{"id":"https://openalex.org/W1547739738","doi":"https://doi.org/10.1684/ecn.2014.0345","title":"Mesenteric ischemia-reperfusion injury up-regulates certain CC, CXC, and XC chemokines and results in multi-organ injury in a time-dependent manner","display_name":"Mesenteric ischemia-reperfusion injury up-regulates certain CC, CXC, and XC chemokines and results in multi-organ injury in a time-dependent manner","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W1547739738","doi":"https://doi.org/10.1684/ecn.2014.0345","mag":"1547739738","pmid":"https://pubmed.ncbi.nlm.nih.gov/24589386"},"language":"en","primary_location":{"id":"doi:10.1684/ecn.2014.0345","doi":"https://doi.org/10.1684/ecn.2014.0345","is_oa":false,"landing_page_url":"https://doi.org/10.1684/ecn.2014.0345","pdf_url":null,"source":{"id":"https://openalex.org/S121125150","display_name":"European Cytokine Network","issn_l":"1148-5493","issn":["1148-5493","1952-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320125","host_organization_name":"John Libbey Eurotext","host_organization_lineage":["https://openalex.org/P4310320125"],"host_organization_lineage_names":["John Libbey Eurotext"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Cytokine Network","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067552229","display_name":"Randeep Singh Jawa","orcid":"https://orcid.org/0000-0002-4482-4699","observed_orcids":["https://orcid.org/0000-0002-4482-4699"]},"institutions":[{"id":"https://openalex.org/I4210087560","display_name":"Stony Brook School","ror":"https://ror.org/003wx9n05","country_code":"US","type":"education","lineage":["https://openalex.org/I4210087560"]},{"id":"https://openalex.org/I4210102711","display_name":"Stony Brook Medicine","ror":"https://ror.org/01882y777","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210102711","https://openalex.org/I59553526"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randeep S. Jawa","raw_affiliation_strings":["Department of Surgery, Stony Brook University School of Medicine, Stony Brook, NY 11794-8191"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Stony Brook University School of Medicine, Stony Brook, NY 11794-8191","institution_ids":["https://openalex.org/I4210087560","https://openalex.org/I4210102711","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056805558","display_name":"Erin E. Quist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Quist","raw_affiliation_strings":["Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198","Department of Pathology & Microbiology, University of Nebraska Medical Center, Omaha, NE 68198"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"Department of Pathology & Microbiology, University of Nebraska Medical Center, Omaha, NE 68198","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030090228","display_name":"Craig W. Boyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig W. Boyer","raw_affiliation_strings":["School of Allied Health Professions, AH Research, University of Nebraska Medical Center, Omaha, NE 68198"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Allied Health Professions, AH Research, University of Nebraska Medical Center, Omaha, NE 68198","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069699129","display_name":"Valerie Shostrom","orcid":"https://orcid.org/0000-0001-8125-8764","observed_orcids":["https://orcid.org/0000-0001-8125-8764"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valerie K. Shostrom","raw_affiliation_strings":["College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111639422","display_name":"David Mercer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David W. Mercer","raw_affiliation_strings":["Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280","institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.314,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.79936298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"4","first_page":"148","last_page":"156"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.09380000084638596,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intestinal-ischemia-reperfusion-injury","display_name":"intestinal ischemia-reperfusion injury","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cc-chemokines","display_name":"CC chemokines","score":0.890999972820282},{"id":"https://openalex.org/keywords/cxc-chemokines","display_name":"CXC chemokines","score":0.9860000014305115},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.8679999709129333},{"id":"https://openalex.org/keywords/superior-mesenteric-artery-occlusion","display_name":"superior mesenteric artery occlusion","score":0.8989999890327454},{"id":"https://openalex.org/keywords/eotaxin","display_name":"eotaxin","score":0.7390000224113464},{"id":"https://openalex.org/keywords/monocyte-chemotactic-protein-3","display_name":"MCP-3","score":0.8059999942779541},{"id":"https://openalex.org/keywords/ccl22","display_name":"CCL22","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ccl19","display_name":"CCL19","score":0.9729999899864197},{"id":"https://openalex.org/keywords/lymphotactin","display_name":"lymphotactin","score":0.8519999980926514},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.7710000276565552},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7519999742507935},{"id":"https://openalex.org/keywords/systemic-cytokine-response","display_name":"systemic cytokine response","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.6646043062210083},{"id":"https://openalex.org/C84913492","wikidata":"https://www.wikidata.org/wiki/Q5014892","display_name":"CXC chemokine receptors","level":5,"score":0.6265091896057129},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6193959712982178},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5571809411048889},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5527502298355103},{"id":"https://openalex.org/C2776696333","wikidata":"https://www.wikidata.org/wiki/Q221463","display_name":"Mesenteric