{"id":"https://openalex.org/W1553900548","doi":"https://doi.org/10.1590/s0066-782x2011000200017","title":"Implica\u00e7\u00f5es farmacogen\u00e9ticas de polimorfismos da eNOS para drogas de a\u00e7\u00e3o cardiovascular","display_name":"Implica\u00e7\u00f5es farmacogen\u00e9ticas de polimorfismos da eNOS para drogas de a\u00e7\u00e3o cardiovascular","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W1553900548","doi":"https://doi.org/10.1590/s0066-782x2011000200017","mag":"1553900548","pmid":"https://pubmed.ncbi.nlm.nih.gov/21445464"},"language":"pt","primary_location":{"id":"doi:10.1590/s0066-782x2011000200017","doi":"https://doi.org/10.1590/s0066-782x2011000200017","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0066-782x2011000200017","pdf_url":"https://www.scielo.br/j/abc/a/MfzV7JxssdJtZjWwH6ctMXP/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S67004851","display_name":"Arquivos Brasileiros de Cardiologia","issn_l":"0066-782X","issn":["0066-782X","1678-4170"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312504","host_organization_name":"Sociedade Brasileira de Cardiologia (SBC)","host_organization_lineage":["https://openalex.org/P4310312504"],"host_organization_lineage_names":["Sociedade Brasileira de Cardiologia (SBC)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Cardiologia","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/abc/a/MfzV7JxssdJtZjWwH6ctMXP/?lang=pt&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038188220","display_name":"P\u00e2mela Souza Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"P\u00e2mela Souza Silva","raw_affiliation_strings":["Departamento de Farmacologia, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Estadual de Campinas, Campinas, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacologia, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Estadual de Campinas, Campinas, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032396598","display_name":"Riccardo Lacchini","orcid":"https://orcid.org/0000-0002-3738-2036","observed_orcids":["https://orcid.org/0000-0002-3738-2036"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Riccardo Lacchini","raw_affiliation_strings":["Faculdade de Ci\u00eancias M\u00e9dicas -Departamento de Farmacologia - Universidade Estadual de Campinas (UNICAMP) , Campinas , SP ;","Universidade Estadual de Campinas Campinas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Ci\u00eancias M\u00e9dicas -Departamento de Farmacologia - Universidade Estadual de Campinas (UNICAMP) , Campinas , SP ;","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Universidade Estadual de Campinas Campinas","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103535538","display_name":"Val\u00e9ria A. Gomes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Val\u00e9ria de Aguiar Gomes","raw_affiliation_strings":["Faculdade de Ci\u00eancias M\u00e9dicas -Departamento de Farmacologia - Universidade Estadual de Campinas (UNICAMP) , Campinas , SP ;","Universidade Estadual de Campinas Campinas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Ci\u00eancias M\u00e9dicas -Departamento de Farmacologia - Universidade Estadual de Campinas (UNICAMP) , Campinas , SP ;","institution_ids":["https://openalex.org/I181391015"]},{"raw_affiliation_string":"Universidade Estadual de Campinas Campinas","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002216895","display_name":"Jos\u00e9 Eduardo Tanus-Santos","orcid":"https://orcid.org/0000-0002-9945-9633","observed_orcids":["https://orcid.org/0000-0002-9945-9633"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Eduardo Tanus-Santos","raw_affiliation_strings":["Faculdade de Medicina de Ribeir\u00e3o Preto -Departamento de Farmacologia - Universidade de S\u00e3o Paulo (USP) 2 , Ribeir\u00e3o Preto , SP - Brasil","Universidade Estadual de Campinas, Ribeir\u00e3o Preto, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Medicina de Ribeir\u00e3o Preto -Departamento de Farmacologia - Universidade de S\u00e3o Paulo (USP) 2 , Ribeir\u00e3o Preto , SP - Brasil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Universidade Estadual de Campinas, Ribeir\u00e3o Preto, Brasil","institution_ids":["https://openalex.org/I181391015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2564,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.1503268,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"96","issue":"2","first_page":"e27","last_page":"e34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.8659999966621399},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cardiovascular-drugs","display_name":"cardiovascular drugs","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8109999895095825},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8259999752044678},{"id":"https://openalex.org/keywords/drug-response","display_name":"drug