{"id":"https://openalex.org/W154685941","doi":null,"title":"IgM and IgD concentrations in the serum and secretions of children with selective IgA deficiency.","display_name":"IgM and IgD concentrations in the serum and secretions of children with selective IgA deficiency.","publication_year":1983,"publication_date":"1983-09-01","ids":{"openalex":"https://openalex.org/W154685941","mag":"154685941","pmid":"https://pubmed.ncbi.nlm.nih.gov/6616961","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1535652"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1535652","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1535652","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1535652","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018481010","display_name":"Alessandro Plebani","orcid":"https://orcid.org/0000-0002-2003-3307","observed_orcids":["https://orcid.org/0000-0002-2003-3307"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Plebani","raw_affiliation_strings":["University of Pavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072291153","display_name":"Emilia Mira","orcid":"https://orcid.org/0000-0002-4226-1829","observed_orcids":["https://orcid.org/0000-0002-4226-1829"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Mira","raw_affiliation_strings":["University of Pavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053388828","display_name":"Emilio Mevio","orcid":"https://orcid.org/0000-0003-3432-3046","observed_orcids":["https://orcid.org/0000-0003-3432-3046"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Mevio","raw_affiliation_strings":["University of Pavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pavia","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083882415","display_name":"V. Monaf\u00f2","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Monafo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029163913","display_name":"Luigi Daniele Notarangelo","orcid":"https://orcid.org/0000-0002-8335-0262","observed_orcids":["https://orcid.org/0000-0002-8335-0262"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L D Notarangelo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074897422","display_name":"Maria Antonietta Avanzini","orcid":"https://orcid.org/0000-0002-6056-9018","observed_orcids":["https://orcid.org/0000-0002-6056-9018"]},"institutions":[{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Avanzini","raw_affiliation_strings":["IRCCS Fondazione Policlinico San Matteo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Fondazione Policlinico San Matteo","institution_ids":["https://openalex.org/I4210151645"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003006976","display_name":"A. G. Ugazio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A G Ugazio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.765,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.68461093,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"53","issue":"3","first_page":"689","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selective-iga-deficiency","display_name":"selective IgA deficiency","score":0.9869999885559082},{"id":"https://openalex.org/keywords/igd","display_name":"IgD","score":0.7289999723434448},{"id":"https://openalex.org/keywords/secretory-igm","display_name":"secretory IgM","score":0.8500000238418579},{"id":"https://openalex.org/keywords/serum-igm","display_name":"serum IgM","score":0.7239999771118164},{"id":"https://openalex.org/keywords/serum-igg","display_name":"serum IgG","score":0.7509999871253967},{"id":"https://openalex.org/keywords/nasal-secretions","display_name":"nasal secretions","score":0.7900000214576721},{"id":"https://openalex.org/keywords/saliva","display_name":"saliva","score":0.9110000133514404},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C48010095","wikidata":"https://www.wikidata.org/wiki/Q79447","display_name":"Immunoglobulin D","level":4,"score":0.943926215171814},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.7919304370880127},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6493250131607056},{"id":"https://openalex.org/C2779102806","wikidata":"https://www.wikidata.org/wiki/Q79453","display_name":"Immunoglobulin A","level":4,"score":0.5770201086997986},{"id":"https://openalex.org/C2776553844","wikidata":"https://www.wikidata.org/wiki/Q79451","display_name":"Immunoglobulin M","level":4,"score":0.5373254418373108},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5026657581329346},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4702005982398987},{"id":"https://openalex.org/C2909735910","wikidata":"https://www.wikidata.org/wiki/Q79453","display_name":"Secretory