{"id":"https://openalex.org/W1548904625","doi":"https://doi.org/10.3928/1542-8877-20020701-16","title":"Local Methotrexate and Dexamethasone Phosphate for the Treatment of Recurrent Primary Intraocular Lymphoma","display_name":"Local Methotrexate and Dexamethasone Phosphate for the Treatment of Recurrent Primary Intraocular Lymphoma","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W1548904625","doi":"https://doi.org/10.3928/1542-8877-20020701-16","mag":"1548904625","pmid":"https://pubmed.ncbi.nlm.nih.gov/12134997"},"language":"en","primary_location":{"id":"doi:10.3928/1542-8877-20020701-16","doi":"https://doi.org/10.3928/1542-8877-20020701-16","is_oa":false,"landing_page_url":"https://doi.org/10.3928/1542-8877-20020701-16","pdf_url":null,"source":{"id":"https://openalex.org/S4210179932","display_name":"Ophthalmic surgery, lasers & imaging retina","issn_l":"1542-8877","issn":["1542-8877","1938-2375","2325-8160","2325-8179"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmic Surgery, Lasers and Imaging Retina","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103510903","display_name":"Gisela Velez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gisela Velez","raw_affiliation_strings":["","Laboratory of Immunology, National Eye Institute, NIH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Immunology, National Eye Institute, NIH, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040363323","display_name":"H. Culver Boldt","orcid":"https://orcid.org/0000-0002-7292-2093","observed_orcids":["https://orcid.org/0000-0002-7292-2093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Culver Boldt","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026165592","display_name":"Scott M. Whitcup","orcid":"https://orcid.org/0000-0003-1892-719X","observed_orcids":["https://orcid.org/0000-0003-1892-719X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott M Whitcup","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016920591","display_name":"Robert Burton Nussenblatt","orcid":"https://orcid.org/0000-0001-6469-1080","observed_orcids":["https://orcid.org/0000-0001-6469-1080"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert B Nussenblatt","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110117668","display_name":"Michael R. Robinson","orcid":"https://orcid.org/0000-0002-0004-6506","observed_orcids":["https://orcid.org/0000-0002-0004-6506"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael R Robinson","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2728,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.90696015,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"33","issue":"4","first_page":"329","last_page":"333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.09380000084638596,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.039500001817941666,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-intraocular-lymphoma","display_name":"primary intraocular lymphoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/recurrent-lymphoma","display_name":"recurrent lymphoma","score":0.8939999938011169},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.8190000057220459},{"id":"https://openalex.org/keywords/dexamethasone-sodium-phosphate","display_name":"dexamethasone sodium phosphate","score":0.9660000205039978},{"id":"https://openalex.org/keywords/intravitreal-injection","display_name":"intravitreal injection","score":0.9369999766349792},{"id":"https://openalex.org/keywords/subtenon-injection","display_name":"subtenon injection","score":0.9879999756813049},{"id":"https://openalex.org/keywords/local-chemotherapy","display_name":"local chemotherapy","score":0.9120000004768372},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.8830000162124634},{"id":"https://openalex.org/keywords/vitreitis","display_name":"vitritis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/electroretinography","display_name":"electroretinogram","score":0.8709999918937683},{"id":"https://openalex.org/keywords/visual-acuity-preservation","display_name":"visual acuity preservation","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8642362356185913},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.8363355398178101},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.7505384683609009},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6956430077552795},{"id":"https://openalex.org/C2778007619","wikidata":"https://www.wikidata.org/wiki/Q6058506","display_name":"Intraocular