{"id":"https://openalex.org/W1553371841","doi":"https://doi.org/10.1158/1538-7445.am2014-5580","title":"Abstract 5580: TGF-\u03b21 enhanced cell migration involving pluripotent transcription factor OCT4 in endometriosis","display_name":"Abstract 5580: TGF-\u03b21 enhanced cell migration involving pluripotent transcription factor OCT4 in endometriosis","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1553371841","doi":"https://doi.org/10.1158/1538-7445.am2014-5580","mag":"1553371841"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-5580","doi":"https://doi.org/10.1158/1538-7445.am2014-5580","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-5580","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021453806","display_name":"Te\u2010Sheng Chang","orcid":"https://orcid.org/0000-0002-1581-6948","observed_orcids":["https://orcid.org/0000-0002-1581-6948"]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210156562","display_name":"Chiayi Chang Gung Memorial Hospital","ror":"https://ror.org/04gy6pv35","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210156562"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Te-Sheng Chang","raw_affiliation_strings":["1Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Chia Yi, Taiwan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Chia Yi, Taiwan;","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210156562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022298815","display_name":"Heng\u2010Kien Au","orcid":"https://orcid.org/0000-0002-1031-4447","observed_orcids":["https://orcid.org/0000-0002-1031-4447"]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Heng-Kien Au","raw_affiliation_strings":["2Taipei Medical University, College of Medicine, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Taipei Medical University, College of Medicine, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033435752","display_name":"Thai\u2010Yen Ling","orcid":"https://orcid.org/0000-0002-3992-883X","observed_orcids":["https://orcid.org/0000-0002-3992-883X"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Thai-Yen Ling","raw_affiliation_strings":["3National Taiwan University, College of Medicine, Taipei, Taiwan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3National Taiwan University, College of Medicine, Taipei, Taiwan;","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009926815","display_name":"Ching\u2010Chi Chi","orcid":"https://orcid.org/0000-0001-5699-0283","observed_orcids":["https://orcid.org/0000-0001-5699-0283"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210156562","display_name":"Chiayi Chang Gung Memorial Hospital","ror":"https://ror.org/04gy6pv35","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210156562"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ching-Chi Chi","raw_affiliation_strings":["4Chang Gung Memorial Hospital, Chiayi, Chang Gung University, Chia Yi, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Chang Gung Memorial Hospital, Chiayi, Chang Gung University, Chia Yi, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210156562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037563008","display_name":"Chii\u2010Ruey Tzeng","orcid":"https://orcid.org/0000-0002-7445-0261","observed_orcids":["https://orcid.org/0000-0002-7445-0261"]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chii-Ruey Tzeng","raw_affiliation_strings":["2Taipei Medical University, College of Medicine, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Taipei Medical University, College of Medicine, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083521052","display_name":"Jui-Hung Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jui-Hung Chang","raw_affiliation_strings":["2Taipei Medical University, College of Medicine, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Taipei Medical University, College of Medicine, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027192230","display_name":"Yen\u2010Hua Huang","orcid":"https://orcid.org/0000-0001-6020-9998","observed_orcids":["https://orcid.org/0000-0001-6020-9998"]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yen-Hua Huang","raw_affiliation_strings":["2Taipei Medical University, College of Medicine, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Taipei Medical University, College of Medicine, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"5580","last_page":"5580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12096","display_name":"Ectopic Pregnancy Diagnosis and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometriosis","display_name":"endometriosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tgf-beta-type-i-receptor","display_name":"TGF-beta type I receptor","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ectopic-endometrium","display_name":"ectopic endometrium","score":0.796999990940094},{"id":"https://openalex.org/keywords/endometrial-stromal-cells","display_name":"endometrial stromal cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.6650000214576721},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.7360000014305115},{"id":"https://openalex.org/keywords/twist","display_name":"Twist","score":0.6959999799728394},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.7110000252723694},{"id":"https://openalex.org/keywords/adenomyosis","display_name":"adenomyosis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/endometrioma","display_name":"endometrioma","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6882562637329102},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.607207179069519},{"id":"https://openalex.org/C2779522080","wikidata":"https://www.wikidata.org/wiki/Q205764","display_name":"Endometriosis","level":2,"score":0.5805431604385376},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5424360632896423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49484580755233765},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.4428485035896301},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35144996643066406},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29196029901504517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2755674123764038},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27113237977027893},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21589303016662598},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-5580","doi":"https://doi.org/10.1158/1538-7445.am2014-5580","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-5580","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2201327900","https://openalex.org/W1981831410","https://openalex.org/W2901604901","https://openalex.org/W2388289521","https://openalex.org/W7216834762","https://openalex.org/W2121048892","https://openalex.org/W2620491135","https://openalex.org/W2590976847","https://openalex.org/W7043514025","https://openalex.org/W2050184368"],"abstract_inverted_index":{"Abstract":[0],"Endometriosis":[1],"is":[2],"the":[3,30,49,59,67,106,124,160,187,214,216,228,260,303,308],"eutopic":[4],"and/or":[5],"ectopic":[6,63,107,249,263],"growth":[7,265],"of":[8,13,21,51,61,70,79,142,189,210,218,230,262,269,302,307],"endometrial":[9,55,181,231,264,270],"tissues.":[10,251],"High":[11],"levels":[12,69,78,168,203],"TGF-\u03b2":[14,34,71,97,157],"in":[15,27,38,53,81,105,134,164,169,179,199,204,247,259,297],"peritoneal":[16],"fluid":[17],"and":[18,35,58,75,91,98,117,144,155,166,192,195,201,221,224,226,237,242],"increased":[19,104,159],"expression":[20,37,77,162,188,255],"OCT4":[22,36,52,143,161,211,243,254,296],"have":[23],"been":[24],"well":[25],"documented":[26],"endometriosis.":[28,64,298],"However,":[29],"molecular":[31],"mechanism":[32],"between":[33],"endometriosis":[39],"still":[40],"remains":[41],"largely":[42],"unknown.":[43],"In":[44],"this":[45],"study,":[46],"we":[47],"examined":[48],"roles":[50],"TGF-\u03b2-induced":[54,215,267],"cell":[56,148,183,290],"migration":[57,229,268,291],"progression":[60],"human":[62,170,205,248],"We":[65],"analyzed":[66],"plasma":[68],"(n":[72,84,110,127],"=":[73,85,111,128],"80)":[74],"gene":[76,165,200],"TGF-\u03b2R1":[80,100],"patient":[82],"tissues":[83,109,116,136],"60)":[86],"by":[87,235],"an":[88],"ELISA":[89],"assay":[90],"quantitative":[92],"real-time":[93],"RT-PCR.":[94],"The":[95,130,252],"serum":[96],"tissue":[99],"expressions":[101,141,217],"were":[102],"significantly":[103,212,245],"endometriotic":[108,135,171,206,250],"54,":[112],"29":[113],"for":[114,119,311],"adenomyosis":[115],"25":[118],"chocolate":[120],"cysts)":[121],"comparing":[122],"with":[123,140,147],"normal":[125],"endometrium":[126],"5).":[129],"TGF\u03b2R1":[131],"transcriptional":[132],"level":[133],"was":[137],"positively":[138],"correlated":[139],"genes":[145,191,220],"associated":[146],"migration,":[149],"such":[150],"as":[151,233],"VIMENTIN,":[152],"TWIST,":[153],"SNAIL":[154],"SLUG.":[156],"dose-dependently":[158,197],"both":[163,198],"protein":[167,202],"stromal":[172,207],"cells":[173,232],"and,":[174],"at":[175],"a":[176],"less":[177],"intensity,":[178],"HEC1A":[180],"carcinoma":[182],"line.":[184],"Additionally,":[185],"TGF-\u03b2increased":[186],"migration-associated":[190,219],"proteins":[193,222],"(SNAIL":[194],"N-CAD)":[196],"cells.":[208,271],"Knockdown":[209],"suppressed":[213],"(N-CAD":[223],"SNAIL),":[225],"promoted":[227],"evidenced":[234],"wound-closure":[236],"transwell":[238],"assays.":[239],"Conclusions:":[240],"TGF-\u03b2,TGF-\u03b2RI,":[241],"are":[244],"upregulated":[246],"significant":[253],"may":[256],"be":[257],"involved":[258],"pathology":[261],"through":[266],"Citation":[272],"Format:":[273],"Te-Sheng":[274],"Chang,":[275,285],"Heng-Kien":[276],"Au,":[277],"Thai-Yen":[278],"Ling,":[279],"Ching-Chi":[280],"Chi,":[281],"Chii-Ruey":[282],"Tzeng,":[283],"Jui-Hung":[284],"Yen-Hua":[286],"Huang.":[287],"TGF-\u03b21":[288],"enhanced":[289],"involving":[292],"pluripotent":[293],"transcription":[294],"factor":[295],"[abstract].":[299],"In:":[300],"Proceedings":[301],"105th":[304],"Annual":[305],"Meeting":[306],"American":[309],"Association":[310],"Cancer":[312,323],"Research;":[313],"2014":[314],"Apr":[315],"5-9;":[316],"San":[317],"Diego,":[318],"CA.":[319],"Philadelphia":[320],"(PA):":[321],"AACR;":[322],"Res":[324],"2014;74(19":[325],"Suppl):Abstract":[326],"nr":[327],"5580.":[328],"doi:10.1158/1538-7445.AM2014-5580":[329]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}