{"id":"https://openalex.org/W1553564565","doi":null,"title":"Mechanisms of Spontaneous Melanoma Regression in MeLiM Pigs","display_name":"Mechanisms of Spontaneous Melanoma Regression in MeLiM Pigs","publication_year":2008,"publication_date":"2008-05-14","ids":{"openalex":"https://openalex.org/W1553564565","mag":"1553564565"},"language":"fr","primary_location":{"id":"mag:1553564565","doi":null,"is_oa":true,"landing_page_url":"https://tel.archives-ouvertes.fr/tel-00433225","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HAL (Le Centre pour la Communication Scientifique Directe)","raw_type":null},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://tel.archives-ouvertes.fr/tel-00433225","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034389010","display_name":"Florian Rambow","orcid":"https://orcid.org/0000-0002-9727-8986","observed_orcids":["https://orcid.org/0000-0002-9727-8986"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Florian Rambow","raw_affiliation_strings":["Laboratoire de radiobiologie et d'\u00e9tude du g\u00e9nome"],"raw_orcid":"https://orcid.org/0000-0002-9727-8986","affiliations":[{"raw_affiliation_string":"Laboratoire de radiobiologie et d'\u00e9tude du g\u00e9nome","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034389010"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.49559998512268066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.49559998512268066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.266400009393692,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.13809999823570251,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spontaneous-tumor-regression","display_name":"spontaneous tumor regression","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cutaneous-melanoma","display_name":"cutaneous melanoma","score":0.9359999895095825},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7149999737739563},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6029999852180481},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cd9","display_name":"CD9","score":0.6940000057220459},{"id":"https://openalex.org/keywords/rarres1","display_name":"RARRES1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.652999997138977},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.609000027179718},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8220000267028809},{"id":"https://openalex.org/keywords/melanocyte-differentiation","display_name":"melanocyte differentiation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7310000061988831},{"id":"https://openalex.org/keywords/host-immune-system","display_name":"host immune system","score":0.46799999475479126},{"id":"https://openalex.org/keywords/time-dependent-gene-expression","display_name":"time-dependent gene expression","score":0.4300000071525574},{"id":"https://openalex.org/keywords/dna-microarrays","display_name":"DNA microarrays","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.9382438063621521},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5358195900917053},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.501023530960083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4455316662788391},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4311484098434448},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.4273000955581665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3647844195365906},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3362693190574646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25212860107421875},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.07397779822349548},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"mag:1553564565","doi":null,"is_oa":true,"landing_page_url":"https://tel.archives-ouvertes.fr/tel-00433225","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HAL (Le Centre pour la Communication Scientifique Directe)","raw_type":null},{"id":"pmh:hdl:10068/814219","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/814219","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:HAL:tel-00433225v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00433225","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://tel.archives-ouvertes.fr/docs/00/43/32/25/PDF/these_final_FR_140508.pdf","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"mag:1553564565","doi":null,"is_oa":true,"landing_page_url":"https://tel.archives-ouvertes.fr/tel-00433225","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HAL (Le Centre pour la Communication Scientifique