{"id":"https://openalex.org/W1552816366","doi":"https://doi.org/10.1111/j.1471-4159.2004.02991.x","title":"An adenosine A2A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats","display_name":"An adenosine A2A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats","publication_year":2005,"publication_date":"2005-02-17","ids":{"openalex":"https://openalex.org/W1552816366","doi":"https://doi.org/10.1111/j.1471-4159.2004.02991.x","mag":"1552816366","pmid":"https://pubmed.ncbi.nlm.nih.gov/15748171"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.2004.02991.x","doi":"https://doi.org/10.1111/j.1471-4159.2004.02991.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2004.02991.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2004.02991.x?download=true","source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2004.02991.x?download=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100528601","display_name":"Zong\u2010Yuan Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zong\u2010Yuan Hong","raw_affiliation_strings":["School of Life Science, University of Science and Technology of China, Hefei, Anhui, China","Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science, University of Science and Technology of China, Hefei, Anhui, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042514704","display_name":"Zhi\u2010Li Huang","orcid":"https://orcid.org/0000-0001-9359-1150","observed_orcids":["https://orcid.org/0000-0001-9359-1150"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi\u2010Li Huang","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka, Japan","Department of Pharmacology, Shanghai Medical College of Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, Shanghai Medical College of Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025461362","display_name":"Wei\u2010Min Qu","orcid":"https://orcid.org/0000-0002-0251-5214","observed_orcids":["https://orcid.org/0000-0002-0251-5214"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei\u2010Min Qu","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110755348","display_name":"Naomi Eguchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naomi Eguchi","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113616205","display_name":"Yoshihiro Urade","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshihiro Urade","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064701201","display_name":"Osamu Hayaishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Osamu Hayaishi","raw_affiliation_strings":["Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Furuedai, Suita, Osaka, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":4.0577,"has_fulltext":false,"cited_by_count":128,"citation_normalized_percentile":{"value":0.93899281,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"92","issue":"6","first_page":"1542","last_page":"1549"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenosine-a2a-receptor","display_name":"adenosine A2A receptor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cgs-21680","display_name":"CGS 21680","score":0.9369999766349792},{"id":"https://openalex.org/keywords/sleep-regulation","display_name":"sleep regulation","score":0.972000002861023},{"id":"https://openalex.org/keywords/gaba-release","display_name":"GABA release","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tuberomammillary-nucleus","display_name":"tuberomammillary nucleus","score":0.9449999928474426},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.8690000176429749},{"id":"https://openalex.org/keywords/histaminergic-system","display_name":"histaminergic system","score":0.9789999723434448},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.6430000066757202},{"id":"https://openalex.org/keywords/picrotoxin","display_name":"picrotoxin","score":0.8960000276565552},{"id":"https://openalex.org/keywords/nrem-sleep","display_name":"NREM sleep","score":0.9259999990463257},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.8100000023841858},{"id":"https://openalex.org/keywords/medial-preoptic-area","display_name":"medial preoptic area","score":0.824999988079071},{"id":"https://openalex.org/keywords/basal-forebrain","display_name":"basal forebrain","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2778501154","wikidata":"https://www.wikidata.org/wiki/Q18349602","display_name":"Histaminergic","level":3,"score":0.9746010899543762},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5814184546470642},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5319006443023682},{"id":"https://openalex.org/C2776287375","wikidata":"https://www.wikidata.org/wiki/Q3407681","display_name":"Basal forebrain","level":3,"score":0.5294541716575623},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5218528509140015},{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.49129146337509155},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40771082043647766},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39273548126220703},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3926592767238617},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3797469437122345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25086119771003723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23152577877044678},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22532087564468384},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.17192456126213074},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1507885456085205},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10823875665664673}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004576","descriptor_name":"Electromyography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005625","descriptor_name":"Frontal