{"id":"https://openalex.org/W1548097432","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.902.7","title":"IKK\u03b2 deletion in intestinal macrophages but not intestinal epithelial cells ameliorates intestinal injury in a neonatal mouse NEC model (902.7)","display_name":"IKK\u03b2 deletion in intestinal macrophages but not intestinal epithelial cells ameliorates intestinal injury in a neonatal mouse NEC model (902.7)","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W1548097432","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.902.7","mag":"1548097432"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.28.1_supplement.902.7","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.902.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.902.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067739110","display_name":"Isabelle G. De Plaen","orcid":"https://orcid.org/0000-0002-1742-2926","observed_orcids":["https://orcid.org/0000-0002-1742-2926"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isabelle De Plaen","raw_affiliation_strings":["Lurie Children's Hospital of CHICAGO Research Center CHICAGO IL United States","1Lurie Children's Hospital of Chicago Research Center Chicago IL United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lurie Children's Hospital of CHICAGO Research Center CHICAGO IL United States","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"1Lurie Children's Hospital of Chicago Research Center Chicago IL United States","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062697407","display_name":"Shirley Liu","orcid":"https://orcid.org/0000-0003-4777-6917","observed_orcids":["https://orcid.org/0000-0003-4777-6917"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shirley Liu","raw_affiliation_strings":["Lurie Children's Hospital of CHICAGO Research Center CHICAGO IL United States","1Lurie Children's Hospital of Chicago Research Center Chicago IL United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lurie Children's Hospital of CHICAGO Research Center CHICAGO IL United States","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"1Lurie Children's Hospital of Chicago Research Center Chicago IL United States","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018884292","display_name":"Elizabeth Z. Managlia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Managlia","raw_affiliation_strings":["Lurie Children's Hospital of CHICAGO Research Center CHICAGO IL United States","1Lurie Children's Hospital of Chicago Research Center Chicago IL United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lurie Children's Hospital of CHICAGO Research Center CHICAGO IL United States","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"1Lurie Children's Hospital of Chicago Research Center Chicago IL United States","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102203915","display_name":"Runlan Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Runlan Tian","raw_affiliation_strings":["Lurie Children's Hospital of CHICAGO Research Center CHICAGO IL United States","1Lurie Children's Hospital of Chicago Research Center Chicago IL United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lurie Children's Hospital of CHICAGO Research Center CHICAGO IL United States","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"1Lurie Children's Hospital of Chicago Research Center Chicago IL United States","institution_ids":["https://openalex.org/I1294278766"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1294278766"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1004875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13206","display_name":"Neonatal skin health care","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necrotizing-enterocolitis","display_name":"necrotizing enterocolitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ikkbeta","display_name":"IKK\u03b2","score":0.8389999866485596},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8859999775886536},{"id":"https://openalex.org/keywords/intestinal-macrophages","display_name":"intestinal macrophages","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":1.0},{"id":"https://openalex.org/keywords/cell-specific-gene-deletion","display_name":"cell-specific gene deletion","score":0.7960000038146973},{"id":"https://openalex.org/keywords/neonatal-intestinal-injury","display_name":"neonatal intestinal injury","score":0.6790000200271606},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4650000035762787},{"id":"https://openalex.org/keywords/commensal-bacteria","display_name":"commensal