{"id":"https://openalex.org/W1549488993","doi":null,"title":"Regulation of epidermal transglutaminase activity and terminal differentiation by retinoids and phorbol esters.","display_name":"Regulation of epidermal transglutaminase activity and terminal differentiation by retinoids and phorbol esters.","publication_year":1983,"publication_date":"1983-12-01","ids":{"openalex":"https://openalex.org/W1549488993","mag":"1549488993","pmid":"https://pubmed.ncbi.nlm.nih.gov/6139162"},"language":"en","primary_location":{"id":"pmid:6139162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6139162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045531616","display_name":"Stuart H. Yuspa","orcid":"https://orcid.org/0000-0003-4785-337X","observed_orcids":["https://orcid.org/0000-0003-4785-337X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S H Yuspa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113539347","display_name":"Theresa L. Ben","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Ben","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002789021","display_name":"Ulrike F. Lichti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Lichti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9438,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.84543903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"43","issue":"12 Pt 1","first_page":"5707","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.3467000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-transglutaminase","display_name":"epidermal transglutaminase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/retinoids","display_name":"retinoids","score":0.8849999904632568},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9160000085830688},{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9950000047683716},{"id":"https://openalex.org/keywords/skin-tumor-promotion","display_name":"skin tumor promotion","score":0.7860000133514404},{"id":"https://openalex.org/keywords/terminal-differentiation","display_name":"terminal differentiation","score":0.6570000052452087},{"id":"https://openalex.org/keywords/keratinization","display_name":"keratinization","score":0.8199999928474426},{"id":"https://openalex.org/keywords/epidermal-basal-cells","display_name":"epidermal basal cells","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cell-selection","display_name":"cell selection","score":0.824999988079071},{"id":"https://openalex.org/keywords/extracellular-calcium","display_name":"extracellular calcium","score":0.8569999933242798},{"id":"https://openalex.org/keywords/induction-kinetics","display_name":"induction kinetics","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.8604602813720703},{"id":"https://openalex.org/C178498320","wikidata":"https://www.wikidata.org/wiki/Q14903608","display_name":"Tissue transglutaminase","level":3,"score":0.8424581289291382},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.6789880990982056},{"id":"https://openalex.org/C2780122803","wikidata":"https://www.wikidata.org/wiki/Q7852681","display_name":"Tumor promotion","level":4,"score":0.607483983039856},{"id":"https://openalex.org/C2779963572","wikidata":"https://www.wikidata.org/wiki/Q29417","display_name":"Tretinoin","level":4,"score":0.5808643102645874},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5659559965133667},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.48771271109580994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4851592183113098},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.4844243824481964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4702557325363159},{"id":"https://openalex.org/C2225953","wikidata":"https://www.wikidata.org/wiki/Q1661899","display_name":"Inducer","level":3,"score":0.45993852615356445},{"id":"https://openalex.org/C132154277","wikidata":"https://www.wikidata.org/wiki/Q5381545","display_name":"Enzyme inducer","level":3,"score":0.44045987725257874},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.41329655051231384},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.38999953866004944},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38050219416618347},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3605952262878418},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2852051556110382},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.08268147706985474},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010704","descriptor_name":"Phorbols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011503","descriptor_name":"Transglutaminases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012176","descriptor_name":"Retinoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6139162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6139162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1549488993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