{"id":"https://openalex.org/W15522975","doi":null,"title":"Stress Compromises HSV-1-Specific Immunity in Latently Infected Sensory Ganglia","display_name":"Stress Compromises HSV-1-Specific Immunity in Latently Infected Sensory Ganglia","publication_year":2007,"publication_date":"2007-12-07","ids":{"openalex":"https://openalex.org/W15522975","mag":"15522975"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:10155","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/10155/1/FreemanML_ETD2007.pdf","pdf_url":"https://d-scholarship.pitt.edu/10155/1/FreemanML_ETD2007.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023290996","display_name":"Michael L. Freeman","orcid":"https://orcid.org/0000-0002-7690-5258","observed_orcids":["https://orcid.org/0000-0002-7690-5258"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael L. Freeman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7690-5258","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5023290996"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00198462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.878000020980835},{"id":"https://openalex.org/keywords/hsv-1-latency","display_name":"HSV-1 latency","score":0.7889999747276306},{"id":"https://openalex.org/keywords/hsv-1-reactivation","display_name":"HSV-1 reactivation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/restraint-stress","display_name":"restraint stress","score":0.6840000152587891},{"id":"https://openalex.org/keywords/psychological-stress","display_name":"psychological stress","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9559999704360962},{"id":"https://openalex.org/keywords/trigeminal-ganglion","display_name":"trigeminal ganglion","score":0.9380000233650208},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7440000176429749},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8679999709129333},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lytic-granules","display_name":"lytic granules","score":0.8159999847412109},{"id":"https://openalex.org/keywords/ocular-herpes","display_name":"ocular herpes","score":0.5920000076293945},{"id":"https://openalex.org/keywords/stress-induced-immunosuppression","display_name":"stress-induced immunosuppression","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6287124156951904},{"id":"https://openalex.org/C2778852064","wikidata":"https://www.wikidata.org/wiki/Q4115619","display_name":"Virus latency","level":4,"score":0.6264176964759827},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5394649505615234},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5011711120605469},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.4963288903236389},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.49545013904571533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4946386516094208},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4831254184246063},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46118810772895813},{"id":"https://openalex.org/C2910737674","wikidata":"https://www.wikidata.org/wiki/Q4115619","display_name":"Latent Virus","level":3,"score":0.43006622791290283},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3573033809661865},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32964247465133667},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2714819312095642},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22905611991882324},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.18863525986671448},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07378515601158142}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:10155","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/10155/1/FreemanML_ETD2007.pdf","pdf_url":"https://d-scholarship.pitt.edu/10155/1/FreemanML_ETD2007.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:15522975","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/10155/1/FreemanML_ETD2007.