{"id":"https://openalex.org/W1553689778","doi":null,"title":"Effect of bisphosphonates and small cyclic peptides on matrix metalloproteinases and human cancer cells","display_name":"Effect of bisphosphonates and small cyclic peptides on matrix metalloproteinases and human cancer cells","publication_year":2005,"publication_date":"2005-06-01","ids":{"openalex":"https://openalex.org/W1553689778","mag":"1553689778"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/20276","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/20276","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/20276","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049713116","display_name":"Pia Heikkil\u00e4","orcid":"https://orcid.org/0000-0002-5925-1993","observed_orcids":["https://orcid.org/0000-0002-5925-1993"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pia Heikkil\u00e4","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5925-1993","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049713116"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.2727000117301941,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":1.0},{"id":"https://openalex.org/keywords/cyclic-peptides","display_name":"cyclic peptides","score":0.9419999718666077},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9929999709129333},{"id":"https://openalex.org/keywords/human-cancer-cells","display_name":"human cancer cells","score":0.8479999899864197},{"id":"https://openalex.org/keywords/tumor-cell-growth-inhibition","display_name":"tumor cell growth inhibition","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.770058274269104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5132839679718018},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.43615901470184326},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4299353361129761},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4053875803947449},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39546632766723633},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34870797395706177},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3137250244617462},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2918504774570465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28162145614624023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26058492064476013},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/20276","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/20276","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral dissertation"},{"id":"mag:1553689778","doi":null,"is_oa":false,"landing_page_url":"http://ethesis.helsinki.fi/julkaisut/laa/hamma/vk/heikkila/effectof.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/20276","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/20276","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral dissertation"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":320,"referenced_works":["https://openalex.org/W21457901","https://openalex.org/W53973778","https://openalex.org/W60551495","https://openalex.org/W66824762","https://openalex.org/W89180169","https://openalex.org/W109911703","https://openalex.org/W174289115","https://openalex.org/W183558284","https://openalex.org/W190590421","https://openalex.org/W191631078","https://openalex.org/W193883077","https://openalex.org/W225647261","https://openalex.org/W230195636","https://openalex.org/W296450459","https://openalex.org/W343881469","https://openalex.org/W1457049491","https://openalex.org/W1482388464","https://openalex.org/W1485071570","https://openalex.org/W1487013731","https://openalex.org/W1487159685","https://openalex.org/W1487423556","https://openalex.org/W1491678226","https://openalex.org/W1496944719","https://openalex.org/W1497025918","https://openalex.org/W1505042995","https://openalex.org/W1505736789","https://openalex.org/W1521095066","https://openalex.org/W1522978223","https://openalex.org/W1528102086","https://openalex.org/W1532091886","https://openalex.org/W1545521314","https://openalex.org/W1550906650","https://openalex.org/W1552949608","https://openalex.org/W1563631631","https://openalex.org/W1565561072","https://openalex.org/W1565818905","https://openalex.org/W1568471160","https://openalex.org/W1571951314","https://openalex.org/W1574172480","https://openalex.org/W1575115634","https://openalex.org/W1575973365","https://openalex.org/W1585182619","https://openalex.org/W1589933893","https://openalex.org/W1600831053","https://openalex.org/W1613549157","https://openalex.org/W1627713802","https://openalex.org/W1668309971","https://openalex.org/W1693984391","https://openalex.org/W1751837226","https://openalex.org/W1800142641","https://openalex.org/W1804633340","https://openalex.org/W1824640790","https://openalex.org/W1829926076","https://openalex.org/W1857752585","https://openalex.org/W1862785984","