{"id":"https://openalex.org/W1551780368","doi":null,"title":"Coordinated Regulation Of Hepatic And Renal Membrane Transporters In Experimental Nonalcoholic Steatohepatitis","display_name":"Coordinated Regulation Of Hepatic And Renal Membrane Transporters In Experimental Nonalcoholic Steatohepatitis","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1551780368","mag":"1551780368"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/333487","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/333487","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008933927","display_name":"Mark Jimenez-Canet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mark Jimenez-Canet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008933927"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0494999997317791,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9309999942779541},{"id":"https://openalex.org/keywords/xenobiotic-transporters","display_name":"xenobiotic transporters","score":0.9110000133514404},{"id":"https://openalex.org/keywords/drug-disposition","display_name":"drug disposition","score":0.6150000095367432},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.8410000205039978},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9039999842643738},{"id":"https://openalex.org/keywords/abcc3","display_name":"ABCC3","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hepatic-uptake-transporters","display_name":"hepatic uptake transporters","score":0.6990000009536743},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7350000143051147},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C3018708256","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic steatohepatitis","level":5,"score":0.8954296708106995},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5847042798995972},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.47132542729377747},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.4674322009086609},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.40866366028785706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4031580984592438},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39012160897254944},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3379945755004883},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32724469900131226},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2535892724990845},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.20981386303901672},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11543935537338257},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07308980822563171}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/333487","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/333487","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:1551780368","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/333487","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":238,"referenced_works":["https://openalex.org/W7319844","https://openalex.org/W13687373","https://openalex.org/W25199929","https://openalex.org/W121658300","https://openalex.org/W1505133202","https://openalex.org/W1545078134","https://openalex.org/W1558228229","https://openalex.org/W1750652828","https://openalex.org/W1842752430","https://openalex.org/W1868407335","https://openalex.org/W1895993106","https://openalex.org/W1902836344","https://openalex.org/W1963760050","https://openalex.org/W1964446176","https://openalex.org/W1964596126","https://openalex.org/W1964767165","https://openalex.org/W1966452132","https://openalex.org/W1967089707","https://openalex.org/W1967357504","https://openalex.org/W1967459588","https://openalex.org/W1967774979","https://openalex.org/W1968384054","https://openalex.org/W1969879564","https://openalex.org/W1969903270","https://openalex.org/W1970461824","https://openalex.org/W1970468480","https://openalex.org/W1971570798","https://openalex.org/W1972385457","https://openalex.org/W1972800410","https://openalex.org/W1974957740","https://openalex.org/W1974960324","https://openalex.org/W1975742715","https