{"id":"https://openalex.org/W1547029682","doi":"https://doi.org/10.1002/9780470015902.a0002838.pub2","title":"Jerne, Niels Kaj","display_name":"Jerne, Niels Kaj","publication_year":2014,"publication_date":"2014-05-15","ids":{"openalex":"https://openalex.org/W1547029682","doi":"https://doi.org/10.1002/9780470015902.a0002838.pub2","mag":"1547029682"},"language":"en","primary_location":{"id":"doi:10.1002/9780470015902.a0002838.pub2","doi":"https://doi.org/10.1002/9780470015902.a0002838.pub2","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470015902.a0002838.pub2","pdf_url":null,"source":{"id":"https://openalex.org/S4363604175","display_name":"Encyclopedia of Life Sciences","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Life Sciences","raw_type":"other"},"volume":{"id":"https://openalex.org/W1905439276","display_name":"Encyclopedia of Life Sciences"},"type":"reference-entry","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108591334","display_name":"Julius M. Cruse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julius M Cruse","raw_affiliation_strings":["University of Mississippi Medical Center, Jackson, Mississippi, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mississippi Medical Center, Jackson, Mississippi, USA","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072416990","display_name":"Robert E. Lewis","orcid":"https://orcid.org/0000-0002-3616-2971","observed_orcids":["https://orcid.org/0000-0002-3616-2971","https://orcid.org/0009-0005-0177-220X"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E Lewis","raw_affiliation_strings":["University of Mississippi Medical Center, Jackson, Mississippi, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mississippi Medical Center, Jackson, Mississippi, USA","institution_ids":["https://openalex.org/I29606459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I29606459"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14275","display_name":"Historical Medical Research and Treatments","score":0.40869998931884766,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14275","display_name":"Historical Medical Research and Treatments","score":0.40869998931884766,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14475","display_name":"History of Science and Medicine","score":0.3402999937534332,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.1509999930858612,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/self-tolerance","display_name":"self-tolerance","score":0.7039999961853027},{"id":"https://openalex.org/keywords/thymus","display_name":"thymus","score":0.8510000109672546},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7620000243186951},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/idiotype","display_name":"idiotype","score":0.6050000190734863},{"id":"https://openalex.org/keywords/antibody-antigen-interaction","display_name":"antigen-antibody reaction","score":0.7670000195503235},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/history-of-immunology","display_name":"history of immunology","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C164622146","wikidata":"https://www.wikidata.org/wiki/Q9035","display_name":"Danish","level":2,"score":0.599590003490448},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.551695704460144},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5432608723640442},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49210232496261597},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42141860723495483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3988046944141388},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.30802416801452637},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9780470015902.a0002838.pub2","doi":"https://doi.org/10.1002/9780470015902.a0002838.pub2","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470015902.a0002838.pub2","pdf_url":null,"source":{"id":"https://openalex.org/S4363604175","display_name":"Encyclopedia of Life Sciences","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Life Sciences","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W580572701","https://openalex.org/W1566766802","https://openalex.org/W2029898057","https://openalex.org/W2063712775","https://openalex.org/W2064008537","https://openalex.org/W2067522988","https://openalex.org/W2896234260","https://openalex.org/W4205639836","https://openalex.org/W4234307110"],"related_works":["https://openalex.org/W2122319302","https://openalex.org/W2588670893","https://openalex.org/W4243142509","https://openalex.org/W172339464","https://openalex.org/W2002840858","https://openalex.org/W2754416876","https://openalex.org/W4211132544","https://openalex.org/W2074697605","https://openalex.org/W7105520","https://openalex.org/W7204687633"],"abstract_inverted_index":{"Abstract":[0],"Niels":[1],"Kaj":[2],"Jerne":[3,33],"(1911\u20131994)":[4],"was":[5,193],"a":[6,11,75],"Danish":[7,137],"immunologist":[8],"who":[9],"proposed":[10,86],"selection":[12,222],"theory":[13,85,223],"of":[14,20,26,66,129,151,163,168,182,186,196,219],"antibody":[15,53,88],"formation,":[16],"the":[17,48,61,64,71,104,136,145,152,166,180,187,197,205],"functional":[18],"network":[19,84],"antibodies":[21,101,113],"and":[22,24,73,80,148,184,215,224],"lymphocytes":[23],"distinction":[25],"self":[27],"from":[28],"nonself":[29],"by":[30],"T":[31],"lymphocytes.":[32],"achieved":[34],"scientific":[35],"acclaim":[36],"for":[37,55,200],"his":[38,220],"theories":[39],"to":[40,93,100,124,127,173,175],"explain":[41],"immune":[42,49,131],"system":[43,50],"interactions.":[44,82],"He":[45,59,107,158,203],"postulated":[46,108],"that":[47,63,87,109],"contains":[51],"specific":[52,94],"populations":[54],"interaction":[56],"with":[57,103,213],"antigens.":[58],"advanced":[60],"concept":[62],"development":[65],"self\u2010tolerance":[67],"takes":[68],"place":[69],"in":[70,115,141,156,209,217],"thymus":[72],"developed":[74],"\u2018network":[76],"theory\u2019":[77],"postulating":[78],"T\u2010":[79],"B\u2010cell":[81],"His":[83],"active":[89],"sites":[90],"are":[91,114],"attracted":[92],"antigens":[95],"(idiotypes)":[96],"as":[97,99,161,177],"well":[98],"reactive":[102],"same":[105],"site.":[106],"under":[110],"physiological":[111],"conditions,":[112],"equilibrium":[116],"or":[117,211],"balance":[118],"which":[119],"is":[120],"interrupted":[121],"on":[122],"exposure":[123],"antigen,":[125],"leading":[126],"activation":[128],"an":[130],"response.":[132],"After":[133],"working":[134],"at":[135,165,179],"National":[138],"Serum":[139],"Institute":[140,199],"Copenhagen,":[142],"he":[143,192],"joined":[144],"Biological":[146],"Standards":[147],"Immunology":[149,201],"Division":[150],"World":[153],"Health":[154],"Organization":[155],"Geneva.":[157],"next":[159],"served":[160],"Chair":[162],"Microbiology":[164],"University":[167,181],"Pittsburg,":[169],"PA":[170],"but":[171],"returned":[172],"Europe":[174],"serve":[176],"Professor":[178],"Frankfurt":[183],"Director":[185,195],"Paul":[188],"Ehrlich":[189],"Institute.":[190],"Later,":[191],"appointed":[194],"Basel":[198],"(1969\u20131980).":[202],"shared":[204],"1984":[206],"Nobel":[207],"Prize":[208],"Physiology":[210],"Medicine":[212],"K\u00f6hler":[214],"Milstein":[216],"recognition":[218],"natural":[221],"related":[225],"immunological":[226],"hypotheses.":[227]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}