{"id":"https://openalex.org/W155366644","doi":null,"title":"Tobacco use in Alzheimer's disease.","display_name":"Tobacco use in Alzheimer's disease.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W155366644","mag":"155366644","pmid":"https://pubmed.ncbi.nlm.nih.gov/2602415"},"language":"en","primary_location":{"id":"pmid:2602415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2602415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in clinical and biological research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001289589","display_name":"Lee Barclay","orcid":"https://orcid.org/0009-0000-5462-3295","observed_orcids":["https://orcid.org/0009-0000-5462-3295"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Barclay","raw_affiliation_strings":["Department of Neurology, University of South Florida College of Medicine, Tampa 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of South Florida College of Medicine, Tampa 33612","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037999838","display_name":"S Kheyfets","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Kheyfets","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3613,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.91151738,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"317","issue":null,"first_page":"189","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.029200000688433647,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tobacco-use","display_name":"tobacco use","score":0.9509999752044678},{"id":"https://openalex.org/keywords/smoking-cessation","display_name":"smoking cessation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/nicotine-withdrawal","display_name":"nicotine withdrawal","score":0.7630000114440918},{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.921999990940094},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.8130000233650208},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9079999923706055},{"id":"https://openalex.org/keywords/preclinical-alzheimer-s-disease","display_name":"preclinical Alzheimer's disease","score":0.6909999847412109},{"id":"https://openalex.org/keywords/appetite-changes","display_name":"appetite changes","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7633985280990601},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.6911358833312988},{"id":"https://openalex.org/C2777495918","wikidata":"https://www.wikidata.org/wiki/Q1196129","display_name":"Spouse","level":2,"score":0.5614041090011597},{"id":"https://openalex.org/C2779177420","wikidata":"https://www.wikidata.org/wiki/Q3961638","display_name":"Nicotine withdrawal","level":3,"score":0.5049980282783508},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5022158622741699},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4964166283607483},{"id":"https://openalex.org/C2777843972","wikidata":"https://www.wikidata.org/wiki/Q2462253","display_name":"Smoking cessation","level":2,"score":0.4246561527252197},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.37743425369262695},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1389920711517334},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014029","descriptor_name":"Tobacco Use Disorder","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D014029","descriptor_name":"Tobacco Use Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2602415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2602415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Progress in clinical and biological research","raw_type":"Journal Article"},{"id":"mag:155366644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2602415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2068231285","https://openalex.org/W1507821648","https://openalex.org/W1980550626","https://openalex.org/W1451002241","https://openalex.org/W4247480227","https://openalex.org/W2070438626","https://openalex.org/W2135134101","https://openalex.org/W2010751599","https://openalex.org/W1973245614","https://openalex.org/W4253244739"],"abstract_inverted_index":{"Cholinergic":[0],"abnormalities":[1],"in":[2,9,21,93,100,109,137,172,237],"Alzheimer's":[3],"disease":[4],"(AD)":[5],"may":[6],"be":[7],"important":[8],"the":[10,103,159,217],"pathogenesis":[11],"of":[12,30,45,57,61,69,73,111,115,119,123,146,150,164,167,174,178,219,224],"memory":[13],"impairment.":[14],"Tobacco":[15],"use,":[16,141],"which":[17],"might":[18],"reflect":[19],"changes":[20,236],"central":[22,238],"nicotinic":[23,239],"receptors,":[24,240],"was":[25,88],"examined":[26],"by":[27,38,42],"chart":[28,54],"review":[29],"272":[31],"patients":[32,47,132,147,175,183],"(M:F":[33,48],"86:186)":[34],"with":[35],"\"probable\"":[36],"AD":[37,79,86],"NIH":[39],"criteria,":[40],"and":[41,50,59,71,85,95,113,121,133,142,148,176,202,227,246],"interviewing":[43],"next-of-kin":[44],"39":[46],"15:24)":[49],"spouse":[51],"controls.":[52,179],"On":[53],"review,":[55],"37%":[56,149],"females":[58,70,94,112,120],"98%":[60],"males":[62,74,124],"had":[63,125,152,186,195],"used":[64],"tobacco,":[65],"but":[66,192],"only":[67],"10%":[68],"14%":[72],"were":[75,135],"still":[76],"smoking":[77,84,106,143,162],"at":[78],"onset.":[80],"Interval":[81],"between":[82],"stopping":[83,213],"onset":[87],"18.3":[89],"+/-":[90,97],"7.7":[91],"years":[92,99],"16.6":[96],"6.8":[98],"males.":[101,116],"Losing":[102],"taste":[104,160],"for":[105,161,205],"preceded":[107],"cessation":[108],"60.3%":[110],"16.2%":[114],"Only":[117],"7.9%":[118],"4.4%":[122],"withdrawal":[126],"symptoms.":[127],"Next-of-kin":[128],"interview":[129],"revealed":[130],"that":[131],"controls":[134,151],"comparable":[136],"demographic":[138],"data,":[139],"alcohol":[140],"habits.":[144],"24%":[145],"stopped":[153],"smoking,":[154],"often":[155,194],"due":[156],"to":[157,181,221],"losing":[158],"(32%":[163],"patients;":[165],"18%":[166],"controls).":[168],"Withdrawal":[169],"symptoms":[170],"occurred":[171],"21%":[173],"41%":[177],"Relative":[180],"controls,":[182],"less":[184],"frequently":[185],"increased":[187],"appetite":[188],"(28%":[189],"vs":[190,200,210],"47%),":[191],"more":[193],"changed":[196],"sex":[197],"drive":[198],"(22%":[199],"0%)":[201],"altered":[203,228],"preference":[204],"specific":[206],"alcoholic":[207],"beverages":[208],"(11%":[209],"0%),":[211],"after":[212],"smoking.":[214],"In":[215],"AD,":[216],"loss":[218],"desire":[220],"smoke,":[222],"lack":[223],"nicotine":[225],"withdrawal,":[226],"appetites":[229],"long":[230],"precede":[231],"cognitive":[232],"symptoms,":[233],"suggesting":[234],"preclinical":[235],"as":[241,243],"well":[242],"possible":[244],"diagnostic":[245],"therapeutic":[247],"strategies.":[248]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}