{"id":"https://openalex.org/W1550606187","doi":"https://doi.org/10.1002/cpdd.58","title":"Pharmacokinetics of a Single 150\u2010mg Intravenous Infusion of Fosaprepitant: Effects of Concentration and Infusion Time in Healthy Japanese Men","display_name":"Pharmacokinetics of a Single 150\u2010mg Intravenous Infusion of Fosaprepitant: Effects of Concentration and Infusion Time in Healthy Japanese Men","publication_year":2013,"publication_date":"2013-08-26","ids":{"openalex":"https://openalex.org/W1550606187","doi":"https://doi.org/10.1002/cpdd.58","mag":"1550606187","pmid":"https://pubmed.ncbi.nlm.nih.gov/27121944"},"language":"en","primary_location":{"id":"doi:10.1002/cpdd.58","doi":"https://doi.org/10.1002/cpdd.58","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cpdd.58","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cpdd.58","source":{"id":"https://openalex.org/S2764863641","display_name":"Clinical Pharmacology in Drug Development","issn_l":"2160-763X","issn":["2160-763X","2160-7648"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology in Drug Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cpdd.58","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029185764","display_name":"Junichi Azuma","orcid":"https://orcid.org/0000-0001-8758-8537","observed_orcids":["https://orcid.org/0000-0001-8758-8537"]},"institutions":[{"id":"https://openalex.org/I108169390","display_name":"Hyogo University of Health Sciences","ror":"https://ror.org/056d9c052","country_code":"JP","type":"education","lineage":["https://openalex.org/I108169390","https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Junichi Azuma","raw_affiliation_strings":["Department of Pharmacy, School of Pharmacy Hyogo University of Health Sciences Kobe Hyogo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, School of Pharmacy Hyogo University of Health Sciences Kobe Hyogo Japan","institution_ids":["https://openalex.org/I108169390"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023716912","display_name":"Hiroyuki Fukase","orcid":"https://orcid.org/0000-0002-9488-0947","observed_orcids":["https://orcid.org/0000-0002-9488-0947"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Fukase","raw_affiliation_strings":["CPC Clinical Trial Hospital, Medical Research Institute, Kagoshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CPC Clinical Trial Hospital, Medical Research Institute, Kagoshima, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029185764"],"corresponding_institution_ids":["https://openalex.org/I108169390"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":0.3187,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.60330726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"2","issue":"4","first_page":"394","last_page":"399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fosaprepitant","display_name":"fosaprepitant","score":0.9490000009536743},{"id":"https://openalex.org/keywords/aprepitant","display_name":"aprepitant","score":0.8389999866485596},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.906000018119812},{"id":"https://openalex.org/keywords/intravenous-infusion","display_name":"intravenous infusion","score":0.8209999799728394},{"id":"https://openalex.org/keywords/infusion-time","display_name":"infusion duration","score":0.8569999933242798},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.5879999995231628},{"id":"https://openalex.org/keywords/nk1-receptor-antagonists","display_name":"NK1 receptor antagonists","score":0.8830000162124634},{"id":"https://openalex.org/keywords/chemotherapy-induced-nausea-and-vomiting","display_name":"chemotherapy-induced nausea and vomiting","score":0.9259999990463257},{"id":"https://openalex.org/keywords/infusion-site-reactions","display_name":"infusion site reactions","score":0.7480000257492065},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.7699999809265137},{"id":"https://openalex.org/keywords/japanese-men","display_name":"Japanese men","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9562049508094788},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7487167119979858},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4469880759716034},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.377936989068985}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/cpdd.58","doi":"https://doi.org/10.1002/cpdd.58","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cpdd.58","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cpdd.58","source":{"id":"https://openalex.org/S2764863641","display_name":"Clinical Pharmacology in