{"id":"https://openalex.org/W1553648772","doi":"https://doi.org/10.1073/pnas.1420811112","title":"TLR4 has a TP53-dependent dual role in regulating breast cancer cell growth","display_name":"TLR4 has a TP53-dependent dual role in regulating breast cancer cell growth","publication_year":2015,"publication_date":"2015-06-10","ids":{"openalex":"https://openalex.org/W1553648772","doi":"https://doi.org/10.1073/pnas.1420811112","mag":"1553648772","pmid":"https://pubmed.ncbi.nlm.nih.gov/26063617","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4485113"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1420811112","doi":"https://doi.org/10.1073/pnas.1420811112","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1420811112","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4485113","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018447438","display_name":"Svasti Haricharan","orcid":"https://orcid.org/0000-0002-4471-8853","observed_orcids":["https://orcid.org/0000-0002-4471-8853"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Svasti Haricharan","raw_affiliation_strings":["Department of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069756775","display_name":"Powel H. Brown","orcid":"https://orcid.org/0000-0002-3398-163X","observed_orcids":["https://orcid.org/0000-0002-3398-163X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Powel Brown","raw_affiliation_strings":["Department of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":3.9385,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.9408819,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"112","issue":"25","first_page":"E3216","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.859000027179718},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8679999709129333},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.765999972820282},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.722000002861023},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9079999923706055},{"id":"https://openalex.org/keywords/tlr4-inhibition","display_name":"TLR4 inhibition","score":0.7160000205039978},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6050364971160889},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.5575766563415527},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46823304891586304},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.412982314825058},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39910221099853516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37992262840270996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3677162826061249},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3097817897796631},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30368584394454956},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13616648316383362},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.10099190473556519},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.1420811112","doi":"https://doi.org/10.1073/pnas.1420811112","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1420811112","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3454732","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4485113","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4485113","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4485113","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:26063617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26063617","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3c15r71m","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3c15r71m","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, vol 112, iss 25","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3454732","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4485113","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1693873790","https://openalex.org/W1819850574","https://openalex.org/W1971274526","https://openalex.org/W1974335344","https://openalex.org/W1978224665","https://openalex.org/W1982276721","https://openalex.org/W1983243361","https://openalex.org/W1987783969","https://openalex.org/W2000389042","https://openalex.org/W2004647500","https://openalex.org/W2014214300","https://openalex.org/W2058603087","https://openalex.org/W2062946715","https://openalex.org/W2079395387","https://openalex.org/W2094704890","https://openalex.org/W2098913212","https://openalex.org/W2099146158","https://openalex.org/W2105616976","https://openalex.org/W2107554353","https://openalex.org/W2113140685","https://openalex.org/W2128334384","https://openalex.org/W2130655121","https://openalex.org/W2136274729","https://openalex.org/W2141941378","https://openalex.org/W2144775044","https://openalex.org/W2149425421","https://openalex.org/W2151832198","https://openalex.org/W2160583073"],"related_works":["https://openalex.org/W755601617","https://openalex.org/W1966490934","https://openalex.org/W2903918902","https://openalex.org/W3190829479","https://openalex.org/W2149425421","https://openalex.org/W2332651822","https://openalex.org/W2183795683","https://openalex.org/W3011797212","https://openalex.org/W2125170732","https://openalex.org/W2099146158"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,35,56,84,108,121],"is":[2,11,49,58,92,130],"a":[3,45,143,150,154,232],"leading":[4],"cause":[5],"of":[6,43,55,62,73,80,112,156,189,208,229],"cancer-related":[7],"death,":[8],"and":[9,57,133,153,220],"it":[10],"important":[12],"to":[13,20,217],"understand":[14],"pathways":[15],"that":[16,28,68,168,205,226],"drive":[17],"the":[18,41,206,227],"disease":[19],"devise":[21],"effective":[22],"therapeutic":[23,233],"strategies.":[24],"Our":[25],"results":[26,163],"show":[27],"Toll-like":[29],"receptor":[30],"4":[31],"(TLR4)":[32],"drives":[33],"breast":[34,64,83,107,120,160,171],"cell":[36,98],"growth":[37,72,79,138,151,173,188],"differentially":[38],"based":[39],"on":[40,212,236],"presence":[42],"TP53,":[44],"tumor":[46,97,157,172,242],"suppressor.":[47],"TP53":[48,74,81,105,118,169,190,209,237],"mutationally":[50],"inactivated":[51],"in":[52,60,96,104,117,159,185,239],"most":[53],"types":[54],"mutated":[59],"30-50%":[61],"diagnosed":[63],"tumors.":[65,161,192],"We":[66],"demonstrate":[67,204],"TLR4":[69,102,115,148,179,182,213,230],"activation":[70,103,116],"inhibits":[71],"wild-type":[75,119,191],"cells,":[76],"but":[77],"promotes":[78],"mutant":[82,106,170],"cells":[85,109,122],"by":[86,94,177,197],"regulating":[87],"proliferation.":[88],"This":[89,140],"differential":[90],"effect":[91,207],"mediated":[93],"changes":[95],"cytokine":[99],"secretion.":[100],"Whereas":[101],"increases":[110,123],"secretion":[111],"progrowth":[113],"cytokines,":[114],"type":[124],"I":[125],"IFN":[126],"(IFN-\u03b3)":[127],"secretion,":[128],"which":[129],"both":[131],"necessary":[132],"sufficient":[134],"for":[135,147],"mediating":[136],"TLR4-induced":[137],"inhibition.":[139],"study":[141],"identifies":[142],"novel":[144],"dichotomous":[145],"role":[146],"as":[149,231],"regulator":[152],"modulator":[155],"microenvironment":[158],"These":[162],"have":[164],"translational":[165],"relevance,":[166],"demonstrating":[167],"can":[174],"be":[175],"suppressed":[176],"pharmacologic":[178],"inhibition,":[180],"whereas":[181],"inhibitors":[183],"may":[184,215],"fact":[186],"promote":[187],"Furthermore,":[193],"using":[194],"data":[195],"generated":[196],"The":[198],"Cancer":[199],"Genome":[200],"Atlas":[201],"consortium,":[202],"we":[203],"mutational":[210],"status":[211,238],"activity":[214],"extend":[216],"ovarian,":[218],"colon,":[219],"lung":[221],"cancers,":[222],"among":[223],"others,":[224],"suggesting":[225],"viability":[228],"target":[234],"depends":[235],"many":[240],"different":[241],"types.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
