{"id":"https://openalex.org/W1551347530","doi":null,"title":"Tumor Heterogeneity in Uveal Melanomas","display_name":"Tumor Heterogeneity in Uveal Melanomas","publication_year":2010,"publication_date":"2010-05-26","ids":{"openalex":"https://openalex.org/W1551347530","mag":"1551347530"},"language":"en","primary_location":{"id":"pmh:oai:repub.eur.nl:19569","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/19569","pdf_url":"http://repub.eur.nl/pub/19569","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repub.eur.nl/pub/19569","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048549381","display_name":"Hanneke W. Mensink","orcid":"https://orcid.org/0000-0002-1245-0549","observed_orcids":["https://orcid.org/0000-0002-1245-0549"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hanneke W. Mensink","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5048549381"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uveal-melanoma","display_name":"uveal melanoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/choroidal-melanoma","display_name":"choroidal melanoma","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ciliary-body-melanoma","display_name":"ciliary body melanoma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/iris-melanoma","display_name":"iris melanoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metastatic-potential","display_name":"metastatic potential","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cytogenetic-analysis","display_name":"cytogenetic analysis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tumor-biopsy","display_name":"tumor biopsy","score":0.6010000109672546},{"id":"https://openalex.org/keywords/metastasis-detection","display_name":"metastasis detection","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.81154465675354},{"id":"https://openalex.org/C2776694393","wikidata":"https://www.wikidata.org/wiki/Q271762","display_name":"Choroid","level":3,"score":0.6542066335678101},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6059707403182983},{"id":"https://openalex.org/C2776713392","wikidata":"https://www.wikidata.org/wiki/Q278859","display_name":"Uvea","level":3,"score":0.5894456505775452},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5260807275772095},{"id":"https://openalex.org/C2778434524","wikidata":"https://www.wikidata.org/wiki/Q1048080","display_name":"Ciliary body","level":2,"score":0.5233516097068787},{"id":"https://openalex.org/C115477683","wikidata":"https://www.wikidata.org/wiki/Q2986954","display_name":"Transillumination","level":2,"score":0.4903123676776886},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4826951026916504},{"id":"https://openalex.org/C2776407710","wikidata":"https://www.wikidata.org/wiki/Q1672638","display_name":"Iridectomy","level":3,"score":0.4115833342075348},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3989922106266022},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.30087777972221375},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2796396315097809},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.08272731304168701},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:repub.eur.nl:19569","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/19569","pdf_url":"http://repub.eur.nl/pub/19569","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:eur:oai:pure.eur.nl:publications/587ae446-7c1f-47e9-8bcf-fe755d4e6535","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/587ae446-7c1f-47e9-8bcf-fe755d4e6535","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:eur:oai:repub.eur.nl:19569","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/19569","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:1551347530","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/19569/100526_Mensink, Hanneke Willemijn.