253],"differed":[254],"liver,":[258],"kidney,":[259],"jejunum,":[260],"ileum,":[261],"placenta,":[262],"lung.":[264],"This":[265],"first":[268],"study":[269],"on":[270]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2016-06-24T00:00:00"}