://openalex.org/W1976173209","https://openalex.org/W1977220675","https://openalex.org/W1978152806","https://openalex.org/W1979488290","https://openalex.org/W1979861889","https://openalex.org/W1980033214","https://openalex.org/W1981102487","https://openalex.org/W1982330330","https://openalex.org/W1984821297","https://openalex.org/W1985333297","https://openalex.org/W1985338499","https://openalex.org/W1985599649","https://openalex.org/W1989535259","https://openalex.org/W1990103407","https://openalex.org/W1990259017","https://openalex.org/W1994834284","https://openalex.org/W1994845027","https://openalex.org/W1994889966","https://openalex.org/W1996358062","https://openalex.org/W1997532751","https://openalex.org/W1998312178","https://openalex.org/W1999656616","https://openalex.org/W2001043181","https://openalex.org/W2002114984","https://openalex.org/W2003626278","https://openalex.org/W2004784202","https://openalex.org/W2005623452","https://openalex.org/W2006327152","https://openalex.org/W2007622252","https://openalex.org/W2008944699","https://openalex.org/W2009046453","https://openalex.org/W2009217617","https://openalex.org/W2009562371","https://openalex.org/W2010409177","https://openalex.org/W2010427019","https://openalex.org/W2014330519","https://openalex.org/W2014424798","https://openalex.org/W2016036960","https://openalex.org/W2017025391","https://openalex.org/W2018582379","https://openalex.org/W2020353733","https://openalex.org/W2021173802","https://openalex.org/W2022169188","https://openalex.org/W2026495679","https://openalex.org/W2028098070","https://openalex.org/W2028533496","https://openalex.org/W2028890879","https://openalex.org/W2028914586","https://openalex.org/W2029583268","https://openalex.org/W2030910975","https://openalex.org/W2034035167","https://openalex.org/W2034619043","https://openalex.org/W2034846190","https://openalex.org/W2034929515","https://openalex.org/W2035970641","https://openalex.org/W2036321136","https://openalex.org/W2037297309","https://openalex.org/W2037355442","https://openalex.org/W2039678693","https://openalex.org/W2039986849","https://openalex.org/W2040109162","https://openalex.org/W2040611122","https://openalex.org/W2042948144","https://openalex.org/W2043534420","https://openalex.org/W2044245966","https://openalex.org/W2044349089","https://openalex.org/W2044720384","https://openalex.org/W2044911368","https://openalex.org/W2045924581","https://openalex.org/W2045978319","https://openalex.org/W2047705730","https://openalex.org/W2048272657","https://openalex.org/W2048563316","https://openalex.org/W2049200136","https://openalex.org/W2049331373","https://openalex.org/W2050524302","https://openalex.org/W2050913224","https://openalex.org/W2051634319","https://openalex.org/W2052630912","https://openalex.org/W2053186448","https://openalex.org/W2053350368","https://openalex.org/W2054208989","https://openalex.org/W2055804474","https://openalex.org/W2056070943","https://openalex.org/W2058380077","https://openalex.org/W2059655597","https://openalex.org/W2060634509","https://openalex.org/W2061587734","https://openalex.org/W2062773689","https://openalex.org/W2063255559","https://openalex.org/W2064459152","https://openalex.org/W2065170814","https://openalex.org/W2065880243","https://openalex.org/W2066412555","https://openalex.org/W2067740038","https://openalex.org/W2070714436","https://openalex.org/W2071355421","https://openalex.org/W2072027127","https://openalex.org/W2073386434","https://openalex.org/W2073438109","https://openalex.org/W2075047816","https://openalex.org/W2079748137","https://openalex.org/W2080094617","https://openalex.org/W2081492147","https://openalex.org/W2081680174","https://openalex.org/W2084295343","https://openalex.org/W2084406499","https://openalex.org/W2085131512","https://openalex.org/W2085824187","https://openalex.org/W2086344031","https://openalex.org/W2088366586","https://openalex.org/W2089264179","https://openalex.org/W2090034709","https://openalex.org/W2091876682","https://openalex.org/W2092412521","https://openalex.org/W2092435069","https