{"id":"https://openalex.org/W1547826006","doi":null,"title":"Induction of glucocorticoid-resistant variants in a murine thymoma line by antitumor drugs.","display_name":"Induction of glucocorticoid-resistant variants in a murine thymoma line by antitumor drugs.","publication_year":1981,"publication_date":"1981-11-01","ids":{"openalex":"https://openalex.org/W1547826006","mag":"1547826006","pmid":"https://pubmed.ncbi.nlm.nih.gov/7306975"},"language":"en","primary_location":{"id":"pmid:7306975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7306975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075073984","display_name":"Marianne Huet-Minkowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Huet-Minkowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111676143","display_name":"Judith C. Gasson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Gasson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5075587189","display_name":"Suzanne Bourgeois","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Bourgeois","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7266,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.80684279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"11 Pt 1","first_page":"4540","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.10140000283718109,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-resistance","display_name":"glucocorticoid resistance","score":0.9900000095367432},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.8870000243186951},{"id":"https://openalex.org/keywords/thymoma","display_name":"thymoma","score":0.7609999775886536},{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.996999979019165},{"id":"https://openalex.org/keywords/streptonigrin","display_name":"streptonigrin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/colcemid","display_name":"colcemid","score":0.9629999995231628},{"id":"https://openalex.org/keywords/alkylating-agents","display_name":"alkylating agents","score":0.9520000219345093},{"id":"https://openalex.org/keywords/dexamethasone-binding","display_name":"dexamethasone binding","score":0.8519999980926514},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.8159999847412109},{"id":"https://openalex.org/keywords/drug-resistance-selection","display_name":"drug resistance selection","score":0.6140000224113464},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2776095844","wikidata":"https://www.wikidata.org/wiki/Q903666","display_name":"Colcemid","level":3,"score":0.785309910774231},{"id":"https://openalex.org/C2779338040","wikidata":"https://www.wikidata.org/wiki/Q19856779","display_name":"Mitomycin C","level":2,"score":0.6953080892562866},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.6455178260803223},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4921240210533142},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.48445701599121094},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46102529764175415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4454461336135864},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.43099868297576904},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4078257381916046},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39524543285369873},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3275870084762573},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20245736837387085},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.163374125957489}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013945","descriptor_name":"Thymoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013945","descriptor_name":"Thymoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013945","descriptor_name":"Thymoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7306975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7306975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1547826006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7306975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2146342653","https://openalex.org/W2619516356","https://openalex.org/W2173774884","https://openalex.org/W1978799355","https://openalex.org/W2155583055","https://openalex.org/W1944904528","https://openalex.org/W1964182158","https://openalex.org/W13434343","https://openalex.org/W1867724118","https://openalex.org/W2473007485"],"abstract_inverted_index":{"Several":[0],"antitumor":[1,173],"drugs":[2,33,174],"are":[3,66,151],"shown":[4],"to":[5,27,74,134],"be":[6,183],"mutagenic":[7,61],"in":[8,91,159,170],"murine":[9],"thymoma":[10],"lines:":[11],"mitomycin":[12,98,121],"C,":[13,99],"bleomycin,":[14],"streptonigrin,":[15,100],"Colcemid,":[16,101],"and":[17,52,102,123,144,153],"BD40,":[18],"an":[19],"analog":[20],"of":[21,38,77,120,128,140],"ellipticine.":[22],"Using":[23],"conditions":[24],"yielding":[25,69],"3":[26],"40%":[28],"cell":[29,179],"survival,":[30],"all":[31],"five":[32],"tested":[34],"increase":[35],"the":[36,47,81,92,118,135,160,163,186],"frequency":[37],"glucocorticoid-resistant":[39,177],"variants.":[40],"Mitomycin":[41],"C":[42,122],"is":[43],"as":[44,46,109],"efficient":[45],"classical":[48],"alkylating":[49,82],"agents":[50],"N-methyl-N'-nitro-N-nitrosoguanidine":[51],"ethyl":[53],"methanesulfonate.":[54],"The":[55],"other":[56],"drugs,":[57],"previously":[58],"untested":[59],"for":[60],"activity":[62,132],"on":[63],"mammalian":[64],"cells,":[65],"weak":[67],"mutagens":[68],"variants":[70,86,129,180],"at":[71],"frequencies":[72],"1":[73],"2":[75],"orders":[76],"magnitude":[78],"lower":[79],"than":[80],"agents.":[83],"All":[84],"152":[85],"obtained":[87],"result":[88,155],"from":[89,156],"defects":[90],"glucocorticoid":[93,164],"receptor.":[94,165],"Variants":[95],"induced":[96],"by":[97,111,185],"BD40":[103],"have":[104],"very":[105],"reduced":[106],"receptor":[107],"activity,":[108],"measured":[110],"dexamethasone":[112,124],"binding.":[113],"In":[114],"contrast,":[115],"bleomycin":[116],"or":[117],"combination":[119,171],"induce":[125,176],"a":[126],"majority":[127],"having":[130],"dexamethasone-binding":[131],"comparable":[133],"parental":[136],"line.":[137],"However,":[138],"assays":[139],"nuclear":[141],"transfer":[142],"capacity":[143],"genetic":[145],"complementation":[146],"show":[147],"that":[148,181],"these":[149],"receptors":[150],"nonfunctional":[152],"may":[154],"point":[157],"mutations":[158],"gene":[161],"encoding":[162],"This":[166],"study":[167],"suggests":[168],"that,":[169],"therapies,":[172],"might":[175],"lymphoid":[178],"could":[182],"selected":[184],"hormone.":[187]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
