{"id":"https://openalex.org/W1553847148","doi":"https://doi.org/10.4049/jimmunol.166.6.3837","title":"A Critical Role for p38 Mitogen-Activated Protein Kinase in the Maturation of Human Blood-Derived Dendritic Cells Induced by Lipopolysaccharide, TNF-\u03b1, and Contact Sensitizers","display_name":"A Critical Role for p38 Mitogen-Activated Protein Kinase in the Maturation of Human Blood-Derived Dendritic Cells Induced by Lipopolysaccharide, TNF-\u03b1, and Contact Sensitizers","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W1553847148","doi":"https://doi.org/10.4049/jimmunol.166.6.3837","mag":"1553847148","pmid":"https://pubmed.ncbi.nlm.nih.gov/11238627"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.166.6.3837","doi":"https://doi.org/10.4049/jimmunol.166.6.3837","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.166.6.3837","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jean-Franc\u0327ois Arrighi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jean-Franc\u0327ois Arrighi","raw_affiliation_strings":["Department of Dermatology, DHURVD, University Hospital , Geneva ,","Division of Immunology and Allergy, University Hospital , Geneva ,","*Department of Dermatology, DHURVD,","\u2020Division of Immunology and Allergy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, DHURVD, University Hospital , Geneva ,","institution_ids":["https://openalex.org/I4210106256"]},{"raw_affiliation_string":"Division of Immunology and Allergy, University Hospital , Geneva ,","institution_ids":["https://openalex.org/I4210106256"]},{"raw_affiliation_string":"*Department of Dermatology, DHURVD,","institution_ids":[]},{"raw_affiliation_string":"\u2020Division of Immunology and Allergy,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113705050","display_name":"Michela C. Rebsamen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michela Rebsamen","raw_affiliation_strings":["Division of Endocrinology and Diabetology, University Hospital , Geneva ,","\u2021Division of Endocrinology and Diabetology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Diabetology, University Hospital , Geneva ,","institution_ids":["https://openalex.org/I4210106256"]},{"raw_affiliation_string":"\u2021Division of Endocrinology and Diabetology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113757928","display_name":"F Rousset","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franc\u0327oise Rousset","raw_affiliation_strings":["L\u2019Ore\u0301al Advanced Recherche , Aulnay-sous-bois ,","\u00b6L\u2019Ore\u0301al Advanced Recherche, Aulnay-sous-bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L\u2019Ore\u0301al Advanced Recherche , Aulnay-sous-bois ,","institution_ids":["https://openalex.org/I14285755"]},{"raw_affiliation_string":"\u00b6L\u2019Ore\u0301al Advanced Recherche, Aulnay-sous-bois, France","institution_ids":["https://openalex.org/I14285755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049249884","display_name":"Vincent Kindler","orcid":"https://orcid.org/0000-0002-5349-1857","observed_orcids":["https://orcid.org/0000-0002-5349-1857"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Vincent Kindler","raw_affiliation_strings":["Division of Hematology, University Hospital , Geneva ,","\u00a7Division of Hematology, University Hospital, Geneva, Switzerland; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, University Hospital , Geneva ,","institution_ids":["https://openalex.org/I4210106256"]},{"raw_affiliation_string":"\u00a7Division of Hematology, University Hospital, Geneva, Switzerland; and","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103677082","display_name":"Conrad Hauser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Conrad Hauser","raw_affiliation_strings":["Department of Dermatology, DHURVD, University Hospital , Geneva ,","Division of Immunology and Allergy, University Hospital , Geneva ,","*Department of Dermatology, DHURVD,","\u2020Division of Immunology and Allergy,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, DHURVD, University Hospital , Geneva ,","institution_ids":["https://openalex.org/I4210106256"]},{"raw_affiliation_string":"Division of Immunology and Allergy, University Hospital , Geneva ,","institution_ids":["https://openalex.org/I4210106256"]},{"raw_affiliation_string":"*Department of Dermatology, DHURVD,","institution_ids":[]},{"raw_affiliation_string":"\u2020Division of Immunology