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repub.eur.nl:19569","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/19569","pdf_url":"http://repub.eur.nl/pub/19569","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1551347530.pdf","grobid_xml":"https://content.openalex.org/works/W1551347530.grobid-xml"},"referenced_works_count":142,"referenced_works":["https://openalex.org/W25292458","https://openalex.org/W112563761","https://openalex.org/W123314342","https://openalex.org/W1491395496","https://openalex.org/W1506680628","https://openalex.org/W1521892020","https://openalex.org/W1542182445","https://openalex.org/W1551046150","https://openalex.org/W1566108832","https://openalex.org/W1590648476","https://openalex.org/W1591942236","https://openalex.org/W1668078587","https://openalex.org/W1922412792","https://openalex.org/W1929745677","https://openalex.org/W1964886243","https://openalex.org/W1972806534","https://openalex.org/W1973066896","https://openalex.org/W1973507943","https://openalex.org/W1974715203","https://openalex.org/W1978376074","https://openalex.org/W1978731309","https://openalex.org/W1983433202","https://openalex.org/W1983781571","https://openalex.org/W1986937402","https://openalex.org/W1987680648","https://openalex.org/W1988019690","https://openalex.org/W1989986928","https://openalex.org/W1991262919","https://openalex.org/W1991347924","https://openalex.org/W1994465394","https://openalex.org/W1995819860","https://openalex.org/W1996449685","https://openalex.org/W1997656125","https://openalex.org/W2002820066","https://openalex.org/W2003006686","https://openalex.org/W2003946492","https://openalex.org/W2013578996","https://openalex.org/W2013944616","https://openalex.org/W2019432751","https://openalex.org/W2019505133","https://openalex.org/W2020166857","https://openalex.org/W2022408230","https://openalex.org/W2024958564","https://openalex.org/W2025701563","https://openalex.org/W2026264906","https://openalex.org/W2026886490","https://openalex.org/W2027998941","https://openalex.org/W2028027318","https://openalex.org/W2029247510","https://openalex.org/W2030013985","https://openalex.org/W2033312370","https://openalex.org/W2033668318","https://openalex.org/W2037479635","https://openalex.org/W2039062929","https://openalex.org/W2040333162","https://openalex.org/W2040429923","https://openalex.org/W2041322119","https://openalex.org/W2042799015","https://openalex.org/W2044643325","https://openalex.org/W2046557593","https://openalex.org/W2046972425","https://openalex.org/W2049484965","https://openalex.org/W2051144764","https://openalex.org/W2053208278","https://openalex.org/W2053520756","https://openalex.org/W2054965969","https://openalex.org/W2055835855","https://openalex.org/W2060084956","https://openalex.org/W2062119090","https://openalex.org/W2062889582","https://openalex.org/W2062948694","https://openalex.org/W2063857182","https://openalex.org/W2066045734","https://openalex.org/W2066251475","https://openalex.org/W2067256262","https://openalex.org/W2068116723","https://openalex.org/W2068508262","https://openalex.org/W2068550037","https://openalex.org/W2070465958","https://openalex.org/W2072461683","https://openalex.org/W2072763798","https://openalex.org/W2073596489","https://openalex.org/W2075206831","https://openalex.org/W2080926419","https://openalex.org/W2082198095","https://openalex.org/W2085228839","https://openalex.org/W2087127698","https://openalex.org/W2089548634","https://openalex.org/W2089920133","https://openalex.org/W2091841363","https://openalex.org/W2094842968","https://openalex.org/W2096956347","https://openalex.org/W2100427081","https://openalex.org/W2100779485","https://openalex.org/W2101087025","https://openalex.org/W2102483598","https://openalex.org/W2107109105","https://openalex.org/W2112480698","https://openalex.org/W2113926943","https://openalex.org/W2116625737","https://openalex.org/W2119013789","https://openalex.org/W2121409748","https://openalex.org/W2121626779","https://openalex.org/W2122689100","https://openalex.org/W2129602789","https://openalex.org/W2130256950","https://openalex.org/W2132060134","https://openalex.org/W2132541143","https://openalex.org/W2133884697","https://openalex.org/W2134435289","https://openalex.org/W2135132914","https://openalex.org/W2137022580","https://openalex.org/W2138064172","https://openalex.org/W2139771875","https://openalex.org/W2140721592","https://openalex.org/W2141975700","https://openalex.org/W2143007752","https://openalex.org/W2143362349","https://openalex.org/W2145999792","https://openalex.org/W2146948473","https://openalex.org/W2149628903","https://openalex.org/W2149864958","https://openalex