bacteria","score":0.7929999828338623},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cold-stress","display_name":"cold stress","score":0.9369999766349792},{"id":"https://openalex.org/keywords/bottle-feeding","display_name":"bottle feeding","score":0.7929999828338623},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.6874254941940308},{"id":"https://openalex.org/C2779303187","wikidata":"https://www.wikidata.org/wiki/Q10859678","display_name":"Necrotizing enterocolitis","level":2,"score":0.566646933555603},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4805786609649658},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.45493608713150024},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4414745271205902},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.42903053760528564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3997386693954468},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39473608136177063},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37624281644821167},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3743132948875427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3396451473236084},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32918089628219604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15863510966300964}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.28.1_supplement.902.7","doi":"https://doi.org/10.1096/fasebj.28.1_supplement.902.7","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.28.1_supplement.902.7","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8011204693","display_name":"Cell-specific role of NF-KB in necrotizing enterocolitis","funder_award_id":"R01HD060876","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2907447871","https://openalex.org/W2507841776","https://openalex.org/W2034649992","https://openalex.org/W4319433922","https://openalex.org/W4400316558","https://openalex.org/W4286771172","https://openalex.org/W2266338421","https://openalex.org/W4389022816","https://openalex.org/W4382631614","https://openalex.org/W2384425904"],"abstract_inverted_index":{"Necrotizing":[0],"enterocolitis":[1],"(NEC)":[2],"is":[3,38],"thought":[4],"to":[5,8,84,144],"be":[6],"due":[7],"an":[9],"exaggerated":[10],"inflammatory":[11],"response":[12],"in":[13,28,34,55,72,89,125,139,158,181,192],"the":[14,25,32,45,65,126,159,189],"premature":[15],"intestine.":[16],"We":[17],"previously":[18],"found":[19],"that":[20,179],"nuclear":[21],"factor\u2010\u03baB":[22],"(NF\u2010\u03baB)":[23],"mediates":[24,188],"intestinal":[26,185,190],"injury":[27,191],"experimental":[29],"NEC.":[30,197],"However,":[31,153],"cell\u2010types":[33],"which":[35],"NF\u2010\u03baB":[36,53,70,180],"activation":[37,54,71],"critical":[39],"are":[40],"unknown.":[41],"Here,":[42],"we":[43],"examine":[44],"respective":[46],"role":[47],"of":[48,106,112,121,131,161,196],"epithelial":[49,186],"cell":[50],"and":[51,79,101,114,167],"macrophage":[52],"a":[56,85],"neonatal":[57,127],"mouse":[58,194],"NEC":[59,86,133,163],"model,":[60],"using":[61],"mice":[62,81],"lacking":[63],"IKK\u03b2,":[64],"upstream":[66],"kinase":[67],"responsible":[68],"for":[69],"these":[73],"cell\u2010types.":[74],"Lys\u2010Cre+/\u2010":[75,140],"IKK\u03b2F/F,":[76],"Villin\u2010Cre+/\u2010":[77,165],"IKK\u03b2F/F":[78,80,141,166],"were":[82,98,155],"exposed":[83],"protocol":[87],"consisting":[88],"adult":[90],"commensal":[91],"bacteria":[92],"inoculation/":[93],"hypoxia/cold":[94],"stress/formula":[95],"feeding.":[96],"Pups":[97],"closely":[99],"observed":[100],"euthanized":[102],"at":[103],"72":[104],"hours":[105],"age":[107],"or":[108],"when":[109],"showing":[110],"signs":[111],"distress":[113],"their":[115],"intestine":[116],"examined":[117],"histologically.":[118],"Cell\u2010specific":[119],"deletion":[120],"IKK\u03b2":[122],"was":[123,136],"confirmed":[124],"pups.":[128],"The":[129],"incidence":[130,160],"severe":[132,162],"(score":[134],"\u88052)":[135],"significantly":[137],"decreased":[138],"pups":[142],"compared":[143],"IKK":[145,168],"\u03b2F/F":[146,169],"controls":[147,170],"(3/23":[148],"vs":[149,172],"16/23,":[150],"\u03c72=12.9,":[151],"p<0.001).":[152],"there":[154],"no":[156],"difference":[157],"between":[164],"(13/28":[171],"19/34,":[173],"\u03c72=0.23,":[174],"NS).":[175],"Our":[176],"data":[177],"suggest":[178],"macrophages":[182],"but":[183],"not":[184],"cells":[187],"our":[193],"model":[195],"Grant":[198],"Funding":[199],"Source":[200],":":[201],"NIH":[202],"(R01\u2010HD060876)":[203]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}