{"id":"https://openalex.org/W1551990174","doi":null,"title":"Entwicklungen in der Hepatitis-B-Diagnostik: Quantitatives HBsAg, HBV-Genotypen, Real-Time PCR HBV-DNA","display_name":"Entwicklungen in der Hepatitis-B-Diagnostik: Quantitatives HBsAg, HBV-Genotypen, Real-Time PCR HBV-DNA","publication_year":2012,"publication_date":"2012-03-08","ids":{"openalex":"https://openalex.org/W1551990174","mag":"1551990174"},"language":"de","primary_location":{"id":"pmh:oai:kup.at:10386","doi":null,"is_oa":true,"landing_page_url":"http://www.kup.at/kup/pdf/10386.pdf","pdf_url":"http://www.kup.at/kup/pdf/10386.pdf","source":{"id":"https://openalex.org/S4306402201","display_name":"Journal f\u00fcr Kardiologie (Krause & Pachernegg GmbH)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"application/pdf"},"volume":null,"type":"other","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.kup.at/kup/pdf/10386.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009232553","display_name":"Theresia Popow\u2010Kraupp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theresia Popow\u2010Kraupp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068360894","display_name":"Robert Paul Stra\u00dfl","orcid":"https://orcid.org/0000-0002-2157-0382","observed_orcids":["https://orcid.org/0000-0002-2157-0382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Stra\u00dfl","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2157-0382","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"1","first_page":"19","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hbsag-quantification","display_name":"HBsAg quantification","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hbv-genotyping","display_name":"HBV genotyping","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hbv-dna-quantification","display_name":"HBV DNA quantification","score":0.8539999723434448},{"id":"https://openalex.org/keywords/real-time-pcr","display_name":"real-time PCR","score":0.9070000052452087},{"id":"https://openalex.org/keywords/persistent-hbv-infection","display_name":"persistent HBV infection","score":0.7710000276565552},{"id":"https://openalex.org/keywords/antiviral-therapy-monitoring","display_name":"antiviral therapy monitoring","score":0.8769999742507935},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.71381676197052},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.6728476881980896},{"id":"https://openalex.org/C189490182","wikidata":"https://www.wikidata.org/wiki/Q1052153","display_name":"cccDNA","level":5,"score":0.5786990523338318},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.46080493927001953},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.43983194231987},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.1891247034072876},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.090535968542099}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kup.at:10386","doi":null,"is_oa":true,"landing_page_url":"http://www.kup.at/kup/pdf/10386.pdf","pdf_url":"http://www.kup.at/kup/pdf/10386.pdf","source":{"id":"https://openalex.org/S4306402201","display_name":"Journal f\u00fcr Kardiologie (Krause & Pachernegg GmbH)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"application/pdf"},{"id":"mag:1551990174","doi":null,"is_oa":false,"landing_page_url":"https://www.kup.at/kup/pdf/10386.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210231978","display_name":"Journal f\u00fcr Gastroenterologische und Hepatologische Erkrankungen","issn_l":"1728-6263","issn":["1728-6263","1728-6271"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal f\u00fcr Gastroenterologische und Hepatologische Erkrankungen","raw_type":null}],"best_oa_location":{"id":"pmh:oai:kup.at:10386","doi":null,"is_oa":true,"landing_page_url":"http://www.kup.at/kup/pdf/10386.pdf","pdf_url":"http://www.kup.at/kup/pdf/10386.pdf","source":{"id":"https://openalex.org/S4306402201","display_name":"Journal f\u00fcr Kardiologie (Krause & Pachernegg GmbH)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"application/pdf"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1551990174.pdf","grobid_xml":"https://content.openalex.org/works/W1551990174.