{"id":"https://openalex.org/W1548847786","doi":null,"title":"Variation in tumor yield in the prostate and other target organs of the rat in response to varied dosage and duration of administration of 3,2'-dimethyl-4-aminobiphenyl.","display_name":"Variation in tumor yield in the prostate and other target organs of the rat in response to varied dosage and duration of administration of 3,2'-dimethyl-4-aminobiphenyl.","publication_year":1988,"publication_date":"1988-08-15","ids":{"openalex":"https://openalex.org/W1548847786","mag":"1548847786","pmid":"https://pubmed.ncbi.nlm.nih.gov/3396013"},"language":"en","primary_location":{"id":"pmid:3396013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3396013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006054960","display_name":"Nobuyasu Ito","orcid":"https://orcid.org/0000-0001-6934-8898","observed_orcids":["https://orcid.org/0000-0001-6934-8898"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Ito","raw_affiliation_strings":["First Department of Pathology, Nagoya City University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Pathology, Nagoya City University Medical School, Japan","institution_ids":["https://openalex.org/I33858575","https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016135291","display_name":"Tsuyoshi Shirai","orcid":"https://orcid.org/0000-0002-2506-5738","observed_orcids":["https://orcid.org/0000-0002-2506-5738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Shirai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110098685","display_name":"Y Tagawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Tagawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079970882","display_name":"Atsushi Nakamura","orcid":"https://orcid.org/0000-0003-4740-6756","observed_orcids":["https://orcid.org/0000-0003-4740-6756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Nakamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108199808","display_name":"S Fukushima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Fukushima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6642,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.82074152,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"48","issue":"16","first_page":"4629","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3-2-dimethyl-4-aminobiphenyl","display_name":"3,2'-dimethyl-4-aminobiphenyl","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dimethylamine-borane","display_name":"dimethylamine borane","score":0.7509999871253967},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7120000123977661},{"id":"https://openalex.org/keywords/ethinyl-estradiol","display_name":"ethinyl estradiol","score":0.968999981880188},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.44600000977516174},{"id":"https://openalex.org/keywords/atypical-hyperplasia","display_name":"atypical hyperplasia","score":0.9039999842643738},{"id":"https://openalex.org/keywords/intestinal-neoplasms","display_name":"intestinal tumors","score":0.7239999771118164},{"id":"https://openalex.org/keywords/pancreatic-tumors","display_name":"pancreatic tumors","score":0.9539999961853027},{"id":"https://openalex.org/keywords/chemical-carcinogenesis","display_name":"chemical carcinogenesis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/fischer-344-rats","display_name":"F344 rats","score":0.9440000057220459}],"concepts":[{"id":"https://openalex.org/C108789577","wikidata":"https://www.wikidata.org/wiki/Q655042","display_name":"Preputial gland","level":2,"score":0.6827532649040222},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.6758542060852051},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6161363124847412},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6126666069030762},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.6065389513969421},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5323842763900757},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.5215451717376709},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.51688551902771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.478960782289505},{"id":"https://openalex.org/C2775904963","wikidata":"https://www.wikidata.org/wiki/Q4818895","display_name":"Atypical hyperplasia","level":3,"score":0.4771537184715271},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45825377106666565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2806558609008789},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22048258781433105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08993342518806458},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000611","descriptor_name":"Aminobiphenyl Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:3396013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3396013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.337.1213","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.337.1213","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/48/16/4629.full.pdf","raw_type":"text"},{"id":"mag:1548847786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3396013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7099249091","https://openalex.org/W2396249549","https://openalex.org/W2015745001","https://openalex.org/W2032119885","https://openalex.org/W2079895723","https://openalex.org/W1999603310","https://openalex.org/W1599958658","https://openalex.org/W2047259964","https://openalex.org/W2122188722","https://openalex.org/W2035228879"],"abstract_inverted_index":{"The":[0,49],"effects":[1],"of":[2,5,14,20,36,43,69,84,87,95,104,117,121,148,163,173,187,197,223,234,246,257,277],"varying":[3],"dosages":[4],"3,2'-dimethyl-4-aminobiphenyl":[6],"(DMAB)":[7],"in":[8,25,58,90,98,107,129,168,179,208,217,249],"combination":[9],"with":[10,33,41,137,237,240],"cyclic":[11,238],"dietary":[12],"administration":[13,233],"ethinyl":[15],"estradiol":[16],"(EE)":[17],"on":[18,46],"induction":[19,276],"prostate":[21,165,247,278],"carcinoma":[22,248],"were":[23,141,157],"investigated":[24],"male":[26],"F344":[27],"rats.":[28],"Animals":[29],"received":[30],"repeated":[31,52],"treatment":[32,136,239],"0.75":[34],"ppm":[35],"EE":[37,241],"for":[38,159,176,274],"3":[39,56,225],"wk":[40,45,178],"intervals":[42],"2":[44,73],"basal":[47,79,143],"diet.":[48],"cycle":[50],"was":[51,126,166],"10,":[53],"5,":[54],"and":[55,62,101,171,193,200,205,251],"times":[57],"Groups":[59,180],"1,":[60,92],"2,":[61,100],"3,":[63,183],"respectively,":[64,184],"a":[65,82,209,243,254,261,267,271],"single":[66],"s.c.":[67],"injection":[68],"DMAB":[70,118,235,258],"being":[71,190,215],"given":[72,142,220,259],"days":[74],"after":[75],"each":[76,130],"change":[77],"to":[78,133,182,266],"diet":[80,144],"at":[81],"dose":[83,116],"50":[85],"mg/kg":[86,94,103,120],"body":[88,96,105,122],"weight":[89,97,106],"Group":[91,99,108],"100":[93],"167":[102,221],"3.":[109],"With":[110],"this":[111],"dosing":[112],"schedule,":[113],"the":[114,127,134,146,149,164,185,198,212,218,228],"total":[115],"(500":[119],"weight)":[123],"per":[124],"rat":[125],"same":[128],"group.":[131],"Subsequent":[132],"last":[135],"EE,":[138],"all":[139,154],"rats":[140,174,250],"until":[145],"end":[147],"experiment":[150,230],"(Wk":[151],"60)":[152],"when":[153],"surviving":[155,175],"animals":[156],"sacrificed":[158],"histological":[160],"examination.":[161],"Carcinoma":[162],"found":[167,216],"58.6,":[169],"45.0,":[170],"25.9%":[172],"60":[177],"1":[181],"incidences":[186,214],"atypical":[188],"hyperplasia":[189],"86.2,":[191],"85.0,":[192],"74.1%.":[194],"However,":[195],"tumors":[196],"small":[199],"large":[201],"intestines,":[202],"preputial":[203],"gland,":[204],"pancreas":[206],"developed":[207],"dosage-dependent":[210],"manner,":[211],"largest":[213],"group":[219],"mg":[222],"carcinogen":[224],"times.":[226],"Thus":[227],"present":[229],"confirmed":[231],"that":[232,253],"combined":[236],"induces":[242],"high":[244,268],"incidence":[245],"demonstrated":[252],"low":[255],"dosage":[256,269],"over":[260,270],"long":[262],"period":[263,273],"is":[264],"superior":[265],"short":[272],"specific":[275],"lesions.":[279]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}