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":280,"referenced_works":["https://openalex.org/W25281948","https://openalex.org/W79466244","https://openalex.org/W177581242","https://openalex.org/W341404584","https://openalex.org/W1268383650","https://openalex.org/W1451617137","https://openalex.org/W1487003048","https://openalex.org/W1489480103","https://openalex.org/W1491399868","https://openalex.org/W1493822493","https://openalex.org/W1497721018","https://openalex.org/W1509514214","https://openalex.org/W1512676188","https://openalex.org/W1517021800","https://openalex.org/W1517571699","https://openalex.org/W1521035635","https://openalex.org/W1522207028","https://openalex.org/W1522773084","https://openalex.org/W1534409678","https://openalex.org/W1543912722","https://openalex.org/W1553620572","https://openalex.org/W1562077797","https://openalex.org/W1572273862","https://openalex.org/W1572668245","https://openalex.org/W1589473146","https://openalex.org/W1601504908","https://openalex.org/W1605178114","https://openalex.org/W1606562486","https://openalex.org/W1608778557","https://openalex.org/W1654634869","https://openalex.org/W1680291521","https://openalex.org/W1743570032","https://openalex.org/W1749209363","https://openalex.org/W1749619545","https://openalex.org/W1806240087","https://openalex.org/W1809128178","https://openalex.org/W1850750660","https://openalex.org/W1880142700","https://openalex.org/W1884861492","https://openalex.org/W1887459435","https://openalex.org/W1894132278","https://openalex.org/W1898710667","https://openalex.org/W1903481747","https://openalex.org/W1916719437","https://openalex.org/W1934070818","https://openalex.org/W1942310387","https://openalex.org/W1948304169","https://openalex.org/W1957140132","https://openalex.org/W1963167619","https://openalex.org/W1963816826","https://openalex.org/W1963871085","https://openalex.org/W1964670668","https://openalex.org/W1964790952","https://openalex.org/W1965710385","https://openalex.org/W1967684158","https://openalex.org/W1968643495","https://openalex.org/W1969211009","https://openalex.org/W1970092944","https://openalex.org/W1971902136","https://openalex.org/W1972880429","https://openalex.org/W1973682675","https://openalex.org/W1974842026","https://openalex.org/W1974906492","https://openalex.org/W1975368664","https://openalex.org/W1976785514","https://openalex.org/W1978061926","https://openalex.org/W1978436252","https://openalex.org/W1981482118","https://openalex.org/W1984915215","https://openalex.org/W1985294654","https://openalex.org/W1985629614","https://openalex.org/W1986868882","https://openalex.org/W1990196659","https://openalex.org/W1993983321","https://openalex.org/W1994340919","https://openalex.org/W1997624180","https://openalex.org/W1999216264","https://openalex.org/W1999332832","https://openalex.org/W2000466396","https://openalex.org/W2000614107","https://openalex.org/W2001894281","https://openalex.org/W2001911522","https://openalex.org/W2003717645","https://openalex.org/W2006985918","https://openalex.org/W2007696393","https://openalex.org/W2008366157","https://openalex.org/W2008667095","https://openalex.org/W2008877590","https://openalex.org/W2013040918","https://openalex.org/W2014161666","https://openalex.org/W2015837052","https://openalex.org/W2015902645","https://openalex.org/W2017415762","https://openalex.org/W2017669223","https://openalex.org/W2019083648","https://openalex.org/W2019102370","https://openalex.org/W2021461394","https://openalex.org/W2021941814","https://openalex.org/W2021989975","https://openalex.org/W2022069273","https://openalex.org/W2023038954","https://openalex.org/W2023170691","https://openalex.org/W2024207873","https://openalex.org/W2024438032","https://openalex.org/W2025409639","https://openalex.org/W2025465431","https://openalex.org/W2025715125","https://openalex.org/W2028376975","https://openalex.org/W2028993725","https://openalex.org/W2029128444","https://openalex.org/W2029410238","https://openalex.org/W2030512306","https://openalex.org/W2031906032","https://openalex.org/W2032025841","https://openalex.org/W2035852466","https://openalex.org/W2037328479","https://openalex.org/W2040623051","https://openalex.org/W2041218370","https://openalex.org/W2041695797","https://openalex.org/W2045011000","https://openalex.org/W2045681339","https://openalex.org/W2047102094