6139162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W110270552","https://openalex.org/W1497338732","https://openalex.org/W1516259788","https://openalex.org/W1816543068","https://openalex.org/W1861771549","https://openalex.org/W1885416547","https://openalex.org/W1982864402","https://openalex.org/W1983851236","https://openalex.org/W1986270436","https://openalex.org/W2009300543","https://openalex.org/W2013704122","https://openalex.org/W2020574771","https://openalex.org/W2038085058","https://openalex.org/W2048820480","https://openalex.org/W2063317467","https://openalex.org/W2072117102","https://openalex.org/W2090322889","https://openalex.org/W2090572658","https://openalex.org/W2092764965","https://openalex.org/W2093186107","https://openalex.org/W2095162564","https://openalex.org/W2097805388","https://openalex.org/W2112737647","https://openalex.org/W2126625988","https://openalex.org/W2141965195","https://openalex.org/W2408605542","https://openalex.org/W2412137015","https://openalex.org/W2464393736","https://openalex.org/W2473920396"],"related_works":["https://openalex.org/W2020574771","https://openalex.org/W2082076255","https://openalex.org/W1538990103","https://openalex.org/W1591071605","https://openalex.org/W1497338732","https://openalex.org/W2017528973","https://openalex.org/W2082940011","https://openalex.org/W2519025071","https://openalex.org/W2126625988","https://openalex.org/W1816543068"],"abstract_inverted_index":{"A":[0,197],"number":[1],"of":[2,4,37,39,59,87,130,171,186,190,199,242,247,286,293,307,314,319],"characteristics":[3],"phorbol":[5,73,79,135,222,249,294],"ester-mediated":[6],"mouse":[7,26,63,102],"skin":[8,64],"tumor":[9,60],"promotion":[10,61],"indicate":[11,154],"that":[12,30,155,282],"cell":[13,261,268,315],"selection":[14,31,316],"is":[15,32,116,271],"the":[16,69,84,127,156,164,183,221,248,259,276,283],"underlying":[17],"biological":[18],"process.":[19],"Studies":[20],"in":[21,24,50,62,100,107,121,169,228,273],"vivo":[22],"and":[23,78,137,148,179,188,206,220,256,267,303,321],"cultured":[25,101,131],"epidermal":[27,82,103,260],"cells":[28,41,105,320],"suggest":[29,281],"based":[33],"on":[34,301],"heterogeneous":[35],"responses":[36],"subpopulations":[38],"basal":[40,104],"which":[42,270],"can":[43],"be":[44,90,289],"induced":[45,158,264],"to":[46,52,72,92,216,253,275],"proliferate":[47],"or":[48],"differentiate":[49],"response":[51,71,274],"promoter":[53,277],"exposure.":[54],"Retinoids":[55],"are":[56,163,225,238],"effective":[57],"inhibitors":[58],"but":[65],"do":[66],"not":[67],"influence":[68],"proliferative":[70],"esters.":[74],"Since":[75],"both":[76,145,217,236],"retinoids":[77,88,202,287,308],"esters":[80,136],"modify":[81],"differentiation,":[83],"antipromoter":[85,213],"action":[86,285,306],"could":[89,288],"related":[91],"differentiation":[93,120,129,266,297],"responses.":[94],"Retinoic":[95],"acid":[96,124,219,244,255],"induces":[97],"transglutaminase":[98,146,172,204,302],"activity":[99,147,170,192],"grown":[106],"less":[108,229],"than":[109,141,230,245],"0.1":[110,142],"mM":[111,143],"Ca2+.":[112],"While":[113],"this":[114],"enzyme":[115],"associated":[117],"with":[118,210,235],"terminal":[119,128,149,265,296],"skin,":[122],"retinoic":[123,218,243,254],"paradoxically":[125],"blocks":[126],"cells.":[132],"In":[133],"contrast,":[134],"extracellular":[138],"calcium":[139],"greater":[140],"induce":[144,203],"differentiation.":[150],"Enzyme":[151],"kinetic":[152],"analyses":[153],"transglutaminases":[157],"by":[159,173,291],"all":[160,174],"three":[161,175],"inducers":[162,176,237],"same":[165],"enzyme.":[166],"The":[167],"increase":[168,187],"requires":[177],"RNA":[178],"protein":[180],"synthesis.":[181],"However,":[182],"time":[184],"course":[185],"decay":[189],"each":[191,195],"differs":[193],"for":[194],"inducer.":[196],"variety":[198],"biologically":[200],"active":[201],"activity,":[205],"their":[207,211],"effectiveness":[208],"correlates":[209],"reported":[212],"activity.":[214],"Exposures":[215],"ester":[223],"12-O-tetradecanoylphorbol-13-acetate":[224,257],"antagonistic":[226],"resulting":[227],"additive":[231],"induction.":[232],"Induction":[233],"kinetics":[234],"more":[239],"like":[240],"those":[241,246],"ester.":[250],"Simultaneous":[251],"exposure":[252],"protects":[258],"population":[262],"from":[263],"loss":[269,318],"observed":[272],"alone.":[278],"These":[279],"results":[280],"antipromoting":[284],"mediated":[290],"modification":[292],"ester-accelerated":[295],"through":[298],"an":[299],"effect":[300],"cornification.":[304],"This":[305],"would":[309],"block":[310],"a":[311],"critical":[312],"aspect":[313],"involving":[317],"subsequent":[322],"regenerative":[323],"hyperplasia,":[324],"although":[325],"simple":[326],"hyperplasia":[327],"may":[328],"still":[329],"occur.":[330]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}