{"id":"https://openalex.org/W155225739","doi":null,"title":"Induction of apoptosis by sulforaphane and curcumin and expression profile of jmjd3, a key histone demethylase in breast cancer cell line MDA-MB-231","display_name":"Induction of apoptosis by sulforaphane and curcumin and expression profile of jmjd3, a key histone demethylase in breast cancer cell line MDA-MB-231","publication_year":2014,"publication_date":"2014-05-10","ids":{"openalex":"https://openalex.org/W155225739","mag":"155225739"},"language":"en","primary_location":{"id":"mag:155225739","doi":null,"is_oa":false,"landing_page_url":"http://ethesis.nitrkl.ac.in/6419/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008128082","display_name":"Rutusmita Mishra","orcid":"https://orcid.org/0000-0002-2851-7963","observed_orcids":["https://orcid.org/0000-0002-2851-7963"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rutusmita Mishra","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2851-7963","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008128082"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.4323999881744385,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.4323999881744385,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.25220000743865967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.08219999819993973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulforaphane","display_name":"sulforaphane","score":0.9660000205039978},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/jmjd3","display_name":"JMJD3","score":0.8920000195503235},{"id":"https://openalex.org/keywords/histone-demethylase","display_name":"histone demethylase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.984000027179718},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.921999990940094},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":1.0},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.843999981880188},{"id":"https://openalex.org/keywords/natural-polyphenols","display_name":"natural polyphenols","score":0.8040000200271606},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.6389999985694885},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.7752377986907959},{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.7561079263687134},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.66326904296875},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6093428134918213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5808601379394531},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5755423307418823},{"id":"https://openalex.org/C2780841255","wikidata":"https://www.wikidata.org/wiki/Q424489","display_name":"Sulforaphane","level":2,"score":0.49534979462623596},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4898962378501892},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.48717185854911804},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4662927985191345},{"id":"https://openalex.org/C114691636","wikidata":"https://www.wikidata.org/wiki/Q5031434","display_name":"Cancer epigenetics","level":5,"score":0.4622468948364258},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.458721399307251},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3068113327026367},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.22682660818099976},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.15496879816055298},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1453016698360443},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1264762282371521}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:155225739","doi":null,"is_oa":false,"landing_page_url":"http://ethesis.nitrkl.ac.in/6419/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W140098831","https://openalex.org/W1745634660","https://openalex.org/W1970592702","https://openalex.org/W1975618936","https://openalex.org/W1981452104","https://openalex.org/W1990802782","https://openalex.org/W1997889012","https://openalex.org/W2001761736","https://openalex.org/W2008757142","https://openalex.org/W2014203415","https://openalex.org/W2025126379","https://openalex.org/W2028907915","https://openalex.org/W2030735294","https://openalex.org/W2033629987","https://openalex.org/W2034269086","https://openalex.org/W2039986962","https://openalex.org/W2043206390","https://openalex.org/W2054020882","https://openalex.org/W2059176821","https://openalex.org/W2063637433","https://openalex.org/W2074496710","https://openalex.org/W2082467262","https://openalex.org/W2086675645","https://openalex.org/W2095111363","https://openalex.org/W2096083625","https://openalex.org/W2097445405","https://openalex.org/W2101406811","https://openalex.org/W2125792588","https://openalex.org/W2127621044","https://openalex.org/W2128399547","https://openalex.org/W2135619346","https://openalex.org/W2137631271","https://openalex.org/W2138498649","https://openalex.org/W2141992776","https://openalex.org/W2145955453","https://openalex.org/W2149433716","https://openalex.org/W2155990718","https://openalex.org/W2157607726","https://openalex.org/W2166847930","https://openalex.org/W2169702314"],"related_works":["https://openalex.org/W3173600049","https://openalex.org/W2141992776","https://openalex.org/W3173449662","https://openalex.org/W2888148541","https://openalex.org/W1999528345","https://openalex.org/W1990928300","https://openalex.org/W49729980","https://openalex.org/W2620126727","https://openalex.org/W2033629987","https://openalex.org/W2072902657"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,10,27,49,63,102,149,222,262,282,293],"is":[2,184],"one":[3],"of":[4,9,19,42,56,62,74,81,113,125,145,157,165,173,186,236,241,245,273,278],"the":[5,39,72,79,110,191,233,276],"most":[6,97],"common":[7],"forms":[8],"occurring":[11],"in":[12,15,38,66,78,83,147,188,260,275,280,295],"females":[13],"resulting":[14],"to":[16,26,32,108,190,252],"high":[17],"rate":[18],"mortality":[20],"worldwide.":[21],"Uncontrolled":[22,51],"cell":[23,52,150],"proliferation":[24,53],"leads":[25],"which":[28,284],"may":[29,212,249,269,285],"be":[30,213,250],"attributed":[31],"genetic":[33],"mutations":[34],"or":[35],"epigenetic":[36,43],"alterations":[37],"genome.":[40],"Deregulations":[41],"mechanisms":[44],"are":[45,58,96,217],"highly":[46],"associated":[47,99],"with":[48,100,124,171,243],"progression.":[50,64],"and":[54,76,93,127,143,162,178,193,238,247],"evasion":[55],"apoptosis":[57,82,146,187,229,258,279],"important":[59],"hall":[60],"marks":[61],"Hence":[65],"this":[67,206],"study":[68],"we":[69,104,208],"have":[70,105,253],"investigated":[71],"role":[73],"sulforaphane":[75,126],"curcumin":[77,128,194,248],"induction":[80,144,185,259,277],"metastatic":[84],"adenocarcinoma":[85],"MDA":[86,152],"MB-231":[87],"cells.":[88,263],"As":[89],"aberrant":[90],"Histone":[91],"methylation":[92],"demethylation":[94],"pathways":[95],"commonly":[98],"breast":[101,148,261,281],"progression":[103],"also":[106,134],"tried":[107],"investigate":[109],"expression":[111,142],"profile":[112],"jmjd3,":[114],"a":[115,138,254,287],"key":[116],"histone":[117],"demethylase,":[118],"at":[119,136,199,224,266],"transcriptome":[120,225],"level":[121,226,268],"after":[122],"treatment":[123,195,244],"for":[129,196,291],"24":[130,197],"hours.":[131],"This":[132],"investigation":[133],"aimed":[135],"finding":[137],"correlation":[139],"between":[140],"jmjd3":[141,237,274],"line":[151],"MB-231.":[153],"The":[154],"down":[155,234,239],"regulation":[156,164,235,240],"anti":[158],"apoptotic":[159,167],"gene":[160,168],"Bcl-2":[161,242],"up":[163],"pro":[166],"Bax":[169],"along":[170],"formation":[172],"chromatin":[174],"condensation,":[175],"DNA":[176,179],"fragmentation":[177],"damage":[180],"suggests":[181],"that":[182,211],"there":[183],"response":[189],"sulphoraphane":[192,246],"hours":[198],"their":[200,219],"corresponding":[201],"IC50":[202],"values.":[203],"From":[204],"all":[205],"investigations":[207],"can":[209],"presume":[210],"these":[214],"natural":[215],"polyphenols":[216],"mediating":[218],"effect":[220,256],"on":[221,257],"cells":[223,283],"by":[227],"inducing":[228],"related":[230],"genes.":[231],"Moreover":[232],"correlated":[251],"conjoint":[255],"Further":[264],"studies":[265],"protein":[267],"unravel":[270],"hidden":[271],"dimensions":[272],"create":[286],"better":[288],"therapeutic":[289],"avenue":[290],"treating":[292],"patients":[294],"future.":[296]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}