{"id":"https://openalex.org/W1552490490","doi":"https://doi.org/10.4049/jimmunol.112.6.2260","title":"The Role of the Classical and Alternate Complement Pathways in Host Defenses Against Cryptococcus Neoformans Infection","display_name":"The Role of the Classical and Alternate Complement Pathways in Host Defenses Against Cryptococcus Neoformans Infection","publication_year":1974,"publication_date":"1974-06-01","ids":{"openalex":"https://openalex.org/W1552490490","doi":"https://doi.org/10.4049/jimmunol.112.6.2260","mag":"1552490490","pmid":"https://pubmed.ncbi.nlm.nih.gov/4596700"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.112.6.2260","doi":"https://doi.org/10.4049/jimmunol.112.6.2260","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.112.6.2260","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108502875","display_name":"Richard D. Diamond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D Diamond","raw_affiliation_strings":["Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001311504","display_name":"Joseph E. May","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E May","raw_affiliation_strings":["Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael A Kane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Kane","raw_affiliation_strings":["Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104101411","display_name":"Michael M. Frank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M Frank","raw_affiliation_strings":["Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075884909","display_name":"John E. Bennett","orcid":"https://orcid.org/0009-0008-1257-098X","observed_orcids":["https://orcid.org/0009-0008-1257-098X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E Bennett","raw_affiliation_strings":["Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.7419,"has_fulltext":false,"cited_by_count":177,"citation_normalized_percentile":{"value":0.88975694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"112","issue":"6","first_page":"2260","last_page":"2270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.25270000100135803,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryptococcus-neoformans","display_name":"Cryptococcus neoformans","score":0.9639999866485596},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.7200000286102295},{"id":"https://openalex.org/keywords/classical-complement-pathway","display_name":"classical complement pathway","score":0.9869999885559082},{"id":"https://openalex.org/keywords/alternative-complement-pathway","display_name":"alternative complement pathway","score":0.9309999942779541},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/opsonization","display_name":"opsonization","score":0.9520000219345093},{"id":"https://openalex.org/keywords/properdin","display_name":"properdin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/c2-deficiency","display_name":"C2 deficiency","score":0.5249999761581421},{"id":"https://openalex.org/keywords/c4-deficiency","display_name":"C4 deficiency","score":0.996999979019165},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cryptococcal-meningitis","display_name":"cryptococcal meningitis","score":0.6740000247955322},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.5809999704360962},{"id":"https://openalex.org/keywords/cobra-venom-factor","display_name":"cobra venom factor","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2777893358","wikidata":"https://www.wikidata.org/wiki/Q131924","display_name":"Cryptococcus neoformans","level":2,"score":0.902658998966217},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.8143201470375061},{"id":"https://openalex.org/C189446657","wikidata":"https://www.wikidata.org/wiki/Q4736500","display_name":"Alternative complement pathway","level":4,"score":0.7238147854804993},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.6618494391441345},{"id":"https://openalex.org/C171279029","wikidata":"https://www.wikidata.org/wiki/Q5128320","display_name":"Classical complement pathway","level":4,"score":0.6004601716995239},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5812764167785645},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.567118763923645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5539412498474121},{"id":"https://openalex.org/C2779413141","wikidata":"https://www.wikidata.org/wiki/Q1470140","display_name":"Cryptococcosis","level":2,"score":0.5487273335456848},{"id":"https://openalex.org/C175773311","wikidata":"https://www.wikidata.org/wiki/Q5156412","display_name":"Complement receptor","level":4,"score":0.48781493306159973},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.4704650342464447},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3867560029029846},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000908","descriptor_name":"Antibodies, Fungal","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000946","descriptor_name":"Antigens, Fungal","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002473","descriptor_name":"Cell