{"id":"https://openalex.org/W1547817405","doi":"https://doi.org/10.1016/0165-1110(83)90034-9","title":"Mutagenicity and genotoxicity of nitroarenes","display_name":"Mutagenicity and genotoxicity of nitroarenes","publication_year":1983,"publication_date":"1983-04-01","ids":{"openalex":"https://openalex.org/W1547817405","doi":"https://doi.org/10.1016/0165-1110(83)90034-9","mag":"1547817405","pmid":"https://pubmed.ncbi.nlm.nih.gov/6300670"},"language":"en","primary_location":{"id":"doi:10.1016/0165-1110(83)90034-9","doi":"https://doi.org/10.1016/0165-1110(83)90034-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-1110(83)90034-9","pdf_url":null,"source":{"id":"https://openalex.org/S4210174318","display_name":"Mutation Research/Reviews in Genetic Toxicology","issn_l":"0165-1110","issn":["0165-1110","1872-9347"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research/Reviews in Genetic Toxicology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073709590","display_name":"Herbert S. Rosenkranz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert S. Rosenkranz","raw_affiliation_strings":["Center for the Environmental Health Sciences and Department of Epidemiology and Community Health, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Environmental Health Sciences and Department of Epidemiology and Community Health, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 U.S.A","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010935727","display_name":"Robert Mermelstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132870","display_name":"Xerox (United States)","ror":"https://ror.org/03jwzwq24","country_code":"US","type":"company","lineage":["https://openalex.org/I4210132870"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Mermelstein","raw_affiliation_strings":["Joseph C. Wilson Center for Technology, Xerox Corporation, Webster, New York 14580 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joseph C. Wilson Center for Technology, Xerox Corporation, Webster, New York 14580 U.S.A","institution_ids":["https://openalex.org/I4210132870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.6517,"has_fulltext":false,"cited_by_count":629,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"114","issue":"3","first_page":"217","last_page":"267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitroaromatic-compounds","display_name":"nitroaromatic compounds","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nitrated-polycyclic-aromatic-hydrocarbons","display_name":"nitro-PAHs","score":0.9490000009536743},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.9409999847412109},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bacterial-mutagenicity","display_name":"bacterial mutagenicity","score":0.8709999918937683},{"id":"https://openalex.org/keywords/metabolic-activation","display_name":"metabolic activation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/nitro-group-reduction","display_name":"nitro group reduction","score":0.8510000109672546},{"id":"https://openalex.org/keywords/ring-oxidation","display_name":"ring oxidation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/unscheduled-dna-synthesis","display_name":"unscheduled DNA synthesis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/sister-chromatid-exchange","display_name":"sister chromatid exchange","score":0.9610000252723694},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/carcinogenicity","display_name":"carcinogenicity","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.7486275434494019},{"id":"https://openalex.org/C2779071816","wikidata":"https://www.wikidata.org/wiki/Q21095324","display_name":"Sister chromatid exchange","level":3,"score":0.6902216672897339},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6752087473869324},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6606336832046509},{"id":"https://openalex.org/C2780639532","wikidata":"https://www.wikidata.org/wiki/Q7041427","display_name":"Nitro","level":3,"score":0.601055383682251},{"id":"https://openalex.org/C2780554229","wikidata":"https://www.wikidata.org/wiki/Q422772","display_name":"Nitro