://openalex.org/W2094610519","https://openalex.org/W2095908153","https://openalex.org/W2095982746","https://openalex.org/W2096171066","https://openalex.org/W2096695647","https://openalex.org/W2097184538","https://openalex.org/W2097752581","https://openalex.org/W2098867544","https://openalex.org/W2099575771","https://openalex.org/W2100799088","https://openalex.org/W2100988019","https://openalex.org/W2102006967","https://openalex.org/W2104243204","https://openalex.org/W2106009044","https://openalex.org/W2107790148","https://openalex.org/W2108295627","https://openalex.org/W2109062146","https://openalex.org/W2111501137","https://openalex.org/W2111794488","https://openalex.org/W2112532934","https://openalex.org/W2113317051","https://openalex.org/W2113524447","https://openalex.org/W2113681412","https://openalex.org/W2113774534","https://openalex.org/W2114288535","https://openalex.org/W2114393933","https://openalex.org/W2114577256","https://openalex.org/W2115178828","https://openalex.org/W2115432763","https://openalex.org/W2116004391","https://openalex.org/W2117192628","https://openalex.org/W2118307385","https://openalex.org/W2119186881","https://openalex.org/W2119236309","https://openalex.org/W2119463649","https://openalex.org/W2121674173","https://openalex.org/W2122742700","https://openalex.org/W2123169375","https://openalex.org/W2124244978","https://openalex.org/W2124575784","https://openalex.org/W2125457175","https://openalex.org/W2125720510","https://openalex.org/W2128874766","https://openalex.org/W2129316761","https://openalex.org/W2130076476","https://openalex.org/W2131448427","https://openalex.org/W2133257033","https://openalex.org/W2134467287","https://openalex.org/W2136795008","https://openalex.org/W2136847049","https://openalex.org/W2137516998","https://openalex.org/W2139121124","https://openalex.org/W2139864041","https://openalex.org/W2140158011","https://openalex.org/W2142030049","https://openalex.org/W2142688525","https://openalex.org/W2145835097","https://openalex.org/W2147298418","https://openalex.org/W2147924866","https://openalex.org/W2148820240","https://openalex.org/W2148878254","https://openalex.org/W2149342673","https://openalex.org/W2149511105","https://openalex.org/W2149843003","https://openalex.org/W2149863648","https://openalex.org/W2150163406","https://openalex.org/W2151444334","https://openalex.org/W2151614363","https://openalex.org/W2153356268","https://openalex.org/W2154429226","https://openalex.org/W2155324869","https://openalex.org/W2157050265","https://openalex.org/W2157199556","https://openalex.org/W2158375646","https://openalex.org/W2160045092","https://openalex.org/W2161041263","https://openalex.org/W2161686984","https://openalex.org/W2163008981","https://openalex.org/W2164412863","https://openalex.org/W2167213027","https://openalex.org/W2167832449","https://openalex.org/W2168536224","https://openalex.org/W2168819707","https://openalex.org/W2169624083","https://openalex.org/W2171791920","https://openalex.org/W2179971667","https://openalex.org/W2318763909","https://openalex.org/W2322140618","https://openalex.org/W2330957393","https://openalex.org/W3126298030"],"related_works":["https://openalex.org/W2100888886","https://openalex.org/W4391378418","https://openalex.org/W4307973582","https://openalex.org/W2129876180","https://openalex.org/W2021173802","https://openalex.org/W3167853780","https://openalex.org/W1994834284","https://openalex.org/W1863862367","https://openalex.org/W1975742715","https://openalex.org/W4367836595"],"abstract_inverted_index":{"Inter-individual":[0],"variability":[1],"in":[2,28,54,79,111,117,141,179,182,189,242,275,288,341,371,423,431,443],"drug":[3,18,126,441],"response":[4,218,337],"is":[5,72,134],"a":[6,23,51,84,130,216,234,278,303,325,334],"significant":[7],"clinical":[8,87],"concern":[9],"and":[10,82,114,146,308,352,383,392,396,420],"may":[11,38,213,426],"lead":[12,120],"to":[13,60,98,121,193,223,280,359,428],"the":[14,29,33,55,73,92,99,122,164,172,183,244,247,263,267,281,289,294,314,321,342,361,364,399,405,436],"development":[15,