Wall","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003453","descriptor_name":"Cryptococcosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003454","descriptor_name":"Cryptococcus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003455","descriptor_name":"Cryptococcus neoformans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.112.6.2260","doi":"https://doi.org/10.4049/jimmunol.112.6.2260","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.112.6.2260","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:4596700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4596700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1971715231","https://openalex.org/W2139309597","https://openalex.org/W2419190643","https://openalex.org/W7095731557","https://openalex.org/W2399369252","https://openalex.org/W2153309282","https://openalex.org/W7100047743","https://openalex.org/W1773077102","https://openalex.org/W1976914087","https://openalex.org/W2129047172"],"abstract_inverted_index":{"Abstract":[0],"The":[1,74,164,246,285],"relationship":[2],"between":[3],"complement":[4,37,66,107,136,155,170,206,287,363],"and":[5,50,64,105,184,196],"the":[6,58,61,69,119,178,189,202,213,267,282,296,312,325,337,367,373],"heat":[7,313],"labile":[8,314],"factors":[9],"known":[10],"to":[11,33,95,118,126,241,254,257,265,273,280,290,294],"be":[12,255,291],"necessary":[13],"for":[14,144,150,160,173,304],"phagocytosis":[15,70,174],"of":[16,35,57,60,71,76,97,169,182,198,201,205,212,231,244,248,259,275,308,311,329,336,369,376,400,410],"Cryptococcus":[17],"neoformans":[18,26],"by":[19,129,177,207,223],"human":[20,48,232],"leukocytes":[21],"has":[22],"been":[23],"examined.":[24],"C.":[25],"or":[27,113,310,361],"purified":[28,111],"cryptococcal":[29,380],"polysaccharide":[30],"consumed":[31],"36.2":[32],"76.3%":[34],"late":[36,167,203],"components":[38,156,168,204],"(C3-9)":[39],"in":[40,68,86,100,216,300,321,340,389],"guinea":[41,52],"pig":[42,53],"serum.":[43],"Phagocytic":[44],"studies":[45,218],"with":[46,88,102,134,186,236,379,403,414],"C2-deficient":[47],"serum":[49,54,199,342,412],"C4-deficient":[51],"permitted":[55],"evaluation":[56],"roles":[59],"classical":[62,104,154,286,338],"(C142)":[63],"alternate":[65,90,106,283,297],"pathways":[67,108,137],"these":[72,217,393],"organisms.":[73],"number":[75],"cryptococci":[77,237,370,386],"ingested":[78],"per":[79],"neutrophil":[80],"(phagocytic":[81],"index)":[82],"at":[83,194,234],"30":[84],"min":[85],"sera":[87,101,133,146,214,233,391],"only":[89],"pathway":[91,269,288,339],"function":[92,335],"was":[93,115,175,252,263,278,302,318,364,383],"40":[94],"60%":[96],"that":[98,166,180],"found":[99,384],"both":[103,135],"intact.":[109],"When":[110],"C2":[112],"C4":[114],"added":[116],"back":[117],"corresponding":[120,131],"deficient":[121,145,320],"sera,":[122],"phagocytic":[123,142,148,162,239],"indices":[124,143,149,240],"increased":[125],"ranges":[127],"obtained":[128,371],"using":[130],"normal":[132,151,341],"active.":[138],"By":[139],"2":[140],"hr,":[141],"equaled":[147],"sera.":[152],"Early":[153],"were":[157,171],"therefore":[158],"required":[159,172,264,279],"optimum":[161],"kinetics.":[163,333],"fact":[165,179],"established":[176],"chelation":[181],"Ca++":[183],"Mg++":[185],"EDTA":[187],"inhibited":[188],"reaction,":[190],"as":[191,270,272],"did":[192,343,352],"heating":[193],"56\u00b0C":[195],"use":[197],"depleted":[200,307],"cobra":[208],"venom":[209],"factor.":[210],"None":[211],"used":[215],"had":[219],"detectable":[220,365],"anti-cryptococcal":[221],"antibody":[222,227,261],"an":[224],"indirect":[225],"fluorescent":[226,357],"technique,":[228],"but":[229,382],"absorption":[230,251],"0\u00b0C":[235],"lowered":[238],"about":[242],"10%":[243],"normal.":[245],"loss":[247,258,274],"activity":[249,409],"after":[250,387],"demonstrated":[253],"due":[256],"specific":[260],"which":[262,277,299],"activate":[266,281,295],"C142":[268],"well":[271],"properdin":[276,309,315,330],"pathway.":[284],"appeared":[289],"functioning":[292],"primarily":[293],"pathway,":[298],"turn":[301],"responsible":[303],"opsonization.":[305,347],"Serum":[306],"factor":[316],"B":[317],"markedly":[319],"opsonic":[322,408],"activity.":[323],"In":[324],"former":[326],"case":[327],"addition":[328],"restored":[331],"optimal":[332],"Thus,":[334],"not":[344,353],"adequately":[345],"mediate":[346],"Unlike":[348],"serum,":[349],"spinal":[350,374],"fluid":[351,375,397],"opsonize":[354],"cryptococci.":[355,415],"With":[356],"anti-human":[358],"\u03b21C,":[359],"little":[360],"no":[362],"on":[366,385],"surface":[368],"from":[372,392,398],"four":[377],"patients":[378,402],"meningitis,":[381],"incubation":[388],"fresh":[390,411],"patients.":[394],"However,":[395],"cerebrospinal":[396],"two":[399],"three":[401],"active":[404],"disease":[405],"could":[406],"restore":[407],"absorbed":[413]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":11},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}