{"id":"https://openalex.org/W1550436698","doi":"https://doi.org/10.4081/hmr.v1i8.297","title":"Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in heavily pretreated patients with hematological malignancies","display_name":"Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in heavily pretreated patients with hematological malignancies","publication_year":2009,"publication_date":"2009-06-03","ids":{"openalex":"https://openalex.org/W1550436698","doi":"https://doi.org/10.4081/hmr.v1i8.297","mag":"1550436698"},"language":"en","primary_location":{"id":"doi:10.4081/hmr.v1i8.297","doi":"https://doi.org/10.4081/hmr.v1i8.297","is_oa":true,"landing_page_url":"https://doi.org/10.4081/hmr.v1i8.297","pdf_url":null,"source":{"id":"https://openalex.org/S5406969797","display_name":"Hematology Meeting Reports","issn_l":"1970-7339","issn":["1970-7339"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319913","host_organization_name":"PAGEPress (Italy)","host_organization_lineage":["https://openalex.org/P4310319913"],"host_organization_lineage_names":["PAGEPress (Italy)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology Meeting Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4081/hmr.v1i8.297","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070856416","display_name":"OA O\u2019Connor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"OA O\u2019Connor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5070856416"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"1","issue":"8","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.9629999995231628},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.9729999899864197},{"id":"https://openalex.org/keywords/heavily-pretreated-patients","display_name":"heavily pretreated patients","score":0.9039999842643738},{"id":"https://openalex.org/keywords/intravenous-formulation","display_name":"intravenous formulation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/oral-formulations","display_name":"oral dosage forms","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.871999979019165},{"id":"https://openalex.org/keywords/histone-acetyltransferase","display_name":"histone acetyltransferase","score":0.7850000262260437},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.45899999141693115},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.7392803430557251},{"id":"https://openalex.org/C2776281265","wikidata":"https://www.wikidata.org/wiki/Q420327","display_name":"Hydroxamic acid","level":2,"score":0.5534378886222839},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5189218521118164},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.4973035156726837},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4584192633628845},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3378661274909973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.323543518781662},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.30963778495788574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2617615759372711},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.06258848309516907},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06052282452583313},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.059764564037323}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.4081/hmr.v1i8.297","doi":"https://doi.org/10.4081/hmr.v1i8.297","is_oa":true,"landing_page_url":"https://doi.org/10.4081/hmr.v1i8.297","pdf_url":null,"source":{"id":"https://openalex.org/S5406969797","display_name":"Hematology Meeting Reports","issn_l":"1970-7339","issn":["1970-7339"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319913","host_organization_name":"PAGEPress (Italy)","host_organization_lineage":["https://openalex.org/P4310319913"],"host_organization_lineage_names":["PAGEPress (Italy)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology Meeting Reports","raw_type":"journal-article"},{"id":"mag:1550436698","doi":null,"is_oa":false,"landing_page_url":"http://www.pagepress.org/journals/index.php/hmr/article/view/297","pdf_url":null,"source":{"id":"https://openalex.org/S4306512029","display_name":"Hematology Meeting Reports (formerly Haematologica Reports)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Hematology Meeting Reports (formerly Haematologica Reports)","raw_type":null}],"best_oa_location":{"id":"doi:10.4081/hmr.v1i8.297","doi":"https://doi.org/10.4081/hmr.v1i8.297","is_oa":true,"landing_page_url":"https://doi.org/10.4081/hmr.v1i8.297","pdf_url":null,"source":{"id":"https://openalex.org/S5406969797","display_name":"Hematology Meeting Reports","issn_l":"1970-7339","issn":["1970-7339"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319913","host_organization_name":"PAGEPress (Italy)","host_organization_lineage":["https://openalex.org/P4310319913"],"host_organization_lineage_names":["PAGEPress (Italy)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology Meeting Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2052453190","https://openalex.org/W4301038577","https://openalex.org/W1965162825","https://openalex.org/W2373366538","https://openalex.org/W2380287092","https://openalex.org/W1991660464","https://openalex.org/W2043721269","https://openalex.org/W2167247938","https://openalex.org/W2581421381","https://openalex.org/W2030145184"],"abstract_inverted_index":{"HDACIs":[0],"are":[1,25,115],"a":[2],"novel":[3],"class":[4],"of":[5,11,28,55,64,67,85],"anti-cancer":[6],"drugs":[7],"whose":[8],"primary":[9],"mechanism":[10],"action":[12],"revolves":[13],"around":[14],"altering":[15],"chromatin":[16],"structure,":[17],"and":[18,37,59,96,122],"subsequently,":[19],"gene":[20],"expression.":[21],"At":[22],"present,":[23],"there":[24],"several":[26,65,83],"classes":[27],"compounds":[29,47],"that":[30,34],"have":[31,48,79,91,107],"been":[32,49,80,92,109],"identified":[33],"inhibit":[35,52,61],"HDACs":[36,58,106,114],"cause":[38],"transformed":[39],"cell":[40],"growth":[41,63],"arrest,":[42],"differentiation":[43],"and/or":[44],"apoptosis.":[45],"These":[46],"shown":[50],"to":[51,60,117],"the":[53,62],"activity":[54],"partially":[56],"purified":[57],"types":[66,84],"cancers":[68],"in":[69,74,82,99,105,111],"tumor":[70,123],"bearing":[71],"models.":[72],"Alterations":[73],"histone":[75],"acetyl":[76],"transferases":[77],"(HATs)":[78],"reported":[81,110],"cancer,":[86,112],"as":[87],"genes":[88],"encoding":[89],"HATS":[90],"translocated,":[93],"amplified,":[94],"over-expressed":[95],"or":[97],"mutated":[98],"different":[100],"malignancies.":[101],"Conversely,":[102],"specific":[103],"alterations":[104],"not":[108],"though":[113],"known":[116],"be":[118],"associated":[119],"with":[120],"oncogenes":[121],"suppressor":[124],"genes.":[125]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-08-19T15:00:24.278416","created_date":"2016-06-24T00:00:00"}