response","score":0.75},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9658626914024353},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.8261170983314514},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.5280680656433105},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.4646002948284149},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42941814661026},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3338358998298645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2973254919052124},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18261617422103882},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.14440858364105225},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09578779339790344},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.05577445030212402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1590/s0066-782x2011000200017","doi":"https://doi.org/10.1590/s0066-782x2011000200017","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0066-782x2011000200017","pdf_url":"https://www.scielo.br/j/abc/a/MfzV7JxssdJtZjWwH6ctMXP/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S67004851","display_name":"Arquivos Brasileiros de Cardiologia","issn_l":"0066-782X","issn":["0066-782X","1678-4170"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312504","host_organization_name":"Sociedade Brasileira de Cardiologia (SBC)","host_organization_lineage":["https://openalex.org/P4310312504"],"host_organization_lineage_names":["Sociedade Brasileira de Cardiologia (SBC)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Cardiologia","raw_type":"journal-article"},{"id":"pmh:002240184","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/pdf/abc/v96n2/v96n2a17.pdf","pdf_url":"http://www.scielo.br/pdf/abc/v96n2/v96n2a17.pdf","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmid:21445464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21445464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos brasileiros de cardiologia","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.unicamp.br:REPOSIP/107875","doi":null,"is_oa":true,"landing_page_url":"http://www.repositorio.unicamp.br/handle/REPOSIP/107875","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scopus","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:repositorio.unicamp.br:REPOSIP/21533","doi":null,"is_oa":true,"landing_page_url":"http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/21533","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SciELO","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:americanae.aecid.es:2835106","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=2835106","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:americanae.aecid.es:3217593","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2011000200017","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SciELO","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:db733eff52c14bf5b96e769e7b81af15","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/db733eff52c14bf5b96e769e7b81af15","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arquivos Brasileiros de Cardiologia, Vol 96, Iss 2, Pp e27-e34 (2011)","raw_type":"article"},{"id":"pmh:oai:scielo:S0066-782X2011000200017","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0066-782X2011000200017","pdf_url":null,"source":{"id":"https://openalex.org/S4306402308","display_name":"The Scientific Electronic Library Online (Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210116822","host_organization_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I4210116822"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arquivos Brasileiros de Cardiologia v.96 n.2 2011","raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":{"id":"doi:10.1590/s0066-782x2011000200017","doi":"https://doi.org/10.1590/s0066-782x2011000200017","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0066-782x2011000200017","pdf_url":"https://www.scielo.br/j/abc/a/MfzV7JxssdJtZjWwH6ctMXP/?lang=pt&format=pdf","source":{"id":"https://openalex.org/S67004851","display_name":"Arquivos Brasileiros de Cardiologia","issn_l":"0066-782X","issn":["0066-782X","1678-4170"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312504","host_organization_name":"Sociedade Brasileira de Cardiologia (SBC)","host_organization_lineage":["https://openalex.org/P4310312504"],"host_organization_lineage_names":["Sociedade Brasileira de Cardiologia (SBC)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Cardiologia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1553900548.pdf","grobid_xml":"https://content.openalex.org/works/W1553900548.