{"id":"https://openalex.org/W1549129669","doi":null,"title":"Metastatic brain tumors: current therapeutic options and historical perspective.","display_name":"Metastatic brain tumors: current therapeutic options and historical perspective.","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W1549129669","mag":"1549129669","pmid":"https://pubmed.ncbi.nlm.nih.gov/23667195"},"language":"en","primary_location":{"id":"pmid:23667195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23667195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the American Osteopathic Association","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016222420","display_name":"Mark A. Rivkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106460735","display_name":"Philadelphia College of Osteopathic Medicine","ror":"https://ror.org/00m9c2804","country_code":"US","type":"education","lineage":["https://openalex.org/I106460735"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Rivkin","raw_affiliation_strings":["Department of Neurosurgery, Philadelphia College of Osteopathic Medicine, Pennsylvania, USA. mrivkin@charter.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Philadelphia College of Osteopathic Medicine, Pennsylvania, USA. mrivkin@charter.net","institution_ids":["https://openalex.org/I106460735"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035006232","display_name":"Richard Bruce Kanoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard B Kanoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3308,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.60187428,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"113","issue":"5","first_page":"418","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9430000185966492},{"id":"https://openalex.org/keywords/neurosurgical-resection","display_name":"neurosurgical resection","score":0.8709999918937683},{"id":"https://openalex.org/keywords/whole-brain-radiotherapy","display_name":"whole brain radiotherapy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/stereotactic-radiosurgery","display_name":"stereotactic radiosurgery","score":0.9229999780654907},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.7229999899864197},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.9449999928474426},{"id":"https://openalex.org/keywords/multidisciplinary-treatment","display_name":"multidisciplinary treatment","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9582002758979797},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.6684367656707764},{"id":"https://openalex.org/C3019692148","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Therapeutic modalities","level":2,"score":0.6591296195983887},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6218519806861877},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5309699773788452},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.5049081444740295},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4839773178100586},{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.4703415036201477},{"id":"https://openalex.org/C3020606620","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Treatment modality","level":2,"score":0.4456928074359894},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.4299252927303314},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.34237805008888245},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2213459312915802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19880685210227966},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18316128849983215},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11384236812591553},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:23667195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23667195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the American Osteopathic Association","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.pcom.edu:scholarly_papers-1298","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.pcom.edu/scholarly_papers/128","pdf_url":null,"source":{"id":"https://openalex.org/S4377196547","display_name":"Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I106460735","host_organization_name":"Philadelphia College of Osteopathic Medicine","host_organization_lineage":["https://openalex.org/I106460735"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PCOM Scholarly Works","raw_type":"text"},{"id":"pmh:oai:digitalcommons.pcom.edu:scholarly_papers-1319","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.pcom.edu/scholarly_papers/177","pdf_url":null,"source":{"id":"https://openalex.org/S4377196547","display_name":"Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I106460735","host_organization_name":"Philadelphia College of Osteopathic Medicine","host_organization_lineage":["https://openalex.org/I106460735"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PCOM Scholarly Works","raw_type":"text"},{"id":"mag:1549129669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23667195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W78101726","https://openalex.org/W122653179","https://openalex.org/W124069250","https://openalex.org/W148295428","https://openalex.org/W244572742","https://openalex.org/W1504953459","https://openalex.org/W1545585391","https://openalex.org/W1964497241","https://openalex.org/W1967467401","https://openalex.org/W1969048867","https://openalex.org/W1970667857","https://openalex.org/W1974473991","https://openalex.org/W1976628810","https://openalex.org/W1977211893","https://openalex.org/W1986848753","https://openalex.org/W1991396578","https://openalex.org/W1993401573","https://openalex.org/W2002031619","https://openalex.org/W2004852620","https://openalex.org/W2016938109","https://openalex.org/W2028835275","https://openalex.org/W2030617475","https://openalex.org/W2039202448","https://openalex.org/W2055689319","https://openalex.org/W2057575590","https://openalex.org/W2057691996","https://openalex.org/W2062247475","https://openalex.org/W2064368835","https://openalex.org/W2067893090","https://openalex.org/W2069308124","https://openalex.org/W2084049437","https://openalex.org/W2094975879","https://openalex.org/W2110391705","https://openalex.org/W2112117200","https://openalex.org/W2124662214","https://openalex.org/W2132495825","https://openalex.org/W2136568031","https://openalex.org/W2143839014","https://openalex.org/W2161744351","https://openalex.org/W2164306710","https://openalex.org/W2166478145","https://openalex.org/W2177244913","https://openalex.org/W2233074420","https://openalex.org/W2329793926","https://openalex.org/W2339444986","https://openalex.org/W2533301708","https://openalex.org/W2608891401","https://openalex.org/W3008770883"],"related_works":["https://openalex.org/W1870893740","https://openalex.org/W2162065895","https://openalex.org/W563093319","https://openalex.org/W2085494016","https://openalex.org/W1538840282","https://openalex.org/W1981727813","https://openalex.org/W2997604769","https://openalex.org/W4212952173","https://openalex.org/W2056187805","https://openalex.org/W1967903833"],"abstract_inverted_index":{"Metastatic":[0],"brain":[1,40],"tumors":[2,18],"affect":[3],"more":[4],"than":[5],"150,000":[6],"patients":[7],"annually":[8],"in":[9],"the":[10,22],"United":[11],"States.":[12],"The":[13,37],"therapeutic":[14,62],"paradigms":[15],"for":[16],"these":[17],"have":[19],"evolved":[20],"over":[21],"years":[23],"and":[24,47,52,64,70,74],"currently":[25],"encompass":[26],"numerous":[27],"modalities":[28],"implemented":[29],"by":[30],"treating":[31],"physicians":[32],"across":[33],"several":[34],"medical":[35],"disciplines.":[36],"armamentarium":[38],"of":[39,72],"tumor":[41],"treatment":[42,92],"involves":[43],"neurosurgical":[44],"intervention,":[45],"whole-brain":[46],"focused":[48],"radiation":[49],"modalities,":[50],"chemotherapy,":[51],"immunotherapy.":[53],"Patient":[54],"selection,":[55],"however,":[56],"remains":[57],"critical":[58],"to":[59,87],"achieve":[60],"maximal":[61],"benefit":[63],"depends":[65],"on":[66],"functional":[67],"status,":[68],"number":[69],"location":[71],"lesions,":[73],"tissue":[75],"histologic":[76],"findings.":[77],"Best":[78],"outcomes":[79],"can":[80],"be":[81],"expected":[82],"with":[83],"a":[84],"multidisciplinary":[85],"approach":[86],"patient":[88],"care":[89],"where":[90],"state-of-the-art":[91],"options":[93],"are":[94],"readily":[95],"available.":[96]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}