and Allergy,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103677082"],"corresponding_institution_ids":["https://openalex.org/I4210106256"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":6.1696,"has_fulltext":false,"cited_by_count":417,"citation_normalized_percentile":{"value":0.9724967,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"166","issue":"6","first_page":"3837","last_page":"3845"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.949999988079071},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/contact-sensitizers","display_name":"contact sensitizers","score":0.8199999928474426},{"id":"https://openalex.org/keywords/sb203580","display_name":"SB203580","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cd83","display_name":"CD83","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cd80","display_name":"CD80","score":0.546999990940094},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.8360000252723694},{"id":"https://openalex.org/keywords/allostimulatory-capacity","display_name":"allostimulatory capacity","score":0.7760000228881836},{"id":"https://openalex.org/keywords/fitc-dextran-uptake","display_name":"FITC-dextran uptake","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cytokine-gene-expression","display_name":"cytokine gene expression","score":0.7160000205039978},{"id":"https://openalex.org/keywords/2-4-dinitrofluorobenzene","display_name":"2,4-dinitrofluorobenzene","score":0.8870000243186951},{"id":"https://openalex.org/keywords/nickel-sulfate","display_name":"nickel sulfate","score":0.9800000190734863},{"id":"https://openalex.org/keywords/irritants","display_name":"irritants","score":0.6990000009536743},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.7130453586578369},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6912714242935181},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6430548429489136},{"id":"https://openalex.org/C2778297628","wikidata":"https://www.wikidata.org/wiki/Q5009843","display_name":"CD80","level":5,"score":0.6246323585510254},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6212873458862305},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5956692099571228},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.520428478717804},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.46718624234199524},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.44779419898986816},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4121703505516052},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4087502956390381},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3583737015724182},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3415600061416626},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.27363598346710205},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17812782526016235},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16793009638786316},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.15578025579452515},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.10676077008247375},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001548","descriptor_name":"Benzalkonium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004139","descriptor_name":"Dinitrofluorobenzene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007509","descriptor_name":"Irritants","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009532","descriptor_name":"Nickel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012967","descriptor_name":"Sodium Dodecyl Sulfate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017449","descriptor_name":"Dermatitis, Allergic Contact","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048057","descriptor_name":"Mitogen-Activated Protein Kinase 