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1551599073","https://openalex.org/W1676377504","https://openalex.org/W1868509006","https://openalex.org/W1912024884","https://openalex.org/W1965270384","https://openalex.org/W1969732006","https://openalex.org/W1976470893","https://openalex.org/W1977141778","https://openalex.org/W1992475294","https://openalex.org/W1997681955","https://openalex.org/W2000242859","https://openalex.org/W2003692477","https://openalex.org/W2006463518","https://openalex.org/W2007807170","https://openalex.org/W2014610820","https://openalex.org/W2022111057","https://openalex.org/W2022627036","https://openalex.org/W2026179924","https://openalex.org/W2031210994","https://openalex.org/W2032812836","https://openalex.org/W2036433095","https://openalex.org/W2037344060","https://openalex.org/W2050571266","https://openalex.org/W2053259740","https://openalex.org/W2055205839","https://openalex.org/W2061551385","https://openalex.org/W2072159851","https://openalex.org/W2074118280","https://openalex.org/W2075498742","https://openalex.org/W2079316096","https://openalex.org/W2082534929","https://openalex.org/W2084870434","https://openalex.org/W2087564721","https://openalex.org/W2089153567","https://openalex.org/W2092319353","https://openalex.org/W2101032357","https://openalex.org/W2103190293","https://openalex.org/W2104969243","https://openalex.org/W2108539255","https://openalex.org/W2110463342","https://openalex.org/W2111245313","https://openalex.org/W2116983532","https://openalex.org/W2145916511","https://openalex.org/W2149606497","https://openalex.org/W2158447627","https://openalex.org/W2395564105","https://openalex.org/W2403855345","https://openalex.org/W2473709616","https://openalex.org/W2943463865"],"related_works":["https://openalex.org/W2334966557","https://openalex.org/W2410181593","https://openalex.org/W3003515842","https://openalex.org/W2915193413","https://openalex.org/W7053239338","https://openalex.org/W2188433204","https://openalex.org/W2089700179","https://openalex.org/W2133520176","https://openalex.org/W2140919243","https://openalex.org/W2931844802"],"abstract_inverted_index":{"Die":[0,65],"Hepatitis-B-Virus-":[1],"(HBV-)":[2],"Infektion":[3,33],"stellt":[4],"aufgrund":[5],"des":[6,117,150],"breiten":[7],"Spektrums":[8],"an":[9],"m\u00f6glichen":[10],"Verlaufsformen":[11,69],"eine":[12],"diagnostische":[13],"Herausforderung":[14],"dar.":[15],"Der":[16],"unabl\u00e4ssigen":[17],"Forschung":[18],"ist":[19,129,153,179],"es":[20],"zu":[21,37,126,164,172],"verdanken,":[22],"dass":[23],"das":[24],"Wissen":[25],"um":[26],"die":[27,44,74,93,96,115,120,132,134,160],"pathogenetischen":[28],"und":[29,36,142],"molekularen":[30,177],"Mechanismen":[31,178],"dieser":[32,83],"stetig":[34],"zugenommen":[35],"signifikanten":[38],"diagnostischen":[39,53],"Verbesserungen":[40],"gef\u00fchrt":[41],"hat.":[42],"Speziell":[43],"quantitative":[45],"Bestimmung":[46],"der":[47,55,67,70,106,176],"HBV-Nukleins\u00e4ure":[48],"mittels":[49],"PCR":[50],"bedeutete":[51],"einen":[52,157],"Meilenstein,":[54],"heute":[56],"fest":[57],"in":[58,159],"den":[59,168],"international":[60],"g\u00fcltigen":[61],"Guidelines":[62],"verankert":[63],"ist.":[64],"Einteilung":[66],"klinischen":[68],"persistierenden":[71],"HBV-Infektion":[72],"sowie":[73],"\u00dcberwachung":[75],"von":[76,123],"Patienten":[77],"unter":[78],"antiviraler":[79],"Therapie":[80,122],"basieren":[81],"auf":[82,119],"anerkannten":[84],"Standardmethode.":[85],"Im":[86],"Gegensatz":[87],"dazu":[88],"stehen":[89],"weitere":[90],"Untersuchungsmethoden,":[91],"wie":[92],"HBV-Genotypisierung":[94],"oder":[95],"HBsAg-Quantifizierung,":[97,133],"deren":[98],"Stellenwert":[99],"derzeit":[100],"noch":[101],"kontroversiell":[102],"diskutiert":[103],"wird.":[104],"Aufgrund":[105],"bisher":[107],"vorliegenden":[108,151],"Daten":[109],"scheinen":[110],"diese":[111,183],"beiden":[112],"Parameter":[113],"f\u00fcr":[114],"Einsch\u00e4tzung":[116],"Ansprechens":[118],"antivirale":[121],"prognostischem":[124],"Nutzen":[125],"sein.":[127],"Hervorzuheben":[128],"hier":[130],"speziell":[131],"sich":[135],"nicht":[136,155],"zuletzt":[137],"wegen":[138],"ihrer":[139,143],"einfachen":[140],"Durchf\u00fchrung":[141],"Kosteneffektivit\u00e4t":[144],"als":[145],"Routineparameter":[146],"etablieren":[147],"k\u00f6nnte.":[148],"Ziel":[149],"Artikels":[152],"es,":[154],"nur":[156],"Einblick":[158],"aktuell":[161],"g\u00fcltige":[162],"Standarddiagnostik":[163],"geben,":[165],"sondern":[166],"auch":[167,184],"derzeitigen":[169],"Forschungsstand":[170],"kritisch":[171],"beleuchten.":[173],"Das":[174],"Verst\u00e4ndnis":[175],"hierf\u00fcr":[180],"essenziell,":[181],"weshalb":[182],"genauer":[185],"dargestellt":[186],"werden.":[187]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}