Lobe","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005625","descriptor_name":"Frontal Lobe","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010627","descriptor_name":"Phenethylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011301","descriptor_name":"Preoptic Area","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011301","descriptor_name":"Preoptic Area","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017551","descriptor_name":"Microdialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018756","descriptor_name":"GABA Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043705","descriptor_name":"Receptor, Adenosine A2A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058787","descriptor_name":"GABA-A Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058908","descriptor_name":"Adenosine A2 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.2004.02991.x","doi":"https://doi.org/10.1111/j.1471-4159.2004.02991.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2004.02991.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2004.02991.x?download=true","source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:15748171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15748171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1471-4159.2004.02991.x","doi":"https://doi.org/10.1111/j.1471-4159.2004.02991.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2004.02991.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2004.02991.x?download=true","source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1552816366.pdf"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W81777342","https://openalex.org/W249845531","https://openalex.org/W1574945783","https://openalex.org/W1640809349","https://openalex.org/W1658437126","https://openalex.org/W1750580626","https://openalex.org/W1895384166","https://openalex.org/W1898430231","https://openalex.org/W1904057448","https://openalex.org/W1966736267","https://openalex.org/W1973920989","https://openalex.org/W1981070044","https://openalex.org/W1983233327","https://openalex.org/W1988514864","https://openalex.org/W1989776859","https://openalex.org/W2000336030","https://openalex.org/W2016355032","https://openalex.org/W2017494261","https://openalex.org/W2017608248","https://openalex.org/W2022628868","https://openalex.org/W2033950872","https://openalex.org/W2035973001","https://openalex.org/W2037388654","https://openalex.org/W2039279998","https://openalex.org/W2041657945","https://openalex.org/W2042040860","https://openalex.org/W2044712116","https://openalex.org/W2050315437","https://openalex.org/W2055628150","https://openalex.org/W2064915622","https://openalex.org/W2066504760","https://openalex.org/W2071542709","https://openalex.org/W2073561633","https://openalex.org/W2074671627","https://openalex.org/W2083612072","https://openalex.org/W2088367343","https://openalex.org/W2089547626","https://openalex.org/W2090116426","https://openalex.org/W2090856094","https://openalex.org/W2092148703","https://openalex.org/W2095352917","https://openalex.org/W2098065200","https://openalex.org/W2105698163","https://openalex.org/W2113836851","https://openalex.org/W2119327355","https://openalex.org/W2163815564","https://openalex.org/W2164431336"],"related_works":["https://openalex.org/W2136414187","https://openalex.org/W2164431336","https://openalex.org/W2157087531","https://openalex.org/W2090116426","https://openalex.org/W2379977937","https://openalex.org/W1981070044","https://openalex.org/W4292640193","https://openalex.org/W2033188572","https://openalex.org/W2603626136","https://openalex.org/W2119327355"],"abstract_inverted_index":{"The":[0,92],"adenosine":[1],"A(2A)":[2],"receptor":[3],"(A(2A)R)":[4],"has":[5],"been":[6],"demonstrated":[7],"to":[8,29,44,72],"play":[9],"a":[10,127,162],"crucial":[11],"role":[12],"in":[13,41,63,88,117,126,135,142,184],"the":[14,17,21,25,46,57,64,73,77,89,99,119,136,143,147,158,170,177,185],"regulation":[15],"of":[16,24,48,59,101,150,157],"sleep":[18,27,54,83,105,174],"process.":[19],"However,":[20],"molecular":[22],"mechanism":[23],"A(2A)R-mediated":[26],"remains":[28],"be":[30],"elucidated.":[31],"Here":[32],"we":[33],"used":[34],"electroencephalogram":[35],"and":[36,55,61,84,122,130],"electromyogram":[37],"recordings":[38],"coupled":[39],"with":[40,98,161],"vivo":[42],"microdialysis":[43],"investigate":[45],"effects":[47],"an":[49],"A(2A)R":[50,171],"agonist,":[51],"CGS21680,":[52],"on":[53,56],"release":[58,87,94,116,133,152,183],"histamine":[60,86,93,115,151],"GABA":[62,132,182],"brain.":[65],"In":[66,110],"freely":[67],"moving":[68],"rats,":[69,112],"CGS21680":[70,113],"applied":[71],"subarachnoid":[74],"space":[75],"underlying":[76],"rostral":[78],"basal":[79],"forebrain":[80],"significantly":[81],"promoted":[82],"inhibited":[85,114],"frontal":[90,120,144],"cortex.":[91,145],"was":[95,153],"negatively":[96],"correlated":[97],"amount":[100],"non-rapid":[102],"eye":[103],"movement":[104],"(r":[106],"=":[107],"-":[108],"0.652).":[109],"urethane-anesthetized":[111],"both":[118],"cortex":[121],"medial":[123],"pre-optic":[124],"area":[125],"dose-dependent":[128],"manner,":[129],"increased":[131],"specifically":[134],"histaminergic":[137,178],"tuberomammillary":[138,159,186],"nucleus":[139,160],"but":[140],"not":[141],"Moreover,":[146],"CGS21680-induced":[148],"inhibition":[149],"antagonized":[154],"by":[155,175],"perfusion":[156],"GABA(A)":[163],"antagonist,":[164],"picrotoxin.":[165],"These":[166],"results":[167],"suggest":[168],"that":[169],"agonist":[172],"induced":[173],"inhibiting":[176],"system":[179],"through":[180],"increasing":[181],"nucleus.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}