{"id":"https://openalex.org/W1551388901","doi":null,"title":"cis-diamminedichloroplatinum(II)-resistant sublines derived from two human ovarian tumor cell lines.","display_name":"cis-diamminedichloroplatinum(II)-resistant sublines derived from two human ovarian tumor cell lines.","publication_year":1988,"publication_date":"1988-06-15","ids":{"openalex":"https://openalex.org/W1551388901","mag":"1551388901","pmid":"https://pubmed.ncbi.nlm.nih.gov/2897238"},"language":"en","primary_location":{"id":"pmid:2897238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2897238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058922925","display_name":"Peter J.K. Kuppen","orcid":"https://orcid.org/0000-0002-0294-3251","observed_orcids":["https://orcid.org/0000-0002-0294-3251"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P J Kuppen","raw_affiliation_strings":["Department of Clinical Oncology, Leiden University Hospital, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Leiden University Hospital, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014967648","display_name":"Hanneke Schuitemaker","orcid":"https://orcid.org/0000-0001-8563-2266","observed_orcids":["https://orcid.org/0000-0001-8563-2266"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Schuitemaker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014135109","display_name":"Laura van \u2018t Veer","orcid":"https://orcid.org/0000-0002-9838-8298","observed_orcids":["https://orcid.org/0000-0002-9838-8298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L J van 't Veer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110105811","display_name":"Ernst A. de Bruijn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E A de Bruijn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111734683","display_name":"A.T. van Oosterom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A T van Oosterom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112789728","display_name":"Peter I. Schrier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P I Schrier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.4757,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.96707638,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"48","issue":"12","first_page":"3355","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0949999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cross-resistance","display_name":"cross-resistance","score":0.6460000276565552},{"id":"https://openalex.org/keywords/platinum-analogues","display_name":"platinum analogues","score":0.5920000076293945},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.367000013589859},{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":0.9340000152587891},{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-accumulation","display_name":"drug accumulation","score":0.3959999978542328},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.871999979019165},{"id":"https://openalex.org/keywords/multidrug-resistance-genes","display_name":"multidrug resistance genes","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.7594848871231079},{"id":"https://openalex.org/C2778080818","wikidata":"https://www.wikidata.org/wiki/Q1788422","display_name":"Cross-resistance","level":2,"score":0.6289325952529907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5425811409950256},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.5353171825408936},{"id":"https://openalex.org/C2779338040","wikidata":"https://www.wikidata.org/wiki/Q19856779","display_name":"Mitomycin C","level":2,"score":0.4660395681858063},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46449756622314453},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45152488350868225},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.4263906478881836},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.419772207736969},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40887293219566345},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32494646310806274},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.27914655208587646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25308865308761597},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.22698253393173218}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmid:2897238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2897238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.318.1372","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.318.1372","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/48/12/3355.full.pdf","raw_type":"text"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/939a1b8b-d941-4300-988e-9eb84647bcf5","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/cisdiamminedichloroplatinumiiresistant-sublines-derived-from-two-human-ovarian-tumor-cell-lines(939a1b8b-d941-4300-988e-9eb84647bcf5).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer research, 48(12), 3355 - 3359. American Association for Cancer Research Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/bdb026e2-b5f8-4a26-940e-aac5e620cb82","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/bdb026e2-b5f8-4a26-940e-aac5e620cb82","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kuppen, P J, Schuitemaker, H, van 't Veer, L J, de Bruijn, E A, van Oosterom, A T & Schrier, P I 1988, 'cis-diamminedichloroplatinum(II)-resistant sublines derived from two human ovarian tumor cell lines', Cancer research, vol. 48, no. 12, pp. 3355-3359.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1551388901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2897238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7098307712","https://openalex.org/W1993732814","https://openalex.org/W1964226854","https://openalex.org/W1587516260","https://openalex.org/W1965510904","https://openalex.org/W1993678081","https://openalex.org/W1997185869","https://openalex.org/W1574590244","https://openalex.org/W2142771324","https://openalex.org/W2169548440"],"abstract_inverted_index":{"In":[0,29],"two":[1,147],"human":[2],"ovarian":[3],"tumor":[4],"cell":[5,52,148,210],"lines,":[6],"resistance":[7,90,112],"to":[8,20,69,82,104,113,130,151,156,167,183],"cis-diamminedichloroplatinum(II)":[9],"(CDDP)":[10],"was":[11,67,91,153,194],"induced":[12,89],"by":[13,120],"continuous":[14],"exposure":[15,36],"of":[16,37,137,159,175,201],"the":[17,26,74,105,114,140,146,162,168,190,208],"parental":[18],"lines":[19,76,79],"an":[21],"increasing":[22],"CDDP":[23,43,66,152],"concentration":[24],"in":[25,50,59,161,186,207],"culture":[27],"medium.":[28,61],"contrast,":[30],"a":[31,51,56,121],"six":[32],"times":[33,71],"repeated":[34],"pulse":[35],"6.7":[38],"microM":[39,42,86],"or":[40,199],"16.7":[41],"for":[44,65,73,139],"1":[45],"h":[46],"did":[47],"not":[48],"result":[49],"line":[53],"that":[54,111,179],"showed":[55,102],"higher":[57,72],"survival":[58],"CDDP-containing":[60],"The":[62,88,99,124,135,171],"ID50":[63],"value":[64],"seven":[68],"eight":[70],"resistant":[75,125,163,209],"and":[77,108,133,173],"those":[78],"were":[80,127],"able":[81],"grow":[83],"at":[84,94],"3.3":[85],"CDDP.":[87],"stable":[92],"during":[93],"least":[95],"25":[96],"doubling":[97],"times.":[98],"CDDP-resistant":[100],"sublines":[101,126],"cross-resistance":[103,138],"CDDP-analogues":[106],"cis-diammine-1,1-cyclobutane-dicarboxylateplatinum(II)":[107],"cis-dichlorobis(isopropylamine)-trans-dihydroxyplatinum(IV)":[109],"indicating":[110],"different":[115],"platinum":[116,160],"compounds":[117],"is":[118],"generated":[119],"common":[122],"mechanism.":[123],"also":[128,195],"cross-resistant":[129],"mitomycin":[131],"C":[132],"melphalan.":[134],"degree":[136],"tested":[141],"drugs":[142],"varied":[143],"widely":[144],"between":[145],"lines.":[149,211],"Resistance":[150],"clearly":[154],"correlated":[155],"decreased":[157],"amounts":[158],"cells":[164],"as":[165],"compared":[166],"sensitive":[169],"cells.":[170],"amplification":[172,198],"expression":[174],"genes":[176,203],"encoding":[177],"proteins":[178],"had":[180],"been":[181],"shown":[182,206],"be":[184,205],"involved":[185],"multidrug":[187],"resistance,":[188],"e.g.,":[189],"Mr":[191],"170,000":[192],"P-glycoprotein":[193],"studied.":[196],"No":[197],"overexpression":[200],"these":[202],"could":[204]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
