{"id":"https://openalex.org/W155120875","doi":null,"title":"VCL-CB01, an injectable bivalent plasmid DNA vaccine for potential protection against CMV disease and infection.","display_name":"VCL-CB01, an injectable bivalent plasmid DNA vaccine for potential protection against CMV disease and infection.","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W155120875","mag":"155120875","pmid":"https://pubmed.ncbi.nlm.nih.gov/19806506","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3539801"},"language":"en","primary_location":{"id":"pmid:19806506","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19806506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in molecular therapeutics","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3539801/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079669354","display_name":"Mark R. Schleiss","orcid":"https://orcid.org/0000-0002-2108-9433","observed_orcids":["https://orcid.org/0000-0002-2108-9433"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark R Schleiss","raw_affiliation_strings":["University of Minnesota, Center for Infectious Diseases and Microbiology Translational Research, Department of Pediatrics, Minneapolis, MN 55455, USA. schleiss@umn.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Center for Infectious Diseases and Microbiology Translational Research, Department of Pediatrics, Minneapolis, MN 55455, USA. schleiss@umn.edu","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079669354"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":0.2808,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.25030525,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"5","first_page":"572","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"human cytomegalovirus","score":0.847000002861023},{"id":"https://openalex.org/keywords/dna-vaccine","display_name":"DNA vaccine","score":0.8849999904632568},{"id":"https://openalex.org/keywords/glycoprotein-b","display_name":"glycoprotein B","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hematopoietic-cell-transplant-recipients","display_name":"hematopoietic cell transplant recipients","score":0.8299999833106995},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.7250000238418579},{"id":"https://openalex.org/keywords/congenital-cytomegalovirus-infection","display_name":"congenital cytomegalovirus infection","score":0.8539999723434448},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.6710000038146973},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.7791303396224976},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.5973275899887085},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5941065549850464},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5907595753669739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5771898031234741},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5616635680198669},{"id":"https://openalex.org/C2777760223","wikidata":"https://www.wikidata.org/wiki/Q6889412","display_name":"Modified vaccinia Ankara","level":5,"score":0.5119484663009644},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5107803344726562},{"id":"https://openalex.org/C2781356689","wikidata":"https://www.wikidata.org/wiki/Q1986297","display_name":"Vaccinia","level":4,"score":0.4483887553215027},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.41310808062553406},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2759774923324585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2640897333621979},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.23763743042945862},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.12692227959632874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11377260088920593},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010330","descriptor_name":"Patents as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D022482","descriptor_name":"Cytomegalovirus Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D022482","descriptor_name":"Cytomegalovirus Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022482","descriptor_name":"Cytomegalovirus Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:19806506","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19806506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in molecular therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3539801","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3539801/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Mol Ther","raw_type":"Text"},{"id":"mag:155120875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19806506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3539801","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3539801/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Mol Ther","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1533193684","display_name":"Vaccines for Prevention of Experimental Congenital CMV","funder_award_id":"R01HD038416","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4697973561","display_name":"Viral immunomodulation and rational CMV vaccine design","funder_award_id":"R01HD044864","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W612006049","https://openalex.org/W1556818178","https://openalex.org/W1604413850","https://openalex.org/W1906427088","https://openalex.org/W1971742580","https://openalex.org/W1998918002","https://openalex.org/W2014576556","https://openalex.org/W2016777057","https://openalex.org/W2029740318","https://openalex.org/W2031041815","https://openalex.org/W2039673714","https://openalex.org/W2051192335","https://openalex.org/W2053901884","https://openalex.org/W2054846547","https://openalex.org/W2060372252","https://openalex.org/W2068392260","https://openalex.org/W2074117200","https://openalex.org/W2076421330","https://openalex.org/W2089878211","https://openalex.org/W2096655931","https://openalex.org/W2102760151","https://openalex.org/W2103849595","https://openalex.org/W2108626188","https://openalex.org/W2117068105","https://openalex.org/W2120365277","https://openalex.org/W2120426862","https://openalex.org/W2120841678","https://openalex.org/W2123440147","https://openalex.org/W2133963802","https://openalex.org/W2138567003","https://openalex.org/W2145301696","https://openalex.org/W2167842251","https://openalex.org/W2185242646","https://openalex.org/W2434360823","https://openalex.org/W2616662114"],"related_works":["https://openalex.org/W7099138142","https://openalex.org/W2076421330","https://openalex.org/W2010740805","https://openalex.org/W2596012696","https://openalex.org/W2089878211","https://openalex.org/W2065120197","https://openalex.org/W2091605282","https://openalex.org/W2051192335","https://openalex.org/W2165458775","https://openalex.org/W2469521588"],"abstract_inverted_index":{"Vaccines":[0],"for":[1,55,64,138,160],"the":[2,26,43,65,87,130,161],"prevention":[3,66,162],"of":[4,37,42,46,67,136,155,163],"human":[5],"CMV":[6],"(hCMV)":[7],"infection":[8,69],"and":[9,70,86,149],"disease":[10,144],"are":[11],"a":[12,34,73,94,109],"major":[13,35,88],"public":[14],"health":[15],"priority.":[16],"Immunization":[17],"with":[18,124],"DNA":[19,47,76],"vaccines":[20,159],"encoding":[21,81],"key":[22],"proteins":[23],"involved":[24],"in":[25,49,98,113,145],"immune":[27],"response":[28],"to":[29,141,152],"hCMV":[30,68,82,89,143,165],"has":[31,52],"emerged":[32],"as":[33],"focus":[36],"hcmv":[38],"vaccine":[39,77],"research.":[40],"Validation":[41],"protective":[44],"effect":[45],"vaccination":[48],"animal":[50],"models":[51],"provided":[53],"support":[54],"clinical":[56],"trials.":[57],"VCL-CB01,":[58],"under":[59],"development":[60],"by":[61],"Vical":[62],"Inc":[63],"disease,":[71],"is":[72],"poloxamer-formulated,":[74],"bivalent":[75],"that":[78],"contains":[79],"plasmids":[80],"tegument":[83],"phosphoprotein":[84],"65":[85],"surface":[90],"glycoprotein":[91],"B.":[92],"In":[93,105],"phase":[95,110,131],"I":[96],"trial":[97,112,133],"healthy":[99],"adults,":[100],"VCL-CB01":[101,119,156],"was":[102],"well":[103],"tolerated.":[104],"interim":[106],"results":[107,128],"from":[108,129],"II":[111,132],"hCMV-seropositive":[114,146],"hematopoietic":[115],"cell":[116],"transplant":[117,147],"recipients,":[118,148],"increased":[120],"T-cell":[121],"responses":[122],"compared":[123],"placebo.":[125],"The":[126],"final":[127],"will":[134],"be":[135],"value":[137],"developing":[139],"strategies":[140],"prevent":[142],"may":[150],"lead":[151],"other":[153],"trials":[154],"or":[157],"related":[158],"congenital":[164],"infection.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}