{"id":"https://openalex.org/W1553420185","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.lb425","title":"The association between Vitamin B6 and cognitive decline is modified by inflammatory state (LB425)","display_name":"The association between Vitamin B6 and cognitive decline is modified by inflammatory state (LB425)","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1553420185","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.lb425","mag":"1553420185"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.28.1_supplement.lb425","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.lb425","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.lb425","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056638320","display_name":"Christina Reginaldo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Reginaldo","raw_affiliation_strings":["Friedman School of Nutrition Science and Policy Tufts University Boston MA United States","1Friedman School of Nutrition Science and Policy, Tufts University Boston MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedman School of Nutrition Science and Policy Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"1Friedman School of Nutrition Science and Policy, Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052971612","display_name":"Hathairat Sawaensgri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hathairat Sawaensgri","raw_affiliation_strings":["Friedman School of Nutrition Science and Policy Tufts University Boston MA United States","1Friedman School of Nutrition Science and Policy, Tufts University Boston MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedman School of Nutrition Science and Policy Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"1Friedman School of Nutrition Science and Policy, Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046756540","display_name":"Tammy Maria Scott","orcid":"https://orcid.org/0000-0002-5186-9430","observed_orcids":["https://orcid.org/0000-0002-5186-9430"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210111395","display_name":"Jean Mayer Human Nutrition Research Center on Aging","ror":"https://ror.org/01d0zz505","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210111395","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammy Scott","raw_affiliation_strings":["JM USDA HNRCA at Tufts University Boston MA United States","2JM USDA HNRCA at Tufts University Boston MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JM USDA HNRCA at Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210111395"]},{"raw_affiliation_string":"2JM USDA HNRCA at Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210111395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052239303","display_name":"Irwin H. Rosenberg","orcid":"https://orcid.org/0009-0000-8248-5678","observed_orcids":["https://orcid.org/0009-0000-8248-5678"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210111395","display_name":"Jean Mayer Human Nutrition Research Center on Aging","ror":"https://ror.org/01d0zz505","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210111395","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irwin Rosenberg","raw_affiliation_strings":["JM USDA HNRCA at Tufts University Boston MA United States","2JM USDA HNRCA at Tufts University Boston MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JM USDA HNRCA at Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210111395"]},{"raw_affiliation_string":"2JM USDA HNRCA at Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210111395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088716375","display_name":"Jacob Selhub","orcid":"https://orcid.org/0000-0003-1103-0945","observed_orcids":["https://orcid.org/0000-0003-1103-0945"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210111395","display_name":"Jean Mayer Human Nutrition Research Center on Aging","ror":"https://ror.org/01d0zz505","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210111395","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Selhub","raw_affiliation_strings":["JM USDA HNRCA at Tufts University Boston MA United States","2JM USDA HNRCA at Tufts University Boston MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JM USDA HNRCA at Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210111395"]},{"raw_affiliation_string":"2JM USDA HNRCA at Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210111395"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072437210","display_name":"Ligi Paul","orcid":"https://orcid.org/0000-0003-1909-4783","observed_orcids":["https://orcid.org/0000-0003-1909-4783"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210111395","display_name":"Jean Mayer Human Nutrition Research Center on Aging","ror":"https://ror.org/01d0zz505","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210111395","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ligi Paul","raw_affiliation_strings":["JM USDA HNRCA at Tufts University Boston MA United States","2JM USDA HNRCA at Tufts University Boston MA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JM USDA HNRCA at Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210111395"]},{"raw_affiliation_string":"2JM USDA HNRCA at Tufts University Boston MA United States","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210111395"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0616178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-b6","display_name":"vitamin