56],"of":[16,26,35,57,86,125,136,150,163,171,200,209,229,246,266,284,296,306,323,328,338,350,363,374,407,438],"adverse":[17,440],"reactions,":[19],"which":[20,37,119,185,212],"are":[21,388],"currently":[22],"top-ten":[24],"cause":[25],"death":[27],"United":[30],"States.":[31],"Recently,":[32],"manifestation":[34,322],"disease,":[36,64,324],"alter":[39],"normal":[40],"physiological":[41],"function,":[42],"has":[43],"gained":[44],"increased":[45,372],"attention":[46],"for":[47,238,398],"its":[48],"role":[49,245],"as":[50,66,215,277,378,380],"contributing":[52],"factor":[53],"inter-individual":[58],"responses":[59],"drugs.":[61],"One":[62],"such":[63],"known":[65],"nonalcoholic":[67,102],"fatty":[68,96],"liver":[69,77,97,151,351,419],"disease":[70,78,345,424],"(NAFLD),":[71],"most":[74],"common":[75],"chronic":[76],"Western":[80],"society":[81],"represents":[83],"spectrum":[85],"morbidities":[88],"that":[89,133,168,191,402,417,425],"range":[90],"from":[91],"usually":[93],"benign":[94],"simple":[95],"more":[100],"advanced":[101],"steatohepatitis":[103],"(NASH).":[104],"Prior":[105],"investigations":[106],"have":[107],"identified":[108,261],"liver-specific":[109],"alterations":[110,430],"xenobiotic":[112,354,432],"transporter":[113,138,180,270,301,355,394],"metabolizing":[115],"enzymes":[116],"NASH,":[118,144,243],"functional":[123,256,348],"disruption":[124],"disposition.":[127],"To":[128,232,291],"identify":[129,418],"useful":[131],"model(s)":[132],"representative":[135,170],"hepatic":[137,201,221,240,285,382,391],"expression":[139,148,199,310],"profiles":[140,149],"humans":[142],"with":[143,206,313,390,445],"gene":[145,307],"protein":[147,309],"membrane":[152,300,339],"transporters":[153,203,287,340],"were":[154,169],"assayed":[155],"across":[156],"several":[157],"commonly":[158],"used":[159,318],"experimental":[160],"rodent":[161,316],"models":[162,167,190,317],"disease.":[165,290],"NASH":[166,276,297,369,403],"human":[173,195,268],"condition":[174],"developed":[175],"global,":[176],"adaptive":[177],"changes":[178],"regulation":[181],"liver,":[184],"was":[186,204,253,260,311,331,357],"not":[187],"present":[188],"failed":[192],"recapitulate":[194],"profiles.":[196],"Specifically,":[197,368],"decreased":[198],"uptake":[202],"coupled":[205],"an":[207],"induction":[208,283,327],"efflux":[210,286,330],"transporters,":[211],"serve":[214],"hepatoprotective":[217],"by":[219],"limiting":[220],"exposure":[222],"potentially":[224],"harmful":[225],"substances":[226],"during":[227],"times":[228],"tissue":[230],"stress.":[231],"link":[233],"possible":[235],"molecular":[236],"mechanism":[237],"these":[239,412],"adaptations":[241,422],"oxidative":[248],"stress-activated":[249],"transcription":[250],"factor,":[251],"Nrf2,":[252],"investigated.":[254],"A":[255],"Nrf2":[257,273],"regulatory":[258],"element":[259],"within":[262],"eighth":[264],"intron":[265],"ABCC3":[269],"gene,":[271],"implicating":[272],"activation":[274],"contributor":[279],"coordinated":[282,336],"further":[292],"clarify":[293],"effects":[295],"on":[298],"renal":[299,329,384,393],"regulation,":[302],"thorough":[304],"analysis":[305],"conducted":[312],"validated":[315],"previously.":[319],"Following":[320],"global":[326,429],"observed,":[332],"suggesting":[333],"compensatory,":[335],"kidney":[343,353],"upon":[344],"induction.":[346],"The":[347],"consequences":[349],"dysregulation":[356,395],"shown":[358],"disrupt":[360],"disposition":[362,406,433],"environmental":[365,408],"toxicant,":[366],"arsenic.":[367],"results":[370],"excretion":[373],"arsenic":[375],"into":[376],"urine":[377],"well":[379],"altered":[381],"exposure.":[385],"These":[386],"findings":[387,416],"associated":[389],"demonstrate":[397],"first":[400],"time":[401],"alters":[404],"toxicants.":[409],"In":[410],"summary,":[411],"studies":[413],"contribute":[414,427],"novel":[415],"kidney-specific":[421],"thereby":[434],"increasing":[435],"likelihood":[437],"developing":[439],"reactions":[442],"patients":[444],"NASH.":[446]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}