{"id":"https://openalex.org/W1546926080","doi":"https://doi.org/10.1002/dneu.22205","title":"Reduction in cortical parvalbumin expression due to intermittent theta\u2010burst stimulation correlates with maturation of the perineuronal nets in young rats","display_name":"Reduction in cortical parvalbumin expression due to intermittent theta\u2010burst stimulation correlates with maturation of the perineuronal nets in young rats","publication_year":2014,"publication_date":"2014-06-24","ids":{"openalex":"https://openalex.org/W1546926080","doi":"https://doi.org/10.1002/dneu.22205","mag":"1546926080","pmid":"https://pubmed.ncbi.nlm.nih.gov/24962557"},"language":"en","primary_location":{"id":"doi:10.1002/dneu.22205","doi":"https://doi.org/10.1002/dneu.22205","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dneu.22205","pdf_url":null,"source":{"id":"https://openalex.org/S73400187","display_name":"Developmental Neurobiology","issn_l":"1932-8451","issn":["1932-8451","1932-846X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Neurobiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091205148","display_name":"Annika Mix","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annika Mix","raw_affiliation_strings":["Department of Neurophysiology; Medical Faculty, Ruhr University Bochum; Bochum, 44780 Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiology; Medical Faculty, Ruhr University Bochum; Bochum, 44780 Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063674479","display_name":"Kathrin Hoppenrath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kathrin Hoppenrath","raw_affiliation_strings":["Department of Neurophysiology, Medical Faculty Ruhr\u2010University Bochum Bochum 44780 Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiology, Medical Faculty Ruhr\u2010University Bochum Bochum 44780 Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043515994","display_name":"Klaus Funke","orcid":"https://orcid.org/0000-0003-2359-8917","observed_orcids":["https://orcid.org/0000-0003-2359-8917"]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Klaus Funke","raw_affiliation_strings":["Department of Neurophysiology, Medical Faculty Ruhr\u2010University Bochum Bochum 44780 Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiology, Medical Faculty Ruhr\u2010University Bochum Bochum 44780 Germany","institution_ids":["https://openalex.org/I904495901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043515994"],"corresponding_institution_ids":["https://openalex.org/I904495901"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":2.1659,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.84273662,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"75","issue":"1","first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.09809999912977219,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intermittent-theta-burst-stimulation","display_name":"intermittent theta burst stimulation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/parvalbumin","display_name":"parvalbumin","score":0.859000027179718},{"id":"https://openalex.org/keywords/perineuronal-nets","display_name":"perineuronal nets","score":0.8679999709129333},{"id":"https://openalex.org/keywords/fast-spiking-interneurons","display_name":"fast-spiking interneurons","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cortical-development","display_name":"cortical development","score":0.546999990940094},{"id":"https://openalex.org/keywords/age-dependent-plasticity","display_name":"age-dependent plasticity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/gad67","display_name":"GAD67","score":0.7170000076293945},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.8349999785423279},{"id":"https://openalex.org/keywords/critical-period","display_name":"critical period","score":0.7720000147819519},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/transcranial-magnetic-stimulation","display_name":"transcranial magnetic stimulation","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C129987498","wikidata":"https://www.wikidata.org/wiki/Q7168586","display_name":"Perineuronal net","level":3,"score":0.8709904551506042},{"id":"https://openalex.org/C141547260","wikidata":"https://www.wikidata.org/wiki/Q2720322","display_name":"Parvalbumin","level":2,"score":0.87041175365448},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.7855596542358398},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.7318440675735474},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.7127234935760498},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6981775760650635},{"id":"https://openalex.org/C2778581513","wikidata":"https://www.wikidata.org/wiki/Q263962","display_name":"Transcranial magnetic stimulation","level":3,"score":0.6735807657241821},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6002997756004333},{"id":"https://openalex.org/C9497952","wikidata":"https://www.wikidata.org/wiki/Q419650","display_name":"Glutamate decarboxylase","level":3,"score":0.5722402930259705},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05886438488960266},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010320","descriptor_name":"Parvalbumins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013826","descriptor_name":"Theta Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050781","descriptor_name":"Transcranial