{"id":"https://openalex.org/W1551665560","doi":null,"title":"Untersuchungen zum Zellkommunikationsprotein Connexin31 in Trophoblast-Stammzellen aus Mus musculus","display_name":"Untersuchungen zum Zellkommunikationsprotein Connexin31 in Trophoblast-Stammzellen aus Mus musculus","publication_year":2009,"publication_date":"2009-03-11","ids":{"openalex":"https://openalex.org/W1551665560","mag":"1551665560"},"language":"de","primary_location":{"id":"pmh:oai:duepublico.uni-duisburg-essen.de:19813","doi":null,"is_oa":true,"landing_page_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=19813","pdf_url":"http://duepublico.uni-duisburg-essen.de/servlets/DerivateServlet/Derivate-21639/Diss_Graevendiek.pdf","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Wissenschaftliche Abschlussarbeiten \u00bb Dissertation"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://duepublico.uni-duisburg-essen.de/servlets/DerivateServlet/Derivate-21639/Diss_Graevendiek.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053941946","display_name":"Tina Graevendiek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tina Graevendiek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5053941946"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07716287,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/connexin-31","display_name":"connexin 31","score":0.9190000295639038},{"id":"https://openalex.org/keywords/trophoblast-stem-cells","display_name":"trophoblast stem cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/gap-junctional-intercellular-communication","display_name":"gap junctional intercellular communication","score":0.7649999856948853},{"id":"https://openalex.org/keywords/placental-insufficiency","display_name":"placental insufficiency","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6079999804496765},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/tumor-induction","display_name":"tumor induction","score":0.7879999876022339},{"id":"https://openalex.org/keywords/mouse-embryonic-fibroblasts","display_name":"mouse embryonic fibroblasts","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4852442741394043},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4191688895225525},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.35469257831573486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3170243501663208},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.21170252561569214}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:duepublico.uni-duisburg-essen.de:19813","doi":null,"is_oa":true,"landing_page_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=19813","pdf_url":"http://duepublico.uni-duisburg-essen.de/servlets/DerivateServlet/Derivate-21639/Diss_Graevendiek.pdf","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Wissenschaftliche Abschlussarbeiten \u00bb Dissertation"},{"id":"pmh:oai:duepublico2.uni-due.de:duepublico_mods_00019813","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:hbz:465-20090317-111536-2","pdf_url":"https://duepublico2.uni-due.de/receive/duepublico_mods_00019813","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation"},{"id":"mag:1551665560","doi":null,"is_oa":false,"landing_page_url":"https://duepublico.uni-duisburg-essen.de:443/servlets/DerivateServlet/Derivate-21639/Diss_Graevendiek.