{"id":"https://openalex.org/W1550055752","doi":"https://doi.org/10.1016/s0021-9258(19)50398-2","title":"Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor.","display_name":"Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor.","publication_year":1992,"publication_date":"1992-05-01","ids":{"openalex":"https://openalex.org/W1550055752","doi":"https://doi.org/10.1016/s0021-9258(19)50398-2","mag":"1550055752","pmid":"https://pubmed.ncbi.nlm.nih.gov/1315748"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)50398-2","doi":"https://doi.org/10.1016/s0021-9258(19)50398-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)50398-2","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)50398-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044286863","display_name":"David P. Olson","orcid":"https://orcid.org/0000-0001-9249-7760","observed_orcids":["https://orcid.org/0000-0001-9249-7760"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"D Olson","raw_affiliation_strings":["Institute of Microbiology, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049156695","display_name":"J P\u00f6ll\u00e4nen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"J P\u00f6ll\u00e4nen","raw_affiliation_strings":["Institute of Microbiology, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083589922","display_name":"Gunilla H\u00f8yer\u2010Hansen","orcid":"https://orcid.org/0000-0003-1007-1585","observed_orcids":["https://orcid.org/0000-0003-1007-1585"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"G H\u00f8yer-Hansen","raw_affiliation_strings":["Institute of Microbiology, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109193342","display_name":"Ebbe R\u00f8nne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"E R\u00f8nne","raw_affiliation_strings":["Institute of Microbiology, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039558836","display_name":"Kazuyasu Sakaguchi","orcid":"https://orcid.org/0000-0002-8434-4171","observed_orcids":["https://orcid.org/0000-0002-8434-4171"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"K Sakaguchi","raw_affiliation_strings":["Institute of Microbiology, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046844370","display_name":"Tze-Chein Wun","orcid":"https://orcid.org/0000-0001-5823-4166","observed_orcids":["https://orcid.org/0000-0001-5823-4166"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"T.C. Wun","raw_affiliation_strings":["Institute of Microbiology, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036354240","display_name":"Ettore Appella","orcid":"https://orcid.org/0000-0003-0569-9722","observed_orcids":["https://orcid.org/0000-0003-0569-9722"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"E Appella","raw_affiliation_strings":["Institute of Microbiology, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011022273","display_name":"Keld Dan\u00f8","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"K Dan\u00f8","raw_affiliation_strings":["Institute of Microbiology, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106122483","display_name":"Francesco Blasi","orcid":"https://orcid.org/0000-0001-9406-1784","observed_orcids":["https://orcid.org/0000-0001-9406-1784"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"F Blasi","raw_affiliation_strings":["Institute of Microbiology, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":13.6318,"has_fulltext":false,"cited_by_count":184,"citation_normalized_percentile":{"value":0.99359175,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"267","issue":"13","first_page":"9129","last_page":"9133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urokinase-receptor","display_name":"urokinase receptor","score":0.9309999942779541},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.8920000195503235},{"id":"https://openalex.org/keywords/receptor-downregulation","display_name":"receptor down-regulation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.8510000109672546},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.7559999823570251},{"id":"https://openalex.org/keywords/receptor-specificity","display_name":"receptor specificity","score":0.4580000042915344},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/phosphatidylinositol-specific-phospholipase-c","display_name":"phosphatidylinositol-specific phospholipase C","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.9136335849761963},{"id":"https://openalex.org/C2776892390","wikidata":"https://www.wikidata.org/wiki/Q7119591","display_name":"Urokinase","level":2,"score":0.8630702495574951},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.7160801887512207},{"id":"https://openalex.org/C56219504","wikidata":"https://www.wikidata.org/wiki/Q7900869","display_name":"Urokinase receptor","level":3,"score":0.6551311016082764},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.596060037612915},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5173918008804321},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32191991806030273},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20180031657218933},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19879639148712158},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1947927176952362},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1600784957408905}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015849","descriptor_name":"Plasminogen Inactivators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043265","descriptor_name":"Phosphatidylinositol Diacylglycerol-Lyase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054801","descriptor_name":"Phosphoinositide Phospholipase C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055293","descriptor_name":"Receptors, Urokinase Plasminogen Activator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0021-9258(19)50398-2","doi":"https://doi.org/10.1016/s0021-9258(19)50398-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)50398-2","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:1315748","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1315748","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/0df7ba00-74d0-11db-bee9-02004c4f4f50","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/0df7ba00-74d0-11db-bee9-02004c4f4f50","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Olson, D, P\u00f6ll\u00e4nen, J, R\u00f8nne, E, H\u00f8yer-Hansen, G, Sakaguchi, S, Wun, T-C, Appella, E, Dan\u00f8, K & Blasi, R 1992, 'Internalization of the urokinase plasminogen activator inhibirot type 1 complex is mediated by the urokinase receptor', The Journal of Biological Chemistry, no. Vol. 267, No. 13, pp. 9129-9133.