Directe)","raw_type":null},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":229,"referenced_works":["https://openalex.org/W100562756","https://openalex.org/W131395641","https://openalex.org/W181486121","https://openalex.org/W192621565","https://openalex.org/W357083270","https://openalex.org/W632712882","https://openalex.org/W957671978","https://openalex.org/W1483726034","https://openalex.org/W1498792929","https://openalex.org/W1513030032","https://openalex.org/W1514590870","https://openalex.org/W1563231374","https://openalex.org/W1575476212","https://openalex.org/W1583927081","https://openalex.org/W1588354839","https://openalex.org/W1594381616","https://openalex.org/W1639637038","https://openalex.org/W1860898248","https://openalex.org/W1869421738","https://openalex.org/W1902123239","https://openalex.org/W1936899298","https://openalex.org/W1946633045","https://openalex.org/W1947075663","https://openalex.org/W1963583797","https://openalex.org/W1965715635","https://openalex.org/W1967342065","https://openalex.org/W1967846044","https://openalex.org/W1967909721","https://openalex.org/W1969464492","https://openalex.org/W1970241639","https://openalex.org/W1970977508","https://openalex.org/W1971512164","https://openalex.org/W1972031617","https://openalex.org/W1972416794","https://openalex.org/W1972977765","https://openalex.org/W1973506087","https://openalex.org/W1974200388","https://openalex.org/W1977441147","https://openalex.org/W1978709430","https://openalex.org/W1978844953","https://openalex.org/W1979276428","https://openalex.org/W1981605211","https://openalex.org/W1981919618","https://openalex.org/W1982635732","https://openalex.org/W1983172399","https://openalex.org/W1990005278","https://openalex.org/W1990757263","https://openalex.org/W1991287153","https://openalex.org/W1992205005","https://openalex.org/W1993065689","https://openalex.org/W1993336164","https://openalex.org/W1996067072","https://openalex.org/W1996379960","https://openalex.org/W1997274895","https://openalex.org/W1997919830","https://openalex.org/W1999149486","https://openalex.org/W2000093333","https://openalex.org/W2001364517","https://openalex.org/W2003632995","https://openalex.org/W2004832301","https://openalex.org/W2005801383","https://openalex.org/W2006983673","https://openalex.org/W2006985176","https://openalex.org/W2007455563","https://openalex.org/W2007957539","https://openalex.org/W2009705286","https://openalex.org/W2013920592","https://openalex.org/W2014301287","https://openalex.org/W2014744183","https://openalex.org/W2015009944","https://openalex.org/W2015466920","https://openalex.org/W2015613845","https://openalex.org/W2016299819","https://openalex.org/W2016983859","https://openalex.org/W2017622305","https://openalex.org/W2019214729","https://openalex.org/W2023296558","https://openalex.org/W2023587649","https://openalex.org/W2023695022","https://openalex.org/W2024102203","https://openalex.org/W2025143710","https://openalex.org/W2026323819","https://openalex.org/W2026470830","https://openalex.org/W2027561246","https://openalex.org/W2029090729","https://openalex.org/W2029848679","https://openalex.org/W2029877603","https://openalex.org/W2030120875","https://openalex.org/W2031646662","https://openalex.org/W2032598681","https://openalex.org/W2034021163","https://openalex.org/W2034048944","https://openalex.org/W2034832045","https://openalex.org/W2035745520","https://openalex.org/W2035920415","https://openalex.org/W2037133729","https://openalex.org/W2038440293","https://openalex.org/W2038953305","https://openalex.org/W2040474892","https://openalex.org/W2041672829","https://openalex.org/W2042939784","https://openalex.org/W2043474283","https://openalex.org/W2043809864","https://openalex.org/W2044560586","https://openalex.org/W2046137334","https://openalex.org/W2046972425","https://openalex.org/W2047423225","https://openalex.org/W2047902191","https://openalex.org/W2048476370","https://openalex.org/W2050359791","https://openalex.org/W2050658465","https://openalex.org/W2051440419","https://openalex.org/W2051681933","https://openalex.org/W2051909973","https://openalex.org/W2052313621","https://openalex.org/W2052912081","https://openalex.org/W2053366954","https://openalex.org/W2054834280","https://openalex.org/W2055972315","https://openalex.org/W2056506974","https://openalex.org/W2058219340","https://openalex.org/W2058680810","https://openalex.org/W2058709111","https://openalex.org/W2058755650","https://openalex.org/W2059599565","https://openalex.org/W2060317877","https://openalex.org/W2062889582","https://openalex.org/W2063192133","https://openalex.org/W2064159199","https://openalex.org/W2068049058","https://openalex.org/W2068289276","https://openalex.org/W2068526230","https://openalex.org/W2068682540","https://openalex.org/W2069659360","https://openalex.org/W2070770200","https://openalex.org/W2071256091","https://openalex.org/W2072078248","https://openalex.org/W2072868135","https://openalex.org/W2074089133","https://openalex.org/W2074127325","https://openalex.org/W2074900804","https://openalex.org/W2077173862","https://openalex.org/W2077477932","https://openalex.org/W2078085351","https://openalex.org/W2078370