{"id":"https://openalex.org/W1546825927","doi":"https://doi.org/10.1182/blood.v95.4.1473.004k50_1473_1480","title":"Tropomyosin isoform 5b is expressed in human erythrocytes: implications of tropomodulin-TM5 or tropomodulin-TM5b complexes in the protofilament and hexagonal organization of membrane skeletons","display_name":"Tropomyosin isoform 5b is expressed in human erythrocytes: implications of tropomodulin-TM5 or tropomodulin-TM5b complexes in the protofilament and hexagonal organization of membrane skeletons","publication_year":2000,"publication_date":"2000-02-15","ids":{"openalex":"https://openalex.org/W1546825927","doi":"https://doi.org/10.1182/blood.v95.4.1473.004k50_1473_1480","mag":"1546825927","pmid":"https://pubmed.ncbi.nlm.nih.gov/10666227"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v95.4.1473.004k50_1473_1480","doi":"https://doi.org/10.1182/blood.v95.4.1473.004k50_1473_1480","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v95.4.1473.004k50_1473_1480","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113462607","display_name":"Lanping Amy Sung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lanping Amy Sung","raw_affiliation_strings":["From the Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA;the Nutritional Science Department, University of Arizona, Tucson, AZ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and the Department of Biological Sciences, University of Iowa, Iowa City, IA","Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","the Department of Biological Sciences, University of Iowa, Iowa City, IA","the Nutritional Science Department, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA;the Nutritional Science Department, University of Arizona, Tucson, AZ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and the Department of Biological Sciences, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I138006243","https://openalex.org/I2750212522","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"the Department of Biological Sciences, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"the Nutritional Science Department, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ke-Ming Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ke-Ming Gao","raw_affiliation_strings":["From the Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA;the Nutritional Science Department, University of Arizona, Tucson, AZ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and the Department of Biological Sciences, University of Iowa, Iowa City, IA","Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","the Department of Biological Sciences, University of Iowa, Iowa City, IA","the Nutritional Science Department, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA;the Nutritional Science Department, University of Arizona, Tucson, AZ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and the Department of Biological Sciences, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I138006243","https://openalex.org/I2750212522","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"the Department of Biological Sciences, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"the Nutritional Science Department, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024590716","display_name":"Leland J. Yee","orcid":"https://orcid.org/0000-0002-0369-5878","observed_orcids":["https://orcid.org/0000-0002-0369-5878"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leland J. Yee","raw_affiliation_strings":["From the Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA;the Nutritional Science Department, University of Arizona, Tucson, AZ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and the Department of Biological Sciences, University of Iowa, Iowa City, IA","Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","the Department of Biological Sciences, University of Iowa, Iowa City, IA","the Nutritional Science Department, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA;the Nutritional Science Department, University of Arizona, Tucson, AZ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and the Department of Biological Sciences, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I138006243","https://openalex.org/I2750212522","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"the Department of Biological Sciences, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"the Nutritional Science Department, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070803103","display_name":"Constance J. Temm","orcid":"https://orcid.org/0000-0002-6619-021X","observed_orcids":["https://orcid.org/0000-0002-6619-021X"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Constance J. Temm-Grove","raw_affiliation_strings":["From the Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA;the Nutritional Science Department, University of Arizona, Tucson, AZ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and the Department of Biological Sciences, University of Iowa, Iowa City, IA","Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","the Department of Biological Sciences, University of Iowa, Iowa City, IA","the Nutritional Science Department, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA;the Nutritional Science Department, University of Arizona, Tucson, AZ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and the Department of Biological Sciences, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I138006243","https://openalex.org/I2750212522","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"the Department of Biological Sciences, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"the Nutritional Science Department, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039994535","display_name":"David M. Helfman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Helfman","raw_affiliation_strings":["From the Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA;the Nutritional