B6","score":0.949999988079071},{"id":"https://openalex.org/keywords/pyridoxal-5-phosphate","display_name":"pyridoxal phosphate","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.972000002861023},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9800000190734863},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9789999723434448},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cvd","display_name":"CVD","score":0.503000020980835},{"id":"https://openalex.org/keywords/neurotransmitter-synthesis","display_name":"neurotransmitter synthesis","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.6458895802497864},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6267147064208984},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6105988025665283},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5941488742828369},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5266518592834473},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5010333061218262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4845661222934723},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.48347097635269165},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39389151334762573},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.35692524909973145},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.27591121196746826},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2045927345752716},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.17461276054382324}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.28.1_supplement.lb425","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.lb425","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.lb425","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2909569150","https://openalex.org/W2929288030","https://openalex.org/W2098565557","https://openalex.org/W2132869607","https://openalex.org/W7101070811","https://openalex.org/W4252125408","https://openalex.org/W211235319","https://openalex.org/W120451117","https://openalex.org/W1873031925","https://openalex.org/W4318263502"],"abstract_inverted_index":{"Individuals":[0],"with":[1,86,122,127,151,190,200,204,214],"inflammatory":[2,174,253,271],"conditions":[3],"like":[4],"CVD,":[5],"diabetes,":[6,166],"and":[7,46,53,62,73,89,158,168,177,187,219,229,239,248,278],"cancer":[8],"have":[9,154],"low":[10,43],"plasma":[11,44,82],"pyridoxal":[12],"5\u2019\u2010phosphate":[13],"(PLP)":[14],"levels,":[15],"a":[16,66,108,243,249],"marker":[17],"of":[18,34,70,110,136,147,224,246,268],"functional":[19],"vitamin":[20],"B6":[21],"deficiency.":[22],"Prior":[23],"studies":[24,261],"suggest":[25],"that":[26,146,232],"during":[27],"inflammation,":[28],"PLP":[29,45,48,83,123,161,178,201,238,277],"is":[30,84],"mobilized":[31],"to":[32,36,42,79,211,264],"sites":[33],"inflammation":[35,247],"modulate":[37],"immune":[38],"response.":[39],"This":[40],"leads":[41],"reduces":[47],"available":[49],"for":[50,140],"neurotransmitter":[51],"synthesis":[52],"their":[54],"downstream":[55],"signaling.":[56],"These":[57],"outcomes":[58],"may":[59],"affect":[60],"cognition":[61,99,118,176,196,228],"depression.":[63],"We":[64],"conducted":[65],"secondary":[67,250],"data":[68,96],"analysis":[69],"the":[71,134,222,235,266,274],"Nutrition":[72],"Memory":[74],"in":[75,107,182,188],"Elders":[76],"(NAME)":[77],"study":[78,93,208],"determine":[80],"whether":[81],"associated":[85,121,181,199,213],"cognitive":[87,138,220],"decline":[88,139],"inflammation.":[90],"The":[91],"NAME":[92],"includes":[94],"cross\u2010sectional":[95],"on":[97,273],"global":[98],"as":[100],"measured":[101],"by":[102,173,258,285],"Mini\u2010Mental":[103],"State":[104],"Examination":[105],"(MMSE)":[106],"population":[109],"Boston\u2010area":[111],"elderly":[112],"(aged":[113],"60+).":[114],"Using":[115,130],"multivariate":[116],"analysis,":[117,133],"was":[119,197],"directly":[120,180],"(p=0.045);":[124],"but":[125,202],"not":[126,203,255],"CRP":[128,157,191,230],"(p=0.71).":[129],"logistic":[131],"regression":[132],"odds":[135],"having":[137],"diabetics":[141],"were":[142,179],"130%":[143],"higher":[144,156,215],"than":[145,163],"non\u2010diabetics":[148],"(p<0.05).":[149],"Subjects":[150],"diabetes":[152,185,210],"also":[153],"28%":[155],"15%":[159],"lower":[160,217],"levels":[162],"subjects":[164,183,189],"without":[165,184],"(p=0.003":[167],"0.001,":[169],"respectively).":[170],"Upon":[171],"stratification":[172],"state,":[175],"(p=0.049)":[186],"<3":[192],"mg/L":[193],"(p=0.03).":[194],"Overall,":[195],"positively":[198],"CRP.":[205,259],"While":[206],"this":[207],"found":[209],"be":[212],"CRP,":[216],"PLP,":[218],"decline,":[221],"lack":[223],"an":[225],"association":[226,275],"between":[227,237,276],"suggests":[231],"mechanisms":[233],"underlying":[234],"relation":[236],"disease":[240,251],"likely":[241],"involve":[242],"generalized":[244],"trigger":[245],"specific":[252,270],"response":[254],"well":[256],"characterized":[257],"Further":[260],"are":[262],"needed":[263],"investigate":[265],"role":[267],"more":[269],"markers":[272],"disease.":[279],"Grant":[280],"Funding":[281],"Source":[282],":":[283],"Supported":[284],"USDA":[286],"Cooperative":[287],"Agreement":[288],"51520\u2010008\u2010045":[289]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}