{"id":"https://openalex.org/W155129271","doi":null,"title":"[Human serum alcaline phosphatase and ageing].","display_name":"[Human serum alcaline phosphatase and ageing].","publication_year":2003,"publication_date":"2003-11-01","ids":{"openalex":"https://openalex.org/W155129271","mag":"155129271","pmid":"https://pubmed.ncbi.nlm.nih.gov/15631850"},"language":"pt","primary_location":{"id":"pmid:15631850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15631850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica portuguesa","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1221","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015251438","display_name":"Rita Negr\u00e3o","orcid":"https://orcid.org/0000-0002-0733-4412","observed_orcids":["https://orcid.org/0000-0002-0733-4412"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"M R Negr\u00e3o","raw_affiliation_strings":["Servi\u00e7o de Bioquimica (U-38 FCT), Faculdade de Medicina, Universidade do Porto, Porto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servi\u00e7o de Bioquimica (U-38 FCT), Faculdade de Medicina, Universidade do Porto, Porto","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100652522","display_name":"Maria Jo\u00e3o Martins","orcid":"https://orcid.org/0000-0002-3560-3261","observed_orcids":["https://orcid.org/0000-0002-3560-3261"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Martins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026161299","display_name":"Elisabete Ramos","orcid":"https://orcid.org/0000-0001-6573-218X","observed_orcids":["https://orcid.org/0000-0001-6573-218X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Ramos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H Barros","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Barros","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011970159","display_name":"C\u00e2ndido Hip\u00f3lito-Reis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Hip\u00f3lito-Reis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101839151","display_name":"Isabel Azevedo","orcid":"https://orcid.org/0000-0002-9814-6846","observed_orcids":["https://orcid.org/0000-0002-9814-6846"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Azevedo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.02174782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"16","issue":"6","first_page":"395","last_page":"400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-alkaline-phosphatase","display_name":"serum alkaline phosphatase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9290000200271606},{"id":"https://openalex.org/keywords/aging-biomarkers","display_name":"aging biomarkers","score":0.6340000033378601},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6779999732971191},{"id":"https://openalex.org/keywords/middle-aged-and-older-adults","display_name":"middle-aged and older adults","score":0.5950000286102295},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.8914881348609924},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.8023895621299744},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.6211726665496826},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6000453233718872},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5940741300582886},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47368717193603516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4414829909801483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3419725298881531},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.331114262342453},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.33044272661209106},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2800074815750122},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23746299743652344},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15631850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15631850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica portuguesa","raw_type":"English Abstract"},{"id":"pmh:oai:ojs.www.actamedicaportuguesa.com:article/1221","doi":null,"is_oa":true,"landing_page_url":"https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1221","pdf_url":"https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1221","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"0870-399X","raw_type":"journal article"},{"id":"mag:155129271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15631850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:ojs.www.actamedicaportuguesa.com:article/1221","doi":null,"is_oa":true,"landing_page_url":"https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1221","pdf_url":"https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1221","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"0870-399X","raw_type":"journal article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W155129271.pdf","grobid_xml":"https://content.openalex.org/works/W155129271.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2342939058","https://openalex.org/W2097090099","https://openalex.org/W2006221657","https://openalex.org/W2369547537","https://openalex.org/W2414203076","https://openalex.org/W2413667128","https://openalex.org/W2473109189","https://openalex.org/W2982225161","https://openalex.org/W2324577900","https://openalex.org/W2139516394"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,53],"experimental":[2,139],"ageing":[3],"models":[4],"an":[5],"inverse":[6],"relationship":[7],"between":[8,108],"age":[9,30,114,129],"and":[10,31,69,113],"alkaline":[11,23,35,58,83,111,121],"phosphatase":[12,24,36,59,84,112,122],"activity":[13,25,123],"has":[14,135],"been":[15,136],"observed.":[16],"OBJECTIVE:":[17],"To":[18],"characterize":[19],"serum":[20,57,82,110],"levels":[21],"of":[22,43,100,128],"in":[26,39,80,130],"humans":[27],"according":[28],"to":[29,65,88,133],"gender.":[32],"METHODS:":[33],"Serum":[34,120],"was":[37,76,103],"determined":[38],"a":[40,77,94,104,126],"random":[41],"sample":[42],"203":[44],"community":[45],"dwellers":[46],"aged":[47],"40":[48],"or":[49],"more":[50],"years.":[51],"RESULTS:":[52],"men":[54],"(n=87)":[55],"total":[56,81,109],"markedly":[60],"increased":[61],"from":[62,85],"the":[63,66,86,89,116],"5th":[64,87],"6th":[67,90],"decade":[68],"then":[70],"stabilized.":[71],"For":[72],"women":[73],"(n=116)":[74],"there":[75],"slight":[78],"increase":[79],"decade,":[91],"followed":[92],"by":[93],"bend":[95],"upward":[96],"after":[97],"69":[98],"years":[99],"age.":[101],"There":[102],"significant":[105],"positive":[106],"correlation":[107],"for":[115,138],"whole":[117],"population.":[118],"CONCLUSIONS:":[119],"appears":[124],"as":[125],"biomarker":[127],"humans,":[131],"similarly":[132],"what":[134],"described":[137],"animal":[140],"models.":[141]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}