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:duepublico.uni-duisburg-essen.de:19813","doi":null,"is_oa":true,"landing_page_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=19813","pdf_url":"http://duepublico.uni-duisburg-essen.de/servlets/DerivateServlet/Derivate-21639/Diss_Graevendiek.pdf","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Wissenschaftliche Abschlussarbeiten \u00bb Dissertation"},"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1551665560.pdf","grobid_xml":"https://content.openalex.org/works/W1551665560.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1487146757","https://openalex.org/W1786431103","https://openalex.org/W1965912922","https://openalex.org/W1970508192","https://openalex.org/W1971364845","https://openalex.org/W1974214405","https://openalex.org/W1975751233","https://openalex.org/W1977527418","https://openalex.org/W1980143799","https://openalex.org/W1980591796","https://openalex.org/W1982533604","https://openalex.org/W1984119085","https://openalex.org/W1985360296","https://openalex.org/W1987594610","https://openalex.org/W1991287650","https://openalex.org/W1992465866","https://openalex.org/W2001848617","https://openalex.org/W2002329350","https://openalex.org/W2013736577","https://openalex.org/W2013955956","https://openalex.org/W2033162180","https://openalex.org/W2036430171","https://openalex.org/W2054851454","https://openalex.org/W2058204036","https://openalex.org/W2058972167","https://openalex.org/W2060571921","https://openalex.org/W2068331562","https://openalex.org/W2073226037","https://openalex.org/W2075023286","https://openalex.org/W2077551373","https://openalex.org/W2087220149","https://openalex.org/W2088239341","https://openalex.org/W2089818198","https://openalex.org/W2091968941","https://openalex.org/W2092393324","https://openalex.org/W2095524977","https://openalex.org/W2101515649","https://openalex.org/W2102534541","https://openalex.org/W2117792063","https://openalex.org/W2118123024","https://openalex.org/W2132069716","https://openalex.org/W2136874026","https://openalex.org/W2140769225","https://openalex.org/W2142258470","https://openalex.org/W2160032357","https://openalex.org/W2166438339","https://openalex.org/W2166470278","https://openalex.org/W2232033595","https://openalex.org/W2503384697","https://openalex.org/W4300058229"],"related_works":["https://openalex.org/W1984119085","https://openalex.org/W342233364","https://openalex.org/W2054851454","https://openalex.org/W62546031","https://openalex.org/W2232033595","https://openalex.org/W7036859395","https://openalex.org/W2075023286","https://openalex.org/W2155564987","https://openalex.org/W2038965422","https://openalex.org/W2056559320"],"abstract_inverted_index":{"Connexine":[0],"sind":[1],"nicht":[2],"nur":[3,50],"f\u00fcr":[4,18],"die":[5,11,19,49,64,100,106,166,173,193,203,233,249,276,280],"Kom\u00admu\u00adni\u00adka\u00ad\u00adtion":[6],"der":[7,26,38,53,70,79,175,261,288,293],"Zellen":[8,113,125,155,176,204,270,279],"unter\u00adeinander":[9],"durch":[10,263],"\u00dcbertragung":[12],"von":[13,34,67,84,179,238],"kleineren":[14],"Mo\u00adle\u00adk\u00fc\u00adlen,":[15],"son\u00addern":[16],"auch":[17],"Induktion":[20],"und":[21,72,92,105,123,191,251,282,290],"damit":[22,291],"eine":[23,168,208],"Ver\u00e4nderung":[24],"in":[25,37,51,69,111,195,216,287,292],"interzellul\u00e4ren":[27],"Sig\u00adnal\u00adkaskade":[28],"\u00fcber":[29,81,207],"Protein-Protein-Wechsel\u00adwir\u00adkun\u00adgen":[30],"ver\u00adant\u00adwort\u00adlich.":[31],"Das":[32],"Fehlen":[33],"Cx31":[35,54,68,119,121,132,153,212,239,268,277],"f\u00fchrt":[36],"Maus":[39],"zu":[40,76,138],"einer":[41],"transienten":[42],"plazentaren":[43],"Dysfunktion":[44],"an":[45],"Tag":[46],"10,5":[47],"pc,":[48],"40%":[52],"defizienten":[55,240],"Schwangerschaften":[56],"\u00fcberwunden":[57],"wer\u00adden":[58],"kann.":[59],"Ungekl\u00e4rt":[60],"bleibt":[61],"weiterhin,":[62],"worin":[63],"essentielle":[65],"Funktion":[66],"Proliferations-":[71],"Dif\u00adfe\u00adren\u00adzierung\u00adskon\u00adtrolle":[73],"besteht.":[74],"Um":[75],"untersuchen,":[77],"ob":[78],"Cx31-Kanal":[80],"den":[82],"Austausch":[83],"Sig\u00adnal\u00admolek\u00fclen":[85],"diese":[86,160,256],"Kon\u00adtrol\u00adle":[87],"aus\u00fcbt,":[88],"wur\u00adden":[89],"Kommunikations-,":[90],"Pro\u00adli\u00adfe\u00adra\u00adtions-":[91],"Tumorinduktionsversuche":[93],"mit":[94,102,228],"Tro\u00ad\u00ad\u00adpho\u00ad\u00ad\u00adblast-Stamm\u00adzellen":[95],"(TSZ)":[96],"durchgef\u00fchrt.":[97],"Dazu":[98],"wurden":[99,126],"Zel\u00adlen":[101,257],"Calcein-AM":[103],"gef\u00e4rbt":[104],"Kopplung":[107],"des":[108],"Gap-Junction-durchl\u00e4ssigen":[109],"Farbstoffes":[110],"un\u00adge\u00adf\u00e4rbte":[112],"gemessen.":[114],"Ver\u00adschie\u00addene":[115],"TZS-Klone,":[116],"namentlich":[117],"Wildtyp,":[118],"de\u00adfi\u00adziente,":[120],"\u00fcber\u00adex\u00adpri\u00admie\u00adren\u00adde":[122],"heterozygote":[124],"zun\u00e4chst":[127],"auf":[128],"ihre":[129,205],"Kom\u00admu\u00adni\u00adka\u00adtions\u00adm\u00f6g\u00adlichkeiten":[130],"getestet.":[131],"defiziente":[133,269],"TSZ":[134,167,217,241,264],"kommunizieren":[135],"im":[136],"Vergleich":[137],"Wild\u00adtyp\u00adzel\u00adlen":[139],"kaum,":[140],"obwohl":[141],"sie":[142],"zus\u00e4tzlich":[143],"noch":[144,152],"ein":[145],"anderes":[146],"Cx,":[147],"Cx31.1":[148],"exprimieren.":[149],"Zieht":[150],"man":[151],"\u00fcber\u00adex\u00adpri\u00admie\u00adrende":[154],"hinzu,":[156],"sieht":[157],"man,":[158],"dass":[159,189,202,224,243,267],"umso":[161],"mehr":[162],"kommunizieren.":[163],"Somit":[164],"besitzen":[165],"Cx31-ab\u00adh\u00e4ngige":[169],"Kom\u00admu\u00adni\u00adka\u00adtions\u00adf\u00e4hig\u00adkeit.":[170],"Zus\u00e4tzlich":[171],"wurde":[172,187],"Proliferationsf\u00e4higkeit":[174],"unter":[177],"Zugabe":[178],"Gap":[180],"Junction":[181],"Kanal":[182],"blockierenden":[183],"Substanzen":[184],"un\u00adter\u00adsucht.":[185],"Hierbei":[186],"festgestellt,":[188],"Carbenoxolon":[190],"18-alpha-gly\u00adcyr\u00adrhe\u00adtin\u00ads\u00e4u\u00adre":[192],"Pro\u00adli\u00adfe\u00adra\u00adtion":[194],"Wildtyp-TSZ":[196],"konzentrations\u00adabh\u00e4n\u00adgig":[197],"hemmen.":[198],"Dies":[199],"spricht":[200],"daf\u00fcr,":[201],"Proliferation":[206,250],"Kanal-Kommunikation":[209],"re\u00adgu\u00adlieren.":[210],"Da":[211],"das":[213],"einzige":[214],"stabil":[215],"exprimierte":[218],"Connexin":[219],"ist,":[220,231,247],"kann":[221],"ge\u00adschlos\u00ad\u00adsen":[222],"werden,":[223],"es":[225,244],"dieses":[226],"Protein":[227,246],"seiner":[229],"Kanalfunktion":[230],"was":[232,248,286],"Re\u00adgu\u00adlation":[234],"steuert.":[235],"Die":[236],"Ver\u00adwen\u00addung":[237],"best\u00e4tigt,":[242],"die\u00adses":[245],"Differenzierung":[252],"steuert,":[253],"da":[254],"sich":[255],"abweichend":[258],"verhalten.":[259],"In":[260],"Tumor\u00adinduktion":[262],"zeigt":[265],"sich,":[266],"sehr":[271],"kleine":[272],"Tumore":[273],"in\u00addu\u00adzieren,":[274],"wobei":[275],"\u00fc\u00adber\u00adex\u00adpri\u00admie\u00adren\u00adden":[278],"gr\u00f6\u00dften":[281],"invasivsten":[283],"Tu\u00admo\u00adre":[284],"bilden,":[285],"Pro\u00adli\u00adfe\u00adra\u00adtions\u00adkapazit\u00e4t":[289],"Zellzahl":[294],"begr\u00fcndet":[295],"liegt.":[296]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}