10","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.166.6.3837","doi":"https://doi.org/10.4049/jimmunol.166.6.3837","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.166.6.3837","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:11238627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11238627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W90568390","https://openalex.org/W1502937057","https://openalex.org/W1516048300","https://openalex.org/W1549679997","https://openalex.org/W1574215966","https://openalex.org/W1587892340","https://openalex.org/W1661544713","https://openalex.org/W1966103571","https://openalex.org/W1969411212","https://openalex.org/W1972366604","https://openalex.org/W1973614704","https://openalex.org/W1973766879","https://openalex.org/W1976385326","https://openalex.org/W1976462601","https://openalex.org/W1977945339","https://openalex.org/W2001399809","https://openalex.org/W2004143904","https://openalex.org/W2004726009","https://openalex.org/W2007986629","https://openalex.org/W2015696927","https://openalex.org/W2019546595","https://openalex.org/W2022212027","https://openalex.org/W2022914311","https://openalex.org/W2028092080","https://openalex.org/W2032731042","https://openalex.org/W2035936653","https://openalex.org/W2051090019","https://openalex.org/W2053383702","https://openalex.org/W2057809738","https://openalex.org/W2062892166","https://openalex.org/W2068406884","https://openalex.org/W2082212691","https://openalex.org/W2102857621","https://openalex.org/W2106877484","https://openalex.org/W2107704309","https://openalex.org/W2111695773","https://openalex.org/W2115760138","https://openalex.org/W2115855421","https://openalex.org/W2126125843","https://openalex.org/W2127404676","https://openalex.org/W2128137492","https://openalex.org/W2131761283","https://openalex.org/W2132552157","https://openalex.org/W2132599616","https://openalex.org/W2139620037","https://openalex.org/W2141575322","https://openalex.org/W2147678437","https://openalex.org/W2149395040","https://openalex.org/W2155229523","https://openalex.org/W2155868854","https://openalex.org/W2341881834","https://openalex.org/W4313309924","https://openalex.org/W4313335068","https://openalex.org/W4313343351","https://openalex.org/W4313347787"],"related_works":["https://openalex.org/W2143032719","https://openalex.org/W1499902555","https://openalex.org/W2093682600","https://openalex.org/W1969174394","https://openalex.org/W1990502407","https://openalex.org/W2129455656","https://openalex.org/W2108557146","https://openalex.org/W7042421223","https://openalex.org/W1610529667","https://openalex.org/W1985611741"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,10,30,35,55,60,69,78,92,95,101,115,133,145,154,165,205,224],"involvement":[3],"of":[4,12,32,34,38,54,71,94,103,117,135,156,167,199,207,226],"mitogen-activated":[5],"protein":[6],"kinases":[7],"(MAPKs)":[8],"in":[9,218],"maturation":[11,80,142,186,206],"CD83(-)":[13],"dendritic":[14],"cells":[15],"(DC)":[16],"derived":[17],"from":[18],"human":[19],"blood":[20],"monocytes.":[21],"Maturating":[22],"agents":[23],"such":[24],"as":[25,130,132,151],"LPS":[26,85,108,127],"and":[27,48,77,86,98,109,121,128,149,159,170,178],"TNF-alpha":[28,122,137],"induced":[29,83,106,138,143],"phosphorylation":[31,166,198,217],"members":[33],"three":[36],"families":[37],"MAPK":[39,191,201,216],"(extracellular":[40],"signal-regulated":[41,62],"kinase":[42,63],"l/2,":[43],"p46/54":[44],"c-Jun":[45],"N-terminal":[46],"kinase,":[47],"p38":[49,56,168,190,200,215],"MAPK).":[50],"SB203580,":[51],"an":[52],"inhibitor":[53],"MAPK,":[57,169],"but":[58],"not":[59,183,188],"extracellular":[61],"l/2":[64],"pathway":[65],"blocker":[66],"PD98059,":[67],"inhibited":[68,91,172],"up-regulation":[70,116,155],"CD1a,":[72],"CD40,":[73],"CD80,":[74,157],"CD86,":[75,158],"HLA-DR,":[76],"DC":[79,141,185,219],"marker":[81],"CD83":[82],"by":[84,107,139,144,153,173],"TNF-alpha.":[87,110],"In":[88],"addition,":[89],"SB203580":[90,112],"enhancement":[93],"allostimulatory":[96],"capacity":[97],"partially":[99,113],"prevented":[100,114],"down-regulation":[102],"FITC-dextran":[104],"uptake":[105],"Likewise,":[111],"IL-1alpha,":[118],"IL-1beta,":[119],"IL-lRa,":[120],"mRNA":[123],"upon":[124],"stimulation":[125],"with":[126],"TNF-alpha,":[129],"well":[131],"release":[134],"bioactive":[136],"LPS.":[140],"contact":[146,229],"sensitizers":[147],"2,4-dinitrofluorobenzene":[148],"NiSO(4),":[150],"seen":[152],"CD83,":[160],"was":[161,171],"also":[162,212],"coupled":[163],"to":[164],"SB203580.":[174],"The":[175],"irritants":[176],"SDS":[177],"benzalkonium":[179],"chloride":[180],"that":[181,197,214],"do":[182],"induce":[184],"did":[187],"trigger":[189],"phosphorylation.":[192],"Together,":[193],"these":[194],"data":[195],"indicate":[196],"is":[202],"critical":[203],"for":[204,223],"immature":[208],"DC.":[209],"These":[210],"results":[211],"suggest":[213],"may":[220],"become":[221],"useful":[222],"identification":[225],"potential":[227],"skin":[228],"sensitizers.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
