{"id":"https://openalex.org/W1552176255","doi":null,"title":"Estimation of human corneal oxygen consumption by noninvasive measurement of tear oxygen tension while wearing hydrogel lenses.","display_name":"Estimation of human corneal oxygen consumption by noninvasive measurement of tear oxygen tension while wearing hydrogel lenses.","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W1552176255","mag":"1552176255","pmid":"https://pubmed.ncbi.nlm.nih.gov/11818379"},"language":"en","primary_location":{"id":"pmid:11818379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11818379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081947536","display_name":"Joseph A. Bonanno","orcid":"https://orcid.org/0000-0002-3842-7646","observed_orcids":["https://orcid.org/0000-0002-3842-7646"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A Bonanno","raw_affiliation_strings":["Borish Center for Ophthalmic Research, Indiana University, School of Optometry, Bloomington, Indiana 47405, USA. jbonanno@indiana.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Borish Center for Ophthalmic Research, Indiana University, School of Optometry, Bloomington, Indiana 47405, USA. jbonanno@indiana.edu","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045923196","display_name":"Thomas E. Stickel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Stickel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113795559","display_name":"Tracy T. Nguyen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tracy Nguyen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071093836","display_name":"Trina Biehl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Trina Biehl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078132472","display_name":"Donna K. Carter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donna Carter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081089981","display_name":"William J.\u201cJoe\u201d Benjamin","orcid":"https://orcid.org/0000-0003-4116-7408","observed_orcids":["https://orcid.org/0000-0003-4116-7408"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William J Benjamin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078799615","display_name":"P. SARITA SONI","orcid":"https://orcid.org/0009-0005-7245-5340","observed_orcids":["https://orcid.org/0009-0005-7245-5340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Sarita Soni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6841,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.88226664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"43","issue":"2","first_page":"371","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogel-contact-lenses","display_name":"hydrogel contact lenses","score":0.949999988079071},{"id":"https://openalex.org/keywords/oxygen-transmissibility","display_name":"oxygen transmissibility","score":0.8240000009536743},{"id":"https://openalex.org/keywords/bovine-serum-albumin","display_name":"bovine serum albumin","score":0.8069999814033508},{"id":"https://openalex.org/keywords/oxygen-diffusion-model","display_name":"oxygen diffusion model","score":0.6209999918937683},{"id":"https://openalex.org/keywords/eyelid-closure","display_name":"eyelid closure","score":0.5830000042915344},{"id":"https://openalex.org/keywords/lens-thickness","display_name":"lens thickness","score":0.3009999990463257}],"concepts":[{"id":"https://openalex.org/C3020124426","wikidata":"https://www.wikidata.org/wiki/Q6639706","display_name":"Silicone hydrogel","level":3,"score":0.7813905477523804},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.6993888020515442},{"id":"https://openalex.org/C2986805488","wikidata":"https://www.wikidata.org/wiki/Q23797","display_name":"Contact lens","level":2,"score":0.6245556473731995},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.5954066514968872},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.50693279504776},{"id":"https://openalex.org/C2993207723","wikidata":"https://www.wikidata.org/wiki/Q4927803","display_name":"Oxygen tension","level":3,"score":0.4399715065956116},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4013250470161438},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.399421751499176},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3590834140777588},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3264368772506714},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3211844563484192},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2537793517112732},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10840645432472229},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003263","descriptor_name":"Contact Lenses, Hydrophilic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003941","descriptor_name":"Diagnostic Techniques, Ophthalmological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008652","descriptor_name":"Mesoporphyrins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008665","descriptor_name":"Metalloporphyrins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020136","descriptor_name":"Hydrogel, Polyethylene Glycol Dimethacrylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11818379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11818379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:1552176255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11818379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8021487526","display_name":"CORNEAL METABOLIC ACTIVITY IN