compound","level":4,"score":0.4963832497596741},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4889568090438843},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4684963822364807},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.4552951157093048},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.4222494065761566},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3537423014640808},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3521852493286133},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3514504134654999},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34207555651664734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2703925371170044},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2527264356613159},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.24851387739181519},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1126568615436554},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005449","descriptor_name":"Fluorenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009052","descriptor_name":"Leukemia Virus, Murine","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009052","descriptor_name":"Leukemia Virus, Murine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009152","descriptor_name":"Mutagenicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009574","descriptor_name":"Nitro Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011083","descriptor_name":"Polycyclic Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012475","descriptor_name":"Salmonella","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012475","descriptor_name":"Salmonella","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012854","descriptor_name":"Sister Chromatid Exchange","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0165-1110(83)90034-9","doi":"https://doi.org/10.1016/0165-1110(83)90034-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-1110(83)90034-9","pdf_url":null,"source":{"id":"https://openalex.org/S4210174318","display_name":"Mutation Research/Reviews in Genetic Toxicology","issn_l":"0165-1110","issn":["0165-1110","1872-9347"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research/Reviews in Genetic Toxicology","raw_type":"journal-article"},{"id":"pmid:6300670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6300670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":196,"referenced_works":["https://openalex.org/W15493636","https://openalex.org/W31881766","https://openalex.org/W51765089","https://openalex.org/W110960268","https://openalex.org/W125143731","https://openalex.org/W198983384","https://openalex.org/W310124193","https://openalex.org/W403632356","https://openalex.org/W571579047","https://openalex.org/W628785963","https://openalex.org/W656323744","https://openalex.org/W964117818","https://openalex.org/W1488896078","https://openalex.org/W1497699798","https://openalex.org/W1499620002","https://openalex.org/W1509077297","https://openalex.org/W1518978805","https://openalex.org/W1526902491","https://openalex.org/W1539778893","https://openalex.org/W1540615676","https://openalex.org/W1543102669","https://openalex.org/W1548160012","https://openalex.org/W1554212227","https://openalex.org/W1557012742","https://openalex.org/W1571486880","https://openalex.org/W1571608325","https://openalex.org/W1762178673","https://openalex.org/W1823522553","https://openalex.org/W1892873680","https://openalex.org/W1952169576","https://openalex.org/W1961623989","https://openalex.org/W1963505796","https://openalex.org/W1963701151","https://openalex.org/W1964133885","https://openalex.org/W1965508650","https://openalex.org/W1966504091","https://openalex.org/W1966668957","https://openalex.org/W1967502884","https://openalex.org/W1969099864","https://openalex.org/W1970468813","https://openalex.org/W1971392827","https://openalex.org/W1971417566","https://openalex.org/W1971777877","https://openalex.org/W1972710373","https://openalex.org/W1973195696","https://openalex.org/W1973253140","https://openalex.org/W1975098708","https://openalex.org/W1976194703","https://openalex.org/W1976258762","https://openalex.org/W1977330475","https://openalex.org/W1978174136","https://openalex.org/W1978223482","https://openalex.org/W1982025175","https://openalex.org/W1982566674","https://openalex.org/W1982867761","https://openalex.org/W1986487848","https://openalex.org/W1986671347","https://openalex.org/W1987741110","https://openalex.org/W1988311572","https://openalex.org/W1988524626","https://openalex.org/W1990994423","https://openalex.org/W1991370334","https://openalex.org/W1994262605","https://openalex.org/W1995961023","https://openalex.org/W1996016898","https://openalex.org/W1996115924","https://openalex.org/W1996197564","https://openalex.org/W1996741419","https://openalex.org/W1999870189","https://openalex.org/W1999909820","https://openalex.org/W2000446234","https://openalex.org/W2001491952","https://openalex.org/W2002616598","https://openalex.org/W2003393366","https://openalex.org/W2005152643","https://openalex.org/W2006034325","https://openalex.org/W2006459696","https://openalex.org/W2007544197","https://openalex.org/W2008003329","https://openalex.org/W2008160834","https://openalex.org/W2008547924","https://openalex.org/W2008750729","https://openalex.org/W2008770449","https://openalex.org/W2009463152","https://openalex.org/W2010219627","https://openalex.org/W2012540837","https://openalex.org/W2012674324","https://openalex.org/W2013240923","https://openalex.org/W2014855843","https://openalex.org/W2015851623","https://openalex.org/W2016235970","https://openalex.org/W2016293030","https://openalex.org/W2017423124","https://openalex.org/W2018054814","https://openalex.org/W2018196907","https://openalex.org/W2018535954","https://openalex.org/W2020853520","https://openalex.org/W2021207615","https://openalex.org/W2024118082","https://openalex.org/W2024120473","https://openalex.org/W2025308782","https://openalex.org/W2027165008","https://openalex.org/W2027457430","https://openalex.org/W2030833980","https://openalex.org/W2031653666","https://openalex.org/W2032231356","https://openalex.org/W2033979048","https://openalex.org/W2034977271","https://openalex.org/W2037012094","https://openalex.org/W2037624432","https://openalex.org/W2038932256","https://openalex.org/W2039420977","https://openalex.org/W2039641512","https://openalex.org/W2042085026","https://openalex.org/W2046645062","https://openalex.org/W2048139887","https://openalex.org/W2048845767","https://openalex.org/W2050701995","https://openalex.org/W2051438853","https://openalex.org/W2052573676","https://openalex.org/W2055678782","https://openalex.org/W2056850911","https://openalex.org/W2057147465","https://openalex.org/W2057606673","https://openalex.org/W2058649221","https://openalex.org/W2058967943","https://openalex.org/W2060095529","https://openalex.org/W2062623521","https://openalex.org/W2064165592","https://openalex.org/W2065342803","https://openalex.org/W2065387864","https://openalex.org/W2065658439","https://openalex.org/W2067827253","https://openalex.org/W2067936467","https://openalex.org/W2068270570","https://openalex.org/W2075179097","https://openalex.org/W2075665751","https://openalex.org/W2076104395","https://openalex.org/W2077085708","https://openalex.org/W2081470193","https://openalex.org/W2084053955","https://openalex.org/W2084274596","https://openalex.org/W2085154842","https://openalex.org/W2085730824","https://openalex.org/W2085861252","https://openalex.org/W2091185220","https://openalex.org/W2094047457","https://openalex.org/W2095399857","https://openalex.org/W2096829553","https://openalex.org/W2099449304","https://openalex.org/W2104090417","https://openalex.org/W2109831614","https://openalex.org/W2113784326","https://openalex.org/W2114368849","https://openalex.org/W2118053731","https://openalex.org/W2120425761","https://openalex.org/W2125292738","https://openalex.org/W2129272895","https://openalex.org/W2129787793","https://openalex.org/W2132760289","https://openalex.org/W2136300200","https://openalex.org/W2142203838","https://openalex.org/W2160460260","https://openalex.org/W2162380976","https://openalex.org/W2164684230","https://openalex.org/W2279242629","https://openalex.org/W2316748587","https://openalex.org/W2324974320","https://openalex.org/W2337968510","https://openalex.org/W2345742615","https://openalex.org/W2398111602","https://openalex.org/W2400324440","https://openalex.org/W2408885688","https://openalex.org/W2409825428","https://openalex.org/W2410852528","https://openalex.org/W2413052449","https://openalex.org/W2415533671","https://openalex.org/W2418268673","https://openalex.org/W2623315487","https://openalex.org/W2773300044","https://openalex.org/W2887198846","https://openalex.org/W2942545804","https://openalex.org/W2953782210","https://openalex.org/W3007678781","https://openalex.org/W4235325740","https://openalex.org/W4243257990","https://openalex.org/W6632753985","https://openalex.org/W6633354899","https://openalex.org/W6654910153","https://openalex.org/W6674316363","https://openalex.org/W6675447241","https://openalex.org/W6677814246","https://openalex.org/W6680119505","https://openalex.org/W6716775755","https://openalex.org/W6739434046","https://openalex.org/W6764283941"],"related_works":["https://openalex.org/W2026937104","https://openalex.org/W2020853520","https://openalex.org/W2067243857","https://openalex.org/W2202101705","https://openalex.org/W2315487034","https://openalex.org/W4221063627","https://openalex.org/W1983822787","https://openalex.org/W1997453512","https://openalex.org/W125143731","https://openalex.org/W32869502"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}