{"id":"https://openalex.org/W155163305","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.8110","title":"Activity of the NEDD8-specific inhibitor MLN 4924 in multiple myeloma and Waldenstr\u00f6m's macroglobulinemia, and effect on miRNA expression.","display_name":"Activity of the NEDD8-specific inhibitor MLN 4924 in multiple myeloma and Waldenstr\u00f6m's macroglobulinemia, and effect on miRNA expression.","publication_year":2010,"publication_date":"2010-05-20","ids":{"openalex":"https://openalex.org/W155163305","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.8110","mag":"155163305"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2010.28.15_suppl.8110","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.8110","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.28.15_suppl.8110","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115591881","display_name":"Douglas W. McMillin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. W. McMillin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026121534","display_name":"Zachary R. Hunter","orcid":"https://orcid.org/0000-0002-1689-1691","observed_orcids":["https://orcid.org/0000-0002-1689-1691"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z. R. Hunter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091354090","display_name":"Jake E. Delmore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Delmore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071222959","display_name":"P Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085651180","display_name":"Ann Birner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Birner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043526996","display_name":"Paul Gerard Guy Richardson","orcid":"https://orcid.org/0000-0002-7426-8865","observed_orcids":["https://orcid.org/0000-0002-7426-8865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. G. Richardson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032464400","display_name":"Kenneth Carl Anderson","orcid":"https://orcid.org/0000-0002-6418-0886","observed_orcids":["https://orcid.org/0000-0002-6418-0886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. C. Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081299017","display_name":"Steven Peter Treon","orcid":"https://orcid.org/0000-0001-6393-6154","observed_orcids":["https://orcid.org/0000-0001-6393-6154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. P. Treon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012712111","display_name":"Constantine S. Mitsiades","orcid":"https://orcid.org/0000-0003-2321-8005","observed_orcids":["https://orcid.org/0000-0003-2321-8005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. S. Mitsiades","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"15_suppl","first_page":"8110","last_page":"8110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/waldenstrom-macroglobulinemia","display_name":"Waldenstr\u00f6m macroglobulinemia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ubiquitin-pathway","display_name":"ubiquitin pathway","score":0.6620000004768372},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.7829999923706055},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.7099999785423279},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6100000143051147},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9449999928474426},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8190000057220459},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tumor-selectivity","display_name":"tumor selectivity","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.821120023727417},{"id":"https://openalex.org/C2781038049","wikidata":"https://www.wikidata.org/wiki/Q1778287","display_name":"Waldenstrom macroglobulinemia","level":3,"score":0.6431031823158264},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5607927441596985},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5445747971534729},{"id":"https://openalex.org/C2776391228","wikidata":"https://www.wikidata.org/wiki/Q4118092","display_name":"Macroglobulinemia","level":3,"score":0.5147335529327393},{"id":"https://openalex.org/C2776243873","wikidata":"https://www.wikidata.org/wiki/Q421230","display_name":"Auranofin","level":3,"score":0.49452874064445496},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.48905715346336365},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4873834252357483},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.48340240120887756},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.4580889940261841},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4386100172996521},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3717184066772461},