Drug Development","issn_l":"2160-763X","issn":["2160-763X","2160-7648"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology in Drug Development","raw_type":"journal-article"},{"id":"pmid:27121944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27121944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology in drug development","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/cpdd.58","doi":"https://doi.org/10.1002/cpdd.58","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cpdd.58","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cpdd.58","source":{"id":"https://openalex.org/S2764863641","display_name":"Clinical Pharmacology in Drug Development","issn_l":"2160-763X","issn":["2160-763X","2160-7648"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology in Drug Development","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320319101","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37"},{"id":"https://openalex.org/F4320327845","display_name":"Ono Pharmaceutical","ror":"https://ror.org/022jefx64"},{"id":"https://openalex.org/F4320332932","display_name":"Merck Sharp and Dohme","ror":"https://ror.org/004nn4n27"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1550606187.pdf","grobid_xml":"https://content.openalex.org/works/W1550606187.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1993434718","https://openalex.org/W1994776603","https://openalex.org/W2003594967","https://openalex.org/W2065765429","https://openalex.org/W2107985230","https://openalex.org/W2116682901","https://openalex.org/W2123267000","https://openalex.org/W2123287399","https://openalex.org/W2151215840","https://openalex.org/W2165395427","https://openalex.org/W2396559747"],"related_works":["https://openalex.org/W2088696807","https://openalex.org/W2075514879","https://openalex.org/W2058365305","https://openalex.org/W4306912690","https://openalex.org/W4408376462","https://openalex.org/W2798041563","https://openalex.org/W3110114426","https://openalex.org/W2462891655","https://openalex.org/W2027199330","https://openalex.org/W2003594967"],"abstract_inverted_index":{"PURPOSE:":[0],"Fosaprepitant":[1],"dimeglumine":[2],"(Proemend\u00ae":[3],"for":[4,25,62,192],"Injection;":[5],"formerly":[6],"ONO-7847)":[7],"is":[8,13,165],"a":[9,46,131,159],"phosphorylated":[10],"prodrug":[11],"that":[12,148,164],"rapidly":[14],"converted":[15],"to":[16,100,167,189],"aprepitant,":[17],"an":[18],"oral":[19],"selective":[20],"neurokinin-1":[21],"receptor":[22],"antagonist":[23],"approved":[24],"the":[26,38,63,90,95,101,112,168,183],"prevention":[27],"of":[28,43,65,92],"chemotherapy-induced":[29],"nausea":[30],"and":[31,41,75,153,161,175,194],"vomiting.":[32],"This":[33],"Phase":[34],"1":[35],"study":[36,121],"evaluated":[37],"pharmacokinetics,":[39],"safety,":[40],"tolerability":[42],"fosaprepitant":[44,80,149,185],"after":[45,89],"single":[47],"intravenous":[48,169],"dose":[49,170],"in":[50,111,119,142],"healthy":[51],"Japanese":[52],"men.":[53],"METHODS:":[54],"All":[55],"fosaprepitant-":[56],"or":[57],"placebo-treated":[58],"subjects":[59,70],"were":[60,71,109,122,140],"assessed":[61],"occurrence":[64],"adverse":[66,116],"events.":[67],"RESULTS:":[68],"Ninety":[69],"randomized":[72],"into":[73],"treatment":[74],"placebo":[76],"groups.":[77],"The":[78,178],"plasma":[79],"concentrations":[81,152],"generally":[82],"reached":[83],"steady":[84],"state":[85],"by":[86,182],"15":[87],"minutes":[88],"start":[91],"infusion.":[93],"Although":[94],"maximum":[96],"concentration":[97],"was":[98],"proportional":[99],"infusion":[102,125,136,156],"time,":[103],"no":[104],"clinically":[105],"important":[106],"pharmacokinetic":[107,160],"differences":[108],"noted":[110],"cohorts":[113],"examined.":[114],"Most":[115],"events":[117,139],"observed":[118],"this":[120],"associated":[123],"with":[124,134],"site":[126],"reactions,":[127],"which":[128],"tended":[129],"toward":[130],"higher":[132],"incidence":[133],"shorter":[135],"times.":[137],"These":[138,145],"mild":[141],"severity.":[143],"CONCLUSIONS:":[144],"findings":[146],"demonstrate":[147],"at":[150],"different":[151,155],"over":[154],"times":[157],"has":[158],"safety":[162],"profile":[163],"comparable":[166],"previously":[171],"established":[172],"as":[173],"efficacious":[174],"well":[176],"tolerated.":[177],"dosing":[179],"flexibility":[180],"afforded":[181],"single-dose":[184],"formulation":[186],"should":[187],"lead":[188],"greater":[190],"convenience":[191],"patients":[193],"health":[195],"care":[196],"providers.":[197]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}