https://openalex.org/W1870486979","https://openalex.org/W1880057253","https://openalex.org/W1886431664","https://openalex.org/W1894541755","https://openalex.org/W1895946034","https://openalex.org/W1905017519","https://openalex.org/W1919303367","https://openalex.org/W1926301789","https://openalex.org/W1927710162","https://openalex.org/W1938414864","https://openalex.org/W1938796902","https://openalex.org/W1944967894","https://openalex.org/W1963681491","https://openalex.org/W1963892785","https://openalex.org/W1964429103","https://openalex.org/W1965423355","https://openalex.org/W1965541995","https://openalex.org/W1966706677","https://openalex.org/W1967197894","https://openalex.org/W1967265143","https://openalex.org/W1967771383","https://openalex.org/W1967869198","https://openalex.org/W1969179229","https://openalex.org/W1969191130","https://openalex.org/W1969921973","https://openalex.org/W1971325550","https://openalex.org/W1974336590","https://openalex.org/W1976837011","https://openalex.org/W1977203209","https://openalex.org/W1978769760","https://openalex.org/W1979390430","https://openalex.org/W1979476810","https://openalex.org/W1979513037","https://openalex.org/W1979847705","https://openalex.org/W1980501623","https://openalex.org/W1980968239","https://openalex.org/W1983102762","https://openalex.org/W1984483611","https://openalex.org/W1985687857","https://openalex.org/W1985781201","https://openalex.org/W1987542353","https://openalex.org/W1988132802","https://openalex.org/W1988757615","https://openalex.org/W1989014251","https://openalex.org/W1990068091","https://openalex.org/W1990858735","https://openalex.org/W1993480392","https://openalex.org/W1993618555","https://openalex.org/W1994596418","https://openalex.org/W1995033273","https://openalex.org/W1995248099","https://openalex.org/W1995252065","https://openalex.org/W1995280874","https://openalex.org/W1996440019","https://openalex.org/W1996647701","https://openalex.org/W1998924309","https://openalex.org/W1999017992","https://openalex.org/W2001821836","https://openalex.org/W2001897537","https://openalex.org/W2003204537","https://openalex.org/W2003500892","https://openalex.org/W2006825597","https://openalex.org/W2007001439","https://openalex.org/W2009317254","https://openalex.org/W2010069724","https://openalex.org/W2010486222","https://openalex.org/W2011134969","https://openalex.org/W2011397767","https://openalex.org/W2013074682","https://openalex.org/W2013559491","https://openalex.org/W2014412886","https://openalex.org/W2015031004","https://openalex.org/W2015359970","https://openalex.org/W2015809080","https://openalex.org/W2016411107","https://openalex.org/W2016433313","https://openalex.org/W2016720337","https://openalex.org/W2017220577","https://openalex.org/W2017654113","https://openalex.org/W2018992560","https://openalex.org/W2022065340","https://openalex.org/W2022210790","https://openalex.org/W2025116429","https://openalex.org/W2025311993","https://openalex.org/W2025361420","https://openalex.org/W2025362099","https://openalex.org/W2026169826","https://openalex.org/W2026192649","https://openalex.org/W2026391181","https://openalex.org/W2026632078","https://openalex.org/W2028289405","https://openalex.org/W2029422059","https://openalex.org/W2029957743","https://openalex.org/W2031299469","https://openalex.org/W2033341544","https://openalex.org/W2033398918","https://openalex.org/W2035122577","https://openalex.org/W2035191551","https://openalex.org/W2035331118","https://openalex.org/W2035673321","https://openalex.org/W2035754366","https://openalex.org/W2038995854","https://openalex.org/W2041868422","https://openalex.org/W2044765617","https://openalex.org/W2046091872","https://openalex.org/W2046128602","https://openalex.org/W2046161327","https://openalex.org/W2046653378","https://openalex.org/W2047039315","https://openalex.org/W2047108476","https://openalex.org/W2048635128","https://openalex.org/W2049220062","https://openalex.org/W2049689451","https://openalex.org/W2050023553","https://openalex.org/W2050039508","https://openalex.org/W2051227781","https://openalex.org/W2051347744","https://openalex.org/W2052972580","https://openalex.org/W2053925700","https://openalex.org/W2055360422","https://openalex.org/W2055758035","https://openalex.org/W2058500908","https://openalex.org/W2058873146","https://openalex.org/W2059072983","https://openalex.org/W2059387208","https://openalex.org/W2059983738","https://openalex.org/W2061699560","https://openalex.org/W2062746203","https://openalex.org/W2062919894","https://openalex.org/W2063017336","https://openalex.org/W2063685694","https://openalex.org/W2065884286","https://openalex.org/W2067502344","https://openalex.org/W2067901911","https://openalex.org/W2068756348","https://openalex.org/W2069508712","https://openalex.org/W2069565881","https://openalex.org/W2070116602","https://openalex.