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.32846465706825256},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2641245722770691},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21083831787109375},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16101130843162537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1208907961845398},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.11938706040382385},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2010.28.15_suppl.8110","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.8110","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.28.15_suppl.8110","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2588115585","https://openalex.org/W4236450287","https://openalex.org/W2082050061","https://openalex.org/W2552096861","https://openalex.org/W2101272346","https://openalex.org/W2602094970","https://openalex.org/W2978593427","https://openalex.org/W2409790327","https://openalex.org/W1893377997","https://openalex.org/W2565742993"],"abstract_inverted_index":{"8110":[0],"Background:":[1],"Bortezomib":[2],"is":[3,18,34],"an":[4,146],"effective":[5],"treatment":[6],"for":[7,70,105,272,299],"both":[8,250,273],"multiple":[9],"myeloma":[10],"(MM)":[11,115],"and":[12,46,55,64,84,91,116,171,185,192,213,217,221,242,246,275,289,308],"Waldenstr\u00f6m":[13],"Macroglobulinemia":[14],"(WM),":[15],"whose":[16],"activity":[17,196,226],"attributed":[19],"to":[20,53,75,100,129,261,286],"blocking":[21],"elimination":[22],"of":[23,42,61,95,111,113,206,208,235,239,282,303],"ubiquitin":[24,44],"tagged":[25],"regulatory":[26,259],"proteins":[27],"by":[28,197],"the":[29,43,136,157,297,300],"proteasome.":[30],"The":[31],"NEDD8-inhibitor":[32],"MLN4924":[33,101,125,209,264],"a":[35,49,121,169,204,237,254],"novel":[36],"agent":[37],"which":[38],"demonstrates":[39],"selective":[40,291],"inhibition":[41],"pathway":[45],"may":[47],"offer":[48],"more":[50,172],"targeted":[51],"approach":[52],"MM":[54,63,83,158,183,274,307],"WM":[56,65,85,160,186,276],"therapy.":[57],"Methods:":[58],"A":[59,108],"panel":[60],"human":[62],"cell":[66,86,161,251,255,266],"lines":[67,87,162,220,252],"were":[68,150],"tested":[69,88,203],"their":[71,96],"in":[72,215,249,306],"vitro":[73],"response":[74,260],"MLN":[76,198,228,304],"4924":[77,305],"using":[78],"MTT":[79],"colorimetric":[80],"survival":[81],"assays.":[82],"exhibited":[89],"dose":[90],"time":[92],"dependent":[93],"decrease":[94],"viability":[97,112],"upon":[98],"exposure":[99],"(IC50=":[102],"25-150":[103],"nM":[104],"72hrs).":[106],"Results:":[107],"longitudinal":[109],"assessment":[110],"MM1S":[114,216],"BCWM1":[117,218],"(WM)":[118],"cells":[119,144,149,219,277,284],"during":[120],"72-hr":[122],"incubation":[123],"with":[124,135,210,227,278],"(500nM)":[126],"showed":[127],"commitment":[128],"death":[130],"<48hrs.":[131],"This":[132],"result,":[133],"coupled":[134],"observation":[137],"that":[138,165],"normal":[139,287],"donor":[140],"peripheral":[141],"blood":[142],"mononuclear":[143],"(PBMCs)":[145],"dHS-5":[147],"stromal":[148],"less":[151],"sensitive":[152],"(IC50":[153],">1,000":[154],"nM)":[155],"than":[156],"or":[159,313,317],"tested,":[163],"suggest":[164],"this":[166],"compound":[167],"exhibits":[168,290],"rapid":[170],"tumor-selective":[173],"effect":[174],"at":[175,223,244,268],"clinically":[176],"relevant":[177],"conditions.":[178],"We":[179],"also":[180],"evaluated":[181],"primary":[182],"(CD138+)":[184],"(CD19+)":[187],"patient":[188],"bone":[189],"marrow":[190],"cells,":[191],"observed":[193,222],"sub-\u03bc":[194,269],"M":[195,270],"4924.":[199,229],"In":[200],"addition,":[201],"we":[202],"series":[205],"combinations":[207],"dexamethasone,":[211],"doxorubicin":[212],"bortezomib":[214],"least":[224],"additive":[225],"Longitudinal":[230],"miRNA":[231,258,292],"profiling":[232],"revealed":[233],"up-regulation":[234],"181c,":[236],"modulator":[238],"Akt":[240],"activity,":[241],"361-5p":[243],"24":[245],"36":[247],"hours":[248],"indicating":[253],"line":[256],"independent":[257],"MLN4924.":[262],"Conclusions:":[263],"induces":[265],"killing":[267],"concentrations":[271],"significantly":[279],"higher":[280],"sensitivity":[281],"tumor":[283],"compared":[285],"tissues,":[288],"regulation.":[293],"These":[294],"studies":[295],"provide":[296],"framework":[298],"clinical":[301],"investigation":[302],"WM.":[309],"Author":[310],"Disclosure":[311],"Employment":[312],"Leadership":[314],"Position":[315],"Consultant":[316],"Advisory":[318],"Role":[319],"Stock":[320],"Ownership":[321],"Honoraria":[322],"Research":[323],"Funding":[324],"Expert":[325],"Testimony":[326],"Other":[327],"Remuneration":[328],"Millennium":[329,330,331,332]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}