IgA","level":3,"score":0.42681124806404114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41180577874183655},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3772525191307068},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35988134145736694},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.3416108191013336},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34050214290618896},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.09865003824234009}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004406","descriptor_name":"Dysgammaglobulinemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005122","descriptor_name":"Exudates and Transudates","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007071","descriptor_name":"Immunoglobulin A, Secretory","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007072","descriptor_name":"Immunoglobulin D","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017098","descriptor_name":"IgA Deficiency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1535652","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1535652","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:6616961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6616961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unibs.it:11379/457159","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11379/457159","pdf_url":null,"source":{"id":"https://openalex.org/S4306400804","display_name":"Institutional Research Information System (Universit\u00e0 degli Studi di Brescia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:154685941","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6616961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1535652","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1535652","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W13295407","https://openalex.org/W82467273","https://openalex.org/W145273907","https://openalex.org/W167127321","https://openalex.org/W194849234","https://openalex.org/W1568196150","https://openalex.org/W1850005700","https://openalex.org/W1971585807","https://openalex.org/W1983727842","https://openalex.org/W1986858900","https://openalex.org/W1993148404","https://openalex.org/W2002983094","https://openalex.org/W2014482706","https://openalex.org/W2025483184","https://openalex.org/W2030123703","https://openalex.org/W2045056908","https://openalex.org/W2051697013","https://openalex.org/W2052884083","https://openalex.org/W2053146299","https://openalex.org/W2061236157","https://openalex.org/W2093547364","https://openalex.org/W2123835826","https://openalex.org/W2154307202","https://openalex.org/W2284365016","https://openalex.org/W2406365795","https://openalex.org/W2412651405","https://openalex.org/W2994593191","https://openalex.org/W4236233462","https://openalex.org/W4295094667","https://openalex.org/W4313306905","https://openalex.org/W4313316451","https://openalex.org/W4324282175"],"related_works":["https://openalex.org/W7029056768","https://openalex.org/W2116726584","https://openalex.org/W125158113","https://openalex.org/W2415851193","https://openalex.org/W145273907","https://openalex.org/W2009308362","https://openalex.org/W2417896965","https://openalex.org/W2019516784","https://openalex.org/W2913930720","https://openalex.org/W1979359930"],"abstract_inverted_index":{"Serum":[0],"IgG":[1,80,104],"and":[2,4,8,20,24,45,54,81,83,105,114,119,137,154,174,187],"serum":[3,42,55,79,103,113,127,173,186],"secretory":[5,61,84,134,175,188],"IgM,":[6,126],"IgA":[7,18,44,56,62,64,76,184],"IgD":[9,29,108,128,135,138,189,207],"levels":[10,129,136,177],"were":[11,47,86,130],"determined":[12,31],"in":[13,21,49,65,72,88,92,111,141,144,148,151,180,192,202,206,208],"14":[14],"children":[15,78,181],"with":[16,63,157,182],"selective":[17,183],"deficiency":[19],"12":[22],"age":[23,51],"sex":[25],"matched":[26],"healthy":[27,40],"controls.":[28],"was":[30,57,98,109,139],"using":[32],"a":[33,199],"highly":[34],"sensitive":[35],"ELISA":[36],"technique.":[37],"In":[38,74],"the":[39,50,75,93,96,112,152,155,161,165,196],"controls":[41,94],"IgG,":[43],"IgM":[46,82,85,176,203],"all":[48,117,120],"normal":[52,193],"range,":[53],"significantly":[58,69,131],"higher":[59,70,89,132],"than":[60,71,91,133,147],"nasal":[66,145],"secretions":[67,115,146],"being":[68],"saliva.":[73],"deficient":[77],"present":[87,140,191],"concentrations":[90,143],"but":[95,121,204],"difference":[97,159],"statistically":[99],"significant":[100],"only":[101],"for":[102],"salivary":[106],"IgM.":[107],"detectable":[110],"of":[116,167,198],"patients":[118,153],"one":[122],"control":[123],"subject.":[124],"Like":[125],"greater":[142],"saliva":[149],"both":[150],"controls,":[156],"no":[158],"between":[160],"two":[162],"groups.":[163],"Thus,":[164],"data":[166],"this":[168],"study":[169],"show":[170],"that":[171],"while":[172],"are":[178,190],"elevated":[179],"deficiency,":[185],"concentrations,":[194],"supporting":[195],"hypothesis":[197],"compensatory":[200],"increase":[201],"not":[205],"such":[209],"patients.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}