HUMANS","funder_award_id":"R01EY012934","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W99382888","https://openalex.org/W107635096","https://openalex.org/W195803149","https://openalex.org/W1499853276","https://openalex.org/W1575111368","https://openalex.org/W1580541669","https://openalex.org/W1901989792","https://openalex.org/W1966334009","https://openalex.org/W1970519606","https://openalex.org/W1981778027","https://openalex.org/W1988438893","https://openalex.org/W2008962443","https://openalex.org/W2032042054","https://openalex.org/W2043720487","https://openalex.org/W2066182283","https://openalex.org/W2066846068","https://openalex.org/W2077748360","https://openalex.org/W2089972246","https://openalex.org/W2091656924","https://openalex.org/W2094207817","https://openalex.org/W2096105943","https://openalex.org/W2097172537","https://openalex.org/W2132905138","https://openalex.org/W2415669017"],"related_works":["https://openalex.org/W2060061681","https://openalex.org/W1499853276","https://openalex.org/W190911190","https://openalex.org/W2048189989","https://openalex.org/W2102796663","https://openalex.org/W2082521649","https://openalex.org/W7128990359","https://openalex.org/W3212768951","https://openalex.org/W2155805655","https://openalex.org/W2413415399"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"devise":[2],"a":[3,115,217,229,302],"procedure":[4],"for":[5,158,187,200,251,286,311,316,410],"direct":[6,395],"estimation":[7],"of":[8,26,111,155,207,245,274,324,375,397,414],"corneal":[9,127,422],"oxygen":[10,17,39,129,142,317,423],"consumption":[11,130,424],"in":[12,103,132,168,221,354,357,369],"human":[13,370],"subjects.":[14],"METHODS:":[15],"Tear":[16,361],"tension":[18],"(PO2)":[19],"was":[20,79,101,166,212],"measured":[21,102,368],"at":[22,342],"the":[23,82,89,104,121,150,188,201,234,248,252,262,278,313,321,325,343,373,376,381,412,421],"posterior":[24,322],"surface":[25,152,323],"two":[27],"standard":[28],"hydrogel":[29,192,254,280,364],"contact":[30,402],"lenses":[31,83,171,365],"(38%":[32],"water,":[33],"0.2":[34],"and":[35,44,56,98,107,126,182,190,195,215,236,261,345,349,356,390,394],"0.06":[36],"mm":[37],"thick,":[38],"transmissibility":[40],"[Dk/t]":[41],"=":[42,64,178,240,256,266,295],"4.2":[43],"14":[45],"x":[46,49,52,54,66,135,332,336,340],"10(-9)":[47],"cm":[48],"mL":[50,133,338],"O2/mL":[51],"sec":[53],"torr)":[55,260],"one":[57],"newly":[58],"available":[59],"hydrogel-silicone":[60,202,263],"polymer":[61],"lens":[62,124,151,264,382,403],"(Dk/t":[63],"99":[65],"10(-9)).":[67],"The":[68,85,384],"oxygen-sensitive":[69],"dye,":[70],"Pd-meso-tetra":[71],"(4-carboxyphenyl)":[72],"porphine,":[73],"bound":[74,148,379],"to":[75,149,233,238,301,318,320,334,352,380,401],"bovine":[76],"serum":[77],"albumin,":[78],"incubated":[80],"with":[81,88,172,277],"overnight.":[84],"lenses,":[86,193],"coated":[87],"protein-dye":[90],"complex,":[91],"were":[92],"placed":[93],"on":[94,420],"four":[95],"subjects'":[96],"eyes,":[97],"tear":[99,122,156,164,210,282],"PO2":[100,157,165,177,211,246,283,294,362],"open":[105],"eye":[106,112,208,226,275,291],"after":[108,225,290],"5":[109,205,272],"minutes":[110,206,273],"closure,":[113,209],"using":[114,372],"time-domain":[116],"phosphorescence":[117,374],"measurement":[118],"system.":[119],"Given":[120],"PO2,":[123],"Dk/t,":[125],"thickness,":[128],"(Q(C),":[131],"O2/cm(3)":[134,339],"sec)":[136,341],"could":[137,308],"be":[138,309,367,408],"calculated":[139],"from":[140,330],"established":[141],"diffusion":[143],"models.":[144],"RESULTS:":[145],"Protein-dye":[146],"complex":[147,378],"enabled":[153],"reporting":[154],"long":[159],"periods.":[160],"As":[161],"expected,":[162],"estimated":[163],"higher":[167,173],"subjects":[169,371],"wearing":[170],"Dk/t:":[174],"mean":[175],"open-eye":[176],"30.6":[179],"+/-":[180,184,197,258,268,297],"3.1":[181],"8.1":[183],"1.3":[185],"torr":[186,199],"thin":[189,253],"thick":[191,279],"respectively,":[194,348],"97.6":[196],"22.9":[198],"lens.":[203,326],"After":[204,271],"significantly":[213],"reduced":[214],"reached":[216],"new":[218,303],"steady":[219,304],"state":[220],"approximately":[222,287],"20":[223],"seconds":[224,289],"opening.":[227],"Fitting":[228],"single":[230],"exponential":[231],"model":[232],"data":[235],"extrapolating":[237],"t":[239],"0":[241],"provided":[242],"an":[243],"estimate":[244],"under":[247],"closed":[249],"lid":[250],"(PO2":[255,265],"7":[257],"2.3":[259],"22.6":[267],"4":[269],"torr).":[270],"closure":[276],"lens,":[281],"remained":[284],"constant":[285],"10":[288],"opening":[292],"(mean":[293],"3.9":[296],"0.7)":[298],"before":[299],"increasing":[300],"state.":[305],"This":[306],"delay":[307],"accounted":[310],"by":[312],"time":[314],"needed":[315],"diffuse":[319],"Calculated":[327],"Q(C)":[328],"ranged":[329],"2.2":[331],"10(-4)":[333],"3.7":[335],"10(-6)":[337],"highest":[344],"lowest":[346],"PO2s,":[347],"is":[350,386],"comparable":[351],"previous":[353],"vitro":[355],"vivo":[358],"estimates.":[359],"CONCLUSIONS:":[360],"behind":[363],"can":[366],"porphyrin-protein":[377],"surface.":[383],"method":[385,406],"simple,":[387],"fast,":[388],"reliable,":[389],"noninvasive,":[391],"allowing":[392],"quick":[393],"estimates":[396],"Q(C).":[398],"In":[399],"addition":[400],"wear,":[404],"this":[405],"should":[407],"useful":[409],"examining":[411],"effects":[413],"disease,":[415],"surgery,":[416],"or":[417],"topical":[418],"drugs":[419],"rate.":[425]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