lymphoma","level":3,"score":0.6459707021713257},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.5558908581733704},{"id":"https://openalex.org/C2778397455","wikidata":"https://www.wikidata.org/wiki/Q50429865","display_name":"Antimetabolite","level":3,"score":0.5442890524864197},{"id":"https://openalex.org/C2776194053","wikidata":"https://www.wikidata.org/wiki/Q280027","display_name":"Uveitis","level":2,"score":0.48454514145851135},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4471745491027832},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4311607778072357},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4034837484359741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1831778883934021}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005134","descriptor_name":"Eye Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005134","descriptor_name":"Eye Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005654","descriptor_name":"Fundus Oculi","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3928/1542-8877-20020701-16","doi":"https://doi.org/10.3928/1542-8877-20020701-16","is_oa":false,"landing_page_url":"https://doi.org/10.3928/1542-8877-20020701-16","pdf_url":null,"source":{"id":"https://openalex.org/S4210179932","display_name":"Ophthalmic surgery, lasers & imaging retina","issn_l":"1542-8877","issn":["1542-8877","1938-2375","2325-8160","2325-8179"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmic Surgery, Lasers and Imaging Retina","raw_type":"journal-article"},{"id":"pmid:12134997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12134997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmic surgery and lasers","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.75,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W176021971","https://openalex.org/W184551449","https://openalex.org/W1481319136","https://openalex.org/W1603214546","https://openalex.org/W1703205024","https://openalex.org/W1965149095","https://openalex.org/W1970613333","https://openalex.org/W1972005608","https://openalex.org/W1985027375","https://openalex.org/W1985848644","https://openalex.org/W1988295204","https://openalex.org/W2005351022","https://openalex.org/W2018712601","https://openalex.org/W2021592080","https://openalex.org/W2027125280","https://openalex.org/W2106860353","https://openalex.org/W2124014329","https://openalex.org/W2135707533","https://openalex.org/W2162342145","https://openalex.org/W2165439369","https://openalex.org/W2166291149","https://openalex.org/W2179658416","https://openalex.org/W2331921363","https://openalex.org/W2409339206","https://openalex.org/W3022789069"],"related_works":["https://openalex.org/W1994918385","https://openalex.org/W2231865806","https://openalex.org/W3094461261","https://openalex.org/W2395719152","https://openalex.org/W2169402566","https://openalex.org/W39483786","https://openalex.org/W1964494072","https://openalex.org/W1979403272","https://openalex.org/W2519263901","https://openalex.org/W2165439369"],"abstract_inverted_index":{"A":[0],"70-year-old":[1],"patient":[2],"with":[3,12,132,188],"recurrent":[4,173],"bilateral":[5],"primary":[6],"intraocular":[7],"lymphoma":[8],"(PIOL)":[9],"was":[10,84,106,130,144],"treated":[11],"local":[13],"injections":[14,42],"of":[15,27,33,39,43,51,66,75,121,127,134,151,156],"methotrexate":[16,44],"and":[17,59,92,114,125,137,175],"periocular":[18],"dexamethasone":[19,67],"phosphate":[20,68],"to":[21,36,101,108,113,171],"both":[22],"eyes":[23],"over":[24],"the":[25,89,96,122,128,154],"course":[26],"5":[28],"months.":[29],"Local":[30,165],"therapy":[31,181],"consisted":[32],"a":[34,48,63,72],"cycle":[35,83],"each":[37,116],"eye":[38,91],"3":[40,93],"intravitreal":[41,163],"(200":[45],"microg":[46],"in":[47,71,153,182],"total":[49,73],"volume":[50,74],"0.1":[52],"cc)":[53,77],"administered":[54,85],"on":[55,78,140],"days":[56],"1,":[57],"5,":[58],"8,":[60],"followed":[61],"by":[62],"subtenon":[64],"injection":[65],"(7.5":[69],"mg":[70],"0.3":[76],"day":[79],"9.":[80],"This":[81],"treatment":[82,117,152,187],"4":[86,100],"times":[87,94],"for":[88,95,146,184],"right":[90],"left":[97],"eye,":[98],"at":[99],"6":[102],"week":[103],"intervals.":[104],"Electroretinography":[105],"used":[107,170],"assess":[109],"retinal":[110],"function":[111],"prior":[112],"during":[115],"regimen.":[118],"Complete":[119],"regression":[120],"lymphomatous":[123],"infiltrates":[124],"resolution":[126],"vitritis":[129],"observed":[131],"preservation":[133],"visual":[135],"acuity":[136],"no":[138],"changes":[139],"electroretinography.":[141],"The":[142],"effect":[143],"sustained":[145],"24":[147],"months":[148],"after":[149],"termination":[150],"absence":[155],"systemic":[157,189],"chemotherapy,":[158],"radiation":[159,192],"treatments,":[160],"or":[161,191],"maintenance":[162],"injections.":[164],"combined":[166],"chemotherapy":[167,190],"can":[168,176],"be":[169],"treat":[172],"PIOL,":[174],"serve":[177],"as":[178],"successful":[179],"palliative":[180],"patients":[183],"whom":[185],"further":[186],"is":[193],"contraindicated.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