Science Department, University of Arizona, Tucson, AZ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and the Department of Biological Sciences, University of Iowa, Iowa City, IA","Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","the Department of Biological Sciences, University of Iowa, Iowa City, IA","the Nutritional Science Department, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA;the Nutritional Science Department, University of Arizona, Tucson, AZ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and the Department of Biological Sciences, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I138006243","https://openalex.org/I2750212522","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"the Department of Biological Sciences, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"the Nutritional Science Department, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111997116","display_name":"Jim Jung\u2010Ching Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jim J.-C. Lin","raw_affiliation_strings":["From the Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA;the Nutritional Science Department, University of Arizona, Tucson, AZ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and the Department of Biological Sciences, University of Iowa, Iowa City, IA","Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","the Department of Biological Sciences, University of Iowa, Iowa City, IA","the Nutritional Science Department, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA;the Nutritional Science Department, University of Arizona, Tucson, AZ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and the Department of Biological Sciences, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I138006243","https://openalex.org/I2750212522","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"the Department of Biological Sciences, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"the Nutritional Science Department, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049706079","display_name":"Majid Mehrpouryan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Majid Mehrpouryan","raw_affiliation_strings":["From the Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA;the Nutritional Science Department, University of Arizona, Tucson, AZ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and the Department of Biological Sciences, University of Iowa, Iowa City, IA","Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","the Department of Biological Sciences, University of Iowa, Iowa City, IA","the Nutritional Science Department, University of Arizona, Tucson, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA;the Nutritional Science Department, University of Arizona, Tucson, AZ; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; and the Department of Biological Sciences, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I138006243","https://openalex.org/I2750212522","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"the Department of Biological Sciences, University of Iowa, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"the Nutritional Science Department, University of Arizona, Tucson, AZ","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.5499,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.88432556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"95","issue":"4","first_page":"1473","last_page":"1480"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.05530000105500221,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tropomyosin-isoforms","display_name":"tropomyosin isoforms","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tropomodulin","display_name":"tropomodulin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/erythrocyte-membrane-skeleton","display_name":"erythrocyte membrane skeleton","score":0.9629999995231628},{"id":"https://openalex.org/keywords/hexagonal-lattice","display_name":"hexagonal lattice","score":0.7620000243186951},{"id":"https://openalex.org/keywords/actin-capping-protein","display_name":"actin capping protein","score":0.6299999952316284},{"id":"https://openalex.org/keywords/molecular-ruler","display_name":"molecular ruler","score":0.6690000295639038},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.5889999866485596},{"id":"https://openalex.org/keywords/actin-binding-affinity","display_name":"actin binding affinity","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C205875245","wikidata":"https://www.wikidata.org/wiki/Q418454","display_name":"Tropomyosin","level":3,"score":0.9162213802337646},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7048478722572327},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.6370821595191956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5254256725311279},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46759694814682007},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32433903217315674},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2086389660835266}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004910","descriptor_name":"Erythrocyte Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014335","descriptor_name":"Tropomyosin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014335","descriptor_name":"Tropomyosin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014335","descriptor_name":"Tropomyosin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051348","descriptor_name":"Tropomodulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v95.4.1473.004k50_1473_1480","doi":"https://doi.org/10.1182/blood.v95.4.1473.004k50_1473_1480","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v95.4.1473.004k50_1473_1480","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:10666227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10666227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:repository.cshl.edu:29455","doi":null,"is_oa":false,"landing_page_url":"https://repository.cshl.edu/id/eprint/29455/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402288","display_name":"Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Paper"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3462740781","display_name":null,"funder_award_id":"DK47673","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4842490454","display_name":"Biomechanics