ischemia","level":3,"score":0.4617294371128082},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33289384841918945},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33267486095428467},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3294747471809387},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2843073606491089},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.056871652603149414}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008643","descriptor_name":"Mesentery","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008643","descriptor_name":"Mesentery","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017538","descriptor_name":"Mesenteric Artery, Superior","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019742","descriptor_name":"Chemokines, CC","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019743","descriptor_name":"Chemokines, CXC","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020556","descriptor_name":"Neutrophil Infiltration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1684/ecn.2014.0345","doi":"https://doi.org/10.1684/ecn.2014.0345","is_oa":false,"landing_page_url":"https://doi.org/10.1684/ecn.2014.0345","pdf_url":null,"source":{"id":"https://openalex.org/S121125150","display_name":"European Cytokine Network","issn_l":"1148-5493","issn":["1148-5493","1952-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320125","host_organization_name":"John Libbey Eurotext","host_organization_lineage":["https://openalex.org/P4310320125"],"host_organization_lineage_names":["John Libbey Eurotext"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Cytokine Network","raw_type":"journal-article"},{"id":"pmid:24589386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24589386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European cytokine network","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1991278403","https://openalex.org/W2314923169","https://openalex.org/W2151994217","https://openalex.org/W4407835993","https://openalex.org/W2469255941","https://openalex.org/W2004396067","https://openalex.org/W2027964136","https://openalex.org/W1968265929","https://openalex.org/W2013301942","https://openalex.org/W4237637504"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Trauma":[1],"patients":[2],"who":[3],"develop":[4],"multi-organ":[5],"dysfunction":[6],"have":[7],"increased":[8,240,271],"systemic":[9,289],"levels":[10,145,236,255,267],"of":[11,26,38,46,54,146,165,192,218,226,256,268,281,287,324],"chemotactic":[12],"cytokines.":[13],"Ischemia-reperfusion":[14],"(IR)":[15],"injury":[16,73,78,315],"to":[17,30,95,137,201,313],"the":[18,43,47,55,63,100,124,128,133,169,219,285,292],"gut":[19],"may":[20,326],"play":[21,327],"a":[22,35,300,310,322,328],"role.":[23],"The":[24,278,307],"purpose":[25],"this":[27,282],"study":[28,283],"was":[29,105,130,135,168],"examine":[31],"chemokine":[32,85,221],"production":[33],"in":[34,254,291,299,330],"mouse":[36,134],"model":[37],"mesenteric":[39,102],"IR":[40,72,98,251,314],"injury.":[41,306,336],"Given":[42],"pre-eminent":[44],"role":[45,329],"neutrophil,":[48],"there":[49],"has":[50],"been":[51],"much":[52],"investigation":[53],"CXC":[56],"chemokines,":[57],"but":[58],"very":[59],"limited":[60],"research":[61],"on":[62,321],"CC":[64,82,207,293],"and":[65,79,83,132,153,158,180,184,215,229,333],"XC":[66,84,220],"chemokines.":[67],"We":[68,245],"hypothesized":[69],"that":[70,318],"intestinal":[71,179,193],"would":[74],"induce":[75],"remote":[76,181,334],"organ":[77,182],"enhance":[80],"serum":[81,144,175,197],"levels.":[86],"METHODS:":[87],"Fasted":[88],"female":[89],"C57BL6":[90],"mice":[91],"were":[92,156,203,237],"anesthetized":[93],"prior":[94],"laparotomy.":[96],"In":[97],"animals,":[99],"superior":[101],"artery":[103],"(SMA)":[104],"occluded":[106],"for":[107,139,173,205],"30,":[108],"45,":[109],"or":[110,259],"75":[111,190],"min,":[112],"while":[113],"controls":[114],"underwent":[115],"sham":[116],"laparotomy,":[117],"n":[118],"=":[119],"5-7":[120],"per":[121],"group.":[122],"After":[123],"indicated":[125],"time":[126,171,264],"point,":[127],"incision":[129],"closed":[131],"allowed":[136],"recover":[138],"six":[140],"hours.":[141],"Following":[142],"euthanasia,":[143],"15":[147],"chemokines":[148,294,317],"(10":[149],"CC,":[150],"4":[151],"CXC,":[152],"1":[154],"XC)":[155],"assessed":[157],"histopathologic":[159],"analyses":[160],"performed.":[161],"RESULTS:":[162],"Seventy-five":[163],"minutes":[164],"SMA":[166],"occlusion":[167],"key":[170],"frame":[172],"significant":[174,250,288],"cytokine":[176],"level":[177],"up-regulation,":[178],"injury,":[183],"neutrophil":[185],"influx":[186],"into":[187],"tissues.":[188],"With":[189],"min":[191,243],"ischemia,":[194],"significantly":[195,239,272],"elevated":[196],"levels,":[198],"as":[199],"compared":[200],"shams,":[202],"noted":[204],"seven":[206],"chemokines:":[208],"MCP-1,":[209],"MCP-3,":[210,296],"MIP-1\u03b2,":[211],"MIP-3\u03b2,":[212],"eotaxin,":[213,295],"MDC,":[214,297],"RANTES.":[216],"Levels":[217,225],"lymphotactin":[222],"also":[223],"increased.":[224],"MIP-2,":[227],"IP-10,":[228],"KC/GRO":[230],"(CXC":[231],"chemokines)":[232],"rose":[233],"significantly.":[234],"MIP-1\u03b1":[235],"only":[238],"at":[241,261],"45":[242],"IR.":[244],"did":[246],"not":[247],"find":[248],"any":[249,262],"injury-induced":[252],"changes":[253],"MCP-5,":[257],"MIP-1\u03b3,":[258],"GCP-2,":[260],"ischemia":[263,275],"frame.":[265],"Serum":[266],"IL-6":[269],"correspondingly":[270],"with":[273,304],"longer":[274],"times.":[276],"CONCLUSIONS:":[277],"novel":[279],"finding":[280],"is":[284],"demonstration":[286],"increases":[290],"MIP-3\u03b2":[298],"time-dependent":[301],"manner,":[302],"along":[303],"tissue":[305,335],"data":[308],"suggest":[309],"complex":[311],"response":[312],"whereby":[316],"are":[319],"active":[320],"variety":[323],"leukocytes":[325],"inducing":[331],"local":[332]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
