{"id":"https://openalex.org/W1546909082","doi":"https://doi.org/10.1016/s1875-5364(12)60006-5","title":"5, 6-Dihydropyranobenzopyrone: a previously undetermined antioxidant isolated from Polygonum amplexicaule","display_name":"5, 6-Dihydropyranobenzopyrone: a previously undetermined antioxidant isolated from Polygonum amplexicaule","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1546909082","doi":"https://doi.org/10.1016/s1875-5364(12)60006-5","mag":"1546909082","pmid":"https://pubmed.ncbi.nlm.nih.gov/23302526"},"language":"en","primary_location":{"id":"doi:10.1016/s1875-5364(12)60006-5","doi":"https://doi.org/10.1016/s1875-5364(12)60006-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1875-5364(12)60006-5","pdf_url":null,"source":{"id":"https://openalex.org/S114839437","display_name":"Chinese Journal of Natural Medicines","issn_l":"1875-5364","issn":["1875-5364","1672-3651","2095-6975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Natural Medicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070540263","display_name":"Mudasir Ahmad Tantry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mudasir A. Tantry","raw_affiliation_strings":["National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, United States. mtantry@olemiss.edu","National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University 38677 MS, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, United States. mtantry@olemiss.edu","institution_ids":["https://openalex.org/I368840534"]},{"raw_affiliation_string":"National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University 38677 MS, United States","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035057631","display_name":"Mohamed M. Radwan","orcid":"https://orcid.org/0000-0002-7393-8601","observed_orcids":["https://orcid.org/0000-0002-7393-8601"]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed M. Radwan","raw_affiliation_strings":["National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University 38677 MS, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University 38677 MS, United States","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110355972","display_name":"Seema Akbar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135388327","display_name":"University of Kashmir","ror":"https://ror.org/032xfst36","country_code":"IN","type":"education","lineage":["https://openalex.org/I135388327"]},{"id":"https://openalex.org/I4210158697","display_name":"Regional Research Institute of Unani Medicine","ror":"https://ror.org/05svfd950","country_code":"IN","type":"government","lineage":["https://openalex.org/I4210158697"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Seema Akbar","raw_affiliation_strings":["Drug Standardisation Research Unit, Regional Research Institute of Unani Medicine (CCRUM), Naseem Bagh Campus, University of Kashmir, Srinagar 190 006, Kashmir India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Standardisation Research Unit, Regional Research Institute of Unani Medicine (CCRUM), Naseem Bagh Campus, University of Kashmir, Srinagar 190 006, Kashmir India","institution_ids":["https://openalex.org/I135388327","https://openalex.org/I4210158697"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049082763","display_name":"Ikhlas Ahmed Khan","orcid":"https://orcid.org/0000-0001-5464-4643","observed_orcids":["https://orcid.org/0000-0001-5464-4643"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]},{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["SA","US"],"is_corresponding":false,"raw_author_name":"Ikhlas A. Khan","raw_affiliation_strings":["Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11557, Saudi Arabia","Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University 38677 MS, United States","National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University 38677 MS, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11557, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University 38677 MS, United States","institution_ids":["https://openalex.org/I368840534"]},{"raw_affiliation_string":"National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University 38677 MS, United States","institution_ids":["https://openalex.org/I368840534"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070540263"],"corresponding_institution_ids":["https://openalex.org/I368840534"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":2.4927,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.87887716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"1","first_page":"28","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.8705999851226807,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12346","display_name":"Phytochemistry and biological activity of medicinal plants","score":0.05570000037550926,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13719","display_name":"Phytochemistry and Bioactivity Studies","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzopyranones","display_name":"benzopyrones","score":0.6230000257492065},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7059999704360962},{"id":"https://openalex.org/keywords/dpph-radical-scavenging-activity","display_name":"DPPH radical scavenging","score":0.9020000100135803},{"id":"https://openalex.org/keywords/phytochemical-isolation","display_name":"phytochemical isolation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/bioassay-guided-fractionation","display_name":"bioassay-guided