","https://openalex.org/W2048576898","https://openalex.org/W2049671131","https://openalex.org/W2049805022","https://openalex.org/W2050196866","https://openalex.org/W2050227969","https://openalex.org/W2052925176","https://openalex.org/W2053776694","https://openalex.org/W2056503140","https://openalex.org/W2056799177","https://openalex.org/W2056998169","https://openalex.org/W2057440281","https://openalex.org/W2060281448","https://openalex.org/W2060530677","https://openalex.org/W2060828809","https://openalex.org/W2062520454","https://openalex.org/W2063429059","https://openalex.org/W2064305818","https://openalex.org/W2066278365","https://openalex.org/W2067225977","https://openalex.org/W2067946746","https://openalex.org/W2070552972","https://openalex.org/W2070570719","https://openalex.org/W2075052419","https://openalex.org/W2075343821","https://openalex.org/W2076534074","https://openalex.org/W2078532650","https://openalex.org/W2078580976","https://openalex.org/W2079946290","https://openalex.org/W2080454806","https://openalex.org/W2081097093","https://openalex.org/W2081504114","https://openalex.org/W2082596446","https://openalex.org/W2082755088","https://openalex.org/W2083778040","https://openalex.org/W2083873191","https://openalex.org/W2085005209","https://openalex.org/W2087422295","https://openalex.org/W2089827317","https://openalex.org/W2089974834","https://openalex.org/W2090578286","https://openalex.org/W2093877605","https://openalex.org/W2094383761","https://openalex.org/W2094628847","https://openalex.org/W2095172849","https://openalex.org/W2097483036","https://openalex.org/W2097486042","https://openalex.org/W2097855813","https://openalex.org/W2097989138","https://openalex.org/W2100767745","https://openalex.org/W2100838905","https://openalex.org/W2101274121","https://openalex.org/W2102264469","https://openalex.org/W2102342549","https://openalex.org/W2102950218","https://openalex.org/W2103263714","https://openalex.org/W2103856154","https://openalex.org/W2105382508","https://openalex.org/W2105895969","https://openalex.org/W2107295413","https://openalex.org/W2107761373","https://openalex.org/W2108726445","https://openalex.org/W2110459643","https://openalex.org/W2112244651","https://openalex.org/W2112265428","https://openalex.org/W2112506009","https://openalex.org/W2112522175","https://openalex.org/W2113148417","https://openalex.org/W2113180936","https://openalex.org/W2114263643","https://openalex.org/W2115772994","https://openalex.org/W2117030721","https://openalex.org/W2117771108","https://openalex.org/W2118167284","https://openalex.org/W2118526748","https://openalex.org/W2119080021","https://openalex.org/W2119319172","https://openalex.org/W2119573232","https://openalex.org/W2119936827","https://openalex.org/W2120042716","https://openalex.org/W2120811539","https://openalex.org/W2120816050","https://openalex.org/W2122140614","https://openalex.org/W2122280181","https://openalex.org/W2129322105","https://openalex.org/W2130098661","https://openalex.org/W2130835671","https://openalex.org/W2130901500","https://openalex.org/W2131585285","https://openalex.org/W2131625721","https://openalex.org/W2131746203","https://openalex.org/W2132211535","https://openalex.org/W2132232951","https://openalex.org/W2132544581","https://openalex.org/W2132668257","https://openalex.org/W2133241248","https://openalex.org/W2133865307","https://openalex.org/W2134783918","https://openalex.org/W2135372888","https://openalex.org/W2135412522","https://openalex.org/W2135514207","https://openalex.org/W2137739271","https://openalex.org/W2138992714","https://openalex.org/W2139103918","https://openalex.org/W2139461240","https://openalex.org/W2139886251","https://openalex.org/W2140066663","https://openalex.org/W2140178603","https://openalex.org/W2140289154","https://openalex.org/W2141205048","https://openalex.org/W2141862597","https://openalex.org/W2141955811","https://openalex.org/W2142536229","https://openalex.org/W2142756909","https://openalex.org/W2143389857","https://openalex.org/W2146603844","https://openalex.org/W2147389449","https://openalex.org/W2148241125","https://openalex.org/W2148817537