of the Heart, Vessels, and Blood Cells","funder_award_id":"P01HL043026","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5780272333","display_name":null,"funder_award_id":"HD-18577","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6276581941","display_name":null,"funder_award_id":"HL43026","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G697816675","display_name":"The Developmental Biology of Cell Motility","funder_award_id":"P01HD018577","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8073367283","display_name":"AUTOIMMUNE MECHANISM IN ULCERATIVE COLITIS","funder_award_id":"R01DK047673","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1514821046","https://openalex.org/W1525081901","https://openalex.org/W1526000693","https://openalex.org/W1536108064","https://openalex.org/W1539899651","https://openalex.org/W1540638801","https://openalex.org/W1573549078","https://openalex.org/W1577296418","https://openalex.org/W1602991363","https://openalex.org/W1606832165","https://openalex.org/W1607077699","https://openalex.org/W1672080028","https://openalex.org/W1965782093","https://openalex.org/W1972131508","https://openalex.org/W1995575464","https://openalex.org/W1995686131","https://openalex.org/W1997817236","https://openalex.org/W2000145618","https://openalex.org/W2005579644","https://openalex.org/W2009237819","https://openalex.org/W2012604733","https://openalex.org/W2034909164","https://openalex.org/W2036983421","https://openalex.org/W2037638295","https://openalex.org/W2040409993","https://openalex.org/W2048367390","https://openalex.org/W2049492301","https://openalex.org/W2061365077","https://openalex.org/W2069033493","https://openalex.org/W2076271536","https://openalex.org/W2081013548","https://openalex.org/W2084418451","https://openalex.org/W2088635839","https://openalex.org/W2089640529","https://openalex.org/W2091246203","https://openalex.org/W2095394161","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2103346857","https://openalex.org/W2119405359","https://openalex.org/W2131810538","https://openalex.org/W2168724903","https://openalex.org/W2168759286","https://openalex.org/W2171042004","https://openalex.org/W6659652230"],"related_works":["https://openalex.org/W193512276","https://openalex.org/W1972988548","https://openalex.org/W2033246610","https://openalex.org/W2089640529","https://openalex.org/W2047589966","https://openalex.org/W2407413636","https://openalex.org/W1510248685","https://openalex.org/W1602991363","https://openalex.org/W275751943","https://openalex.org/W2043952275"],"abstract_inverted_index":{"The":[0,177],"human":[1,61,67],"erythrocyte":[2,153],"membrane":[3],"skeleton":[4],"consists":[5],"of":[6,15,36,45,54,74,80,93,109,228,252,260],"hexagonal":[7,250],"lattices":[8],"with":[9,146,158],"junctional":[10],"complexes":[11,24,222],"containing":[12],"F-actin":[13,201,225],"protofilaments":[14,216],"approximately":[16,46,192,229],"33-37":[17,230],"nm":[18,194,231],"in":[19,85,152,226],"length.":[20],"We":[21,56,87],"hypothesize":[22],"that":[23],"formed":[25],"by":[26,115,130,214,265],"tropomodulin,":[27,170],"a":[28,42,72,91,120,241],"globular":[29],"capping":[30],"protein":[31],"at":[32],"the":[33,52,60,75,81,94,99,105,110,131,147,159,209,212,249,253],"pointed":[34],"end":[35],"actin":[37],"filaments,":[38],"and":[39,65,118,155,196,202,236,245,256],"tropomyosin":[40],"(TM),":[41],"rod-like":[43],"molecule":[44],"33-35":[47,193],"nm,":[48],"may":[49,207,223],"contribute":[50],"to":[51,97,169,211,262],"formation":[53],"protofilaments.":[55],"have":[57,188,197],"previously":[58],"cloned":[59],"tropomodulin":[62],"complementary":[63],"DNA":[64],"identified":[66],"TM":[68,83,102,149,161,175,180],"isoform":[69,108],"5":[70],"(hTM5),":[71],"product":[73,92],"gamma-TM":[76],"gene,":[77,96,112,133],"as":[78,240],"one":[79],"major":[82,101,150,162,179],"isoforms":[84],"erythrocytes.":[86],"now":[88],"identify":[89],"TM5b,":[90,164],"alpha-TM":[95,111],"be":[98,208,263],"second":[100],"isoform.":[103],"TM5a,":[104],"alternatively":[106],"spliced":[107],"which":[113,215],"differs":[114],"1":[116],"exon":[117],"has":[119],"weaker":[121],"actin-binding":[122],"affinity,":[123],"however,":[124],"is":[125,134],"not":[126,135],"present.":[127],"TM4,":[128],"encoded":[129],"delta-TM":[132],"present":[136],"either.":[137],"In":[138],"sodium":[139],"dodecyl":[140],"sulfate-polyacrylamide":[141],"gel":[142],"electrophoresis,":[143],"hTM5":[144],"comigrated":[145,157],"slower":[148],"species":[151],"membranes,":[154],"hTM5b":[156],"faster":[160],"species.":[163],"like":[165],"TM5,":[166],"binds":[167],"strongly":[168],"more":[171],"so":[172],"than":[173],"other":[174],"isoforms.":[176],"2":[178],"isoforms,":[181],"therefore,":[182,238],"share":[183],"several":[184],"common":[185,205],"features:":[186],"They":[187],"248":[189],"residues,":[190],"are":[191,217],"long,":[195],"high":[198],"affinities":[199],"toward":[200],"tropomodulin.":[203,266],"These":[204],"features":[206],"key":[210],"mechanism":[213],"formed.":[218],"Tropomodulin-TM5":[219],"or":[220],"tropomodulin-TM5b":[221],"stabilize":[224],"segments":[227],"during":[232],"erythroid":[233],"terminal":[234],"differentiation":[235],"may,":[237],"function":[239],"molecular":[242],"ruler.":[243],"TM5":[244],"TM5b":[246],"further":[247],"define":[248],"geometry":[251],"skeletal":[254],"network":[255],"allow":[257],"actin-regulatory":[258],"functions":[259],"TMs":[261],"modulated":[264],"(Blood.":[267],"2000;95:1473-1480)":[268]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