.org/W2153579158","https://openalex.org/W2157070790","https://openalex.org/W2157635590","https://openalex.org/W2157993533","https://openalex.org/W2158207797","https://openalex.org/W2160706109","https://openalex.org/W2160903712","https://openalex.org/W2161389383","https://openalex.org/W2166771927","https://openalex.org/W2167054318","https://openalex.org/W2169392527","https://openalex.org/W2178428592","https://openalex.org/W2236375555","https://openalex.org/W2290326436","https://openalex.org/W2328582512","https://openalex.org/W2339359539","https://openalex.org/W2402192857","https://openalex.org/W2419764759","https://openalex.org/W2500925439","https://openalex.org/W2595157283"],"related_works":["https://openalex.org/W4211100001","https://openalex.org/W2894389878","https://openalex.org/W3206647117","https://openalex.org/W2990345573","https://openalex.org/W4214697062","https://openalex.org/W1954955632","https://openalex.org/W1535379562","https://openalex.org/W2017118651","https://openalex.org/W2527296714","https://openalex.org/W2300594963"],"abstract_inverted_index":{"Uveal":[0],"melanoma":[1,70],"(UM)":[2],"is":[3,48,169],"the":[4,24,44,67,85,96,107,122,128,140,145,157,172,176,192,220,242],"most":[5],"common":[6,109],"primary":[7,221],"intraocular":[8],"malignancy":[9],"in":[10,28,41,43,55,58,95,144,162],"adults\\nwith":[11],"an":[12],"incidence":[13],"of":[14,32,61,121,139,175,194,200,216,219,236,241],"7-10/":[15],"million":[16],"and":[17,30,87,102,110,136,159,187,231],"has":[18,36],"a":[19,39,115,151],"predilection":[20],"for":[21,51,198,210,226],"hematogenous":[22],"dissemination\\nto":[23],"liver.":[25],"Despite":[26],"improvements":[27],"diagnosis":[29,168,193,218,237],"treatment":[31],"this":[33],"intraocular\\ntumor,":[34],"there":[35],"not":[37],"been":[38],"change":[40],"survival":[42],"past":[45],"decades.":[46],"There":[47],"no":[49],"effective\\ntreatment":[50],"liver":[52,232],"metastases":[53,227],"resulting":[54],"tumor-related":[56],"death":[57],"about":[59],"45%":[60],"UM\\npatients":[62],"within":[63],"15":[64],"years":[65],"after":[66],"initial":[68],"diagnosis.\\nUveal":[69],"usually":[71,125],"arises":[72],"\u2018de":[73],"novo\u2019":[74],"from":[75,78],"melanocytes":[76],"derived":[77],"neural":[79],"crest\\ncells":[80],"that":[81],"have":[82],"migrated":[83],"to":[84,112,127],"epidermis":[86],"uveal":[88],"tract":[89],"during":[90],"embryogenesis.":[91],"Intraocular\\nmelanoma":[92],"may":[93],"arise":[94],"choroid":[97],"(70-80%),":[98],"ciliary":[99,146],"body":[100,147],"(10-20%)":[101],"iris\\n(5-10%).":[103],"Iris":[104,130],"melanomas":[105,155],"are":[106,124,148,224],"least":[108],"tend":[111],"present":[113],"at":[114],"smaller":[116],"size,\\nprobably":[117],"because":[118],"pigmented":[119],"lesions":[120],"iris":[123],"visible":[126],"patient.":[129],"melanomas\\ncan":[131],"cause":[132],"drainage":[133],"angle":[134],"blockage":[135],"secondary":[137],"elevation":[138],"intraocular\\npressure.4":[141],"Melanomas":[142],"located":[143],"associated":[149],"with":[150],"high":[152],"metastatic\\npotential.":[153],"Choroidal":[154],"compromise":[156],"majority":[158],"grow":[160],"subretinal":[161],"a\\ndiscoid,":[163],"dome-shaped":[164],"or":[165],"mushroom-shaped":[166],"pattern.\\nThe":[167],"based":[170],"on":[171,178],"clinical":[173],"appearance":[174],"tumor":[177,204],"ophthalmic":[179],"examination.\\nAncillary":[180],"tests":[181,230],"include":[182],"(Doppler-)":[183],"ultrasonography,":[184],"transillumination,":[185],"fluorescein\\nangiography":[186],"optical":[188],"coherence":[189],"tomography.":[190],"For":[191],"melanoma,":[195],"biopsy\\nis":[196],"reserved":[197],"tumors":[199],"uncertain":[201],"origin.":[202],"Conversely,":[203],"biopsy":[205],"gains":[206],"territory":[207],"in\\nvision-sparing":[208],"therapies":[209],"cytogenetic":[211],"analysis":[212],"providing":[213],"risk":[214],"assessment":[215],"metastatic\\ndisease.\\nUpon":[217],"tumor,":[222],"patients":[223,243],"screened":[225],"by":[228],"liver\\nenzyme":[229],"ultrasound.":[233],"At":[234],"time":[235],"less":[238],"than":[239],"2%":[240],"have\\ndetectable":[244],"metastases.":[245]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}