{"id":"https://openalex.org/W1554005703","doi":"https://doi.org/10.2337/dc07-0048","title":"Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes","display_name":"Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes","publication_year":2007,"publication_date":"2007-05-25","ids":{"openalex":"https://openalex.org/W1554005703","doi":"https://doi.org/10.2337/dc07-0048","mag":"1554005703","pmid":"https://pubmed.ncbi.nlm.nih.gov/17363746","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2665929"},"language":"en","primary_location":{"id":"doi:10.2337/dc07-0048","doi":"https://doi.org/10.2337/dc07-0048","is_oa":false,"landing_page_url":"https://doi.org/10.2337/dc07-0048","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2665929","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5143887705","display_name":"The Look AHEAD Research Group","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"The Look AHEAD Research Group","raw_affiliation_strings":["Address correspondence and reprint requests to Mark Espeland, PhD, Division of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157. E-mail:","Authors and members of the Look AHEAD trial are listed in the appendix"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address correspondence and reprint requests to Mark Espeland, PhD, Division of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157. E-mail:","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Authors and members of the Look AHEAD trial are listed in the appendix","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5143887705"],"corresponding_institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"],"apc_list":null,"apc_paid":null,"fwci":57.4374,"has_fulltext":false,"cited_by_count":1540,"citation_normalized_percentile":{"value":0.99953195,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"30","issue":"6","first_page":"1374","last_page":"1383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/intensive-lifestyle-intervention","display_name":"intensive lifestyle intervention","score":0.9929999709129333},{"id":"https://openalex.org/keywords/diabetes-support-and-education","display_name":"diabetes support and education","score":0.9290000200271606},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.6940000057220459},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.6769999861717224},{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.7519999742507935},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6660000085830688},{"id":"https://openalex.org/keywords/lipid-lowering-drugs","display_name":"lipid-lowering drugs","score":0.7350000143051147},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.6800000071525574},{"id":"https://openalex.org/keywords/medication-reduction","display_name":"medication reduction","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9422875046730042},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7676823735237122},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.7601262331008911},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.7313960790634155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6102175712585449},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4847547709941864},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.4802851378917694},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4744066894054413},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.423534631729126},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.4182606041431427},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4014267921447754},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.32444605231285095},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008019","descriptor_name":"Life Style","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010353","descriptor_name":"Patient Education as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010809","descriptor_name":"Physical Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012648","descriptor_name":"Self Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2337/dc07-0048","doi":"https://doi.org/10.2337/dc07-0048","is_oa":false,"landing_page_url":"https://doi.org/10.2337/dc07-0048","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},{"id":"pmid:17363746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17363746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2665929","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2665929","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Diabetes Care","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.521.4411","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.521.4411","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://care.diabetesjournals.org/content/early/2007/03/15/dc07-0048.