873","https://openalex.org/W2078610083","https://openalex.org/W2081527131","https://openalex.org/W2082224552","https://openalex.org/W2083382501","https://openalex.org/W2085483616","https://openalex.org/W2085806003","https://openalex.org/W2087159673","https://openalex.org/W2092926536","https://openalex.org/W2093304762","https://openalex.org/W2095864883","https://openalex.org/W2095970568","https://openalex.org/W2096554723","https://openalex.org/W2100123199","https://openalex.org/W2100373655","https://openalex.org/W2101654319","https://openalex.org/W2104040074","https://openalex.org/W2104843167","https://openalex.org/W2107914050","https://openalex.org/W2109513968","https://openalex.org/W2109972881","https://openalex.org/W2110666579","https://openalex.org/W2110735056","https://openalex.org/W2112572166","https://openalex.org/W2114677291","https://openalex.org/W2115738123","https://openalex.org/W2116519605","https://openalex.org/W2118903985","https://openalex.org/W2122533036","https://openalex.org/W2122544338","https://openalex.org/W2123830992","https://openalex.org/W2124446900","https://openalex.org/W2124662474","https://openalex.org/W2125523949","https://openalex.org/W2125536613","https://openalex.org/W2127218421","https://openalex.org/W2127956110","https://openalex.org/W2128174296","https://openalex.org/W2129234309","https://openalex.org/W2131128075","https://openalex.org/W2131147451","https://openalex.org/W2132005771","https://openalex.org/W2133820317","https://openalex.org/W2134017014","https://openalex.org/W2134960406","https://openalex.org/W2137471841","https://openalex.org/W2139186046","https://openalex.org/W2140330371","https://openalex.org/W2140905796","https://openalex.org/W2141529421","https://openalex.org/W2141543852","https://openalex.org/W2142354018","https://openalex.org/W2142874602","https://openalex.org/W2142942192","https://openalex.org/W2144038313","https://openalex.org/W2147695327","https://openalex.org/W2148605435","https://openalex.org/W2148615450","https://openalex.org/W2150536104","https://openalex.org/W2151246207","https://openalex.org/W2151276935","https://openalex.org/W2152315800","https://openalex.org/W2152482554","https://openalex.org/W2156270220","https://openalex.org/W2160893227","https://openalex.org/W2161619500","https://openalex.org/W2161724145","https://openalex.org/W2164134009","https://openalex.org/W2164395223","https://openalex.org/W2166923617","https://openalex.org/W2167028317","https://openalex.org/W2170668820","https://openalex.org/W2171249564","https://openalex.org/W2189329705","https://openalex.org/W2322794165","https://openalex.org/W2323623110","https://openalex.org/W2325794166","https://openalex.org/W2403304800","https://openalex.org/W2404423076","https://openalex.org/W2408590861","https://openalex.org/W2408606979","https://openalex.org/W2410766123","https://openalex.org/W2418135327","https://openalex.org/W2464271580","https://openalex.org/W2753095269"],"related_works":["https://openalex.org/W1914292641","https://openalex.org/W2735646802","https://openalex.org/W1231578283","https://openalex.org/W2043474283","https://openalex.org/W4394996196","https://openalex.org/W7135487092","https://openalex.org/W2986284752","https://openalex.org/W2621966917","https://openalex.org/W7080059581","https://openalex.org/W2763297216"],"abstract_inverted_index":{"Cutaneous":[0],"melanoma,":[1,121],"the":[2,36,63,78,144,228,265,300,353,363,366,403,423,431,458,464,485,491,496,501,509,524,561,565,569],"most":[3],"aggressive":[4],"form":[5],"of":[6,38,65,83,91,147,154,170,191,267,346,379,402,422,441,451,466,526,544,560,572],"skin":[7],"cancer,":[8],"is":[9,29,46,67,75,94,107,307,320,461,568],"a":[10,24,108,167,175,213,240,292,308,313,321,335,387,399,448,530],"tumor":[11,114,179,210,233,284,315,419,545],"originating":[12],"from":[13,119,195,232],"melanocytes":[14],"with":[15,20,250,495],"rapidly":[16],"increasing":[17],"incidence.":[18],"Patients":[19],"advanced":[21,92],"disease":[22],"have":[23],"poor":[25],"prognosis":[26],"since":[27],"melanoma":[28,45,66,85,93,136,156,199,245,253,297,409,489],"mostly":[30],"resistant":[31],"to":[32,54,72,76,100,111,134,151,200,203,238,351,474,480,514,522,548,575,582],"current":[33],"therapies.":[34],"Therefore,":[35],"development":[37],"novel":[39,50],"strategies":[40],"for":[41,59,243,511,595],"preventing":[42],"and":[43,58,97,125,177,197,260,283,289,302,311,369,414,425,487,503,532,557],"treating":[44],"important.":[47,68],"To":[48],"explore":[49],"therapies":[51],"we":[52,165,225,324,374,392,417,472,538],"need":[53],"find":[55],"appropriate":[56],"targets":[57,590],"that":[60,246,348,384,471,550,591],"knowledge":[61],"about":[62],"biology":[64],"One":[69],"elegant":[70],"way":[71,537],"do":[73],"so,":[74],"study":[77,112,164,515],"natural":[79],"but":[80],"rare":[81],"phenomenon":[82],"spontaneous":[84,89