{"id":"https://openalex.org/W1552290465","doi":null,"title":"Changing incidence of hepatocellular carcinoma in Japan.","display_name":"Changing incidence of hepatocellular carcinoma in Japan.","publication_year":1987,"publication_date":"1987-09-15","ids":{"openalex":"https://openalex.org/W1552290465","mag":"1552290465","pmid":"https://pubmed.ncbi.nlm.nih.gov/3040235"},"language":"en","primary_location":{"id":"pmid:3040235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3040235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111651903","display_name":"Kunio Okuda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Okuda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070579475","display_name":"Isaburo Fujimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Fujimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060813020","display_name":"Aya Hanai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Hanai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110164098","display_name":"Yoshinori Urano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Urano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.1081,"has_fulltext":false,"cited_by_count":326,"citation_normalized_percentile":{"value":0.98766447,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"18","first_page":"4967","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/incidence-trends","display_name":"incidence trends","score":0.9589999914169312},{"id":"https://openalex.org/keywords/japan","display_name":"Japan","score":0.7730000019073486},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/chronic-non-a-non-b-hepatitis","display_name":"chronic non-A non-B hepatitis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/sex-differences-in-cancer-incidence","display_name":"sex differences in cancer incidence","score":0.7720000147819519},{"id":"https://openalex.org/keywords/autopsy-findings","display_name":"autopsy findings","score":0.6050000190734863},{"id":"https://openalex.org/keywords/cancer-registry-data","display_name":"cancer registry data","score":0.7559999823570251},{"id":"https://openalex.org/keywords/vital-statistics","display_name":"vital statistics","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2778527826","wikidata":"https://www.wikidata.org/wiki/Q1787017","display_name":"Cancer registry","level":3,"score":0.8203005790710449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8004537224769592},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7550287842750549},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.7411115765571594},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.7084917426109314},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.6986726522445679},{"id":"https://openalex.org/C521751864","wikidata":"https://www.wikidata.org/wiki/Q1729207","display_name":"Christian ministry","level":2,"score":0.6553215980529785},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.5910378694534302},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5140029788017273},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4965234398841858},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.4206644296646118},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39804214239120483},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3873487710952759},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.1461867392063141},{"id":"https://openalex.org/C27206212","wikidata":"https://www.wikidata.org/wiki/Q34178","display_name":"Theology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001344","descriptor_name":"Autopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3040235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3040235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1552290465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3040235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W134995697","https://openalex.org/W314782195","https://openalex.org/W1492157159","https://openalex.org/W1494699412","https://openalex.org/W1527781018","https://openalex.org/W1549983642","https://openalex.org/W1676199213","https://openalex.org/W1964829819","https://openalex.org/W1993126248","https://openalex.org/W2002601143","https://openalex.org/W2060421500","https://openalex.org/W2062843165","https://openalex.org/W2080485848","https://openalex.org/W2096808350","https://openalex.org/W2128526893","https://openalex.org/W2300362692","https://openalex.org/W2395795055","https://openalex.org/W2406523402","https://openalex.org/W2423492680","https://openalex.org/W2913280072","https://openalex.org/W3114918841"],"related_works":["https://openalex.org/W1987569797","https://openalex.org/W2152235647","https://openalex.org/W2007757676","https://openalex.org/W3201478026","https://openalex.org/W2062077306","https://openalex.org/W2164194466","https://openalex.org/W2144445581","https://openalex.org/W2122842590","https://openalex.org/W2462313106","https://openalex.org/W2056922235"],"abstract_inverted_index":{"A":[0],"trend":[1,94],"in":[2,9,23,51,72,76,90,142,164],"the":[3,14,17,26,30,41,52,77,99,109,115,122,140,148,154,159],"incidence":[4,166],"of":[5,16,28,33,36,102,124,158,162,171],"hepatocellular":[6],"carcinoma":[7],"(HCC)":[8],"Japan":[10,42],"was":[11,95,119],"studied":[12,113],"from":[13,55],"data":[15,62],"Osaka":[18],"Cancer":[19],"Registry":[20,44],"(population,":[21],"8,512,351":[22],"1981)":[24],"for":[25,126,132],"period":[27,54],"1963-1983,":[29],"Vital":[31,110],"Statistics":[32],"Japan,":[34],"Ministry":[35],"Health":[37],"and":[38,40,63,85,105,108,130,135,144],"Welfare,":[39],"Autopsy":[43],"which":[45],"contained":[46],"594,132":[47],"individually":[48],"filed":[49],"cases":[50],"26-year":[53],"1958":[56],"to":[57],"1983.":[58],"Both":[59],"cancer":[60,100],"registry":[61],"autopsy":[64,116],"records":[65],"showed":[66],"a":[67,86],"more":[68],"than":[69,168],"2-fold":[70],"increase":[71,89,163],"HCC":[73,129,133,165],"incidence,":[74],"particularly":[75],"last":[78],"10":[79],"years":[80],"or":[81],"so,":[82],"among":[83],"males":[84],"less":[87],"pronounced":[88],"females.":[91],"The":[92],"same":[93,141],"borne":[96],"out":[97],"by":[98],"registries":[101],"Nagasaki":[103],"City":[104],"Miyagi":[106],"Prefecture":[107],"Statistics.":[111],"When":[112],"with":[114,173],"data,":[117],"it":[118],"found":[120],"that":[121,145],"numbers":[123],"autopsies":[125,131],"cirrhosis":[127],"without":[128,136],"(with":[134],"cirrhosis)":[137],"were":[138],"about":[139,151],"1958-1961":[143],"currently":[146],"(1980-1983)":[147],"latter":[149],"is":[150,179],"2":[152],"times":[153],"former.":[155],"As":[156],"one":[157],"possible":[160],"causes":[161],"other":[167],"prolonged":[169],"survival":[170],"patients":[172],"cirrhosis,":[174],"chronic":[175],"non-A,":[176],"non-B":[177],"hepatitis":[178],"discussed.":[180]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}