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)50398-2","doi":"https://doi.org/10.1016/s0021-9258(19)50398-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)50398-2","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W23122061","https://openalex.org/W45293395","https://openalex.org/W347725972","https://openalex.org/W1491824111","https://openalex.org/W1511550220","https://openalex.org/W1552642838","https://openalex.org/W1558212310","https://openalex.org/W1572187798","https://openalex.org/W1581591459","https://openalex.org/W1584486859","https://openalex.org/W1611413521","https://openalex.org/W1853643611","https://openalex.org/W1964469282","https://openalex.org/W1970218306","https://openalex.org/W1977659044","https://openalex.org/W1997526503","https://openalex.org/W2011936885","https://openalex.org/W2018906560","https://openalex.org/W2019144916","https://openalex.org/W2026433576","https://openalex.org/W2030244371","https://openalex.org/W2049631846","https://openalex.org/W2053808100","https://openalex.org/W2056274413","https://openalex.org/W2074352600","https://openalex.org/W2089693544","https://openalex.org/W2114656038","https://openalex.org/W2115598567","https://openalex.org/W2115947409","https://openalex.org/W2121141343","https://openalex.org/W2121516329","https://openalex.org/W2124325733","https://openalex.org/W2125311110","https://openalex.org/W2130630969","https://openalex.org/W2143067833","https://openalex.org/W2154671319","https://openalex.org/W2162740250","https://openalex.org/W2341981318"],"related_works":["https://openalex.org/W45293395","https://openalex.org/W2017954937","https://openalex.org/W1497917975","https://openalex.org/W1606058059","https://openalex.org/W2402194021","https://openalex.org/W7098399962","https://openalex.org/W2128647783","https://openalex.org/W1583346750","https://openalex.org/W1541085066","https://openalex.org/W2040888618"],"abstract_inverted_index":{"The":[0,189,283],"role":[1],"of":[2,10,26,111,121,142,159,171,175,222,249,260,303],"the":[3,8,11,23,46,51,71,91,107,112,122,125,155,168,178,203,234,281,288,304],"urokinase":[4],"receptor":[5,195],"(uPAR)":[6],"in":[7,86,202],"internalization":[9,204,302],"urokinase-plasminogen":[12],"activator":[13],"inhibitor":[14],"type-1":[15],"(uPA.PAI-1)":[16],"complex":[17,93,194,211,253,272,290,306],"has":[18],"been":[19,277],"investigated.":[20],"First,":[21],"exploiting":[22],"species":[24],"specificity":[25],"uPA":[27,102,228,274],"binding,":[28],"we":[29,244],"show":[30,78,246],"that":[31,85,191,247,275,287,301],"mouse":[32,38],"LB6":[33,54,87],"cells":[34,250],"(that":[35],"express":[36,59],"a":[37,60,119,129,163,192,209,255],"uPAR)":[39],"were":[40,238],"unable":[41],"to":[42,70,114,124,145,214,271,273,280,299],"bind":[43],"or":[44,173,199],"degrade":[45],"human":[47,62,72],"uPA.PAI-1":[48,65,92,135,143,187,216,252,305],"complex.":[49],"On":[50],"other":[52],"hand,":[53],"clone":[55,88],"19":[56,89],"cells,":[57,90],"which":[58,232],"transfected":[61],"uPAR,":[63,140],"degraded":[64],"complexes":[66,221],"with":[67,82,128,154,162,181,224,251],"kinetics":[68],"identical":[69],"monocytic":[73],"U937":[74],"cells.":[75],"We":[76],"also":[77,245],"by":[79,139,309],"immunofluorescence":[80],"experiments":[81],"anti-uPA":[83],"antibodies":[84],"is":[94,137,292,307],"indeed":[95],"internalized.":[96,293],"While":[97],"at":[98,106],"4":[99],"degrees":[100,116],"C":[101,117,184],"fluorescence":[103],"was":[104,206,265,269],"visible":[105],"cell":[108,179],"surface,":[109],"shift":[110],"temperature":[113],"37":[115],"caused":[118,254],"displacement":[120],"immunoreactivity":[123],"cytoplasmic":[126],"compartment,":[127],"pattern":[130],"indicating":[131],"lysosomal":[132],"localization.":[133],"If":[134],"internalization/degradation":[136],"mediated":[138,308],"inhibition":[141],"binding":[144,169,217,236],"uPAR":[146,172,176,235],"should":[147],"block":[148],"degradation.":[149,188,219],"Three":[150],"different":[151],"treatments,":[152],"competition":[153],"agonist":[156],"amino-terminal":[157],"fragment":[158],"uPA,":[160],"treatment":[161,248],"monoclonal":[164],"antibody":[165],"directed":[166],"toward":[167],"domain":[170],"release":[174],"from":[177],"surface":[180],"phosphatidylinositol-specific":[182],"phospholipase":[183],"completely":[185],"prevented":[186],"possibility":[190,284],"serpin-enzyme":[193,210],"might":[196],"be":[197],"primarily":[198],"secondarily":[200],"involved":[201],"process":[205],"excluded":[207],"since":[208],"peptide":[212],"failed":[213],"inhibit":[215],"and":[218],"Similarly,":[220],"PAI-1":[223,268],"low":[225],"molecular":[226],"mass":[227],"(33":[229],"kDa":[230],"uPA),":[231],"lacks":[233],"domain,":[237],"neither":[239],"bound":[240,279],"nor":[241],"degraded.":[242],"Finally":[243],"specific":[256],"but":[257],"partial":[258],"down-regulation":[259],"uPAR.":[261,310],"A":[262],"similar":[263],"result":[264],"obtained":[266],"when":[267],"allowed":[270],"had":[276],"previously":[278],"receptor.":[282],"therefore":[285],"exists":[286],"entire":[289],"uPA.PAI-1-uPAR":[291],"All":[294],"these":[295],"data":[296],"allow":[297],"us":[298],"conclude":[300]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