,113,135,155,318,527],"regression.":[86,115,390],"Unfortunately,":[87],"complete":[88],"regression":[90,137,157,268,298,319,347,430,459,528,573],"extremely":[95],"rare,":[96],"therefore":[98],"hard":[99],"investigate.":[101],"The":[102],"Melanoblastoma-bearing":[103],"Libechov":[104],"Minipig":[105],"(MeLiM)":[106],"great":[109],"opportunity":[110],"MeLiM":[116,159],"pigs,":[117],"suffering":[118],"hereditary":[120],"develop":[122],"tumors":[123],"naturally":[124],"regress":[126],"them":[127],"completely":[128],"without":[129],"external":[130],"influence.":[131],"Mechanisms":[132],"leading":[133],"are":[138],"poorly":[139],"understood":[140],"at":[141,264,343],"present.":[142],"Therefore":[143],"overall":[145],"objective":[146],"this":[148,512,536,579],"PhD":[149],"was":[150],"investigate":[152],"mechanisms":[153],"in":[158,217,272,334,362,389,407,434],"pigs.":[160],"In":[161,535],"an":[162,376,437,540,558],"initial":[163],"gained":[166],"global":[168],"overview":[169],"differentially":[171],"expressed":[172],"genes":[173,215,249,383],"between":[174,205,219,484],"growing":[176,196,244],"regressing":[178,198],"by":[180,209,447,463],"conducting":[181],"Subtractive":[182],"Suppression":[183],"Hybridization":[184],"(SSH).":[185],"We":[186,235,338],"also":[187,521],"performed":[188,325],"SSH":[189,222,229],"analysis":[190],"cell":[192,280,367,380],"cultures":[193],"isolated":[194],"be":[201,576,593],"able":[202,237,350],"distinguish":[204],"expressional":[206],"changes":[207],"induced":[208],"microenvironment.":[211],"Only":[212],"few":[214],"were":[216,236,269,349,359],"common":[218,248],"these":[220],"two":[221,435],"analyses.":[223],"Thus":[224],"focused":[226],"on":[227,299,490,500,529],"results":[230],"obtained":[231],"tissue.":[234],"identify":[239],"gene":[241,328,341,357,396],"signature":[242],"demonstrated":[247],"human":[251,488,516,583],"progressive":[252],"(TYR,":[254],"MITF,":[255],"MLANA,":[256],"SDCBP,":[257],"SILV,":[258],"TYRP":[259],"ZFP106).":[261],"Genes":[262],"overexpressed":[263],"beginning":[266],"mainly":[270,360,452],"involved":[271,361],"functional":[273],"classes":[274],"such":[275],"as":[276,586],"differentiation,":[277],"immune":[278,364,395,405,427,562,566],"system,":[279],"cycle":[281,381],"arrest,":[282],"suppression.":[285],"Two":[286],"genes,":[287],"CD9":[288,306],"RARRES1,":[290],"showed":[291,375],"strong":[293],"upregulation":[294],"during":[295],"early":[296,377,438,541],"mRNA":[301],"protein":[303,310],"level":[304,493],"whereas":[305],"motility-related":[309],"RARRES1":[312],"putative":[314],"suppressor.":[316],"Since":[317],"dynamic":[322],"process,":[323],"time":[326],"dependent":[327],"expression":[329],"profiling":[330],"using":[331,412],"DNA":[332],"chips":[333],"second":[336],"study.":[337],"identified":[339,393],"significant":[340],"signatures":[342,358],"different":[344,394],"stages":[345],"explain":[352],"corresponding":[354],"phenotype.":[355],"Identified":[356],"response,":[365],"cycle,":[368],"melanocyte":[370],"differentiation/pigmentation":[371],"processes.":[372],"Interestingly,":[373],"downregulation":[378],"related":[382],"could":[385,592],"play":[386],"role":[388,401],"Also,":[391],"signatures,":[397],"suggesting":[398],"major":[400],"host's":[404],"system":[406],"eradicating":[408],"cells.":[410],"By":[411],"immunohistology":[413],"flow":[415],"cytometry":[416],"characterized":[418],"infiltrating":[420],"cells":[421,444,470],"innate":[424],"adaptive":[426],"system.":[428,563],"During":[429],"infiltration":[432,450],"occurred":[433],"phases:":[436],"phase":[439],"consisting":[440],"antigen":[442],"presenting":[443],"(SWC3+),":[445],"followed":[446],"later":[449],"cytotoxic":[453],"T":[454],"lymphocytes":[455],"(CD8+).":[456],"Furthermore":[457],"process":[460,525],"accompanied":[462],"presence":[465],"big":[467],"highly":[468],"pigmented":[469],"began":[473],"characterize.":[475],"This":[476,518],"work":[477,519,580],"allowed":[478],"us":[479],"point":[481],"out":[482],"similarities":[483],"pig":[486],"transcriptomic":[492],"along":[494],"already":[497],"observed":[498,539],"parallels":[499],"clinical":[502],"genetic":[504],"level.":[505,534],"These":[506],"findings":[507],"underline":[508],"utility":[510],"model":[513],"melanoma.":[517],"helped":[520],"decipher":[523],"cellular":[531],"molecular":[533],"mitotic":[542],"arrest":[543],"cells,":[546],"linked":[547],"regression,":[549],"has":[551],"not":[552],"been":[553],"described":[554],"so":[555],"far,":[556],"implication":[559],"If":[564],"response":[567],"real":[570],"inducer":[571],"needs":[574],"verified.":[577],"Already,":[578],"contributes":[581],"anti-melanoma":[584],"therapy":[585],"it":[587],"provides":[588],"potential":[589],"used":[594],"developing":[596],"new":[597],"strategies.":[598]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