Magnetic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/dneu.22205","doi":"https://doi.org/10.1002/dneu.22205","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dneu.22205","pdf_url":null,"source":{"id":"https://openalex.org/S73400187","display_name":"Developmental Neurobiology","issn_l":"1932-8451","issn":["1932-8451","1932-846X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Neurobiology","raw_type":"journal-article"},{"id":"pmid:24962557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24962557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental neurobiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1535558863","https://openalex.org/W1689956239","https://openalex.org/W1950188661","https://openalex.org/W1963685656","https://openalex.org/W1972287603","https://openalex.org/W1983948453","https://openalex.org/W1985654472","https://openalex.org/W2001954021","https://openalex.org/W2003580269","https://openalex.org/W2004229492","https://openalex.org/W2022755800","https://openalex.org/W2025603247","https://openalex.org/W2025692046","https://openalex.org/W2029645045","https://openalex.org/W2035293573","https://openalex.org/W2044384772","https://openalex.org/W2044655131","https://openalex.org/W2045133630","https://openalex.org/W2055289920","https://openalex.org/W2058249590","https://openalex.org/W2060600395","https://openalex.org/W2064656928","https://openalex.org/W2065637628","https://openalex.org/W2072133859","https://openalex.org/W2073584827","https://openalex.org/W2077740203","https://openalex.org/W2077960037","https://openalex.org/W2083920471","https://openalex.org/W2088475496","https://openalex.org/W2088959932","https://openalex.org/W2089296341","https://openalex.org/W2091187766","https://openalex.org/W2093389758","https://openalex.org/W2099040370","https://openalex.org/W2099314926","https://openalex.org/W2099408092","https://openalex.org/W2120149411","https://openalex.org/W2144492575","https://openalex.org/W2146369085","https://openalex.org/W2149561999","https://openalex.org/W2153308935","https://openalex.org/W2153738580","https://openalex.org/W2161547851","https://openalex.org/W2163815564","https://openalex.org/W2168993502","https://openalex.org/W2169820343","https://openalex.org/W2171584675"],"related_works":["https://openalex.org/W61736868","https://openalex.org/W2055289920","https://openalex.org/W4392324882","https://openalex.org/W2949903506","https://openalex.org/W3031913802","https://openalex.org/W6945957037","https://openalex.org/W3165490951","https://openalex.org/W2925619918","https://openalex.org/W3200344446","https://openalex.org/W4401834265"],"abstract_inverted_index":{"We":[0,82],"recently":[1],"showed":[2],"that":[3,84,175],"intermittent":[4],"theta-burst":[5],"stimulation":[6,11],"(iTBS)":[7],"using":[8],"transcranial":[9,240],"magnetic":[10,241],"strongly":[12],"reduces":[13],"the":[14,59,135,153,158,163,166,176,180,210,224],"number":[15,119],"of":[16,33,39,50,76,96,106,113,120,152,179,183,209,216,246],"rat":[17],"neocortical":[18],"interneurons":[19,52,185,233],"expressing":[20,122],"glutamic":[21],"acid":[22],"decarboxylase":[23],"67":[24],"kDa":[25],"(GAD67)":[26],"and":[27,70,102,133,213,249],"parvalbumin":[28],"(PV),":[29],"indicating":[30],"changed":[31],"activity":[32],"fast-spiking":[34],"(FS)":[35],"interneurons.":[36],"In":[37],"advance":[38],"in":[40,47,87,131,137,165,196],"vitro":[41],"studies":[42],"intended":[43],"to":[44,93,188,202],"characterize":[45],"changes":[46,245],"electrical":[48],"properties":[49],"FS":[51],"under":[53],"these":[54,171],"conditions,":[55],"we":[56,173],"tested":[57],"whether":[58],"iTBS":[60,77,143,167],"effect":[61],"is":[62,192,221],"age-dependent.":[63,147],"Conscious":[64],"Sprague-Dawley":[65],"rats":[66,197],"aged":[67],"between":[68],"28":[69],"90":[71],"days":[72],"received":[73],"three":[74],"blocks":[75],"at":[78,110],"15":[79],"min":[80],"intervals.":[81],"found":[83],"iTBS-related":[85],"reduction":[86,109],"PV+":[88,159,184,232],"cells":[89,121],"was":[90,144],"absent":[91],"up":[92],"an":[94,111],"age":[95,112,130],"32":[97],"days,":[98],"then":[99],"gradually":[100],"increased,":[101],"approached":[103],"a":[104,149],"maximum":[105],"about":[107,114],"40%":[108],"40":[115],"days.":[116],"The":[117],"relative":[118],"PV":[123],"(PV+,":[124],"8-9%)":[125],"did":[126],"not":[127,145,193],"change":[128],"with":[129,186],"sham-controls":[132],"also":[134,251],"increase":[136,164],"cortical":[138,218,226],"c-Fos":[139],"expression":[140],"induced":[141],"by":[142],"principally":[146],"However,":[148],"prominent":[150],"growth":[151],"perineuronal":[154,211],"nets,":[155],"typically":[156],"surrounding":[157],"cells,":[160],"exactly":[161],"paralleled":[162],"effect.":[168],"Based":[169],"on":[170],"findings,":[172],"conclude":[174],"functional":[177],"development":[178],"inhibitory":[181],"network":[182],"regard":[187],"intracortical":[189],"synaptic":[190,252],"connectivity":[191],"sufficiently":[194,236],"matured":[195],"younger":[198],"than":[199],"35":[200],"d":[201],"enable":[203],"activity-dependent":[204],"modifications":[205],"during":[206],"iTBS.":[207],"Outgrowth":[208],"nets":[212],"associated":[214],"maturation":[215],"excitatory":[217],"inputs,":[219],"as":[220],"characteristic":[222],"for":[223],"critical":[225],"period,":[227],"may":[228],"take":[229],"place":[230],"before":[231],"can":[234],"be":[235],"activated":[237],"via":[238],"repetitive":[239],"stimulation,":[242],"allowing":[243],"plastic":[244],"molecular":[247],"phenotype":[248],"likely":[250],"plasticity.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}