org/W2070595030","https://openalex.org/W2071507111","https://openalex.org/W2072103796","https://openalex.org/W2072796605","https://openalex.org/W2073203689","https://openalex.org/W2073259535","https://openalex.org/W2073478172","https://openalex.org/W2073797247","https://openalex.org/W2074187493","https://openalex.org/W2074380563","https://openalex.org/W2074892144","https://openalex.org/W2077483002","https://openalex.org/W2077955277","https://openalex.org/W2078241670","https://openalex.org/W2079152631","https://openalex.org/W2079655998","https://openalex.org/W2083179059","https://openalex.org/W2083487959","https://openalex.org/W2084480843","https://openalex.org/W2084651782","https://openalex.org/W2086118606","https://openalex.org/W2089410776","https://openalex.org/W2092049566","https://openalex.org/W2093241596","https://openalex.org/W2094554330","https://openalex.org/W2094875212","https://openalex.org/W2095258584","https://openalex.org/W2095480305","https://openalex.org/W2096353669","https://openalex.org/W2097362318","https://openalex.org/W2097707959","https://openalex.org/W2098097319","https://openalex.org/W2098576665","https://openalex.org/W2099270619","https://openalex.org/W2099499481","https://openalex.org/W2101630029","https://openalex.org/W2101754579","https://openalex.org/W2101844493","https://openalex.org/W2101960107","https://openalex.org/W2102482103","https://openalex.org/W2102884576","https://openalex.org/W2104087667","https://openalex.org/W2104355490","https://openalex.org/W2106169455","https://openalex.org/W2109111910","https://openalex.org/W2109647778","https://openalex.org/W2111166654","https://openalex.org/W2112327424","https://openalex.org/W2114441322","https://openalex.org/W2115335453","https://openalex.org/W2116305904","https://openalex.org/W2117328200","https://openalex.org/W2117803560","https://openalex.org/W2119421056","https://openalex.org/W2120212237","https://openalex.org/W2121513486","https://openalex.org/W2126091070","https://openalex.org/W2127571585","https://openalex.org/W2128049766","https://openalex.org/W2128938772","https://openalex.org/W2130453040","https://openalex.org/W2131268988","https://openalex.org/W2131284079","https://openalex.org/W2133562234","https://openalex.org/W2134559504","https://openalex.org/W2135124706","https://openalex.org/W2136348600","https://openalex.org/W2136909982","https://openalex.org/W2138960046","https://openalex.org/W2140295594","https://openalex.org/W2143573041","https://openalex.org/W2144763197","https://openalex.org/W2144860907","https://openalex.org/W2145711223","https://openalex.org/W2146303187","https://openalex.org/W2147160932","https://openalex.org/W2147613373","https://openalex.org/W2147862420","https://openalex.org/W2148244435","https://openalex.org/W2150001961","https://openalex.org/W2150365936","https://openalex.org/W2151762172","https://openalex.org/W2152487395","https://openalex.org/W2152667145","https://openalex.org/W2154401382","https://openalex.org/W2156255424","https://openalex.org/W2156301058","https://openalex.org/W2158739925","https://openalex.org/W2159083326","https://openalex.org/W2159868431","https://openalex.org/W2161061591","https://openalex.org/W2161576473","https://openalex.org/W2161592516","https://openalex.org/W2161917366","https://openalex.org/W2161998309","https://openalex.org/W2162585191","https://openalex.org/W2163035305","https://openalex.org/W2165809621","https://openalex.org/W2169473039","https://openalex.org/W2170782044","https://openalex.org/W2171215167","https://openalex.org/W2172114097","https://openalex.org/W2183019695","https://openalex.org/W2243273878","https://openalex.org/W2271351171","https://openalex.org/W2275054261","https://openalex.org/W2287547524","https://openalex.org/W2298323837","https://openalex.org/W2314428698","https://openalex.org/W2316096113","https://openalex.org/W2326495145","https://openalex.org/W2341715540","https://openalex.org/W2343907402","https://openalex.org/W2344776828","https://openalex.org/W2394886450","https://openalex.org/W2395471404","https://openalex.org/W2397221260","https://openalex.org/W2399697781","https://openalex.org/W2408051866","https://openalex.org/W2408836120","https://openalex.org/W2412805687","https://openalex.org/W2412832730","https://openalex.org/W2414183822","https://openalex.org/W2415811580","https://openalex.org/W2419676527","https://openalex.org/W2428625101","https://openalex.org/W4239150310"],"related_works":["https://openalex.org/W1516825900","https://openalex.org/W2238019628","https://openalex.org/W2411813553","https://openalex.org/W7219380813","https://openalex.org/W7067920286","https://openalex.org/W2403150477","https://openalex.org/W4302495295","https://openalex.org/W2059086475","https://openalex.org/W7066166781","https://openalex.org/W6980258173"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}