{"id":"https://openalex.org/W1547599546","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.490.3","title":"The role of SWI/SNF in regulating smooth muscle differentiation","display_name":"The role of SWI/SNF in regulating smooth muscle differentiation","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W1547599546","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.490.3","mag":"1547599546"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.23.1_supplement.490.3","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.490.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.490.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012096156","display_name":"B. Paul Herring","orcid":"https://orcid.org/0000-0002-2889-2464","observed_orcids":["https://orcid.org/0000-0002-2889-2464"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Paul Herring","raw_affiliation_strings":["Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100574425","display_name":"Min Zhang","orcid":"https://orcid.org/0009-0004-4883-8379","observed_orcids":["https://orcid.org/0009-0004-4883-8379"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Zhang","raw_affiliation_strings":["Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026793153","display_name":"Jiliang Zhou","orcid":"https://orcid.org/0000-0002-2375-4636","observed_orcids":["https://orcid.org/0000-0002-2375-4636"]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiliang Zhou","raw_affiliation_strings":["Center for Cardiovascular Sciences, Albany Medical College, Albany, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Sciences, Albany Medical College, Albany, NY","institution_ids":["https://openalex.org/I4405260259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07687282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/swi-snf-chromatin-remodeling","display_name":"SWI/SNF chromatin remodeling","score":0.871999979019165},{"id":"https://openalex.org/keywords/brg1","display_name":"SMARCA4","score":0.9039999842643738},{"id":"https://openalex.org/keywords/mrtf","display_name":"MRTF","score":0.8569999933242798},{"id":"https://openalex.org/keywords/serum-response-factor","display_name":"serum response factor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/smooth-muscle-cell-differentiation","display_name":"smooth muscle differentiation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.7789999842643738},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/intestinal-development","display_name":"intestinal development","score":0.7070000171661377},{"id":"https://openalex.org/keywords/smooth-muscle-contractility","display_name":"smooth muscle contractility","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C69053785","wikidata":"https://www.wikidata.org/wiki/Q907394","display_name":"Serum response factor","level":4,"score":0.8915345072746277},{"id":"https://openalex.org/C2780286377","wikidata":"https://www.wikidata.org/wiki/Q18048730","display_name":"Myocardin","level":5,"score":0.8203931450843811},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.7533530592918396},{"id":"https://openalex.org/C166941617","wikidata":"https://www.wikidata.org/wiki/Q421708","display_name":"SWI/SNF","level":5,"score":0.7515807151794434},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7190945148468018},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6679675579071045},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.6558530330657959},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.60442054271698},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.588047981262207},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4803127646446228},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.47512131929397583},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4489976465702057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44572675228118896},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.44537240266799927},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3866662085056305},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3831363022327423},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22145822644233704}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.23.1_supplement.490.3","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.490.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.490.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2020820932","https://openalex.org/W2562247447","https://openalex.org/W2103136476","https://openalex.org/W3168869944","https://openalex.org/W2008638145","https://openalex.org/W7099679746","https://openalex.org/W1547610032","https://openalex.org/W2275431712","https://openalex.org/W3186030980","https://openalex.org/W1964820861"],"abstract_inverted_index":{"The":[0,52],"myocardin":[1],"related":[2],"transcription":[3,26],"factors":[4],"(MRTFs)":[5],"play":[6],"a":[7,35,130,163,183],"critical":[8],"role":[9],"in":[10,31,114,132,139,179,190],"regulating":[11],"serum":[12],"response":[13],"factor's":[14],"(SRF)":[15],"ability":[16,147],"to":[17,43,58,83,150,154,200,206],"drive":[18],"smooth":[19,28,87,111,118,158,164],"muscle":[20,119],"differentiation.":[21],"MRTFs":[22,61,75,128,138,149],"can":[23,62,76],"induce":[24],"the":[25,38,44,84,146,155],"of":[27,40,46,54,86,95,98,104,108,117,148,157,167,174],"muscle\u2010specific":[29,88,112,159,165],"genes":[30,89,113],"nonmuscle":[32],"cells":[33],"through":[34],"mechanism":[36],"involving":[37],"induction":[39],"SRF":[41,64,109,126,152],"binding":[42,65,94,153],"promoters":[45,85,156],"these":[47,175],"genes,":[48],"within":[49,66],"intact":[50],"chromatin.":[51],"goal":[53],"our":[55],"studies":[56],"is":[57],"understand":[59],"how":[60],"facilitate":[63],"an":[67,197,203],"otherwise":[68],"closed":[69],"chromatin":[70,80],"landscape.":[71],"We":[72],"found":[73],"that":[74,124],"recruit":[77],"SWI/SNF":[78],"ATP\u2010dependent":[79],"remodeling":[81],"complexes,":[82],"thereby":[90],"permitting":[91],"high":[92],"affinity":[93],"SRF.":[96],"Expression":[97],"dominant":[99],"negative":[100,142],"Brg1":[101,105,135,143,168,191],"or":[102],"knockdown":[103],"attenuated":[106,145,188],"expression":[107],"dependent":[110],"primary":[115],"cultures":[116],"cells.":[120],"Immunoprecipitation":[121],"assays":[122],"revealed":[123,177],"Brg1,":[125],"and":[127,134,171,202],"form":[129],"complex":[131],"vivo":[133],"directly":[136],"binds":[137],"vitro.":[140],"Dominant":[141],"significantly":[144,184],"increase":[151],"genes.":[160],"Mice":[161],"harboring":[162],"knockout":[166,192],"were":[169],"generated":[170],"preliminary":[172],"analysis":[173],"mice":[176],"defects":[178],"GI":[180],"development,":[181],"including":[182],"shorter":[185],"gut":[186],"with":[187],"contractility":[189],"mice.":[193],"Supported":[194],"by":[195],"DK61130,":[196],"AHA":[198,204],"fellowship":[199],"MZ":[201],"SDG":[205],"LZ.":[207]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}