","https://openalex.org/W2149736250","https://openalex.org/W2149748445","https://openalex.org/W2150098469","https://openalex.org/W2151608013","https://openalex.org/W2153790089","https://openalex.org/W2153802235","https://openalex.org/W2154073366","https://openalex.org/W2154381591","https://openalex.org/W2154947167","https://openalex.org/W2155661903","https://openalex.org/W2156449737","https://openalex.org/W2156820097","https://openalex.org/W2156964094","https://openalex.org/W2157199182","https://openalex.org/W2160419609","https://openalex.org/W2160726743","https://openalex.org/W2161373442","https://openalex.org/W2161737006","https://openalex.org/W2163001100","https://openalex.org/W2163186208","https://openalex.org/W2164897233","https://openalex.org/W2165436746","https://openalex.org/W2165645574","https://openalex.org/W2165684303","https://openalex.org/W2165756490","https://openalex.org/W2167283993","https://openalex.org/W2168749590","https://openalex.org/W2168899864","https://openalex.org/W2169344740","https://openalex.org/W2169753137","https://openalex.org/W2170819606","https://openalex.org/W2171315725","https://openalex.org/W2222659350","https://openalex.org/W2316285546","https://openalex.org/W2405415780","https://openalex.org/W2416315077","https://openalex.org/W2434807312","https://openalex.org/W3135537746","https://openalex.org/W4303116013","https://openalex.org/W4313333711"],"related_works":["https://openalex.org/W2112265428","https://openalex.org/W954249720","https://openalex.org/W1963816826","https://openalex.org/W1965710385","https://openalex.org/W57966686","https://openalex.org/W1979126484","https://openalex.org/W2474104144","https://openalex.org/W1973682675","https://openalex.org/W1969211009","https://openalex.org/W2140756031"],"abstract_inverted_index":{"Recurrent":[0],"HSV-1":[1,33,63,187,200],"ocular":[2],"disease":[3],"results":[4,142],"from":[5,35,67,202],"reactivation":[6,34,201],"of":[7,22,46,77,87,101,109,112,120,147,159,185,214],"latent":[8,186],"virus":[9],"in":[10,37,42,69,104,117,127,143,153,182,206],"trigeminal":[11],"ganglia":[12],"(TG),":[13],"often":[14],"following":[15],"immunosuppression":[16],"or":[17,24,57],"exposure":[18,58],"to":[19,59,64,123,129],"a":[20,74,84,144],"variety":[21],"psychological":[23],"physical":[25],"stressors.":[26],"HSV-specific":[27,79],"CD8+":[28,53,80,189,210],"T":[29,54,81,171,190,211],"cells":[30,89,110,122,152],"can":[31],"block":[32],"latency":[36,68,203],"ex":[38],"vivo":[39,183],"TG":[40,155],"cultures":[41],"part":[43,207],"through":[44],"production":[45],"IFN-\u03b3.":[47],"Here":[48],"we":[49],"establish":[50,134],"that":[51,90,135,197],"either":[52],"cell":[55,172,212],"depletion":[56],"restraint":[60,136],"stress":[61,72,102,137,198],"permits":[62],"transiently":[65],"escape":[66],"vivo.":[70],"Restraint":[71],"caused":[73],"glucocorticoid-associated":[75],"reduction":[76,108,146],"TG-resident":[78],"cells,":[82,191],"and":[83,115,192],"functional":[85],"compromise":[86],"those":[88,121],"survive,":[91],"at":[92,156,204],"least":[93,205],"partly":[94],"mediated":[95],"by":[96,188,208],"catecholamines.":[97],"Together,":[98],"these":[99],"effects":[100],"resulted":[103],"an":[105],"approximate":[106],"65%":[107],"capable":[111],"producing":[113],"IFN-\u03b3,":[114],"impairment":[116],"the":[118,139,154,157,195],"ability":[119],"release":[124],"lytic":[125],"granules,":[126],"response":[128,173],"reactivating":[130],"virus.":[131],"We":[132],"also":[133],"during":[138,168],"primary":[140],"infection":[141],"54%":[145],"virus-specific":[148],"IL-7R\u03b1+":[149],"memory":[150],"precursor":[151],"peak":[158],"expansion.":[160],"When":[161],"mice":[162],"stressed":[163,166],"early":[164],"were":[165],"again":[167],"latency,":[169],"their":[170],"may":[174],"be":[175],"further":[176],"compromised.":[177],"Our":[178],"findings":[179],"demonstrate":[180],"persistent":[181],"regulation":[184],"strongly":[193],"support":[194],"concept":[196],"induces":[199],"compromising":[209],"surveillance":[213],"latently":[215],"infected":[216],"neurons.":[217]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}