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2665929","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2665929","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Diabetes Care","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1187123934","display_name":null,"funder_award_id":"M01-RR-0021140","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1825392443","display_name":null,"funder_award_id":"DK 57002","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2037811546","display_name":null,"funder_award_id":"(DK 046204","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2713223456","display_name":"General Clinical Research Center","funder_award_id":"M01RR002719","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2967219653","display_name":"Action for Health in Diabetes Continuation (Look AHEAD-E)","funder_award_id":"U01DK057149","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3115283370","display_name":"05/16 Action for Health in Diabetes Extension Study - Research Project","funder_award_id":"U01DK057151","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3179863328","display_name":"10/16 Action for Health in Diabetes Extension Study Research Project","funder_award_id":"U01DK057135","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3396019356","display_name":"General Clinical Research Center","funder_award_id":"M01RR000056","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3399207219","display_name":"14/16 Action for Health in Diabetes Extension Study Research Project","funder_award_id":"U01DK057131","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3409640804","display_name":"02/16 Action for Health in Diabetes Extension Study Research Study","funder_award_id":"U01DK056990","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3482496003","display_name":"General Clinical Research Center","funder_award_id":"M01RR000051","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3493866547","display_name":"General Clinical Research Center","funder_award_id":"M01RR001066","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3548634124","display_name":"GENERAL CLINICAL RESEARCH CENTER","funder_award_id":"M01RR001346","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4330784724","display_name":"16/16 Action for Health in Diabetes Extension Study Biostatistics Research Center","funder_award_id":"U01DK057136","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G529409446","display_name":"09/16 Action for Health in Diabetes Extension Study Research Project","funder_award_id":"U01DK057178","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5644054591","display_name":"08/16 Action for Health in Diabetes Extension Study Research Project","funder_award_id":"U01DK057182","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5768226661","display_name":"07/16 Action for Health in Diabetes Extension Study Research Project","funder_award_id":"U01DK057078","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6266044974","display_name":"04/16 Action for Health in Diabetes Extension Study Research Project","funder_award_id":"U01DK057154","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6436410918","display_name":"03/16 Action for Health in Diabetes Extension Study Research Project","funder_award_id":"U01DK057008","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G670438486","display_name":"13/16 Action for Health in Diabetes Extension Study Research Project","funder_award_id":"U01DK057171","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7086067632","display_name":"11/16 Action for Health in Diabetes Extension Study Research Project","funder_award_id":"U01DK057002","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7552036767","display_name":"15/16 Action for Health in Diabetes Extension Study Research Project","funder_award_id":"U01DK057219","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8062708784","display_name":"Obesity/Nutrition Research Center","funder_award_id":"5p30dk046204-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8345446149","display_name":"12/16 Action for Health in Diabetes Extension Study Research Project","funder_award_id":"U01DK056992","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8506099271","display_name":"06/16 Action for Health in Diabetes Extension Study Research Project","funder_award_id":"U01DK057177","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000884917","display_name":"Colorado Nutrition Obesity Research Center","funder_award_id":"P30DK048520","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000907652","display_name":"Boston Area Nutrition Obesity Research Center (NORC)","funder_award_id":"P30DK040561","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G955307958","display_name":null,"funder_award_id":"P30-DK046204","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1542485098","https://openalex.org/W1963888873","https://openalex.org/W1987282451","https://openalex.org/W1991112339","https://openalex.org/W1993959691","https://openalex.org/W2003983465","https://openalex.org/W2006992929","https://openalex.org/W2007991363","https://openalex.org/W2017602185","https://openalex.org/W2021385303","https://openalex.org/W2023821775","https://openalex.org/W2029035160","https://openalex.org/W2036052614","https://openalex.org/W2038187728","https://openalex.org/W2059158127","https://openalex.org/W2071997139","https://openalex.org/W2116404316","https://openalex.org/W2124529018","https://openalex.org/W2138652556","https://openalex.org/W2141777618","https://openalex.org/W2147307613","https://openalex.org/W2153808530","https://openalex.org/W2158822657","https://openalex.org/W2160905473","https://openalex.org/W2162596964","https://openalex.org/W2166321747","https://openalex.org/W2170165809","https://openalex.org/W2277297397","https://openalex.org/W2303071711","https://openalex.org/W2332951586","https://openalex.org/W2345682597","https://openalex.org/W2607031541","https://openalex.org/W3172478362","https://openalex.org/W4205288846","https://openalex.org/W4212961339","https://openalex.org/W4238251256","https://openalex.org/W4242364069","https://openalex.org/W4245134435","https://openalex.org/W4248772906","https://openalex.org/W4249825849"],"related_works":["https://openalex.org/W7097326815","https://openalex.org/W1580839177","https://openalex.org/W1957007052","https://openalex.org/W1973366122","https://openalex.org/W7100312280","https://openalex.org/W2055479972","https://openalex.org/W1996645842","https://openalex.org/W2013302209","https://openalex.org/W2332205942","https://openalex.org/W7100936689"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1],"effectiveness":[2],"of":[3,37,45,56,62,124,153],"intentional":[4],"weight":[5,95,127,215],"loss":[6,96,216],"in":[7,13,24,28,130,139,145,158,171,181,197,212,217,238],"reducing":[8],"cardiovascular":[9],"disease":[10],"(CVD)":[11],"events":[12],"type":[14,66,220],"2":[15,67,221],"diabetes":[16,109,228],"is":[17],"unknown.":[18],"This":[19,53,223],"report":[20],"describes":[21],"1-year":[22],"changes":[23,250],"CVD":[25,47,231,256],"risk":[26,232],"factors":[27,233],"a":[29,57,108],"trial":[30,61],"designed":[31],"to":[32,91,118,169,179],"examine":[33],"the":[34,43],"long-term":[35],"effects":[36],"an":[38,121],"intensive":[39,82],"lifestyle":[40,83],"intervention":[41,84,243],"on":[42],"incidence":[44],"major":[46],"events.":[48],"RESEARCH":[49],"DESIGN":[50],"AND":[51],"METHODS:":[52],"study":[54],"consisted":[55],"multicentered,":[58],"randomized,":[59],"controlled":[60],"5,145":[63],"individuals":[64],"with":[65,72,107,219,226],"diabetes,":[68,159],"aged":[69],"45-74":[70],"years,":[71],"BMI":[73],">25":[74],"kg/m2":[75,77],"(>27":[76],"if":[78],"taking":[79],"insulin).":[80],"An":[81],"(ILI)":[85],"involving":[86],"group":[87,132],"and":[88,93,101,111,161,184,190,230,234,244,253],"individual":[89],"meetings":[90],"achieve":[92],"maintain":[94],"through":[97],"decreased":[98],"caloric":[99],"intake":[100],"increased":[102,138],"physical":[103],"activity":[104],"was":[105,224],"compared":[106],"support":[110],"education":[112],"(DSE)":[113],"condition.":[114],"RESULTS:":[115],"Participants":[116],"assigned":[117],"ILI":[119,140,154,172,198,210,239],"lost":[120],"average":[122],"8.6%":[123],"their":[125],"initial":[126],"vs.":[128,143,176],"0.7%":[129],"DSE":[131,146,200],"(P":[133,147,173],"<":[134,148,174,204],"0.001).":[135,149],"Mean":[136,164],"fitness":[137],"by":[141],"20.9":[142],"5.8%":[144],"A":[150],"greater":[151],"proportion":[152],"participants":[155,201],"had":[156],"reductions":[157],"hypertension,":[160],"lipid-lowering":[162],"medicines.":[163],"A1C":[165],"dropped":[166],"from":[167,177],"7.3":[168,178],"6.6%":[170],"0.001)":[175],"7.2%":[180],"DSE.":[182,241],"Systolic":[183],"diastolic":[185],"pressure,":[186],"triglycerides,":[187],"HDL":[188],"cholesterol,":[189],"urine":[191],"albumin-to-creatinine":[192],"ratio":[193],"improved":[194,227],"significantly":[195],"more":[196],"than":[199],"(all":[202],"P":[203],"0.01).":[205],"CONCLUSIONS:":[206],"At":[207],"1":[208],"year,":[209],"resulted":[211],"clinically":[213],"significant":[214],"people":[218],"diabetes.":[222],"associated":[225],"control":[229],"reduced":[235],"medicine":[236],"use":[237],"versus":[240],"Continued":[242],"follow-up":[245],"will":[246,254],"determine":[247],"whether":[248],"these":[249],"are":[251],"maintained":[252],"reduce":[255],"risk.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":50},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":49},{"year":2022,"cited_by_count":50},{"year":2021,"cited_by_count":60},{"year":2020,"cited_by_count":56},{"year":2019,"cited_by_count":67},{"year":2018,"cited_by_count":75},{"year":2017,"cited_by_count":82},{"year":2016,"cited_by_count":99},{"year":2015,"cited_by_count":119},{"year":2014,"cited_by_count":101},{"year":2013,"cited_by_count":117},{"year":2012,"cited_by_count":121}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}