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W70647308","https://openalex.org/W1519102962","https://openalex.org/W1599315080","https://openalex.org/W1968409126","https://openalex.org/W1974708789","https://openalex.org/W1981885121","https://openalex.org/W1983565552","https://openalex.org/W1987424257","https://openalex.org/W1989310986","https://openalex.org/W1991253788","https://openalex.org/W1992746042","https://openalex.org/W1995896668","https://openalex.org/W1999762173","https://openalex.org/W2000906636","https://openalex.org/W2003140298","https://openalex.org/W2003252904","https://openalex.org/W2004464684","https://openalex.org/W2009150846","https://openalex.org/W2009165423","https://openalex.org/W2009609368","https://openalex.org/W2010092889","https://openalex.org/W2011846988","https://openalex.org/W2014287777","https://openalex.org/W2015235751","https://openalex.org/W2015329920","https://openalex.org/W2015941287","https://openalex.org/W2016054237","https://openalex.org/W2019044547","https://openalex.org/W2021012027","https://openalex.org/W2025749741","https://openalex.org/W2026425756","https://openalex.org/W2030142374","https://openalex.org/W2034504203","https://openalex.org/W2040492786","https://openalex.org/W2046905152","https://openalex.org/W2048330051","https://openalex.org/W2048484328","https://openalex.org/W2053834581","https://openalex.org/W2058401000","https://openalex.org/W2060449867","https://openalex.org/W2064729564","https://openalex.org/W2064997430","https://openalex.org/W2066171493","https://openalex.org/W2071118021","https://openalex.org/W2077003605","https://openalex.org/W2083054959","https://openalex.org/W2084426932","https://openalex.org/W2091128750","https://openalex.org/W2093518775","https://openalex.org/W2103636227","https://openalex.org/W2108407026","https://openalex.org/W2109978768","https://openalex.org/W2112491025","https://openalex.org/W2114887001","https://openalex.org/W2115203492","https://openalex.org/W2116999983","https://openalex.org/W2117872775","https://openalex.org/W2118272405","https://openalex.org/W2120402092","https://openalex.org/W2122986826","https://openalex.org/W2125049295","https://openalex.org/W2133548759","https://openalex.org/W2135119053","https://openalex.org/W2135978289","https://openalex.org/W2141537184","https://openalex.org/W2145653235","https://openalex.org/W2147534219","https://openalex.org/W2155033804","https://openalex.org/W2155043219","https://openalex.org/W2155766891","https://openalex.org/W2156121263","https://openalex.org/W2161822370","https://openalex.org/W2166280606","https://openalex.org/W2167615310","https://openalex.org/W2168909179","https://openalex.org/W2171751937","https://openalex.org/W2313326603"],"related_works":["https://openalex.org/W2954369823","https://openalex.org/W2899564391","https://openalex.org/W1903598576","https://openalex.org/W7073898812","https://openalex.org/W2056210715","https://openalex.org/W4306909828","https://openalex.org/W2091128750","https://openalex.org/W2516383340","https://openalex.org/W2794331458","https://openalex.org/W2343149004"],"abstract_inverted_index":{"The":[0,11,41,95],"pharmacogenetics":[1],"is":[2,78],"one":[3,109],"of":[4,9,13,38,50,59,63,66,103,110,141],"the":[5,14,26,39,47,57,71,88,91,100,104,111,115,119,123,132,138,144,148,152],"most":[6],"promising":[7],"fields":[8],"medicine.":[10],"conclusion":[12],"Genome":[15],"Project":[16],"allowed":[17],"this":[18],"field":[19],"to":[20,28,70,73,80,90,118,147],"start":[21],"discovering":[22],"complex":[23,67],"factors":[24],"modulating":[25],"response":[27],"drugs,":[29],"and":[30,52,54,143],"new":[31],"technologies":[32],"are":[33,44],"close":[34],"a":[35,60],"great":[36],"expansion":[37],"area.":[40],"cardiovascular":[42,124,153],"diseases":[43,125],"currently":[45,92],"among":[46,137],"major":[48],"causes":[49],"hospitalizations":[51],"death,":[53],"have":[55],"been":[56,108],"target":[58],"large":[61],"part":[62],"genetic":[64,84,139],"studies":[65],"diseases.":[68],"Parallel":[69],"susceptibility":[72],"disease":[74],"markers":[75],"identification,":[76],"it":[77],"necessary":[79],"investigate":[81],"how":[82],"different":[83],"profiles":[85],"can":[86],"change":[87],"responses":[89,117,146],"used":[93,121,150],"drugs.":[94],"biological":[96],"system":[97],"that":[98],"controls":[99],"endothelial":[101],"production":[102],"nitric":[105],"oxide":[106],"has":[107],"greatest":[112],"targets":[113],"in":[114,122,151],"pharmacological":[116,145],"drugs":[120,149],"therapy.":[126],"This":[127],"review":[128],"aims":[129],"at":[130],"approaching":[131],"current":[133],"knowledge":[134],"on":[135],"interaction":[136],"variations":[140],"eNOS":[142],"system.":[154]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