fractionation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/catechins","display_name":"catechins","score":0.7910000085830688},{"id":"https://openalex.org/keywords/rutin","display_name":"rutin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/chlorogenic-acid","display_name":"chlorogenic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/caffeic-acid","display_name":"caffeic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gallic-acid","display_name":"gallic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/natural-compounds","display_name":"natural compounds","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C2776077704","wikidata":"https://www.wikidata.org/wiki/Q271400","display_name":"Polygonum","level":2,"score":0.6178335547447205},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5923718810081482},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47069764137268066},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3820343017578125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2840650677680969},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23389053344726562}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003374","descriptor_name":"Coumarins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010851","descriptor_name":"Picrates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028502","descriptor_name":"Polygonum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/s1875-5364(12)60006-5","doi":"https://doi.org/10.1016/s1875-5364(12)60006-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1875-5364(12)60006-5","pdf_url":null,"source":{"id":"https://openalex.org/S114839437","display_name":"Chinese Journal of Natural Medicines","issn_l":"1875-5364","issn":["1875-5364","1672-3651","2095-6975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Natural Medicines","raw_type":"journal-article"},{"id":"doi:10.3724/sp.j.1009.2012.00028","doi":"https://doi.org/10.3724/sp.j.1009.2012.00028","is_oa":false,"landing_page_url":"https://doi.org/10.3724/sp.j.1009.2012.00028","pdf_url":null,"source":{"id":"https://openalex.org/S114839437","display_name":"Chinese Journal of Natural Medicines","issn_l":"1875-5364","issn":["1875-5364","1672-3651","2095-6975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Natural Medicines","raw_type":"journal-article"},{"id":"pmid:23302526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23302526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese journal of natural medicines","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G435912836","display_name":"Science Based Authentication of Dietary Supplements","funder_award_id":"5u01fd002071-10","funder_id":"https://openalex.org/F4320332163","funder_display_name":"U.S. Food and Drug Administration"},{"id":"https://openalex.org/G5847201459","display_name":null,"funder_award_id":"1U01FD003871-02","funder_id":"https://openalex.org/F4320332163","funder_display_name":"U.S. Food and Drug Administration"}],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1965857957","https://openalex.org/W1966108982","https://openalex.org/W1998359367","https://openalex.org/W2012299398","https://openalex.org/W2018730381","https://openalex.org/W2043876718","https://openalex.org/W2053850561","https://openalex.org/W2065547415","https://openalex.org/W2310339883","https://openalex.org/W2316503503","https://openalex.org/W2356138888"],"related_works":["https://openalex.org/W2401631096","https://openalex.org/W2376314407","https://openalex.org/W2181821849","https://openalex.org/W2020402208","https://openalex.org/W2343270111","https://openalex.org/W3004006066","https://openalex.org/W3094835796","https://openalex.org/W4244234986","https://openalex.org/W1985582210","https://openalex.org/W2361495509"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"study":[2],"the":[3,25,52],"chemical":[4],"constituents":[5],"and":[6,22,33,37,94],"their":[7],"bioactivity":[8],"of":[9,15,24,43,47,54],"Polygonum":[10,48],"amplexicaule.":[11],"METHODS:":[12],"The":[13],"isolation":[14,53],"compounds":[16,67],"was":[17,27],"achieved":[18],"by":[19,29],"chromatographic":[20],"techniques":[21],"structure":[23],"isolates":[26],"established":[28],"UV,":[30],"IR,":[31],"HRESI-MS":[32],"NMR":[34],"including":[35],"1D":[36],"2D":[38],"experiments.":[39],"RESULTS:":[40],"Bioassay-guided":[41],"fractionation":[42],"an":[44],"ethanolic":[45],"extract":[46],"amplexicaule":[49],"led":[50],"to":[51],"a":[55,109],"hitherto":[56],"unidentified":[57],"compound,":[58],"5,":[59],"6-dihydropyranobenzopyrone":[60],"(1)":[61],"along":[62],"with":[63],"nine":[64],"previously":[65],"known":[66],"(2-10).":[68],"Compounds":[69,102],"2-10":[70],"were":[71],"identified":[72],"as":[73],"amplexicine":[74],"(2),":[75],"catechin":[76],"(3),":[77],"rutin":[78],"(4),":[79],"quercetin-3-O-\u03b2-D-galactopyranoside":[80],"(5),":[81],"chlorogenic":[82],"acid":[83,89,92],"(6),":[84],"galloyl":[85],"glucose":[86],"(7),":[87],"caffeic":[88],"(8),":[90],"gallic":[91],"(9)":[93],"scopletin":[95],"(10).":[96],"CONCLUSION:":[97],"Compound":[98],"1":[99],"is":[100],"new.":[101],"1-10":[103],"exhibited":[104],"considerable":[105],"antioxidant":[106],"activity":[107],"in":[108],"1,":[110],"1-diphenyl-2-picrylhydrazyl":[111],"(DPPH)":[112],"radical-scavenging":[113],"assay.":[114]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}